公开(公告)号：US20170040152A1

公开(公告)日：2017-02-09

申请号：US15332734

申请日：2016-10-24

Applicant: Thermo Fisher Scientific (Bremen) GmbH

Inventor： Alexander Alekseevich MAKAROV

IPC: H01J49/28 ,  H01J49/08 ,  H01J49/02

CPC classification number: H01J49/282 ,  H01J49/027 ,  H01J49/08 ,  H01J49/38 ,  H01J49/4245

Abstract: Mass analyzers and methods of ion detection for a mass analyzer are provided. An electrostatic field generator provides an electrostatic field causing ion packets to oscillate along a direction. A pulse transient signal is detected over a time duration that is significantly shorter than a period of the ion oscillation or using pulse detection electrodes having a width that is significantly smaller than a span of ion harmonic motion. A harmonic transient signal is also detected. Ion intensity with respect to mass-to-charge ratio is then identified based on the pulse transient signal and the harmonic transient signal.

Abstract translation: 提供了用于质量分析仪的质量分析仪和离子检测方法。 静电场发生器提供静电场，使离子包沿着一个方向振荡。 在比离子振荡的周期短的持续时间内检测脉冲瞬态信号，或使用具有明显小于离子谐波运动的跨度的宽度的脉冲检测电极。 还检测到谐波瞬态信号。 然后基于脉冲瞬态信号和谐波瞬态信号来识别关于质荷比的离子强度。

公开(公告)号：US09472389B2

公开(公告)日：2016-10-18

申请号：US14440767

申请日：2013-11-15

Applicant: Thermo Fisher Scientific (Bremen) GmbH

Inventor： Michael Krummen ,  Michael Deerberg ,  Johannes Schwieters

IPC: H01J49/28 ,  H01J49/10 ,  H01J49/16

CPC classification number: H01J49/10 ,  H01J49/168 ,  H01J49/28

Abstract: An ion source assembly for a static mass spectrometer, comprises: a mounting element for locating the assembly within the static mass spectrometer; an ion source for generating ions to be analyzed in the static mass spectrometer, the ion source being spaced from the mounting element and arranged to be held in use at a first relatively high potential V1 with respect to the mounting element; and a spacer mounted between the mounting element and the ion source, the spacer arranged to be held in use at a second potential V2 with respect to the mounting element, which is less than the first potential V1.

Abstract translation: 一种用于静态质谱仪的离子源组件，包括：用于将组件定位在静态质谱仪内的安装元件; 用于在所述静态质谱仪中产生要分析的离子的离子源，所述离子源与所述安装元件间隔开并且布置成相对于所述安装元件保持在第一相对高电位V1的使用中; 以及安装在所述安装元件和所述离子源之间的间隔件，所述间隔件布置成相对于所述安装元件保持在使用中的第二电位V2小于所述第一电位V1。

公开(公告)号：US09324552B2

公开(公告)日：2016-04-26

申请号：US13713792

申请日：2012-12-13

Applicant: Academia Sinica

Inventor： Kent J. Gillig ,  Chung-Hsuan Chen

IPC: H01J49/28 ,  G01N27/62 ,  H01J49/26 ,  H01J49/22 ,  H01J49/00

CPC classification number: H01J49/26 ,  G01N27/624 ,  H01J49/0031 ,  H01J49/22

Abstract: A periodic field differential mobility analyzer apparatus for separating and identifying ionic analytes employs a series of elongated parallel channels, a pump, a first voltage providing an electric field Ex in a direction opposing the gas flow, a second voltage providing an electric field Ey in a direction perpendicular to the gas flow, an ion source, and a detector. The periodic field differential mobility analyzer provides high resolution and sensitivity.

Abstract translation: 用于分离和鉴定离子分析物的周期性场差分迁移率分析仪装置采用一系列细长的平行通道，泵，在与气流相反的方向上提供电场Ex的第一电压，在第一电压中提供电场Ey 垂直于气流的方向，离子源和检测器。 周期场差分迁移率分析仪提供高分辨率和灵敏度。

公开(公告)号：US20150357175A1

公开(公告)日：2015-12-10

申请号：US14760639

申请日：2014-01-07

Applicant: LUXEMBOURG INSTITUTE OF SCIENCE AND TECHNOLOGY (LIST)

Inventor： Hung Quang Hoang ,  David Dowsett ,  Tom Wirtz

IPC: H01J49/28 ,  H01J49/20 ,  H01J49/02

CPC classification number: H01J49/28 ,  H01J49/025 ,  H01J49/20 ,  H01J49/30

Abstract: The present invention relates to a compact and portable mass spectrometer device comprising a source of ions, a non-scanning magnetic sector for separating ions originating at the source of ions according to their mass-to-charge ratios, and a detection means. The magnetic sector comprises an ion entrance plane and at least two ion exit planes, which allow to optimize the resolving power of the mass spectrometer for specific mass-to charge ratio sub-ranges.

Abstract translation: 本发明涉及一种包括离子源的紧凑且便携的质谱仪装置，以及用于根据其质荷比分离源自离子源的离子的​​非扫描磁性扇区和检测装置。 磁性部分包括离子入射面和至少两个离子出射平面，其允许优化用于特定质量 - 电荷比子范围的质谱仪的分辨能力。

公开(公告)号：US20150340220A1

公开(公告)日：2015-11-26

申请号：US14717369

申请日：2015-05-20

Applicant: Thermo Fisher Scientific (Bremen) GmbH

Inventor： Christian Albrecht HOCK ,  Dmitry GRINFELD ,  Richard HEMING

IPC: H01J49/06 ,  H01J49/28 ,  H01J49/42 ,  H01J49/04 ,  H01J49/40

CPC classification number: H01J49/427 ,  H01J49/0031 ,  H01J49/0481 ,  H01J49/063 ,  H01J49/282 ,  H01J49/40 ,  H01J49/4225 ,  H01J49/424 ,  H01J49/4245

Abstract: A method of ejecting ions to be analysed from a quadrupole ion trap in which a trapping field is created by one or more RF voltages applied to one or more electrodes of the trap, the method comprising the steps of cooling the ions to be analysed within the quadrupole ion trap until the ions are thermalized, reducing the amplitude of one or more RF voltages applied to the quadrupole ion trap and applying the reduced amplitude RF voltages for one half cycle after the one or more RF voltages have reached a zero crossing point, turning off the RF voltages applied to the quadrupole ion trap, and ejecting the ions to be analysed from the quadrupole ion trap.

Abstract translation: 从四极离子阱中排出要分析的离子的方法，其中通过施加到阱的一个或多个电极的一个或多个RF电压产生捕获场，该方法包括以下步骤：将待分析的离子冷却在 四极离子阱，直到离子被热化，减少施加到四极离子阱的一个或多个RF电压的幅度，并且在一个或多个RF电压已经达到过零点之后将减小幅度的RF电压施加一个半周期，转动 关闭施加到四极离子阱的RF电压，并从四极离子阱中喷射待分析的离子。

公开(公告)号：US09117638B2

公开(公告)日：2015-08-25

申请号：US14365982

申请日：2012-11-28

Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.

Inventor： Mauro Aiello

IPC: B01D59/44 ,  H01J49/00 ,  H01J49/28 ,  G01N27/62 ,  G01N30/72

CPC classification number: H01J49/0031 ,  G01N27/622 ,  G01N30/72 ,  H01J49/004

Abstract: A scan of a separating sample mixture is received from a mass spectrometer at each interval of a plurality of intervals. It is determined at a first interval that a received mass spectrometry scan at the first interval and one or more preceding received mass spectrometry scans include a varying ion signal that represents an ion of a known compound and has an intensity above a threshold level. The mass spectrometer is instructed to perform a dependent scan for the ion at the first interval producing a spectrum for the known compound. A second interval is selected after the first interval where the varying ion signal has an intensity that is not above the threshold level. The mass spectrometer is instructed to perform a dependent scan for the ion at the second interval producing a spectrum for a background.

Abstract translation: 从质谱仪以多个间隔的每个间隔接收分离样品混合物的扫描。 在第一间隔确定接收的质谱扫描在第一间隔和一个或多个先前接收的质谱扫描包括表示已知化合物的离子并且具有高于阈值水平的强度的变化的离子信号。 指示质谱仪在第一个间隔对离子进行依赖扫描，产生已知化合物的光谱。 在第一间隔之后选择第二间隔，其中变化的离子信号具有不高于阈值水平的强度。 指示质谱仪在第二间隔对离子进行依赖扫描，产生背景光谱。

公开(公告)号：US09111654B2

公开(公告)日：2015-08-18

申请号：US14003487

申请日：2012-03-07

Applicant: Kevin Giles ,  Martin Raymond Green ,  Daniel James Kenny ,  David J. Langridge ,  Jason Lee Wildgoose

Inventor： Kevin Giles ,  Martin Raymond Green ,  Daniel James Kenny ,  David J. Langridge ,  Jason Lee Wildgoose

IPC: H01J49/26 ,  G21K1/00 ,  H01J49/42 ,  H01J49/28

CPC classification number: G21K1/00 ,  H01J49/062 ,  H01J49/28 ,  H01J49/427

Abstract: An ion guide is disclosed comprising a plurality of electrodes. A first device is arranged and adapted to apply a RF voltage to at least some of the electrodes in order to form, in use, a pseudo-potential well which acts to confine ions in a first direction within the ion guide. A second device is arranged and adapted to apply a DC voltage to at least some of the electrodes in order to form, in use, a DC potential well which acts to confine ions in a second direction within the ion guide. A third device is arranged and adapted to cause ions having desired or undesired mass to charge ratios to be mass to charge ratio selectively ejected from the ion guide in the second direction.

Abstract translation: 公开了一种离子导向器，其包括多个电极。 第一装置被布置并适于将RF电压施加到至少一些电极，以在使用中形成用于将离子限制在离子导向器内的第一方向上的伪电位阱。 第二装置被布置并适于将DC电压施加到至少一些电极，以在使用中形成用于在离子导向器内沿第二方向限制离子的DC势阱。 第三装置被布置并适于使具有期望或不需要的质量的充电比例的离子成为从第二方向从离子导向器选择性地喷射的质荷比。

公开(公告)号：US09087684B2

公开(公告)日：2015-07-21

申请号：US14084549

申请日：2013-11-19

Applicant: Thermo Finnigan LLC

Inventor： Alexander Alekseevich Makarov

IPC: H01J49/28 ,  H01J49/00 ,  H01J49/42 ,  H01J49/22

CPC classification number: H01J49/282 ,  H01J49/0009 ,  H01J49/0031 ,  H01J49/22 ,  H01J49/424 ,  H01J49/425

Abstract: This invention relates generally to multi-reflection electrostatic systems, and more particularly to improvements in and relating to the Orbitrap electrostatic ion trap. A method of operating an electrostatic ion trapping device having an array of electrodes operable to mimic a single electrode is proposed, the method comprising determining three or more different voltages that, when applied to respective electrodes of the plurality of electrodes, generate an electrostatic trapping field that approximates the field that would be generated by applying a voltage to the single electrode, and applying the three or more so determined voltages to the respective electrodes. Further improvements lie in measuring a plurality of features from peaks with different intensities from one or more collected mass spectra to derive characteristics, and using the measured characteristics to improve the voltages to be applied to the plurality of electrodes.

Abstract translation: 本发明一般涉及多反射静电系统，更具体地涉及Orbitrap静电离子阱的改进和涉及。 提出了一种操作具有可操作以模拟单个电极的电极阵列的静电离子捕获装置的方法，所述方法包括确定当施加到多个电极的各个电极时产生静电捕获场的三个或更多个不同的电压 其近似于将通过向单个电极施加电压而产生的场，以及将三个或更多个如此确定的电压施加到各个电极。 进一步的改进在于从具有不同强度的峰与一个或多个收集的质谱测量多个特征以导出特性，并且使用测量的特性来改善施加到多个电极的电压。

公开(公告)号：US08933397B1

公开(公告)日：2015-01-13

申请号：US13758282

申请日：2013-02-04

Applicant: University of Northern Iowa Research Foundation

Inventor： Curtiss Dwight Hanson

IPC: H01J49/00 ,  H01J49/30 ,  H01J49/42 ,  H01J49/28

CPC classification number: H01J49/065 ,  H01J9/14 ,  H01J49/0027 ,  H01J49/0031 ,  H01J49/10 ,  H01J49/282 ,  H01J49/42 ,  H01J49/4225 ,  H01J49/4235 ,  H01J49/425

Abstract: In one aspect of the invention, an ion trap mass analyzer includes a variable- or multi-potential type ion guide (MPIG) assembly which has been pre-configured to produce a parabolic-type potential field. Each MPIG electrode has a resistive coating of designed characteristics. In one example the coating varies in thickness long the length of an underlying uniform substrate. The MPIG assembly can be a single MPIG electrode or an array of a plurality of MPIG electrodes. An array can facilitate delocalization for improved performance. This chemical modification of a uniform underlying substrate promotes cheaper and flexible instruments. The modified MPIG electrodes also allow miniaturization (e.g. micro and perhaps even nano-scale), which allows miniaturization of the instrument in which the single or plural modified MPIG electrode(s) are placed. This promotes portability and field use instead of limitation to laboratory settings.

Abstract translation: 在本发明的一个方面，离子阱质量分析器包括已经预配置成产生抛物线型电场的可变或多电位型离子导向器（MPIG）组件。 每个MPIG电极具有设计特性的电阻涂层。 在一个实例中，涂层的厚度长度在下面的均匀基底的长度上变化。 MPIG组件可以是单个MPIG电极或多个MPIG电极的阵列。 阵列可以促进离域化以提高性能。 统一的底层衬底的这种化学改性促进了便宜和灵活的仪器。 改进的MPIG电极还允许小型化（例如微量甚至是纳米尺度），这允许其中放置单个或多个修改的MPIG电极的仪器的小型化。 这促进了可移植性和现场使用，而不是限于实验室设置。

公开(公告)号：US20140048696A1

公开(公告)日：2014-02-20

申请号：US14003487

申请日：2012-03-07

Applicant: Kevin Giles ,  Martin Raymond Green ,  Daniel James Kenny ,  David J. Langridge ,  Jason Lee Wildgoose

Inventor： Kevin Giles ,  Martin Raymond Green ,  Daniel James Kenny ,  David J. Langridge ,  Jason Lee Wildgoose

IPC: G21K1/00 ,  H01J49/28

CPC classification number: G21K1/00 ,  H01J49/062 ,  H01J49/28 ,  H01J49/427

Abstract: An ion guide is disclosed comprising a plurality of electrodes. A first device is arranged and adapted to apply a RF voltage to at least some of the electrodes in order to form, in use, a pseudo-potential well which acts to confine ions in a first direction within the ion guide. A second device is arranged and adapted to apply a DC voltage to at least some of the electrodes in order to form, in use, a DC potential well which acts to confine ions in a second direction within the ion guide. A third device is arranged and adapted to cause ions having desired or undesired mass to charge ratios to be mass to charge ratio selectively ejected from the ion guide in the second direction.

Abstract translation: 公开了一种离子导向器，其包括多个电极。 第一装置被布置并适于将RF电压施加到至少一些电极，以在使用中形成用于将离子限制在离子导向器内的第一方向上的伪电位阱。 第二装置被布置并适于将DC电压施加到至少一些电极，以在使用中形成用于在离子导向器内沿第二方向限制离子的DC势阱。 第三装置被布置并适于使具有期望或不需要的质量的充电比例的离子成为从第二方向从离子导向器选择性地喷射的质荷比。