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公开(公告)号：ZA201103411B
公开(公告)日：2012-09-26
申请号：ZA201103411
申请日：2011-05-10
Applicant: VERTEX PHARMA
Inventor： CHARRIER JEAN-DAMIEN , DURRANT STEVEN , KAY DAVID , O'DONNELL MICHAEL , KNEGTEL RONALD , MACCORMICK SOMHAIRLE , PINDER JOANNE , VIRANI ANISA , YOUNG STEPHEN , BINCH HAYLEY , CLEVELAND THOMAS , FANNING LEV T D , HURLEY DENNIS J , JOSHI PRAMOD , SHETH URVI , SILINA ALINA , REAPER PHILIP MICHAEL
IPC: C07D20060101 , A61K20060101 , A61P20060101
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公开(公告)号：BRPI0619706A2
公开(公告)日：2011-10-11
申请号：BRPI0619706
申请日：2006-11-03
Applicant: VERTEX PHARMA
Inventor： BINCH HAYLEY , MORTIMORE MICHAEL , FRAYSSE DAMIEN , DAVIS CHRIS , O'DONNELL MICHAEL , EVERITT SIMON , ROBINSON DANIEL , PINDER JOANNE , MILLER ANDREW
Abstract: The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising those compounds and methods of using the compounds and compositions in the treatment of various disease, conditions, and disorders. The invention also provides processes for preparing compounds of the invention.
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公开(公告)号：MX2011006503A
公开(公告)日：2011-09-06
申请号：MX2011006503
申请日：2009-12-18
Applicant: VERTEX PHARMA
Inventor： MORTIMORE MICHAEL , CHARRIER JEAN-DAMIEN , KAY DAVID , KNEGTEL RONALD , RUTHERFORD ALISTAIR , DURRANT STEVEN , O'DONNELL MICHAEL , YOUNG STEPHEN , PINDER JOANNE , MACCORMICK SOMHAIRLE , VIRANI ANISA NIZARALI , REAPER PHILIP MICHAEL
IPC: C07D413/04 , A61K31/497 , A61P35/00 , C07D401/14 , C07D403/12 , C07D409/14 , C07D413/12 , C07D417/04 , C07D417/12 , C07D471/04
Abstract: La presente invención se refiere a opuestos de pirazina útiles como inhibidores de la proteína cinasa ATR. La invención también se refiere a composiciones farmacéuticamente aceptables que comprenden los compuestos de esta invención; métodos para tratar diversas enfermedades, trastornos y afecciones usando los compuestos de esta invención; procesos para preparar los compuestos de esta invención; intermedios para la preparación de los compuestos de esta invención y métodos para usar los compuestos en aplicaciones in vitro, tales como el estudio de cinasas en fenómenos biológicos y patológicos; el estudio de vías de transducción de señales intracelulares mediadas por las cinasa y la evaluación comparativa de nuevos inhibidores de cinasas. Los compuestos de esta invención tiene fórmula (I): donde las variables son tal como se definen en la presente.
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公开(公告)号：AU2004225977B2
公开(公告)日：2011-03-24
申请号：AU2004225977
申请日：2004-03-25
Applicant: VERTEX PHARMA
Inventor： WANG JIAN , KNEGTEL RONALD , SALITURO FRANCESCO G , FARMER LUC J , STUDLEY JOHN R , O'DONNELL MICHAEL , HARRINGTON EDMUND MARTIN , BRENCHLEY GUY
IPC: C07D417/00 , A61K31/506 , A61P29/00 , A61P35/00 , A61P37/00 , C07D417/04 , C07D417/14
Abstract: The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
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公开(公告)号：NZ549665A
公开(公告)日：2010-09-30
申请号：NZ54966505
申请日：2005-02-28
Applicant: VERTEX PHARMA
Inventor： STUDLEY JOHN R , CHARRIER JEAN-DAMIEN , DURRANT STEVEN , MORTIMORE MICHAEL , O'DONNELL MICHAEL , RUTHERFORD ALISTAIR , RAMAYA SHARN , TRUDEAU MARTIN , LOOKER ADAM
IPC: C07D207/16 , A61K31/401 , A61K31/4025 , A61K31/403 , A61K31/443 , A61K38/04 , A61K38/06 , A61P37/00 , C07D209/52 , C07D401/12 , C07D401/14 , C07D405/12 , C07D417/06 , C07D417/12 , C07K5/02 , C07K5/04
Abstract: Disclosed are compounds of formula I, wherein the substituents are as defined in the specification, processes for their preparation and intermediates for use therein. The compounds are caspase inhibitors useful in the treatment of IL-1 mediated diseases.
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Patent Agency Ranking
公开(公告)号：CA3013000A1
公开(公告)日：2010-06-24
申请号：CA3013000
申请日：2009-12-18
Applicant: VERTEX PHARMA
Inventor： CHARRIER JEAN-DAMIEN , DURRANT STEVEN , KAY DAVID , KNEGTEL RONALD , MACCORMICK SOMHAIRLE , MORTIMORE MICHAEL , O'DONNELL MICHAEL , PINDER JOANNE , REAPER PHILIP MICHAEL , RUTHERFORD ALISTAIR , VIRANI ANISA NIZARALI , YOUNG STEPHEN
IPC: C07D401/14 , A61K31/4965 , A61K31/497 , A61K31/551 , A61K31/553 , C07D241/28 , C07D401/10 , C07D403/04 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/12 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04
Abstract: The present invention relates to pyrazine compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. The compounds of this invention have formula (I): (See Formula I) wherein the variables are as defined herein.
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公开(公告)号：CA2747252A1
公开(公告)日：2010-06-24
申请号：CA2747252
申请日：2009-12-18
Applicant: VERTEX PHARMA
Inventor： CHARRIER JEAN-DAMIEN , DURRANT STEVEN , KAY DAVID , KNEGTEL RONALD , MACCORMICK SOMHAIRLE , MORTIMORE MICHAEL , O'DONNELL MICHAEL , PINDER JOANNE , RUTHERFORD ALISTAIR , VIRANI ANISA NIZARALI , YOUNG STEPHEN , REAPER PHILIP MICHAEL
IPC: C07D413/04 , A61K31/497 , A61P35/00 , C07D401/14 , C07D403/12 , C07D409/14 , C07D413/12 , C07D417/04 , C07D417/12 , C07D471/04
Abstract: The present invention relates to pyrazine compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. The compounds of this invention have formula (I):wherein the variables are as defined herein.
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公开(公告)号：NO20092668A
公开(公告)日：2009-09-21
申请号：NO20092668
申请日：2009-07-13
Applicant: VERTEX PHARMA
Inventor： CHARRIER JEAN DAMIEN , BRENCHLEY GUY , KNEGTEL RONALD , DURRANT STEVEN , MORTIMORE MICHAEL , YOUNG STEPHEN CLINTON , EVERITT SIMON ROBERT LORRIE , PINDER JOANNE LOUISE , RUTHERFORD ALISTAIR PETER , O'DONNELL MICHAEL
IPC: C07D471/04 , A61K31/506 , A61P3/00
CPC classification number: C07D471/04
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公开(公告)号：HK1099757A1
公开(公告)日：2007-08-24
申请号：HK07107033
申请日：2007-07-03
Applicant: VERTEX PHARMA
Inventor： JEAN-DAMIEN CHARRIER J , DURRANT STEVEN , MORTIMORE MICHAEL , O'DONNELL MICHAEL , RUTHERFORD ALISTAIR , RAMAYA SHARN , STUDLEY JOHN R , TRUDEAU MARTIN , LOOKER ADAM
IPC: A61K20060101 , A61K38/04 , A61K38/06 , A61P20060101 , C07D20060101 , C07D207/16 , C07D209/52 , C07D401/12 , C07D401/14 , C07D405/12 , C07D417/06 , C07D417/12 , C07K5/02 , C07K5/04
Abstract: The present invention provides a compound of formula (I): wherein the variables are as defined herein. The present invention also provides processes for preparing the compounds of formula (I), and intermediates thereof, pharmaceutical compositions comprising those compounds, and methods of using the compounds and compositions.
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公开(公告)号：AU2006311831A1
公开(公告)日：2007-05-18
申请号：AU2006311831
申请日：2006-11-03
Applicant: VERTEX PHARMA
Inventor： EVERITT SIMON , MILLER ANDREW , PINDER JOANNE , BINCH HAYLEY , DAVIS CHRIS , FRAYSSE DAMIEN , O'DONNELL MICHAEL , MORTIMORE MICHAEL , ROBINSON DANIEL
Abstract: The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising those compounds and methods of using the compounds and compositions in the treatment of various disease, conditions, and disorders. The invention also provides processes for preparing compounds of the invention.
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