公开(公告)号：AU5804596A

公开(公告)日：1996-12-30

申请号：AU5804596

申请日：1996-05-28

Applicant: ABBOTT LAB

Inventor： HOLLADAY MARK W ,  LIN NAN-HORNG ,  RYTHER KEITH B ,  HE YUN

IPC: A61K31/00 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/4439 ,  A61P25/00 ,  A61P25/04 ,  C07D401/12 ,  C07D403/12 ,  C07D417/12

Abstract: Novel 3-pyridyloxymethyl heterocyclic ether compounds having formula (I), wherein * is a chiral center and n, X, R , R , A andB are specifically defined, which are useful in controlling chemical synaptic transmission; therapeutically-effective pharmaceutical compositions therof; and use of said compositions to selectively control synaptic transmission in mammals.

公开(公告)号：CA2223062A1

公开(公告)日：1996-12-19

申请号：CA2223062

申请日：1996-05-28

Applicant: ABBOTT LAB

Inventor： LIN NAN-HORNG ,  HE YUN ,  RYTHER KEITH B ,  HOLLADAY MARK W

IPC: A61K31/00 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/4439 ,  A61P25/00 ,  A61P25/04 ,  C07D401/12 ,  C07D403/12 ,  C07D417/12

Abstract: Novel 3-pyridyloxymethyl heterocyclic ether compounds having formula (I), wherein * is a chiral center and n, X, R1, R2, A andB are specifically defined, which are useful in controlling chemical synaptic transmission; therapeutically-effective pharmaceutical compositions therof; and use of said compositions to selectively control synaptic transmission in mammals.

公开(公告)号：PT100525A

公开(公告)日：1993-09-30

申请号：PT10052592

申请日：1992-05-28

Applicant: ABBOTT LAB

Inventor： GARVEY DAVID S ,  SHUE YOUE-KONG ,  ARNERIC STEPHEN P ,  LIN NAN-HORNG ,  CARRERA GEORGE M JR ,  HE YUN

IPC: A61K31/415 ,  A61K31/42 ,  A61K31/422 ,  A61K31/425 ,  A61K31/40 ,  A61K31/427 ,  A61K31/44 ,  A61P25/00 ,  A61P25/22 ,  A61P25/28 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14 ,  C07D413/00 ,  C07D417/00

Abstract: Novel isoxazole isothiazole and pyrazole compounds of the formula: wherein A, R1, and R2 are specifically defined, or pharmaceutical salts thereof, are selective and potent cholinergic ligands at neuronal nicotinic receptors, useful in the treatment of cognitive, neurological and mental disorders characterized by decreased cholinergic function, as well as in the treatment of alcohol intoxication and petit real absence epilepsy.

公开(公告)号：ES2229364T3

公开(公告)日：2005-04-16

申请号：ES97927830

申请日：1997-06-04

Applicant: ABBOTT LAB

Inventor： LIN NAN-HORNG ,  HE YUN ,  HOLLADAY MARK W ,  RYTHER KEITH ,  LI YIHONG ,  BAI HAO

IPC: A61K31/44 ,  A61K31/4427 ,  A61K31/4436 ,  A61K31/4439 ,  A61K31/445 ,  A61K31/4545 ,  A61K31/465 ,  A61K31/4709 ,  A61K31/497 ,  A61K31/501 ,  A61K31/505 ,  A61K31/506 ,  A61P25/00 ,  A61P43/00 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D407/14 ,  C07D409/14

Abstract: LA INVENCION SE REFIERE A NUEVOS COMPUESTOS DE ETER HETEROCICLICO DE 3 - PIRIDILOXIMETILO DE FORMULA (I) O A LAS SALES FARMACEUTICAMENTE ACEPTABLES O PROFARMACOS DE LOS MISMOS, QUE SON LIGANDOS SELECTIVOS Y POTENTES EN LOS RECEPTORES DE LOS CANALES COLINERGICOS NICOTINICOS NEURONALES, Y SON EFECTIVOS PARA CONTROLAR LA TRANSMISION SINAPTICA. SE DESCRIBEN ASIMISMO INTERMEDIARIOS Y PROCEDIMIENTOS CLAVE PARA PRODUCIR COMPUESTOS DE FORMULA (I), CON LAS VARIABLES DEFINIDAS EN LA DESCRIPCION.

公开(公告)号：DE69822668T2

公开(公告)日：2005-03-10

申请号：DE69822668

申请日：1998-12-18

Applicant: ABBOTT LAB

Inventor： HOLLADAY W ,  ABREO A ,  GUNN E ,  LIN NAN-HORNG ,  GARVEY S ,  RYTHER KEITH ,  LEBOLD A ,  ELLIOTT L ,  HE YUN ,  WASIAK T ,  BAI HAO ,  DART J ,  EHRLICH P ,  LI YIHONG ,  KINCAID F ,  SCHKERYANTZ M ,  LYNCH K

IPC: A61K31/427 ,  A61K31/4427 ,  A61K31/4439 ,  A61K31/4545 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/497 ,  A61K31/501 ,  A61K31/506 ,  A61P25/00 ,  A61P25/22 ,  A61P25/28 ,  A61P25/30 ,  A61P43/00 ,  C07D401/12 ,  C07D403/12 ,  C07D417/12 ,  C07D455/02 ,  C07D487/04 ,  A61K31/40 ,  A61K31/425 ,  A61K31/44 ,  A61K31/47 ,  A61K31/50 ,  A61K31/505

公开(公告)号：PT934308E

公开(公告)日：2004-11-30

申请号：PT97927830

申请日：1997-06-04

Applicant: ABBOTT LAB

Inventor： BAI HAO ,  LIN NAN-HORNG ,  HE YUN ,  HOLLADAY MARK W ,  RYTHER KEITH ,  LI YIHONG

IPC: A61K31/44 ,  A61K31/4427 ,  A61K31/4436 ,  A61K31/4439 ,  A61K31/445 ,  A61K31/4545 ,  A61K31/465 ,  A61K31/4709 ,  A61K31/497 ,  A61K31/501 ,  A61K31/505 ,  A61K31/506 ,  A61P25/00 ,  A61P43/00 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D407/14 ,  C07D409/14

Abstract: Novel 3-pyridyloxymethyl heterocyclic ether compounds of the formula: or the pharmaceutically-acceptable salts or prodrugs thereof are selective and potent ligands at neuronal nicotinic cholinergic channel receptors, and are effective in controlling synaptic transmission.

公开(公告)号：DE69822668D1

公开(公告)日：2004-04-29

申请号：DE69822668

申请日：1998-12-18

Applicant: ABBOTT LAB

Inventor： HOLLADAY W ,  ABREO A ,  GUNN E ,  LIN NAN-HORNG ,  GARVEY S ,  RYTHER KEITH ,  LEBOLD A ,  ELLIOTT L ,  HE YUN ,  WASIAK T ,  BAI HAO ,  DART J ,  EHRLICH P ,  LI YIHONG ,  KINCAID F ,  SCHKERYANTZ M ,  LYNCH K

IPC: A61K31/427 ,  A61K31/4427 ,  A61K31/4439 ,  A61K31/4545 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/497 ,  A61K31/501 ,  A61K31/506 ,  A61P25/00 ,  A61P25/22 ,  A61P25/28 ,  A61P25/30 ,  A61P43/00 ,  C07D401/12 ,  C07D403/12 ,  C07D417/12 ,  C07D455/02 ,  C07D487/04 ,  A61K31/40 ,  A61K31/425 ,  A61K31/44 ,  A61K31/47 ,  A61K31/50 ,  A61K31/505

公开(公告)号：DE69427361T2

公开(公告)日：2002-04-18

申请号：DE69427361

申请日：1994-08-30

Applicant: ABBOTT LAB

Inventor： LIN NAN-HORNG ,  HE YUN ,  ELLIOTT L ,  CHORGHADE S ,  WITTENBERGER J ,  BUNNELLE H ,  NARAYANAN A ,  SINGAM PULLA R ,  ESCH K ,  BEER O ,  WITZIG C ,  HERZIG C ,  RAO V RAMA

IPC: C07D413/04 ,  C07D207/09

Abstract: A novel process for preparing enantiomerically-pure 3-methyl-5-(1-(C1-C3-alkyl)-2-pyrrolidinyl)isoxazole in high yield, wherein a protected pyrrolidine or 2-oxo-pyrrolidine starting material is reacted with a suitable organic anion and a resulting beta-keto oxime intermediate is cyclized and dehydrated, as well as intermediates useful in the preparation thereof.

公开(公告)号：GR3036387T3

公开(公告)日：2001-11-30

申请号：GR20010401243

申请日：2001-08-14

Applicant: ABBOTT LAB

Inventor： LIN NAN-HORNG ,  HE YUN ,  ELLIOTT RICHARD L ,  CHORGHADE MUKUND S ,  WITTENBERGER STEVEN J ,  BUNNELLE WILLIAM H ,  NARAYANAN BIKSHANDAR A ,  SINGAM PULLA R ,  ESCH THOMAS K J ,  BEER DIETER O ,  WITZIG CHRISTIAN C ,  HERZIG THOMAS C ,  RAO ALLA V RAMA

IPC: C07D413/04 ,  C07D207/09

Abstract: A novel process for preparing enantiomerically-pure 3-methyl-5-(1-(C1-C3-alkyl)-2-pyrrolidinyl)isoxazole in high yield, wherein a protected pyrrolidine or 2-oxo-pyrrolidine starting material is reacted with a suitable organic anion and a resulting beta-keto oxime intermediate is cyclized and dehydrated, as well as intermediates useful in the preparation thereof.

公开(公告)号：ES2153360T3

公开(公告)日：2001-03-01

申请号：ES92912971

申请日：1992-05-28

Applicant: ABBOTT LAB

Inventor： GARVEY DAVID S ,  CARRERA GEORGE M JR ,  ARNERIC STEPHEN P ,  SHUE YOUE-KONG ,  LIN NAN-HORNG ,  HE YUN

IPC: A61K31/40 ,  A61K31/415 ,  A61K31/42 ,  A61K31/422 ,  A61K31/425 ,  A61K31/427 ,  A61K31/44 ,  A61P25/00 ,  A61P25/22 ,  A61P25/28 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14

Abstract: Novel isoxazole isothiazole and pyrazole compounds of the formula: wherein A, R1, and R2 are specifically defined, or pharmaceutical salts thereof, are selective and potent cholinergic ligands at neuronal nicotinic receptors, useful in the treatment of cognitive, neurological and mental disorders characterized by decreased cholinergic function, as well as in the treatment of alcohol intoxication and petit real absence epilepsy.