公开(公告)号：US11830717B2

公开(公告)日：2023-11-28

申请号：US18134887

申请日：2023-04-14

Applicant: Purdue Research Foundation

Inventor： Robert Graham Cooks ,  Zane Baird ,  Wen-Ping Peng

IPC: H01J49/06 ,  H01J49/10 ,  H01J49/16 ,  H01J49/26

CPC classification number: H01J49/067 ,  H01J49/06 ,  H01J49/10 ,  H01J49/165 ,  H01J49/26

Abstract: The invention generally relates to apparatuses for focusing ions at or above ambient pressure and methods of use thereof. In certain embodiments, the invention provides an apparatus for focusing ions that includes an electrode having a cavity, at least one inlet within the electrode configured to operatively couple with an ionization source, such that discharge generated by the ionization source is injected into the cavity of the electrode, and an outlet. The cavity in the electrode is shaped such that upon application of voltage to the electrode, ions within the cavity are focused and directed to the outlet, which is positioned such that a proximal end of the outlet receives the focused ions and a distal end of the outlet is open to ambient pressure.

公开(公告)号：US11823884B2

公开(公告)日：2023-11-21

申请号：US17674356

申请日：2022-02-17

Applicant: Elemental Scientific, Inc.

Inventor： Austin Schultz

IPC: G01N30/20 ,  H01J49/04 ,  H01J49/10 ,  G01N30/02

CPC classification number: H01J49/0431 ,  G01N30/20 ,  H01J49/105 ,  G01N2030/027

Abstract: Systems and methods are described to concentrate and homogenize a remote sample for analysis. A sample concentration and homogenization system embodiment includes, but is not limited to, at least a first valve, at least a first column fluidically coupled to the first valve, a flow meter fluidically coupled with the first column when the first valve is in a first flow path configuration to measure an amount of the liquid sample passed through the first column, and a homogenization valve including a sample homogenizing loop in which the concentrated sample is homogenized.

公开(公告)号：US11756781B2

公开(公告)日：2023-09-12

申请号：US17221075

申请日：2021-04-02

Applicant: Thermo Finnigan LLC

Inventor： Christopher Mullen

IPC: H01J49/10 ,  H01J49/04 ,  H01J49/26 ,  H01J49/00

CPC classification number: H01J49/107 ,  H01J49/0072 ,  H01J49/0468 ,  H01J49/0495 ,  H01J49/26

Abstract: Disclosed herein is an apparatus for supplying reagent ions, for example ETD or PTR reagent ions, to a mass spectrometer. The apparatus includes a reagent material reservoir, coupled to a carrier gas supply, which delivers an entrained reagent vapor flow to an inlet of a mixing junction through a first flow restrictor. A control gas flow of carrier gas is delivered to another inlet of the mixing junction via a variable pressure regulator and a second flow restrictor. The outlet of the mixing junction is coupled via a third flow restrictor and a reagent transfer junction to an inlet of an ionizer, such as a glow-discharge ionizer. By dynamic adjustment of the output pressure of the variable pressure regulator, the flow rate of reagent vapor may be controlled over a broad range, even for reagent materials of relatively high volatility.

公开(公告)号：US11742194B2

公开(公告)日：2023-08-29

申请号：US17356753

申请日：2021-06-24

Applicant: Bruker Scientific LLC

Inventor： Jordan Krechmer ,  Brian D. Musselman

IPC: H01J49/04 ,  H01J49/14 ,  G01N27/64 ,  H01J49/00 ,  H01J27/26 ,  H01J49/12 ,  G01N27/626 ,  H01J49/10 ,  H01J49/24

CPC classification number: H01J49/049 ,  G01N27/626 ,  G01N27/64 ,  H01J27/26 ,  H01J49/004 ,  H01J49/04 ,  H01J49/0431 ,  H01J49/10 ,  H01J49/126 ,  H01J49/14 ,  H01J49/24 ,  Y10T436/24

Abstract: The present invention is directed to a method and device to desorb an analyte using heat to allow desorption of the analyte molecules, where the desorbed analyte molecules are ionized with ambient temperature ionizing species. In various embodiments of the invention a current is passed through a mesh upon which the analyte molecules are present. The current heats the mesh and results in desorption of the analyte molecules which then interact with gas phase metastable neutral molecules or atoms to form analyte ions characteristic of the analyte molecules.

公开(公告)号：US11733247B2

公开(公告)日：2023-08-22

申请号：US16604933

申请日：2018-04-13

Applicant: Micromass UK Limited

Inventor： Stevan Bajic ,  Jeffery Mark Brown

IPC: H01J49/10 ,  G01N33/68 ,  G01N30/72 ,  H01J49/00 ,  H01J49/16 ,  H01J49/06 ,  H01J49/04

CPC classification number: G01N33/6857 ,  G01N30/7266 ,  G01N33/6848 ,  H01J49/0068 ,  H01J49/045 ,  H01J49/062 ,  H01J49/165 ,  H01J49/168

Abstract: A method of ionising a sample is disclosed comprising nebulising a sample which includes first biomolecules such as bovine insulin comprising one or more disulphide (S—S) bonds. A stream of droplet or charged droplets comprising one or more disulphide (S—S) bonds is directed so as to impact upon a target (106) or electrode so as to cause the breaking of a portion of the disulphide bonds. Alternatively, charged droplets may pass through an electric field region determined by an electrode (106) arranged downstream of a nebuliser or electrospray probe and an ion inlet (104) of a mass spectrometer so as to cause the breaking of a portion of the disulphide bonds.

公开(公告)号：US20230260772A1

公开(公告)日：2023-08-17

申请号：US18134887

申请日：2023-04-14

Applicant: Purdue Research Foundation

Inventor： Robert Graham Cooks ,  Zane Baird ,  Wen-Ping Peng

IPC: H01J49/06 ,  H01J49/10 ,  H01J49/16 ,  H01J49/26

CPC classification number: H01J49/067 ,  H01J49/06 ,  H01J49/10 ,  H01J49/165 ,  H01J49/26

Abstract: The invention generally relates to apparatuses for focusing ions at or above ambient pressure and methods of use thereof. In certain embodiments, the invention provides an apparatus for focusing ions that includes an electrode having a cavity, at least one inlet within the electrode configured to operatively couple with an ionization source, such that discharge generated by the ionization source is injected into the cavity of the electrode, and an outlet. The cavity in the electrode is shaped such that upon application of voltage to the electrode, ions within the cavity are focused and directed to the outlet, which is positioned such that a proximal end of the outlet receives the focused ions and a distal end of the outlet is open to ambient pressure.

公开(公告)号：US11710627B2

公开(公告)日：2023-07-25

申请号：US17558925

申请日：2021-12-22

Applicant: Micromass UK Limited

Inventor： Emrys Jones ,  Steven Derek Pringle ,  Keith Richardson ,  James Ian Langridge ,  Zoltan Takats

IPC: G01N30/72 ,  H01J49/04 ,  A61B10/02 ,  A61B18/00 ,  A61B18/14 ,  A61B18/20 ,  G01N3/00 ,  G01N9/00 ,  G01N33/68 ,  H01J49/00 ,  H01J49/06 ,  H01J49/16 ,  G16B20/50 ,  G01N27/623 ,  A61B90/13 ,  A61B1/04 ,  A61B1/273 ,  A61B5/00 ,  A61B5/01 ,  A61B5/0507 ,  A61B5/055 ,  A61B6/03 ,  A61B8/13 ,  A61B10/00 ,  A61B17/00 ,  A61B18/04 ,  A61B18/18 ,  A61F13/38 ,  C12Q1/02 ,  C12Q1/04 ,  C12Q1/18 ,  C12Q1/24 ,  G01N1/22 ,  G01N27/624 ,  G01N33/487 ,  G01N33/92 ,  H01J49/02 ,  H01J49/10 ,  H01J49/14 ,  H01J49/24 ,  H01J49/26 ,  G16B20/00 ,  A61B17/32 ,  G16H10/40 ,  G16H15/00 ,  G16H50/20 ,  A61B1/00 ,  A61B1/31 ,  A61B5/145

CPC classification number: H01J49/049 ,  A61B1/041 ,  A61B1/2736 ,  A61B5/0066 ,  A61B5/0075 ,  A61B5/015 ,  A61B5/055 ,  A61B5/0507 ,  A61B6/032 ,  A61B6/037 ,  A61B8/13 ,  A61B10/00 ,  A61B10/0041 ,  A61B10/0233 ,  A61B10/0283 ,  A61B17/00 ,  A61B18/00 ,  A61B18/04 ,  A61B18/042 ,  A61B18/14 ,  A61B18/1445 ,  A61B18/1815 ,  A61B18/20 ,  A61B90/13 ,  A61F13/38 ,  C12Q1/025 ,  C12Q1/04 ,  C12Q1/18 ,  C12Q1/24 ,  G01N1/2202 ,  G01N3/00 ,  G01N9/00 ,  G01N27/623 ,  G01N27/624 ,  G01N30/724 ,  G01N33/487 ,  G01N33/6848 ,  G01N33/6851 ,  G01N33/92 ,  G16B20/50 ,  H01J49/0004 ,  H01J49/0027 ,  H01J49/0031 ,  H01J49/0036 ,  H01J49/025 ,  H01J49/044 ,  H01J49/0404 ,  H01J49/0409 ,  H01J49/0422 ,  H01J49/0445 ,  H01J49/0459 ,  H01J49/0463 ,  H01J49/0468 ,  H01J49/061 ,  H01J49/068 ,  H01J49/10 ,  H01J49/14 ,  H01J49/16 ,  H01J49/164 ,  H01J49/24 ,  H01J49/26 ,  A61B1/00013 ,  A61B1/31 ,  A61B5/14542 ,  A61B17/320068 ,  A61B2010/0083 ,  A61B2017/320069 ,  A61B2018/00577 ,  A61B2018/00589 ,  A61B2018/00994 ,  A61B2218/002 ,  A61B2218/008 ,  G01N33/48735 ,  G01N2001/2223 ,  G01N2333/195 ,  G01N2405/00 ,  G01N2405/04 ,  G01N2405/08 ,  G01N2570/00 ,  G01N2800/26 ,  G16B20/00 ,  G16H10/40 ,  G16H15/00 ,  G16H50/20

Abstract: A method of analysis using mass spectrometry and/or ion mobility spectrometry is disclosed comprising: (a) using a first device to generate smoke, aerosol or vapour from a target in vitro or ex vivo cell population; (b) mass analysing and/or ion mobility analysing said smoke, aerosol or vapour, or ions derived therefrom, in order to obtain spectrometric data; and (c) analysing said spectrometric data in order to identify and/or characterise said target cell population or one or more cells and/or compounds present in said target cell population.

公开(公告)号：US20230170197A1

公开(公告)日：2023-06-01

申请号：US18059107

申请日：2022-11-28

Applicant: COMMISSARIA À L'ÉNERGIE ATOMIQUE ET AUX ÉNERGIES ALTERNATIVES

Inventor： Isabelle Isnard ,  Marta Garcia-Cortes

IPC: H01J49/00 ,  H01J49/10

CPC classification number: H01J49/005 ,  H01J49/0027 ,  H01J49/105

Abstract: A method for measuring a sample comprising silicon by mass spectrometry is implemented from an inductively coupled plasma-tandem mass spectrometer, or ICP-MS/MS. The measurement method comprises a step of measuring by mass spectrometry by a reactive gas. The reactive gas comprising nitrous oxide.

公开(公告)号：US11664208B2

公开(公告)日：2023-05-30

申请号：US17097961

申请日：2020-11-13

Applicant: INSTITUTE OF GEOLOGY AND GEOPHYSICS, CHINESE ACADEMY OF SCIENCES

Inventor： Shitou Wu ,  Yadong Wu ,  Yueheng Yang ,  Hao Wang ,  Chao Huang ,  Liewen Xie

IPC: H01J49/00 ,  G01N33/24 ,  H01J49/04 ,  H01J49/10 ,  H01J49/16

CPC classification number: H01J49/0036 ,  G01N33/24 ,  H01J49/0463 ,  H01J49/105 ,  H01J49/164

Abstract: The present disclosure provides a method for simultaneously measuring the value of forsterite and trace elements in olivine, comprising the following steps: Step S1: selecting samples, wherein the samples are olivine samples; Step S2: placing the samples in a sample chamber of LA-ICP-MS, and adjusting the position of the samples in the optical axis direction so that the laser beam is well focused; Step S3: optimizing the instrument to make the signal-to-noise ratio of 57Fe be the best; Step S4: adopting LA-ICP-MS peak hopping mode and receiving all the mass peaks of the samples by single electron multiplier (SEM). The present disclosure overcomes the disadvantages of long test cycle and high test cost in the prior art.

公开(公告)号：US11630050B2

公开(公告)日：2023-04-18

申请号：US17382764

申请日：2021-07-22

Applicant: Fluidigm Canada Inc.

Inventor： Alexandre Loboda

IPC: G01N15/10 ,  H01J49/10 ,  G01N15/14 ,  H01J49/04 ,  G01N15/00 ,  H01J49/40

Abstract: The invention relates to methods and devices for analysis of samples using laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS). The invention provides methods and devices in which individual ablation plumes are distinctively captured and transferred to the ICP, followed by analysis by mass cytometry.