公开(公告)号：US08781560B2

公开(公告)日：2014-07-15

申请号：US13228717

申请日：2011-09-09

Applicant: Shabbir Bakir Bambot ,  Mark Faupel ,  Jonathan David Mongin

Inventor： Shabbir Bakir Bambot ,  Mark Faupel ,  Jonathan David Mongin

IPC: A61B5/00

CPC classification number: A61B5/4331 ,  A61B5/0059 ,  A61B5/0068 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0077 ,  G01J3/02 ,  G01J3/0208 ,  G01J3/0218 ,  G01J3/0229 ,  G01J3/0232 ,  G01J3/0262 ,  G01J3/0264 ,  G01J3/027 ,  G01J3/0272 ,  G01J3/0283 ,  G01J3/0291 ,  G01J3/10 ,  G01J3/28 ,  G01J3/4406 ,  G01J2003/1213 ,  G01J2003/2866 ,  G01N21/274 ,  G01N21/31 ,  G01N21/474 ,  G01N21/645 ,  G01N2021/6417 ,  G01N2021/6423 ,  G01N2021/6484 ,  G01N2201/0221

Abstract: A method and apparatus are provided that interrogate, receive, and analyze full emission spectra for at least one fluorescence excitation wavelength and for at least one reflectance measurement to determine tissue characteristics and correlate same to photographic images. Further, the system and method accomplish this measurement rapidly by increasing the light throughput by integrating optics into a hand held unit and avoiding the need for a coherent fiber optic bundle being used. The method includes illuminating a first portion of a target tissue with optical energy, forming a first image of the target tissue, illuminating a second portion of the target tissue with optical energy, performing spectroscopic measurements on optical energy reflected and/or emitted by the target tissue upon illumination of the second portion of the target tissue with optical energy, and determining tissue characteristics of the target tissue based on the results of the spectroscopic measurements.

Abstract translation: 提供了一种方法和装置，用于询问，接收和分析至少一种荧光激发波长的全发射光谱，以及至少一次反射测量以确定组织特征并将其与摄影图像相关联。 此外，该系统和方法通过将光学器件集成到手持式单元中并且避免对使用的相干光纤束的需要而增加光通量而快速地完成该测量。 该方法包括用光能照射目标组织的第一部分，形成目标组织的第一图像，用光能照射目标组织的第二部分，对目标反射和/或发射的光能进行光谱测量 基于光谱测量的结果确定目标组织的第二部分的光能量的组织，以及确定靶组织的组织特征。

公开(公告)号：US08730047B2

公开(公告)日：2014-05-20

申请号：US13444989

申请日：2012-04-12

Applicant: Trent Ridder ,  Ben Ver Steeg ,  Oscar Lazaro

Inventor： Trent Ridder ,  Ben Ver Steeg ,  Oscar Lazaro

IPC: G08B13/14 ,  A61B5/1455

CPC classification number: A61B5/0075 ,  A61B5/0088 ,  A61B5/117 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/1495 ,  G01J3/02 ,  G01J3/0205 ,  G01J3/0218 ,  G01J3/0229 ,  G01J3/0264 ,  G01J3/0291 ,  G01J3/10 ,  G01J3/14 ,  G01J2003/1286 ,  G01N21/274 ,  G01N21/359 ,  G01N21/474 ,  G01N2201/129

Abstract: An apparatus and method for noninvasive determination of analyte properties of human tissue by quantitative infrared spectroscopy to clinically relevant levels of precision and accuracy. The system includes subsystems optimized to contend with the complexities of the tissue spectrum, high signal-to-noise ratio and photometric accuracy requirements, tissue sampling errors, calibration maintenance problems, and calibration transfer problems. The subsystems can include an illumination/modulation subsystem, a tissue sampling subsystem, a data acquisition subsystem, a computing subsystem, and a calibration subsystem. The invention can provide analyte property determination and identity determination or verification from the same spectroscopic information, making unauthorized use or misleading results less likely than in systems that use separate analyte and identity determinations. The invention can be used to control and monitor individuals accessing controlled environments.

Abstract translation: 一种用于通过定量红外光谱法非临床确定人体组织的分析物质的临床相关水平的精确度和准确度的装置和方法。 该系统包括优化的子系统，以应对组织光谱的复杂性，高信噪比和光度精度要求，组织采样误差，校准维护问题和校准转移问题。 子系统可以包括照明/调制子系统，组织采样子系统，数据采集子系统，计算子系统和校准子系统。 本发明可以提供来自相同光谱信息的分析物质性质确定和鉴别确定或验证，使得未经授权的使用或误导结果比使用单独的分析物和身份确定的系统更不可能。 本发明可用于控制和监视访问受控环境的个人。

公开(公告)号：US08723139B2

公开(公告)日：2014-05-13

申请号：US13156877

申请日：2011-06-09

Applicant: Daniel Stock ,  Michael Katzlinger

Inventor： Daniel Stock ,  Michael Katzlinger

IPC: G01N21/64

CPC classification number: G01J3/027 ,  G01J3/0264 ,  G01J3/4406 ,  G01N2021/6419 ,  G01N2021/6421

Abstract: A system for performing spectrofluorometry of a fluorophore sample is provided. The system includes an input module that receives user input corresponding to spectrofluorometer settings. A control module transmits control signals for controlling the spectrofluorometer during respective wavelength scans of a fluorophore sample and a blank sample. The control signals provide for automatic execution of the wavelength scans over an excitation wavelength range and an emission wavelength range. A signal-to-background determination module automatically determines multiple signal-to-background ratios based on fluorescence measurements of the fluorophore sample and the blank sample received from the spectrofluorometer. A signal-to-background analysis module automatically determines the maximum signal-to-background ratio from the multiple signal-to-background ratios.

Abstract translation: 提供了一种用于进行荧光团样品的分光荧光测定的系统。 该系统包括输入模块，其接收对应于分光荧光计设置的用户输入。 控制模块在荧光团样品和空白样品的相应波长扫描期间传输用于控制分光荧光计的控制信号。 控制信号提供在激发波长范围和发射波长范围内自动执行波长扫描。 信号对背景确定模块基于荧光团样品和从分光荧光计接收的空白样品的荧光测量自动确定多个信号与背景比。 信号到背景分析模块自动确定从多个信号到背景比的最大信号对背景比。

公开(公告)号：US20140078507A1

公开(公告)日：2014-03-20

申请号：US14022783

申请日：2013-09-10

Applicant: BlueLight Analytics, Inc.

Inventor： Daniel LABRIE ,  Ivan Kostylev ,  Chris Felix

IPC: G01M11/02 ,  G02B5/02

CPC classification number: G01J1/0474 ,  A61C19/003 ,  G01J1/0204 ,  G01J1/0219 ,  G01J1/0271 ,  G01J1/0425 ,  G01J1/0488 ,  G01J3/0205 ,  G01J3/0218 ,  G01J3/0254 ,  G01J3/0256 ,  G01J3/0264 ,  G01J2001/0481 ,  G01J2001/4247 ,  G01M11/0235 ,  G01N21/55 ,  G02B5/02 ,  G02B5/021 ,  G02B5/0284

Abstract: The invention features devices and methods for collecting and measuring light from external light sources. In general, the devices of the invention feature a light diffusing element, e.g., as a component of a light collector, connected by a light conducting conduit, e.g., a fiber optic cable, to a light measuring device, e.g., a spectrometer. This light diffusing element allows, e.g., for substantially uniform light diffusion across its surface and thus accurate measurements, while permitting the total footprint of the device to remain relatively small and portable. This light diffusing element also allows flexibility in scaling of the device to permit use in a wide range of applications.

Abstract translation: 本发明的特征在于用于收集和测量来自外部光源的光的装置和方法。 通常，本发明的装置的特征在于光漫射元件，例如作为光收集器的部件，通过诸如光纤电缆的导光导管连接到诸如光谱仪的光测量装置。 该光漫射元件允许例如在其表面上实质上均匀的光扩散，从而允许精确的测量，同时允许设备的总占地面积保持相对较小和便携。 该光散射元件还允许设备的缩放的灵活性，以允许在广泛的应用中使用。

公开(公告)号：US20140071445A1

公开(公告)日：2014-03-13

申请号：US14025050

申请日：2013-09-12

Applicant: Seiko Epson Corporation

Inventor： Tomonori MATSUSHITA ,  Nozomu Hirokubo

IPC: G02B26/00 ,  G01J3/28

CPC classification number: G02B26/001 ,  G01J3/0264 ,  G01J3/027 ,  G01J3/0291 ,  G01J3/06 ,  G01J3/10 ,  G01J3/26 ,  G01J3/28 ,  G01J3/2823 ,  G01J3/32 ,  G01J3/42 ,  G01J3/50

Abstract: An optical module includes a wavelength variable interference filter having a fixed reflective film, a movable reflective film which faces the fixed reflective film with a gap between reflective films interposed therebetween, and an electrostatic actuator that changes the gap between reflective films, and a gap control unit that controls the electrostatic actuator. The gap control unit controls the electrostatic actuator on the basis of an order which is set in accordance with a wavelength to be measured, and changes the gap between the reflective films.

Abstract translation: 光学模块包括具有固定反射膜的波长可变干涉滤光器，面对固定反射膜的可移动反射膜，其间插入反射膜之间的间隙，以及改变反射膜之间的间隙的静电致动器，以及间隙控制 控制静电执行器的单元。 间隙控制单元基于根据要测量的波长设置的顺序来控制静电致动器，并且改变反射膜之间的间隙。

公开(公告)号：US08638340B2

公开(公告)日：2014-01-28

申请号：US12799930

申请日：2010-05-05

Applicant: Richard A. Holub

Inventor： Richard A. Holub

IPC: G09G5/02

CPC classification number: H04N9/735 ,  G01J3/02 ,  G01J3/0202 ,  G01J3/0218 ,  G01J3/0262 ,  G01J3/0264 ,  G01J3/0272 ,  G01J3/0289 ,  G01J3/0291 ,  G01J3/18 ,  G01J3/28 ,  G01J3/462 ,  G01J3/463 ,  G01J3/50 ,  G01J3/506 ,  G01J2003/2866 ,  G01J2003/466 ,  G01N21/274 ,  G03B27/547 ,  G06T7/80 ,  G06T7/90 ,  G06T2207/10024 ,  G06T2207/20072 ,  G09G3/3413 ,  G09G5/02 ,  G09G2320/0285 ,  G09G2320/0626 ,  G09G2320/0666 ,  G09G2320/0693 ,  G09G2330/021 ,  G09G2360/144 ,  G09G2360/147 ,  H04N1/6033 ,  H04N1/6052 ,  H04N9/09 ,  H04N9/12 ,  H04N9/3182 ,  H04N9/3194 ,  H04N9/68 ,  H04N9/73 ,  H04N17/02 ,  H04N17/045

Abstract: Color calibration of color image rendering devices, such as large color displays, which operate by either projection or emission of images, utilize internal color measurement instrument or external color measurement modules locatable on a wall or speaker. A dual use camera is provided for a portable or laptop computer, or a cellular phone, handset, personal digital assistant or other handheld device with a digital camera, in which one of the camera or a display is movable with respect to the other to enable the camera in a first mode to capture images of the display for enabling calibration of the display, and in a second mode for capturing image other than of the display. The displays may represent rendering devices for enabling virtual proofing in a network, or may be part of stand-alone systems and apparatuses for color calibration. Improved calibration is also provided for sensing and correcting for non-uniformities of rendering devices, such as color displays, printer, presses, or other color image rendering device.

Abstract translation: 彩色图像渲染设备的颜色校准，例如通过投影或发射图像进行操作的大型彩色显示器，可利用位于墙壁或扬声器上的内部颜色测量仪器或外部颜色测量模块。 提供了一种用于便携式或膝上型计算机或具有数字照相机的便携式电话，手机，个人数字助理或其他手持设备的双用途照相机，其中照相机或显示器中的一个相对于另一个可移动以使得能够 所述相机处于第一模式以捕获所述显示器的图像，以使得能够校准所述显示器，以及用于捕获除了所述显示器之外的图像的第二模式。 显示器可以表示用于在网络中启用虚拟打样的渲染设备，或者可以是用于颜色校准的独立系统和设备的一部分。 还提供了改进的校准以用于感测和校正诸如彩色显示器，打印机，印刷机或其它彩色图像渲染装置之类的再现装置的不均匀性。

公开(公告)号：US08526097B2

公开(公告)日：2013-09-03

申请号：US13626336

申请日：2012-09-25

Applicant: Aaron Boyd Cole

Inventor： Aaron Boyd Cole

IPC: G02B26/00

CPC classification number: G01J3/18 ,  G01J3/02 ,  G01J3/0264 ,  G01J3/0294 ,  G01J3/36

Abstract: A tunable bandwidth selector is disclosed. The tunable bandwidth selector may include a plurality of spaced apart electron sheets which selectively separate a first bandwidth from an input spectrum.

Abstract translation: 公开了一种可调谐带宽选择器。 可调谐带宽选择器可以包括多个间隔开的电子薄片，其选择性地将第一带宽与输入光谱分离。

公开(公告)号：US20130201475A1

公开(公告)日：2013-08-08

申请号：US13879459

申请日：2011-10-27

Applicant: Toshio Yamazaki

Inventor： Toshio Yamazaki

IPC: G01J3/02

CPC classification number: G01J3/0256 ,  G01J3/0208 ,  G01J3/021 ,  G01J3/0237 ,  G01J3/0243 ,  G01J3/0264 ,  G01J3/04 ,  G01J3/2823 ,  G01N21/31 ,  G01N2021/1793 ,  G02B27/1066 ,  G02B27/143

Abstract: A spectroscopic measuring apparatus with monitoring capability includes a first optical path that extends from a measuring object through an optical system and a slit of a slit-mirror block to a spectroscope main body and a second optical path that extends from the measuring object through the optical system and a mirror face of the slit-mirror block to a two-dimensional photographing unit. The slit and spectroscope main body are integrated into a spectroscopic unit.

Abstract translation: 具有监测能力的光谱测量装置包括从测量对象通过光学系统延伸的第一光路和狭缝镜块的狭缝到分光镜主体和从测量对象通过光学器件延伸的第二光路 系统和狭缝镜块的镜面到二维拍摄单元。 狭缝和分光镜主体集成到分光单元中。

公开(公告)号：US20130200276A1

公开(公告)日：2013-08-08

申请号：US13616084

申请日：2012-09-14

Applicant: Wade POTEET ,  James Ryles ,  Malcolm Philips

Inventor： Wade POTEET ,  James Ryles ,  Malcolm Philips

IPC: G01J3/44

CPC classification number: G01J3/4406 ,  G01J3/02 ,  G01J3/0256 ,  G01J3/0264 ,  G01J3/027 ,  G01J3/0272 ,  G01J3/0278 ,  G01J3/0289 ,  G01J3/42 ,  G01J3/443 ,  G01N21/645 ,  G01N2021/6417 ,  G01N2201/0221

Abstract: A handheld or portable detection system with a high degree of specificity and accuracy, capable of use at small and substantial standoff distances (e.g., greater than 12 inches) is utilized to identify specific substances and mixtures thereof in order to provide information to officials for identification purposes and assists in determinations related to the legality, hazardous nature and/or disposition decision of such substance(s). The system uses a synchronous detector and visible light filter to enhance detection capabilities.

Abstract translation: 利用具有高度特异性和准确性的手持式或便携式检测系统，能够以小而实质的间隔距离（例如，大于12英寸）使用，以识别特定物质及其混合物，以向官员提供信息以进行识别 目的，并协助与此类物质的合法性，危险性质和/或处置决定有关的决定。 该系统使用同步检测器和可见光滤波器来增强检测能力。

公开(公告)号：US20130070246A1

公开(公告)日：2013-03-21

申请号：US13613463

申请日：2012-09-13

Applicant: Dar-Bin SHIEH ,  Pau-Choo CHUNG

Inventor： Dar-Bin SHIEH ,  Pau-Choo CHUNG

IPC: G01J3/00

CPC classification number: G01N21/255 ,  A61B5/0075 ,  A61B5/6898 ,  A61B2560/0431 ,  A61B2562/046 ,  G01J3/0205 ,  G01J3/0218 ,  G01J3/0264 ,  G01J3/10 ,  G01J3/2803 ,  G01N21/251 ,  G01N21/474 ,  G01N21/49 ,  G01N2021/4742 ,  G01N2201/067 ,  G01N2201/0833

Abstract: An optical detection apparatus used for detecting a tissue includes a light-emitting unit, a spectroscopic unit and a light-sensing array. The light-emitting unit emits light entering into the tissue. The spectroscopic unit receives the light outputted from the tissue and divides the received light into a plurality of rays with different wavelengths. The light-sensing array senses the rays outputted from the spectroscopic unit so as to generate an array spectrum. By the spectroscopic unit, the detection of the rays of multiple wavelengths can be performed without using plural light-emitting diodes for emitting light of different wavelengths. Besides, the user can perceive the detection result (e.g. the location of the abnormal tissue) intuitively by integrating the light-sensing array and the spectroscopic unit.

Abstract translation: 用于检测组织的光学检测装置包括发光单元，分光单元和光感测阵列。 发光单元发射进入组织的光。 分光单元接收从组织输出的光，并将接收的光分成具有不同波长的多个光线。 感光阵列感测从分光单元输出的光线，以产生阵列光谱。 通过分光单元，可以不使用多个用于发射不同波长的光的发光二极管来执行多个波长的光线的检测。 此外，通过集成光感测阵列和分光单元，用户可以直观地感知检测结果（例如异常组织的位置）。