中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

99 records (took 0.041 seconds)

    UNIFORM SURFACES FOR HYBRID MATERIAL SUBSTRATES AND METHODS FOR MAKING AND USING SAME
    72.
    发明专利
    UNIFORM SURFACES FOR HYBRID MATERIAL SUBSTRATES AND METHODS FOR MAKING AND USING SAME 未知

    公开(公告)号：CA2631248C

    公开(公告)日：2016-01-12

    申请号：CA2631248

    申请日：2006-11-27

    Applicant: PACIFIC BIOSCIENCES CALIFORNIA

    Inventor： KORLACH JONAS

    IPC: C23C16/00

    Abstract: Devices, systems and methods of using same where hybrid substrate materials are provided with a substantially uniform surface to provide uniformity of properties, including interaction with their environments. Uniform surfaces are applied as coatings over, e.g., hybrid metal/silica, metal/polymer, metal/metal surfaces to mask different chemical properties of differing regions of the surface and to afford a protective surface for the hybrid structure.

    Real-time sequencing methods and systems
    73.
    发明专利
    Real-time sequencing methods and systems 未知

    公开(公告)号：AU2010245304B2

    公开(公告)日：2015-06-04

    申请号：AU2010245304

    申请日：2010-04-26

    Applicant: PACIFIC BIOSCIENCES CALIFORNIA INC

    Inventor： KORLACH JONAS ,  TURNER STEPHEN ,  SCHADT ERIC

    IPC: C12N15/10 ,  C12Q1/68

    Abstract: The present invention is generally directed to compositions, methods, and systems for performing single-molecule, real-time analysis of a variety of different biological reactions. The ability to analyze such reactions provides an opportunity to study those reactions as well as to potentially identify factors and/or approaches for impacting such reactions, e.g., to either enhance or inhibit such reactions. In certain preferred embodiments, RNA templates are used in single-molecule real-time sequencing reactions.

    Modified base detection with nanopore sequencing
    75.
    发明专利
    Modified base detection with nanopore sequencing 未知

    公开(公告)号：GB2517875A

    公开(公告)日：2015-03-04

    申请号：GB201500009

    申请日：2013-06-10

    Applicant: PACIFIC BIOSCIENCES CALIFORNIA

    Inventor： TURNER STEPHEN ,  KORLACH JONAS

    IPC: C12Q1/68

    Abstract: Methods, compositions, and systems are provided for characterization of modified nucleic acids. Nanopore sequencing is performed using a processive enzyme to control the rate of translation of a single strand of a nucleic acid through a nanopore. The presence and identity of a modified base can be determined by monitoring the kinetics of translation through the pore even though the events that lead to the kinetic changes are separated in time and space from the translation of the modified base or it's compliment through the nanopore. The invention also comprises the use of hemi-genomic DNA in nanopore sequencing.

    REAL-TIME SEQUENCING METHODS AND SYSTEMS
    78.
    发明专利
    REAL-TIME SEQUENCING METHODS AND SYSTEMS 未知

    公开(公告)号：CA2760155A1

    公开(公告)日：2010-11-11

    申请号：CA2760155

    申请日：2010-04-26

    Applicant: PACIFIC BIOSCIENCES CALIFORNIA

    Inventor： KORLACH JONAS ,  TURNER STEPHEN ,  SCHADT ERIC

    IPC: C12Q1/68 ,  C12N15/10

    Abstract: The present invention is generally directed to compositions, methods, and systems for performing single-molecule, real-time analysis of a variety of different biological reactions. The ability to analyze such reactions provides an opportunity to study those reactions as well as to potentially identify factors and/or approaches for impacting such reactions, e.g., to either enhance or inhibit such reactions. In certain preferred embodiments, RNA templates are used in single-molecule real-time sequencing reactions.

Patent Agency Ranking