公开(公告)号：DE2727481A1

公开(公告)日：1979-01-11

申请号：DE2727481

申请日：1977-06-18

Applicant: BASF AG

Inventor： LEBKUECHER ROLF ,  THYES MARCO DIPL CHEM DR ,  KOENIG HORST DIPL CHEM DR ,  LEHMANN HANS DIETER DR MED ,  GRIES JOSEF DR MED ,  LENKE DIETER PROF DR ,  KUNZE JOHANNES DR MED

IPC: C07D237/00 ,  A61K31/50 ,  A61P7/02 ,  A61P9/12 ,  C07D237/04

Abstract: 6-(p-Acylaminophenyl)-4,5-dihydropyridaz-3-ones of the formula I I where R1 is hydrogen or alkyl of 1 to 3 carbon atoms and R2, if R1 is hydrogen, is halogen-substituted alkyl of 3 to 6 carbon atoms or beta -haloethyl or, if R1 is alkyl of 1 to 3 carbon atoms, is halogen-substituted alkyl of 1 to 6 carbon atoms, their manufacture, and therapeutic agents which contain, as the active ingredient, a compound of the formula I, where R2 may also be halomethyl or alpha -haloethyl if R1 is hydrogen. These compounds may be used as anti-hypertensive agents and for the prophylaxis and therapy of thromboembolic disorders.

公开(公告)号：CA968800A

公开(公告)日：1975-06-03

申请号：CA151763

申请日：1972-09-14

Applicant: BASF AG

Inventor： LEBKUECHER ROLF ,  KOENIG HORST ,  AMANN AUGUST ,  GIERTZ HUBERT ,  SCHUSTER JOERG

IPC: C07D237/12 ,  A61K20060101 ,  A61K31/50 ,  C07D20060101 ,  C07D237/04

公开(公告)号：CA990296A

公开(公告)日：1976-06-01

申请号：CA142033

申请日：1972-05-10

Applicant: BASF AG

Inventor： LEBKUECHER ROLF ,  KOENIG HORST ,  AMANN AUGUST ,  GIERTZ HUBERT ,  SCHUSTER JOERG

IPC: A61K31/50 ,  C07D237/04 ,  C07D295/14 ,  C07D401/12 ,  C07D403/12 ,  C07D413/12

Abstract: 1386150 6 - Acylaminophenyl - 4,5 - dihydropyridazones BADISCHE ANILINSODAFABRIK AG 10 May 1972 [11 May 1971] 21734/72 Heading C2C Novel 6 - acylamino - 4,5 - dihydropyridazone compounds of general Formula (1): in which R is H or C 1-8 alkyl, and X is an amino or ammonium radical containing directly attached to the N atom at least one C atom but not more than one aromatic ring, and acid addition salts thereof, may be prepared by reacting an amine XH or a trialkylamine with a dihydropyridazone of the Formula (2): which in turn may be prepared by reacting compounds of Formula (4) with compounds of Formula (5) to form compounds of Formula (6) which are then cyclized with hydrazine The novel compounds I exhibit pharmaceutical properties, having the effect of lowering blood pressure, dilating the coronary arteries and combating inflammation.

公开(公告)号：AT329900T

公开(公告)日：2006-07-15

申请号：AT02797938

申请日：2002-08-30

Applicant: BASF AG

Inventor： RUDLOFF MARTIN ,  STOPS PETER ,  HENKES ERHARD ,  SCHMIDTKE HELMUT ,  FISCHER ROLF-HARTMUTH ,  JULIUS MANFRED ,  LEBKUECHER ROLF ,  ROSS KARL-HEINZ

IPC: C07D207/26 ,  C07D201/08 ,  C07D207/267

Abstract: A process for continuously preparing 2-pyrrolidone by reacting gamma-butyrolactone with ammonia in the liquid phase in the presence of water, wherein the reaction is carried out at a temperature of from 275 to 300° C. and an absolute pressure of from 140 to 180 bar.

公开(公告)号：CA1108614A

公开(公告)日：1981-09-08

申请号：CA305625

申请日：1978-06-16

Applicant: BASF AG

Inventor： LEBKUECHER ROLF ,  THYES MARCO ,  KOENIG HORST ,  LEHMANN HANS D ,  GRIES JOSEF ,  LENKE DIETER ,  KUNZE JOHANNES

IPC: C07D237/00 ,  A61K31/50 ,  A61P7/02 ,  A61P9/12 ,  C07D237/04

Abstract: O.Z. 32,647 6-(p-Acylaminophenyl)-4,5-dihydropyridaz-3-ones of the formula I I where R1 is hydrogen or alkyl of 1 to 3 carbon atoms and R2, if R1 is hydrogen, is halogen-substituted alkyl of 3 to 6 carbon atoms or .beta.-haloethyl or, if R1 is alkyl of 1 to 3 carbon atoms, is halogen-substituted alkyl of 1 to 6 carbon atoms, their manufacture, and therapeutlc agents which contain, as the active ingredient, a compound of the formula I, where R2 may also be halomethyl or .alpha.-haloethyl if R1 is hydrogen. These compounds may be used as anti-hypertensive agents and for the prophylaxis and therapy of thrombo-embolic disorders.

公开(公告)号：DE50207212D1

公开(公告)日：2006-07-27

申请号：DE50207212

申请日：2002-08-30

Applicant: BASF AG

Inventor： RUDLOFF MARTIN ,  STOPS PETER ,  HENKES ERHARD ,  SCHMIDTKE HELMUT ,  FISCHER ROLF-HARTMUTH ,  JULIUS MANFRED ,  LEBKUECHER ROLF ,  ROSS KARL-HEINZ

IPC: C07D207/26 ,  C07D201/08 ,  C07D207/267

Abstract: A process for continuously preparing 2-pyrrolidone by reacting gamma-butyrolactone with ammonia in the liquid phase in the presence of water, wherein the reaction is carried out at a temperature of from 275 to 300° C. and an absolute pressure of from 140 to 180 bar.

公开(公告)号：CA2228613A1

公开(公告)日：1998-09-07

申请号：CA2228613

申请日：1998-03-05

Applicant: BASF AG

Inventor： LEBKUECHER ROLF ,  BECKER RAINER ,  NEUHAUSER HORST ,  SIMON JOACHIM

IPC: C07D295/02 ,  B01J23/72 ,  B01J23/78 ,  B01J23/86 ,  C07B61/00 ,  C07C209/16 ,  C07C211/03 ,  C07D295/023 ,  C07D295/03 ,  C07C209/60

Abstract: In a process for the N-alkylation of amines in which alcohols are reacted with alkylamines or dialkylamines in the presence of hydrogen, the reaction takes place on a catalyst based on copper and magnesium silicate and containing, in each case independently, 0 to 2 % by weight of BaO, Cr2O3 and/or ZnO. The amines employed are mono- or dimethylamine or mono- or diethylamine, the alcohols employed are .alpha.,.omega.-diols, in parti cular diethylene glycol or pentanediol. In particular there is reaction of diethylene glycol with monomethylamine and/or monoethylamine to give N-methylmorpholine and/or N-ethylmorpholine.