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公开(公告)号：AU2013205040A1
公开(公告)日：2013-05-16
申请号：AU2013205040
申请日：2013-04-13
Applicant: ABBOTT LAB , ENANTA PHARM INC
Inventor： KU YIYIN , MCDANIEL KEITH F , CHEN HUI-JU , SHANLEY JASON P , KEMPF DALE J , GRAMPOVNIK DAVID J , SUN YING , LIU DONG , YONGHUA GAI , OR YAT SUN , WAGAW SABLE H , ENGSTROM KEN , GRIEME TIM , SHEIKH AHMAD , MEI JIANZHANG
Abstract: MACROCYCLIC HEPATITIS C SERINE PROTEASE Abstract The present invention relates to novel macrocyclic compounds and methods of use thereof. The present invention further relates to pharmaceutical compositions comprising the compounds of the present invention, or pharmaceutical acceptable salts, esters, or prodrugs thereof, in combination with a pharmaceutical carrier or excipient.
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公开(公告)号：ES2395386T3
公开(公告)日：2013-02-12
申请号：ES06849251
申请日：2006-12-20
Applicant: ABBOTT LAB
Inventor： BETEBENNER DAVID A , DEGOEY DAVID A , MARING CLARENCE J , KRUEGER ALLAN C , IWASAKI NOBUHIKO , ROCKWAY TODD W , COOPER CURT S , ANDERSON DAVID D , DONNER PAMELA L , GREEN BRIAN E , KEMPF DALE J , LIU DACHUN , MCDANIEL KEITH F , MADIGAN DAROLD L , MOTTER CHRISTOPHER E , PRATT JOHN K , SHANLEY JASON P , TUFANO MICHAEL D , WAGNER ROLF , ZHANG RONG , MOLLA AKHTERUZZAMAN , MO HONGMEI , PILOT-MATIAS TAMI J , MASSE SHERIE , CARRICK ROBERT J , HE WEPING , LU LIANGJUN , GRAMPOVNIK DAVID J
IPC: C07D495/04 , C07D471/04 , C07D513/04
Abstract: Un compuesto, un tautómero del compuesto, o una sal aceptable desde el punto de vista farmacéutico delcompuesto o tautómero, en donde el compuesto se selecciona del grupo que consiste en:un compuesto que tiene la Fórmula II:en donde:R6 se selecciona del grupo que consiste en hidrógeno y ciano;R8 se selecciona del grupo que consiste en hidrógeno y arilalquilo;R25 se selecciona del grupo que consiste en hidrógeno y alquilo;R37 se selecciona del grupo que consiste en hidrógeno, alquilo, hidroxialquilo, y cicloalquilo;R42 se selecciona del grupo que consiste en arilsulfanilo, heteroarilsulfanilo, y ariloxi; en donde R42 estásustituido en forma opcional con uno o más sustituyentes seleccionados en forma independiente de R46;R46 es uno o más sustituyentes seleccionados del grupo que consiste en hidrógeno, hidroxi, amino,halógeno, dialquilamino, y alcoxicarbonilamino;R70 se selecciona del grupo que consiste en arilo, y heterociclo; en donde R70 está sustituido en formaopcional con R75;R75 es uno o más sustituyentes seleccionados en forma independiente del grupo que consiste enhidrógeno, halógeno, alcoxi, ciano, alquilo, haloalquilo, y arilo.un compuesto que tiene la Fórmula III:
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公开(公告)号：SG179414A1
公开(公告)日：2012-04-27
申请号：SG2012014080
申请日：2009-09-10
Applicant: ABBOTT LAB , ENANTA PHARM INC
Inventor： KU YIYIN , MCDANIEL KEITH F , CHEN HUI-JU , SHANLEY JASON P , KEMPF DALE J , GRAMPOVNIK DAVID J , SUN YING , LIU DONG , GAI YONGHUA , OR YAT SUN , WAGAW SABLE H , ENGSTROM KEN , GRIEME TIM , SHEIKH AHMAD , MEI JIANZHANG
Abstract: The present invention relates to novel macrocyclic compounds and methods of use thereof. The present invention further relates to pharmaceutical compositions comprising the compounds of the present invention, or pharmaceutically acceptable salts, esters, or prodrugs thereof, in combination with a pharmaceutically acceptable carrier or excipient.
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公开(公告)号：CR20110123A
公开(公告)日：2011-07-11
申请号：CR20110123
申请日：2011-03-07
Applicant: ENANTA PHARM INC , ABBOTT LAB
Inventor： KU YIYIN , MCDANIEL KEITH F , CHEN HUI-JU , SHANLEY JASON P , KEMPF DALE J , GRAMPOVNIK DAVID J , SUN YING , LIU DONG , GAI YONGHUA , OR YAT SUN , WAGAW SABLE H , ENGSTROM KEN , GRIEME TIM , SHEIKH AHMAD , MEI JIANZHANG
Abstract: La presente invención se relaciona con nuevos compuestos macrocíclicos y con métodos de uso de los mismos. La presente invención también se relaciona con composiciones farmacéuticas que comprenden los compuestos de la presente invención, o las sales, ésteres o prodrogas farmacéuticamente aceptables, en combinación con un vehículo o excipiente farmacéuticamente aceptable.
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公开(公告)号：AT475660T
公开(公告)日：2010-08-15
申请号：AT06848056
申请日：2006-12-20
Applicant: ABBOTT LAB
Inventor： ROCKWAY TODD W , BETEBENNER DAVID A , KRUEGER ALLAN C , IWASAKI NOBUHIKO , COOPER CURT S , ANDERSON DAVID D , KEMPF DALE J , MADIGAN DAROLD L , MOTTER CHRISTOPHER E , SHANLEY JASON P , TUFANO MICHAEL D , WAGNER ROLF , ZHANG RONG , MOLLA AKHTERUZZAMAN , MO HONGMEI , PILOT-MATIAS TAMI , MASSE SHERIE VL , CARRICK ROBERT J , HE WEPING , LU LIANGJUN
IPC: C07D471/04
Abstract: Compounds effective in inhibiting replication of Hepatitis C virus (HCV) or other viruses are disclosed. This invention is also directed to compositions comprising such compounds, co-formulation or co-administration of such compounds with other anti-viral or therapeutic agents, processes and intermediates for the syntheses of such compounds, and methods of using such compounds for the treatment of HCV or other viral infections.
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Patent Agency Ranking
公开(公告)号：HK1122292A1
公开(公告)日：2009-05-15
申请号：HK09101289
申请日：2009-02-11
Applicant: ABBOTT LAB DEPT
Inventor： ROCKWAY TODD W , BETEBENNER DAVID A , KRUEGER ALLAN C , IWASAKI NOBUHIKO , COOPER CURT S , ANDERSON DAVID D , KEMPF DALE J , MADIGAN DAROLD L , MOTTER CHRISTOPHER E , SHANLEY JASON P , TUFANO MICHAEL D , WAGNER ROLF , ZHANG RONG , MOLLA AKHTERUZZAMAN , MO HONGMEI , PILOT-MATIAS TAMI , MASSE SHERIE VL , CARRICK ROBERT J , HE WEPING , LU LIANGJUN
IPC: C07D20060101
Abstract: Compounds effective in inhibiting replication of Hepatitis C virus (HCV) or other viruses are disclosed. This invention is also directed to compositions comprising such compounds, co-formulation or co-administration of such compounds with other anti-viral or therapeutic agents, processes and intermediates for the syntheses of such compounds, and methods of using such compounds for the treatment of HCV or other viral infections.
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公开(公告)号：HK1121765A1
公开(公告)日：2009-04-30
申请号：HK09101934
申请日：2009-03-02
Applicant: ABBOTT LAB
Inventor： BETEBENNER DAVID A , DEGOEY DAVID A , MARING CLARENCE J , KRUEGER ALLAN C , IWASAKI NOBUHIKO , ROCKWAY TODD W , COOPER CURT S , ANDERSON DAVID D , DONNER PAMELA L , GREEN BRIAN E , KEMPF DALE J , LIU DACHUN , MCDANIEL KEITH F , MADIGAN DAROLD L , MOTTER CHRISTOPHER E , PRATT JOHN K , SHANLEY JASON P , TUFANO MICHAEL D , WAGNER ROLF , ZHANG RONG , MOLLA AKHTERUZZAMAN , MO HONGMEI , PILOT-MATIAS TAMI J , MASSE SHERIE VL , CARRICK ROBERT J , HE WEPING , LU LIANGJUN , GRAMPOVNIK DAVID J
IPC: C07D20060101
Abstract: Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) or other viruses are disclosed. This invention is also directed to compositions comprising such compounds, co-formulation or co-administration of such compounds with other anti-viral or therapeutic agents, processes and intermediates for the syntheses of such compounds, and methods of using such compounds for the treatment of HCV or other viral infections.
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公开(公告)号：CA2502856C
公开(公告)日：2009-01-20
申请号：CA2502856
申请日：1993-12-16
Applicant: ABBOTT LAB
Inventor： NORBECK DANIEL W , COOPER ARTHUR J , SHAM HING LEUNG , RENO DANIEL S , SOWIN THOMAS J , ZHAO CHEN , HAIGHT ANTHONY R , KEMPF DALE J
IPC: C07D275/02 , C07F5/02 , A61K31/395 , A61K31/415 , A61K31/4164 , A61K31/42 , A61K31/421 , A61K31/422 , A61K31/425 , A61K31/426 , A61K31/427 , A61K31/535 , A61K31/5375 , A61K31/5377 , A61K31/54 , A61K38/00 , A61K45/06 , A61P31/12 , A61P31/18 , A61P35/00 , A61P35/02 , A61P37/04 , A61P43/00 , C07C33/46 , C07C43/164 , C07C43/174 , C07C43/205 , C07C43/215 , C07C43/23 , C07C43/30 , C07C43/315 , C07C45/00 , C07C45/29 , C07C45/56 , C07C45/62 , C07C45/67 , C07C45/74 , C07C53/134 , C07C69/34 , C07C69/65 , C07C69/732 , C07C211/27 , C07C215/18 , C07C215/20 , C07C215/28 , C07C229/08 , C07C229/26 , C07C229/34 , C07C233/36 , C07C233/40 , C07C235/10 , C07C235/12 , C07C235/34 , C07C235/78 , C07C237/10 , C07C237/20 , C07C237/22 , C07C239/10 , C07C239/18 , C07C239/20 , C07C247/10 , C07C251/40 , C07C271/20 , C07C271/22 , C07C271/34 , C07C275/16 , C07C275/24 , C07C311/03 , C07C311/13 , C07C311/18 , C07C317/10 , C07C317/28 , C07C317/44 , C07C323/12 , C07C323/25 , C07C381/00 , C07D20060101 , C07D213/26 , C07D213/30 , C07D213/34 , C07D213/40 , C07D213/54 , C07D213/56 , C07D213/61 , C07D213/75 , C07D233/54 , C07D233/84 , C07D235/10 , C07D235/14 , C07D235/16 , C07D239/26 , C07D241/12 , C07D261/06 , C07D261/08 , C07D263/24 , C07D263/30 , C07D263/32 , C07D263/48 , C07D265/30 , C07D277/22 , C07D277/24 , C07D277/28 , C07D277/30 , C07D277/32 , C07D277/34 , C07D277/36 , C07D277/40 , C07D277/42 , C07D277/56 , C07D295/13 , C07D295/205 , C07D295/215 , C07D303/36 , C07D307/42 , C07D333/16 , C07D401/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D521/00 , C07F5/04 , C07K5/06 , C07K5/065
Abstract: Borooxazine compounds of the formula are used as intermediates in processes to compounds of the formula
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公开(公告)号：DE69133610D1
公开(公告)日：2009-01-08
申请号：DE69133610
申请日：1991-11-04
Applicant: ABBOTT LAB
Inventor： KEMPF DALE J , CODACOVI LYNN M , NORBECK DANIEL W , PLATTNER JACOB J , SHAM HING L , WITTENBERGER STEVEN J , ZHAO CHEN
IPC: A61K31/42 , C07D277/24 , A61K31/421 , A61K31/425 , A61K31/426 , A61K31/427 , A61K31/435 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/4418 , A61K31/4427 , A61K31/443 , A61K31/444 , A61K38/00 , A61P31/12 , A61P31/18 , A61P43/00 , C07C53/134 , C07C211/00 , C07C215/18 , C07C215/20 , C07C215/28 , C07C215/30 , C07C215/80 , C07C219/18 , C07C233/40 , C07C237/10 , C07C237/22 , C07C269/04 , C07C271/02 , C07C271/16 , C07C271/20 , C07C271/22 , C07C271/34 , C07C275/24 , C07D20060101 , C07D213/00 , C07D213/26 , C07D213/30 , C07D213/34 , C07D213/36 , C07D213/40 , C07D213/54 , C07D213/56 , C07D213/61 , C07D213/75 , C07D213/79 , C07D215/20 , C07D233/54 , C07D233/84 , C07D235/14 , C07D235/16 , C07D237/10 , C07D239/26 , C07D241/12 , C07D261/08 , C07D261/12 , C07D263/20 , C07D263/32 , C07D277/20 , C07D277/28 , C07D277/30 , C07D277/32 , C07D277/34 , C07D277/36 , C07D277/40 , C07D277/42 , C07D277/56 , C07D295/02 , C07D295/13 , C07D295/205 , C07D295/215 , C07D303/36 , C07D307/34 , C07D307/42 , C07D307/66 , C07D333/16 , C07D333/36 , C07D401/12 , C07D405/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D521/00 , C07K1/113 , C07K5/06 , C07K5/065 , C07K5/08 , C07K14/81
Abstract: An intermediate of the formula: and an intermediate of the formula: or an acid addition salt thereof.M
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公开(公告)号：MX2008011222A
公开(公告)日：2008-11-14
申请号：MX2008011222
申请日：2007-02-27
Applicant: ABBOTT LAB
Inventor： KEMPF DALE J , RANDOLPH JOHN T , FLENTGE CHARLES A , KLEIN LARRY L , HUANG PEGGY
Abstract: Los compuestos novedosos de la fórmula I, o una sal farmacéuticamente aceptable de los mismos inhiben la monooxigenasa de citocromo P450.
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