公开(公告)号：US11642051B2

公开(公告)日：2023-05-09

申请号：US16777851

申请日：2020-01-30

Applicant: Benjamin Mbouombouo ,  Alan Abul-Haj ,  Roxanne Abul-Haj ,  Christopher Slawinski ,  Alodeep Sanyal ,  Kevin Hazen

Inventor： Benjamin Mbouombouo ,  Alan Abul-Haj ,  Roxanne Abul-Haj ,  Christopher Slawinski ,  Alodeep Sanyal ,  Kevin Hazen

IPC: A61B5/1455 ,  A61B5/00 ,  A61B5/145 ,  G01N33/49 ,  G01J3/10

CPC classification number: A61B5/1455 ,  A61B5/0022 ,  A61B5/0051 ,  A61B5/0053 ,  A61B5/14532 ,  A61B5/6824 ,  A61B5/6832 ,  G01J3/10 ,  G01N33/49 ,  A61B5/0004 ,  A61B5/7264 ,  A61B2562/0233 ,  A61B2562/0238 ,  A61B2562/046 ,  G01J2003/102 ,  G01J2003/106

Abstract: The invention comprises a method and apparatus for sampling a common tissue volume and/or a common skin layer skin of a person as a part of noninvasive analyte property determination system, comprising the steps of: providing an analyzer, comprising at least three detectors at least partially embedded in a probe housing, the probe housing comprising a sample side surface, the detectors including a first and second range of detection zones of differing radial distances from a first illumination zone and second illumination zone, respectively coupled to separate sources; repetitively illuminating the illumination zones of the skin with photons in a range of 1200 to 2500 nm; and detecting portions of light from the sources with the at least three detectors, the detectors positioned on a common line with the sources.

公开(公告)号：US10071205B2

公开(公告)日：2018-09-11

申请号：US15315621

申请日：2015-06-09

Applicant: SANOFI-AVENTIS DEUTSCHLAND GMBH

Inventor： Gertrud Blei ,  Gunter Heumann

IPC: A61M5/31 ,  G01N21/55

CPC classification number: A61M5/31 ,  A61M5/168 ,  A61M5/1723 ,  A61M2005/3126 ,  A61M2205/3306 ,  A61M2205/3313 ,  A61M2205/50 ,  A61M2205/502 ,  A61M2205/52 ,  A61M2205/6081 ,  A61M2205/8206 ,  G01J3/0208 ,  G01J3/021 ,  G01J3/0229 ,  G01J3/0256 ,  G01J3/0289 ,  G01J3/10 ,  G01J2003/104 ,  G01J2003/106 ,  G01N21/55 ,  G01N2201/062 ,  G01N2201/08 ,  G06K9/2018 ,  G06K9/2027 ,  G06K9/4652 ,  G06K2209/01

Abstract: Apparatus for determining information associated with reflection characteristics of a surface comprising a sensor (60) configured to generate sensor output dependent on an intensity of light incident on the sensor and having a field of view directed at an external surface (57) in use; an illumination source (58) configured to emit light onto the external surface in use; an optically transparent window (61) located such as to allow light to pass from the illumination source to the external surface and to allow light to pass to the sensor from the external surface in use; a light concentrator (66) fixed to or integral with the window, the light concentrator being configured to concentrate at least some light from the illumination source onto the external surface in use such that the concentrated light may be reflected from the external surface onto the sensor via the window; and a processor (40) configured to use the sensor output to determine information associated with reflection characteristics of the external surface.

公开(公告)号：US20180100788A1

公开(公告)日：2018-04-12

申请号：US15830513

申请日：2017-12-04

Applicant: The Penn State Research Foundation

Inventor： Benjamin Hall ,  Jonathan Lynch ,  Edward W. Reutzel ,  Galen Lynch ,  Brian T. Reinhardt

IPC: G01N1/44 ,  G01J3/28 ,  G01N1/06 ,  G01J3/00 ,  G01N1/28 ,  G01N1/04

CPC classification number: G01N1/44 ,  G01J3/00 ,  G01J3/2823 ,  G01J3/44 ,  G01J3/443 ,  G01J2003/106 ,  G01N1/06 ,  G01N2001/045 ,  G01N2001/2886 ,  G01N2201/06113

Abstract: A laser ablation tomography system includes a specimen stage for supporting a specimen. A specimen axis is defined such that a specimen disposed generally on the axis may be imaged. A laser system is operable to produce a laser sheet in a plane intersecting the specimen axis and generally perpendicular thereto. An imaging system is operable to image the area where the laser sheet intersects the specimen axis.

公开(公告)号：US09526427B2

公开(公告)日：2016-12-27

申请号：US15151419

申请日：2016-05-10

Applicant: Hypermed Imaging, Inc.

Inventor： Mark Anthony Darty ,  Michael Tilleman ,  Peter Meenen ,  Dmitry Yudovsky

IPC: G01N21/25 ,  A61B5/00 ,  A61B5/145 ,  G01J3/28 ,  G01J3/02

CPC classification number: A61B5/0075 ,  A61B5/0079 ,  A61B5/145 ,  A61B5/443 ,  A61B5/444 ,  A61B2090/309 ,  A61B2562/0238 ,  G01J3/0208 ,  G01J3/0294 ,  G01J3/10 ,  G01J3/2803 ,  G01J3/2823 ,  G01J2003/106 ,  G01J2003/1239 ,  G01J2003/2826 ,  G02B27/106 ,  H04N5/2256 ,  H04N5/23293 ,  H04N5/2354 ,  H04N5/332 ,  H04N9/045 ,  H04N9/097

Abstract: Provided are methods and systems for concurrent imaging at multiple wavelengths. In one aspect, an imaging device includes at least one objective lens configured to receive light backscattered by an object, a plurality of pixel array photo-sensors, a plurality of bandpass filters covering respective photo-sensors, where each bandpass filter is configured to allow a different respective spectral band to pass through the filter, and a beam steering assembly in optical communication with the at least one objective lens and the photo-sensors. The beam steering assembly directs light received by at least one objective lens from the tissue of a subject to at least one pixel array photo-sensor in the plurality of pixel array photo-sensors.

Abstract translation: 提供了用于在多个波长下并发成像的方法和系统。 一方面，一种成像装置包括至少一个物镜，其被配置为接收由物体反向散射的光，多个像素阵列光传感器，覆盖相应光传感器的多个带通滤光器，其中每个带通滤光器被配置为允许 通过滤光器的不同的相应光谱带，以及与所述至少一个物镜和光传感器光学通信的光束转向组件。 光束转向组件将由至少一个物镜接收的光从受试者的组织引导到多个像素阵列光传感器中的至少一个像素阵列光传感器。

公开(公告)号：US20150211928A1

公开(公告)日：2015-07-30

申请号：US14427481

申请日：2014-06-20

Applicant: Panasonic Intellectual Property Management Co., Lt

Inventor： Tatsuo Itoh ,  Koichi Kusukame ,  Aki Yoneda

IPC: G01J3/427 ,  G01J3/10

CPC classification number: G01J3/427 ,  G01J3/0208 ,  G01J3/021 ,  G01J3/0224 ,  G01J3/0237 ,  G01J3/0243 ,  G01J3/0278 ,  G01J3/0289 ,  G01J3/10 ,  G01J3/2803 ,  G01J3/32 ,  G01J3/42 ,  G01J3/433 ,  G01J2001/4242 ,  G01J2003/064 ,  G01J2003/102 ,  G01J2003/104 ,  G01J2003/106 ,  G01N21/359

Abstract: A light radiating portion (11a, 11b, 12, 51, 52) radiates light with wavelength λ1 having predetermined absorptivity for an object (16) and light with wavelength λ2 having smaller absorptivity for the object (16) than the wavelength λ1, to a target, so as to scan in 2-dimensional directions. A light receiving portion (17) receives scattered lights reflected by the target based on light with wavelength λ1 and light with wavelength λ2. A measuring portion (18) generates information used for detection of the object (16) at the target, based on difference between the two scattered lights with wavelength λ1 and wavelength λ2 received by the light receiving portion (17). An output portion (53) outputs whether or not the object is present at the target, by 2-dimensional area information, based on scanning by the light radiating portion (11a, 11b, 12, 51, 52) and information generated by the measuring portion (18).

Abstract translation: 光辐射部分（11a，11b，12,51,52）将对物体（16）具有预定吸收率的波长λ1的光和对象（16）的波长λ1的波长λ2的波长比波长λ1辐射到 目标，以便在二维方向扫描。 光接收部分（17）基于具有波长λ1的光和波长λ2的光接收由目标反射的散射光。 测量部分（18）基于由光接收部分（17）接收的波长λ1和波长λ2的两个散射光之间的差异，生成用于目标物体（16）的检测的信息。 输出部（53）基于由光照射部（11a，11b，12,51,52）的扫描和由测量生成的信息，通过二维区域信息，输出对象是否存在于目标 部分（18）。

公开(公告)号：US20140002809A1

公开(公告)日：2014-01-02

申请号：US13931091

申请日：2013-06-28

Applicant: ON-SITE ANALYSIS INC

Inventor： James GREER ,  Robert J. GUTHRIE ,  John COATES

IPC: G01J3/42

CPC classification number: G01J3/42 ,  G01J3/0218 ,  G01J3/0264 ,  G01J3/027 ,  G01J3/0291 ,  G01J3/0294 ,  G01J3/10 ,  G01J3/427 ,  G01J2003/106 ,  G01N21/0303 ,  G01N21/31 ,  G01N21/33 ,  G01N21/3577

Abstract: A simple and compact apparatus, and a method, for determining the characteristics of a number of fluids used in the truck and automotive industries including coolant, bio-diesel, gas-ethanol and diesel engine fluid (DEF). The apparatus includes a sample container providing optical paths of different lengths for making measurements on a sample. The dual path length design allows the apparatus to capture both NIR and UV spectral ranges. The qualitative and quantitative properties of the fluid under test are compared to test results under normal conditions or to the properties of unused fluid. Two light sources are used within a spectrometer with each source being associated with a different optical path length.

Abstract translation: 用于确定卡车和汽车工业中使用的许多流体的特性的简单且紧凑的装置和方法，包括冷却剂，生物柴油，汽油 - 乙醇和柴油机流体（DEF）。 该装置包括提供不同长度的光路以便对样品进行测量的样品容器。 双路径长度设计允许设备捕获NIR和UV光谱范围。 将待测流体的定性和定量性质与正常条件下的试验结果或未使用流体的性质进行比较。 在光谱仪中使用两个光源，每个光源与不同的光路长度相关联。

公开(公告)号：US08351032B2

公开(公告)日：2013-01-08

申请号：US12947612

申请日：2010-11-16

Applicant: Heinrich Grueger ,  Jens Knobbe ,  Thomas Egloff ,  Michael Mueller

Inventor： Heinrich Grueger ,  Jens Knobbe ,  Thomas Egloff ,  Michael Mueller

IPC: G01J3/28

CPC classification number: G01J3/18 ,  G01J3/0256 ,  G01J3/10 ,  G01J2003/106 ,  G01J2003/1282 ,  G01J2003/1286 ,  Y10T29/49826

Abstract: A radiation generation device for generating resulting electromagnetic radiation having an adjustable spectral composition includes: a multitude of radiation elements (configured to generate a radiation element specific electromagnetic radiation, respectively, upon being activated, a first radiation element of the multitude of radiation elements being activatable independently of a second radiation element of the multitude of radiation elements; a dispersive optical element; and an optical opening; the dispersive optical element being configured to deflect the radiation element specific electromagnetic radiations, in dependence on their wavelength and on a position of the radiation element generating the respective radiation element specific electromagnetic radiation, such that a particular spectral range of each of the radiation element specific electromagnetic radiations may exit through the optical opening, so that the spectral composition of the resulting electromagnetic radiation exiting through the optical opening is adjustable by selectively activating the multitude of radiation elements.

Abstract translation: 用于产生具有可调光谱组成的所得电磁辐射的辐射产生装置包括：多个辐射元件（被配置为分别在激活时产生辐射元件特定的电磁辐射，多个辐射元件的第一辐射元件可激活 独立于多个辐射元件的第二辐射元件;分散光学元件;以及光学开口;所述分散光学元件被配置为根据它们的波长和放射线的位置偏转辐射元件特定的电磁辐射 产生相应的辐射元件特定电磁辐射的元件，使得每个辐射元件特定电磁辐射的特定光谱范围可以通过光学开口离开，使得所得到的电磁辐射的光谱组成 通过选择性地激活多个辐射元件可以调节通过光学开口的出射。

公开(公告)号：US12104956B2

公开(公告)日：2024-10-01

申请号：US17690100

申请日：2022-03-09

Applicant: SEOUL VIOSYS CO., LTD.

Inventor： Seong Tae Jang ,  Stella Park ,  Sung Il Park ,  Ji Ye Song ,  Woong Ki Jeong

IPC: G01J3/42 ,  A61B5/00 ,  G01J3/02 ,  G01J3/10 ,  G01J3/28 ,  G01N21/31 ,  G02B6/12 ,  G02B7/02 ,  G01N21/27 ,  G01N21/64

CPC classification number: G01J3/42 ,  A61B5/0075 ,  A61B5/441 ,  A61B5/6898 ,  G01J3/0256 ,  G01J3/027 ,  G01J3/0291 ,  G01J3/0297 ,  G01J3/10 ,  G01J3/2803 ,  G01J3/2823 ,  G01N21/31 ,  G02B6/12 ,  G02B7/02 ,  G01J2003/104 ,  G01J2003/106 ,  G01J2003/2859 ,  G01J2003/2866 ,  G01J2003/425 ,  G01N21/278 ,  G01N2021/3181 ,  G01N21/6456 ,  G01N21/6486 ,  G01N2201/0221 ,  G01N2201/0627 ,  G02B2006/12083

Abstract: In one aspect, a hyperspectral image measurement device is provided to include: a main body; an illumination module disposed in the main body and including LEDs having different peak wavelengths to irradiate light to a subject; a camera disposed on the main body and receiving light reflected from the subject to acquire an image of the subject; a barrel having a contact surface contacting the subject, the contact surface located to be spaced apart from the illumination module and the camera module by a predetermined distance; and a reference cover located on the contact surface and including a standard reflection layer for reflecting light irradiated from the illumination module toward the camera module.

公开(公告)号：US12050127B2

公开(公告)日：2024-07-30

申请号：US17476595

申请日：2021-09-16

Applicant: CHROMA ATE INC.

Inventor： Hsuan-An Chen ,  Chi-Ming Wen

IPC: G01J3/02 ,  G01J3/10 ,  G01J3/44

CPC classification number: G01J3/0235 ,  G01J3/0202 ,  G01J3/4406 ,  G01J2003/106

Abstract: A fluorescence detection system is provided and adapted to provide a selectable excitation beam to an optical transmission path for irradiation of a device under test, including a driving module, a lighting module, a first optical module and a second optical module. The driving module includes a first shaft and a second shaft parallel thereto. The lighting module is fixed to the first shaft. The first optical module and the second optical module are fixed to the second shaft. A driving operation enables the driving module to rotate the lighting module, the first optical module and the second optical module simultaneously, determining quickly a combination of one light source, one filter and one spectroscopic module on the optical transmission path, with the combination corresponding in position to the device under test, so as to reduce the volume and cost the fluorescence detection system.

公开(公告)号：US12042279B2

公开(公告)日：2024-07-23

申请号：US16777829

申请日：2020-01-30

Applicant: LIFEPLUS Inc.

Inventor： Christopher Slawinski ,  Kevin Hazen ,  Roxanne Abul-Haj ,  Benjamin Mbouombouo ,  Alodeep Sanyal ,  Alan Abul-Haj

IPC: A61B5/1455 ,  A61B5/00 ,  A61B5/145 ,  G01J3/10 ,  G01N33/49

CPC classification number: A61B5/1455 ,  A61B5/0022 ,  A61B5/0051 ,  A61B5/0053 ,  A61B5/14532 ,  A61B5/6824 ,  A61B5/6832 ,  G01J3/10 ,  G01N33/49 ,  A61B5/0004 ,  A61B5/7264 ,  A61B2562/0233 ,  A61B2562/0238 ,  A61B2562/046 ,  G01J2003/102 ,  G01J2003/106

Abstract: The invention comprises a method and apparatus for selecting optical pathways sampling a common tissue position, such as a lateral mean range in the dermis, of a person for analysis in a noninvasive analyte property determination system, comprising the steps of: probing skin with a range of illumination zone-to-detection zone distances with at least two wavelength ranges, which optionally overlap, and selecting, using a metric, illumination zone-to-detection zone distances having mean optical pathways probing the common tissue layer, such as without the mean optical pathways entering the subcutaneous fat layer of the person. Optionally, the skin tissue layers are modulated and/or treated via tissue displacement before and/or during data collection.