公开(公告)号：US20180202919A1

公开(公告)日：2018-07-19

申请号：US15921173

申请日：2018-03-14

Applicant: THERMO ELECTRON SCIENTIFIC INSTRUMENTS LLC

Inventor： Damian W. ASHMEAD ,  James V. HOWARD ,  Kevin K. KIM ,  Andrew Martin BRAASCH

IPC: G01N21/03 ,  G01N21/27 ,  G01N21/31 ,  G01R33/07 ,  G01R33/09 ,  G01D5/14

CPC classification number: G01N21/0303 ,  G01D5/145 ,  G01N21/27 ,  G01N21/31 ,  G01N2021/035 ,  G01N2021/036 ,  G01N2201/0668 ,  G01N2201/08 ,  G01R33/07 ,  G01R33/093

Abstract: An embodiment of a path length calibration system is described that comprises a swing arm coupled to a first surface; a base coupled to a second surface configured to receive the sample; a position sensor system comprising a first component coupled to the swing arm and a second component coupled to the base, wherein the position sensor system is configured to provide an output voltage when the swing arm is in a down position; and a processor configured to calibrate a zero path length using the output voltage.

公开(公告)号：US20180196193A1

公开(公告)日：2018-07-12

申请号：US15737743

申请日：2016-06-17

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Aydogan Ozcan ,  Brandon Berg ,  Bingen Cortazar ,  Derek Tseng ,  Steve Wei Feng ,  Haydar Ozkan ,  Omai Garner ,  Dino Di Carlo

IPC: G02B6/06 ,  G01N21/25 ,  G06F15/18 ,  H04N5/225

CPC classification number: G02B6/06 ,  G01N21/253 ,  G01N2201/0221 ,  G01N2201/08 ,  G06N20/00 ,  H04N5/225

Abstract: A micro-plate reader for use with a portable electronic device having a camera includes an opto-mechanical attachment configured to attach/detach to the portable electronic device and includes an array of illumination sources. A slot in the opto-mechanical attachment is dimensioned to receive an optically transparent plate containing an array of wells. Optical fibers are located in the opto-mechanical attachment and transmit light from each well to a reduced size header having, wherein the fiber array in the header has a cross-sectional area that is ≤10× the cross-sectional area of the wells in the plate. A lens located in the opto-mechanical attachment transmits light from the header fibers to the camera. Software executed on the portable electronic device or other computer is used to process the images to generate qualitative clinical determinations and/or quantitative index values for the separate wells.

公开(公告)号：US20180188181A1

公开(公告)日：2018-07-05

申请号：US15736797

申请日：2016-07-13

Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION

Inventor： Shunichiro NOBUKI ,  Muneo MAESHIMA ,  Kenta IMAI

IPC: G01N21/76 ,  G01N35/10

CPC classification number: G01N21/76 ,  G01N21/0303 ,  G01N21/253 ,  G01N35/1002 ,  G01N2201/08 ,  G02B6/0096 ,  G02B6/4298

Abstract: A highly reflective light-guide system has a highly reflective light-guide surface for reflecting light that has been emitted from a sample and has entered from an entry port opposing a window material and propagating the same to an exit port opposing a light reception surface of a photodetector. An optical filter is provided in a space surrounded by the window material, the photodetector, and the highly reflective light-guide system and transmits the signal luminescence to be measured that is emitted from the sample between the window material and photodetector. The optical filter is fixed to the window material or photodetector by an adhesive, and the peripheral shape of the optical filter is smaller than the shape of the inside of a fitting part to which the optical filter is fitted and that is formed on the highly reflective light-guide system.

公开(公告)号：US20180155781A1

公开(公告)日：2018-06-07

申请号：US15786215

申请日：2017-10-17

Applicant: Pacific Biosciences of California, Inc.

Inventor： Nathaniel Joseph MCCAFFREY ,  Stephen TURNER ,  Ravi SAXENA, JR. ,  Scott Edward HELGESEN

IPC: C12Q1/6874 ,  C12Q1/6825

CPC classification number: C12Q1/6874 ,  B01L3/502707 ,  B01L3/502715 ,  B01L2300/0654 ,  B01L2300/0663 ,  B01L2300/0816 ,  B01L2300/168 ,  B82Y20/00 ,  C12Q1/6825 ,  C12Q1/6869 ,  G01N21/03 ,  G01N21/0303 ,  G01N21/05 ,  G01N21/64 ,  G01N21/6428 ,  G01N21/645 ,  G01N21/6452 ,  G01N21/6454 ,  G01N21/6456 ,  G01N21/648 ,  G01N21/75 ,  G01N21/77 ,  G01N33/54373 ,  G01N2021/0346 ,  G01N2021/6434 ,  G01N2021/6439 ,  G01N2021/6441 ,  G01N2021/6463 ,  G01N2021/757 ,  G01N2021/7786 ,  G01N2201/067 ,  G01N2201/068 ,  G01N2201/08 ,  G02B6/1226 ,  Y10T436/143333

Abstract: An analytical assembly within a unified device structure for integration into an analytical system. The analytical assembly is scalable and includes a plurality of analytical devices, each of which includes a reaction cell, an optical sensor, and at least one optical element positioned in optical communication with both the reaction cell and the sensor and which delivers optical signals from the cell to the sensor. Additional elements are optionally integrated into the analytical assembly. Methods for forming and operating the analytical system are also disclosed.

公开(公告)号：US20180120280A1

公开(公告)日：2018-05-03

申请号：US15855201

申请日：2017-12-27

Applicant: Omni Medsci, Inc.

Inventor： Mohammed N. ISLAM

IPC: G01N33/15 ,  A61B5/00 ,  A61B5/1455 ,  A61B5/145 ,  G01J3/10 ,  G01J3/28 ,  G01J3/453 ,  G01N21/359 ,  G01N21/3563 ,  G01N21/39 ,  G01N21/88 ,  G01N33/02 ,  G01N33/44 ,  G01N33/49

CPC classification number: G01N33/15 ,  A61B5/0013 ,  A61B5/0022 ,  A61B5/0075 ,  A61B5/0086 ,  A61B5/0088 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/4547 ,  A61B2562/0233 ,  A61B2562/0238 ,  A61B2562/146 ,  A61B2576/02 ,  G01J3/108 ,  G01J3/14 ,  G01J3/1838 ,  G01J3/28 ,  G01J3/2823 ,  G01J3/453 ,  G01J2003/104 ,  G01J2003/2826 ,  G01M3/38 ,  G01N21/3504 ,  G01N21/3563 ,  G01N21/359 ,  G01N21/39 ,  G01N21/88 ,  G01N33/02 ,  G01N33/442 ,  G01N33/49 ,  G01N2021/3513 ,  G01N2021/399 ,  G01N2201/061 ,  G01N2201/062 ,  G01N2201/08 ,  G01N2201/12 ,  H01S3/302

Abstract: A measurement system includes a light source having semiconductor sources configured to generate an input optical beam, a multiplexer configured form an intermediate optical beam from the input optical beam, fibers including a fused silica fiber configured to receive the intermediate optical beam and to form an output optical beam. The output optical beam comprises wavelengths between 700 and 2500 nanometers with a bandwidth of at least 10 nanometers. A measurement apparatus is configured to deliver the output beam to a sample to generate a spectroscopy output beam. A receiver is configured to receive and process the spectroscopy output beam to generate an output signal, wherein the receiver processing includes chemometrics or multivariate analysis methods to permit identification of materials within the sample, the light source and the receiver are remote from the sample, and the sample includes plastics or food industry goods.

公开(公告)号：US20180120229A1

公开(公告)日：2018-05-03

申请号：US15845996

申请日：2017-12-18

Applicant: Quantum-Si Incorporated

Inventor： Jonathan M. Rothberg ,  Ali Kabiri ,  Jason W. Sickler ,  Brett J. Gyarfas ,  Jeremy Lackey ,  Gerard Schmid ,  Lawrence C. West ,  Keith G. Fife ,  Benjamin Cipriany ,  Farshid Ghasemi

IPC: G01N21/64

CPC classification number: G01N21/6408 ,  C12Q1/6869 ,  C12Q1/6874 ,  G01N21/6428 ,  G01N21/6454 ,  G01N21/648 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6439 ,  G01N2021/6463 ,  G01N2201/0696 ,  G01N2201/08 ,  G01N2201/12

Abstract: System and methods for analyzing single molecules and performing nucleic acid sequencing. An integrated device includes multiple pixels with sample wells configured to receive a sample, which when excited, emits radiation. The integrated device includes at least one waveguide configured to propagate excitation energy to the sample wells from a region of the integrated device configured to couple with an excitation energy source. A pixel may also include at least one element for directing the emission energy towards a sensor within the pixel. The system also includes an instrument that interfaces with the integrated device. The instrument may include an excitation energy source for providing excitation energy to the integrated device by coupling to an excitation energy coupling region of the integrated device. One of multiple markers distinguishable by temporal parameters of the emission energy may label the sample and configuration of the sensor within a pixel may allow for detection of a temporal parameter associated with the marker labeling the sample.

公开(公告)号：US20180067112A1

公开(公告)日：2018-03-08

申请号：US15696806

申请日：2017-09-06

Applicant: Toshiba Medical Systems Corporation

Inventor： Naoko MURASE ,  Isao Nawata ,  Shoichi Kanayama

IPC: G01N33/543 ,  G01N21/77

CPC classification number: G01N33/54373 ,  G01N21/552 ,  G01N21/77 ,  G01N21/7703 ,  G01N2201/08

Abstract: According to one embodiment, a specimen measurement apparatus includes a detector, a reaction promoter and processing circuitry. The detector generates an electrical signal based on a reactive state in a reaction chamber in which a mixture of a test substance and a reagent is contained. The reaction promoter supplies to the reaction chamber energy to promote reaction in the reaction chamber. The processing circuitry switches an energy supply state in accordance with a predetermined time schedule, determines a stationary state of the test substance based on an electrical signal generated after the energy supply state is switched, and outputs the stationary state obtained by the determination.

公开(公告)号：US09912121B2

公开(公告)日：2018-03-06

申请号：US15149595

申请日：2016-05-09

Applicant: Palo Alto Research Center Incorporated

Inventor： Thomas Wunderer ,  Christopher L. Chua ,  Brent S. Krusor ,  Noble M. Johnson

IPC: G01N21/41 ,  H01S5/00 ,  H01S3/08 ,  H01S5/183 ,  G02B5/08 ,  H01S5/343 ,  B82Y20/00 ,  G01N21/17

CPC classification number: H01S5/18363 ,  B82Y20/00 ,  G01N21/17 ,  G01N21/41 ,  G01N2201/0635 ,  G01N2201/08 ,  G02B5/0816 ,  G02B5/085 ,  H01S5/18308 ,  H01S5/18341 ,  H01S5/18369 ,  H01S5/18377 ,  H01S5/34333 ,  H01S2304/04

Abstract: A device includes one or more reflector components. Each reflector component comprises layer pairs of epitaxially grown reflective layers and layers of a non-epitaxial material, such as air. Vias extend through at least some of the layers of the reflector components. The device may include a light emitting layer.

公开(公告)号：US09897537B2

公开(公告)日：2018-02-20

申请号：US14949284

申请日：2015-11-23

Applicant: International Business Machines Corporation

Inventor： Tymon Barwicz ,  William M. Green ,  Yves C. Martin ,  Jason S. Orcutt ,  Lionel Tombez

IPC: G01N21/00 ,  G01N21/39 ,  G01N21/3504 ,  G01J3/42 ,  G01N21/552 ,  G01J3/02 ,  G02B6/12 ,  G02B6/122

CPC classification number: G01N21/39 ,  G01J3/0218 ,  G01J3/0256 ,  G01J3/42 ,  G01J2003/423 ,  G01N21/3504 ,  G01N21/552 ,  G01N2021/399 ,  G01N2201/06113 ,  G01N2201/063 ,  G01N2201/08 ,  G02B6/12004 ,  G02B6/12007 ,  G02B6/122 ,  G02B2006/12138 ,  G02B2006/1215

Abstract: A method of fabricating a gas sensor on a substrate and a gas sensor fabricated on a substrate that includes optical and electronic components are described. The method includes fabricating a laser to output light over a range of wavelengths within a waveguide, fabricating a splitter to split the light output by the laser to a reference waveguide and to a detection waveguide, fabricating a reference cell to house the reference waveguide and a reference gas. An output of the reference waveguide is coupled to a first optical detector and an output of the detection waveguide is coupled to a second optical detector to identify or quantify an ambient gas.

公开(公告)号：US09891109B2

公开(公告)日：2018-02-13

申请号：US14974040

申请日：2015-12-18

Applicant: Nix Sensor Ltd.

Inventor： Matthew Sheridan

IPC: G01J3/46 ,  G01J3/50 ,  G01N21/25 ,  G01N21/47

CPC classification number: G01J3/50 ,  G01J3/0202 ,  G01J3/0205 ,  G01J3/0216 ,  G01J3/0262 ,  G01J3/0264 ,  G01J3/0272 ,  G01J3/0291 ,  G01J3/501 ,  G01N21/251 ,  G01N2021/4757 ,  G01N2201/0221 ,  G01N2201/062 ,  G01N2201/08

Abstract: The present concept is a portable color sensor for measuring color of a substrate that includes a single flat printed circuit board with a top and bottom side which includes at least one LED light and one color sensor and at least one light pipe receiving light from the LED and transmitting it onto a substrate at an angle theta. It also includes a tube frame including an optical tube for receiving light reflections from the substrate and directing the reflections to the color sensor. The light pipes and the tube frame, are mounted and compression fit between the printed circuit board and a lower housing.