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    System and method for applying curtain gas flow in a mass spectrometer
    115.
    发明授权
    System and method for applying curtain gas flow in a mass spectrometer 有权
    在质谱仪中应用帘式气流的系统和方法

    公开(公告)号：US09437410B2

    公开(公告)日：2016-09-06

    申请号：US14359853

    申请日：2012-11-21

    Applicant: DH Technologies Development Pte. Ltd.

    Inventor： Bruce A. Thomson ,  Mircea Guna

    IPC: H01J49/26 ,  H01J49/04

    CPC classification number: H01J49/0422 ,  H01J49/044 ,  H01J49/26

    Abstract: A system of mass spectrometry is disclosed having an ion source for generating ions at substantially atmospheric pressure. The system has a sampling member with an orifice disposed therein. The sampling member forms a vacuum chamber with a mass spectrometer. The system also has a curtain plate between the ion source and the sampling member. The curtain plate has an aperture therein, having a cross-section and being spaced from the sampling member to define a flow passage between the curtain plate and the sampling member, and to define an annular gap between the orifice and the aperture. The area of the annular gap is less than the cross-sectional area of the aperture. The system also has a power supply for applying a voltage to the curtain plate, and a curtain gas flow mechanism for directing a curtain gas into the flow passage and the annular gap.

    Abstract translation: 公开了一种质谱系统，其具有用于在基本上大气压下产生离子的离子源。 该系统具有设置在其中的孔口的取样构件。 采样构件形成具有质谱仪的真空室。 该系统还在离子源和采样构件之间具有帘板。 帘板在其中具有孔，其具有横截面并且与采样构件间隔开以限定在帘板和采样构件之间的流动通道，并且在孔和孔之间限定环形间隙。 环形间隙的面积小于孔的横截面面积。 该系统还具有用于向帘板施加电压的电源，以及用于将帘式气体引导到流动通道和环形间隙中的帘式气体流动机构。

    Interface for Ion Source and Vacuum Housing
    116.
    发明申请
    Interface for Ion Source and Vacuum Housing 有权
    离子源和真空外壳接口

    公开(公告)号：US20160233074A1

    公开(公告)日：2016-08-11

    申请号：US15023099

    申请日：2014-09-17

    Applicant: MICROMASS UK LIMITED

    Inventor： Anthony Hess ,  Steve O'Brien ,  Ian Trivett

    IPC: H01J49/24 ,  H01J49/00 ,  G01N27/62

    CPC classification number: H01J49/02 ,  G01N27/622 ,  H01J49/0013 ,  H01J49/0031 ,  H01J49/044 ,  H01J49/049 ,  H01J49/10

    Abstract: A mass spectrometer or ion mobility spectrometer is disclosed comprising: an ion block (2) for receiving ions; a heater (8) for heating the ion block (2); a vacuum housing (6); and an interface block (4) arranged between the ion block (2) and the vacuum housing (6); wherein the interface block (4) is formed from a polymer. The polymer interface block (4) inhibits the heat transfer from the ion block (2) to the vacuum housing (6) and also electrically isolates the ion block (2) and vacuum housing (6). The interface block (4) further comprises at least one conduit (12) through the body of the interface block (4). This enables gas to be transmitted through the interface block (4) to the ion block (2), and also enables the interface block (4) to be cooled.

    Abstract translation: 公开了一种质谱仪或离子迁移谱仪，包括：用于接收离子的离子块（2） 用于加热离子块（2）的加热器（8）; 真空壳体（6）; 和布置在离子块（2）和真空壳体（6）之间的界面块（4）; 其中所述界面块（4）由聚合物形成。 聚合物界面块（4）抑制从离子块（2）到真空壳体（6）的热传递，并且电离离子块（2）和真空壳体（6）。 接口块（4）还包括穿过接口块（4）的主体的至少一个导管（12）。 这使得气体能够通过界面块（4）传递到离子块（2），并且还使接口块（4）能够被冷却。

    MASS SPECTROMETRY USING LASERSPRAY IONIZATION
    117.
    发明申请
    MASS SPECTROMETRY USING LASERSPRAY IONIZATION 审中-公开
    使用激光离子化的质谱法

    公开(公告)号：US20160211126A1

    公开(公告)日：2016-07-21

    申请号：US14918269

    申请日：2015-10-20

    Applicant: Sarah Trimpin

    Inventor： Sarah Trimpin

    IPC: H01J49/04 ,  H01J49/16

    CPC classification number: H01J49/044 ,  H01J27/24 ,  H01J49/0468 ,  H01J49/164

    Abstract: Disclosed herein are systems and methods for mass spectrometry using laserspray ionization (LSI). LSI can create multiply-charged ions at atmospheric pressure for analysis and allows for analysis of high molecular weight molecules including molecules over 4000 Daltons. The analysis can be solvent-based or solvent-free. Solvent-free analysis following LSI allows for improved spatial resolution beneficial in surface and/or tissue imaging.

    Abstract translation: 本文公开了使用激光喷射电离（LSI）的质谱的系统和方法。 LSI可以在大气压下产生多电荷离子进行分析，并允许分析高分子量分子，包括超过4000道尔顿的分子。 分析可以是溶剂型或无溶剂型。 在LSI之后的无溶剂分析允许有利于表面和/或组织成像的改善的空间分辨率。

    IONIZATION CHAMBER WITH TEMPERATURE-CONTROLLED GAS FEED
    118.
    发明申请
    IONIZATION CHAMBER WITH TEMPERATURE-CONTROLLED GAS FEED 有权
    具有温度控制气体进料的离子室

    公开(公告)号：US20160086784A1

    公开(公告)日：2016-03-24

    申请号：US14826388

    申请日：2015-08-14

    Applicant: Bruker Daltonik GmbH

    Inventor： Andreas BREKENFELD ,  Martin ENGEL

    IPC: H01J49/04 ,  H01J49/10

    CPC classification number: H01J49/0486 ,  C03B19/12 ,  C04B35/14 ,  H01J49/0422 ,  H01J49/044 ,  H01J49/045 ,  H01J49/0477 ,  H01J49/10 ,  Y02P40/57

    Abstract: The invention relates to an ionization chamber for connection to a mass spectrometer. The ionization chamber has a temperature-control block with a gas inlet and a gas channel which starts at the gas inlet and leads into a gas outlet. A temperature-control device is positioned along the gas channel and ensures that a gas flowing in the gas channel is brought to a specific temperature, i.e. it is heated or cooled, before it enters the ionization chamber. The temperature-control block has a formed part into which a structure of the gas channel is incorporated and which is fabricated by means of a sol-gel process, for example out of a glass or ceramic material.

    Abstract translation: 本发明涉及一种用于连接到质谱仪的电离室。 电离室具有温度控制块，其具有气体入口和气体通道，其从气体入口开始并导入气体出口。 温度控制装置沿着气体通道定位，并且确保在气体通道中流动的气体在进入电离室之前被带到特定温度，即被加热或冷却。 温度控制块具有形成部分，其中结合有气体通道的结构，并且其通过溶胶 - 凝胶法制造，例如由玻璃或陶瓷材料制成。

    OFF-AXIS CHANNEL IN ELECTROSPRAY IONIZATION FOR REMOVAL OF PARTICULATE MATTER
    119.
    发明申请
    OFF-AXIS CHANNEL IN ELECTROSPRAY IONIZATION FOR REMOVAL OF PARTICULATE MATTER 有权
    用于去除颗粒物的电离离子离轴通道

    公开(公告)号：US20150364314A1

    公开(公告)日：2015-12-17

    申请号：US14301431

    申请日：2014-06-11

    Applicant: Bruker Daltonics, Inc.

    Inventor： David KENNEDY ,  Kerry NUGENT

    IPC: H01J49/16

    CPC classification number: H01J49/0404 ,  H01J49/044 ,  H01J49/165 ,  H01J49/167

    Abstract: The present invention relates to electrospray ionization (ESI) at atmospheric pressure coupled with a mass spectrometer, in particular to a special kind of micro-electrospray with liquid flows in the range of 0.1 to 100 microliters per minute. The invention describes the use of an off-axis pre-entrance channel in an ESI ion source to prevent particulate matter with higher inertia than the (charged) gas molecules, such as droplets, from entering the mass spectrometer. The elimination of the particulate matter improves the quantitative precision of an LC/MS bioassay, minimizes the contamination of the mass spectrometer and improves the robustness for high throughput assays.

    Abstract translation: 本发明涉及在大气压力下与质谱联用的电喷雾离子化（ESI），特别涉及一种特殊类型的微电喷雾，液体流速为0.1至100微升/分钟。 本发明描述了在ESI离子源中使用离轴预入口通道来防止比（带电）的气体分子（例如液滴）更高的惯性的颗粒物质进入质谱仪。 颗粒物的消除提高了LC / MS生物测定的定量精度，最大限度地降低了质谱仪的污染，并提高了高通量测定的鲁棒性。

    MASS ANALYSER INTERFACE
    120.
    发明申请
    MASS ANALYSER INTERFACE 有权
    质量分析仪界面

    公开(公告)号：US20140197333A1

    公开(公告)日：2014-07-17

    申请号：US13740985

    申请日：2013-01-14

    Applicant: Charles Jolliffe ,  Lisa Cousins ,  Gholamreza Javahery

    Inventor： Charles Jolliffe ,  Lisa Cousins ,  Gholamreza Javahery

    IPC: H01J49/04

    CPC classification number: H01J49/044 ,  H01J49/062

    Abstract: A mass analyzer includes a desolvation chamber into which an upstream gas is injected to provide a counter-flow to said downstream flow in the chamber. The counter-flow may slow the downstream flow of solvated ionized particles in the chamber, while allowing lighter desolvated ions to travel toward an outlet aperture of the desolvation chamber.

    Abstract translation: 质量分析器包括去溶剂化室，注入上游气体以向腔室中的所述下游流动提供逆流。 逆流可以减缓腔室中溶剂化的离子化颗粒的下游流动，同时允许较轻的去溶剂离子朝向去溶剂化室的出口孔行进。

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