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公开(公告)号：AU9115101A
公开(公告)日：2002-04-02
申请号：AU9115101
申请日：2001-09-20
Applicant: ABBOTT LAB
Inventor： MCCLELLAN WILLIAM , OOST THORSTEN , BRUNCKO MILAN , WANG XILU , AUGERI DAVID J , BAUMEISTER STEVEN A , DICKMAN DANIEL A , DING HONG , DINGES JURGEN , FESIK STEPHEN W , HAJDUK PHILIP J , KUNZER AARON R , NETTESHEIM DAVID G , PETROS ANDREW M , ROSENBERG SAUL H , SHEN WANG , THOMAS SHEELA A , WENDT MICHAEL D
IPC: A61K31/18 , A61K31/428 , A61K31/63 , A61K31/635 , A61P9/10 , A61P25/16 , A61P25/28 , A61P29/00 , A61P31/12 , A61P31/18 , A61P35/00 , A61P37/02 , C07C311/46 , C07C311/51 , C07C317/28 , C07C323/12 , C07C323/17 , C07C323/25 , C07C323/30 , C07C323/37 , C07C323/43 , C07C323/44 , C07C323/48 , C07C323/58 , C07C323/60 , C07D203/10 , C07D205/04 , C07D205/12 , C07D207/09 , C07D207/24 , C07D207/40 , C07D207/404 , C07D209/08 , C07D209/52 , C07D209/54 , C07D209/96 , C07D211/14 , C07D211/44 , C07D211/70 , C07D211/74 , C07D213/56 , C07D213/61 , C07D213/64 , C07D213/69 , C07D213/70 , C07D213/71 , C07D215/14 , C07D215/22 , C07D215/227 , C07D215/38 , C07D215/48 , C07D217/04 , C07D221/20 , C07D231/12 , C07D233/60 , C07D235/08 , C07D235/26 , C07D241/08 , C07D241/16 , C07D249/04 , C07D263/32 , C07D263/56 , C07D263/58 , C07D277/62 , C07D277/64 , C07D295/13 , C07D295/155 , C07D295/16 , C07D295/185 , C07D295/20 , C07D295/205 , C07D295/215 , C07D295/26 , C07D307/14 , C07D317/54 , C07D333/28 , C07D333/68 , C07D333/70 , C07D401/06 , C07D401/12 , C07D405/04 , C07D405/06 , C07D417/12 , C07D451/02 , C07D491/107 , C07C311/00
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公开(公告)号：PE12322001A1
公开(公告)日：2001-12-08
申请号：PE0002992001
申请日：2001-03-30
Applicant: ABBOTT LAB
Inventor： DICKMAN DANIEL A , CHEMBURKAR SANJAY , HENRY RODGER F , NIU YUPING , PORTER WILLIAM , LECHUGA-BALLESTEROS DAVID , FORT JAMES J
IPC: A61K31/513 , A61P31/18 , A61P43/00 , C07D239/00 , C07D239/10
CPC classification number: C07D239/10
Abstract: SE REFIERE A LA FORMA CRISTALINA HIDRATADA O SOLVATADA DE LOPINAVIR (2S,3S,5S)-2-(2,6-DIMETILFENOXIACETIL)AMIN-3-HIDROXI-5-(2-(1-TETRAHIDROPIRIMID-2-ONIL)-3-METILBUTANOL)AMIN-1,6-DIFENILHEXANO) DE FORMULA I CARACTERIZADA POR PRESENTAR UN ESPECTRO INFRARROJO; UN PATRON DE DIFRACCION DE RAYOS X. EL LOPINAVIR ES UN INHIBIDOR DE PROTEASA DEL VIH
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公开(公告)号：AU725369B2
公开(公告)日：2000-10-12
申请号：AU1342297
申请日：1996-12-06
Applicant: ABBOTT LAB
Inventor： SHAM HING LEUNG , NORBECK DANIEL W , CHEN XIAOQI , BETEBENNER DAVID A , KEMPF DALE J , HERRIN THOMAS R , KUMAR GONDI N , CONDON STEPHEN L , COOPER ARTHUR J , DICKMAN DANIEL A , HANNICK STEVEN M , KOLACZKOWSKI LAWRENCE , OLIVER PATRICIA A , PLATA DANIEL J , STENGEL PETER J , STONER ERIC J , TIEN JIEH-HEH J , LIU JIH-HUA , PATEL KETAN M
IPC: C07D253/00 , A61K31/00 , A61K31/40 , A61K31/4015 , A61K31/41 , A61K31/415 , A61K31/4164 , A61K31/4166 , A61K31/4184 , A61K31/42 , A61K31/421 , A61K31/425 , A61K31/427 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/4439 , A61K31/47 , A61K31/495 , A61K31/496 , A61K31/4965 , A61K31/505 , A61K31/513 , A61K31/53 , A61K31/55 , A61K38/05 , A61K45/00 , A61P31/18 , A61P43/00 , C07C231/12 , C07C235/20 , C07C273/18 , C07C275/16 , C07D20060101 , C07D207/22 , C07D207/26 , C07D207/27 , C07D207/273 , C07D207/34 , C07D207/40 , C07D207/404 , C07D207/408 , C07D207/416 , C07D211/72 , C07D211/84 , C07D223/06 , C07D233/28 , C07D233/30 , C07D233/32 , C07D233/36 , C07D233/40 , C07D233/42 , C07D233/66 , C07D239/06 , C07D239/10 , C07D239/20 , C07D239/22 , C07D241/06 , C07D241/08 , C07D241/18 , C07D243/04 , C07D253/06 , C07D263/16 , C07D263/20 , C07D263/22 , C07D263/34 , C07D265/04 , C07D267/04 , C07D277/12 , C07D277/32 , C07D277/34 , C07D279/06 , C07D281/02 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12
Abstract: A compound comprising a substituent of the formula (II) is disclosed as an HIV protease inhibitor. Intermediates for making such compounds and processes for making such intermediates are also disclosed.
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公开(公告)号：HK1115055A1
公开(公告)日：2008-11-21
申请号：HK08104997
申请日：2008-05-05
Applicant: ABBOTT LAB
Inventor： WENDT MICHAEL D , SHEN WANG , DICKMAN DANIEL A , DING HONG , THOMAS SHEELA A , AUGERI DAVID , ELMORE STEVEN W
IPC: A61K20060101 , A61P20060101 , C07C20060101
Abstract: The present invention relates to biaryl carboxylic acid compounds which inhibit the activity of anti-apoptotic Mcl-1 protein, compositions containing these compounds and methods of treating diseases which express the Mcl-1 protein.
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公开(公告)号：AU2007231810A1
公开(公告)日：2007-11-29
申请号：AU2007231810
申请日：2007-11-01
Applicant: ABBOTT LAB
Inventor： PLATA DANIEL J , TIEN JIEH-HEH J , COOPER ARTHUR J , KEMPF DALE J , PATEL KETAN M , CHEN XIAOQI , DICKMAN DANIEL A , STONER ERIC J , KOLACZKOWSKI LAWRENCE , CONDON STEPHEN L , BETEBENNER DAVID A , OLIVER PATRICIA A , KUMAR GONDI N , STENGEL PETER J , HANNICK STEVEN M , HERRIN THOMAS R , NORBECK DANIEL W , SHAM HING LEUNG , LIU JIH-HUA
IPC: C07D239/10 , A61K31/415 , C07D207/26 , C07D207/40 , C07D233/32 , C07D239/22 , C07D241/08 , C07D263/22
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Patent Agency Ranking
公开(公告)号：CZ296915B6
公开(公告)日：2006-07-12
申请号：CZ2004762
申请日：1996-12-06
Applicant: ABBOTT LAB
Inventor： SHAM HING LEUNG , NORBECK DANIEL W , CHEN XIAOQI , BETEBENNER DAVID A , KEMPF DALE J , HERRIN THOMAS R , KUMAR GONDI N , CONDON STEPHEN L , COOPER ARTHUR J , DICKMAN DANIEL A , HANNICK STEVEN M , KOLACZKOWSKI LAWRENCE , OLIVER PATRICIA A , PLATA DANIEL J , STENGEL PETER J , STONER ERIC J , TIEN JIEH-HEH J , LIU JIH-HUA , PATEL KETAN M
IPC: C07D239/10 , C07D253/00 , A61K31/00 , A61K31/40 , A61K31/4015 , A61K31/41 , A61K31/415 , A61K31/4164 , A61K31/4166 , A61K31/4184 , A61K31/42 , A61K31/421 , A61K31/425 , A61K31/427 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/4439 , A61K31/47 , A61K31/495 , A61K31/496 , A61K31/4965 , A61K31/505 , A61K31/513 , A61K31/53 , A61K31/55 , A61K38/05 , A61K45/00 , A61P31/00 , A61P31/18 , A61P31/22 , A61P43/00 , C07C231/12 , C07C235/20 , C07C273/18 , C07C275/16 , C07D20060101 , C07D207/22 , C07D207/26 , C07D207/27 , C07D207/273 , C07D207/34 , C07D207/40 , C07D207/404 , C07D207/408 , C07D207/416 , C07D211/72 , C07D211/84 , C07D223/06 , C07D233/28 , C07D233/30 , C07D233/32 , C07D233/36 , C07D233/40 , C07D233/42 , C07D233/66 , C07D239/06 , C07D239/20 , C07D239/22 , C07D241/06 , C07D241/08 , C07D241/18 , C07D243/04 , C07D253/06 , C07D263/16 , C07D263/20 , C07D263/22 , C07D263/34 , C07D265/04 , C07D267/04 , C07D277/12 , C07D277/32 , C07D277/34 , C07D279/06 , C07D281/02 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12
Abstract: Slouceniny obecného vzorce III a IV, které jsou meziprodukty pro prípravu inhibitoru retrovirových proteáz.
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公开(公告)号：CA2285119C
公开(公告)日：2005-09-20
申请号：CA2285119
申请日：1996-12-06
Applicant: ABBOTT LAB
Inventor： HERRIN THOMAS R , BETEBENNER DAVID A , KEMPF DALE J , KOLACZKOWSKI LAWRENCE , OLIVER PATRICIA A , CHEN XIAOQI , PLATA DANIEL J , NORBECK DANIEL W , COOPER ARTHUR J , DICKMAN DANIEL A , SHAM HING LEUNG , STENGEL PETER J , HANNICK STEVEN M , CONDON STEPHEN L , STONER ERIC J , TIEN JIEH-HEH J , LIU JIH-HUA , KUMAR GONDI N , PATEL KETAN M
IPC: C07D253/00 , A61K31/00 , A61K31/40 , A61K31/4015 , A61K31/41 , A61K31/415 , A61K31/4164 , A61K31/4166 , A61K31/4184 , A61K31/42 , A61K31/421 , A61K31/425 , A61K31/427 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/4439 , A61K31/47 , A61K31/495 , A61K31/496 , A61K31/4965 , A61K31/505 , A61K31/513 , A61K31/53 , A61K31/55 , A61K38/05 , A61K45/00 , A61P31/18 , A61P43/00 , C07C231/12 , C07C235/20 , C07C273/18 , C07C275/16 , C07D20060101 , C07D207/22 , C07D207/26 , C07D207/27 , C07D207/273 , C07D207/34 , C07D207/40 , C07D207/404 , C07D207/408 , C07D207/416 , C07D211/72 , C07D211/84 , C07D223/06 , C07D233/28 , C07D233/30 , C07D233/32 , C07D233/36 , C07D233/40 , C07D233/42 , C07D233/66 , C07D239/06 , C07D239/10 , C07D239/20 , C07D239/22 , C07D241/06 , C07D241/08 , C07D241/18 , C07D243/04 , C07D253/06 , C07D263/16 , C07D263/20 , C07D263/22 , C07D263/34 , C07D265/04 , C07D267/04 , C07D277/12 , C07D277/32 , C07D277/34 , C07D279/06 , C07D281/02 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12
Abstract: A compound of formula (I) is disclosed as an HIV protease inhibitor. Methods and compositions for inhibiting an HIV infection are also disclose d. (see formula I)
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公开(公告)号：HK1058031A1
公开(公告)日：2004-04-30
申请号：HK03108723
申请日：2003-11-28
Applicant: ABBOTT LAB
Inventor： MCCLELLAN WILLIAM , OOST THORSTEN , BRUNCKO MILAN , WANG XILU , AUGERI DAVID J , BAUMEISTER STEVEN A , DICKMAN DANIEL A , DING HONG , DINGES JURGEN , FESIK STEPHEN W , HAJDUK PHILIP J , KUNZER AARON R , NETTESHEIM DAVID G , PETROS ANDREW M , ROSENBERG SAUL H , SHEN WANG , THOMAS SHEELA A , WENDT MICHAEL A
IPC: C07C20060101 , A61K31/18 , A61K31/428 , A61K31/63 , A61K31/635 , A61P9/10 , A61P25/16 , A61P25/28 , A61P29/00 , A61P31/12 , A61P31/18 , A61P35/00 , A61P37/02 , C07C311/46 , C07C311/51 , C07C317/28 , C07C323/12 , C07C323/17 , C07C323/25 , C07C323/30 , C07C323/37 , C07C323/43 , C07C323/44 , C07C323/48 , C07C323/58 , C07C323/60 , C07D20060101 , C07D203/10 , C07D205/04 , C07D205/12 , C07D207/09 , C07D207/24 , C07D207/40 , C07D207/404 , C07D209/08 , C07D209/52 , C07D209/54 , C07D209/96 , C07D211/14 , C07D211/44 , C07D211/70 , C07D211/74 , C07D213/56 , C07D213/61 , C07D213/64 , C07D213/69 , C07D213/70 , C07D213/71 , C07D215/14 , C07D215/22 , C07D215/227 , C07D215/38 , C07D215/48 , C07D217/04 , C07D221/20 , C07D231/12 , C07D233/60 , C07D235/08 , C07D235/26 , C07D241/08 , C07D241/16 , C07D249/04 , C07D263/32 , C07D263/56 , C07D263/58 , C07D277/62 , C07D277/64 , C07D295/13 , C07D295/155 , C07D295/16 , C07D295/185 , C07D295/20 , C07D295/205 , C07D295/215 , C07D295/26 , C07D307/14 , C07D317/54 , C07D333/28 , C07D333/68 , C07D333/70 , C07D401/06 , C07D401/12 , C07D405/04 , C07D405/06 , C07D417/12 , C07D451/02 , C07D491/107
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公开(公告)号：AR033360A1
公开(公告)日：2003-12-17
申请号：ARP010101522
申请日：2001-03-29
Applicant: ABBOTT LAB
Inventor： HENRY RODGER F , LECHUGA-BALLESTEROS DAVID , NIU YUPING , PORTER WILLIAM , DICKMAN DANIEL A , CHEMBURKAR S , FORT JAMES J
IPC: A61K20060101 , A61K31/513 , A61P20060101 , A61P31/18 , A61P43/00 , C07D20060101 , C07D239/10 , A61K31/505
Abstract: Formas cristalinas del compuesto (2S, 3S, 5S)-2-(2,6-dimetilfenoxiacetil) amin-3-hidroxi-5-(2-(1-tetrahidropirimid-2-onil)-3-metilbutanoíl)amin-1,6-difenoxihexano(lopinavir). Se describen las formas cristalinas hidratadas solvatadas, las formas cristalinas y las formas cristalinas no solvatadas de lopinavir así como las formas sustancialmente puras de todas las formas anteriormente mencionadas. El lopinavir es de utilidad en la inhibicion de la proteasa del VIH y la inhibicion de una infeccion por VIH.
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公开(公告)号：ZA200206962B
公开(公告)日：2003-09-25
申请号：ZA200206962
申请日：2002-08-29
Applicant: ABBOTT LAB
Inventor： DICKMAN DANIEL A , FORT JAMES J , LECHUGA-BALLESTEROS DAVID , PORTER WILLIAM , CHEMBURKAR SANJAY , HENRY RODGER F , NIU YUPING
IPC: A61K20060101 , A61P20060101 , C07D20060101 , C07D , A61K , A61P
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