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11.发明专利
公开(公告)号：CA2744708A1
公开(公告)日：2010-06-10
申请号：CA2744708
申请日：2009-12-04
Applicant: ABBOTT LAB
Inventor： BRUNCKO MILAN , DAI YUJIA , DING HONG , DOHERTY GEORGE A , ELMORE STEVEN W , HASVOLD LISA , HEXAMER LAURA , KUNZER AARON R , MANTEI ROBERT A , MCCLELLAN WILLIAM J , PARK CHANG H , PARK CHEOL-MIN , PETROS ANDREW M , SONG XIAOHONG , SOUERS ANDREW J , SULLIVAN GERARD M , TAO ZHI-FU , WANG GARY T , WANG LE , WANG XILU , WENDT MICHAEL D
IPC: C07D405/12 , A61K31/395 , A61K31/496 , A61P35/00 , C07D295/04 , C07D309/00 , C07D401/00 , C07D403/12
Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
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公开(公告)号：MY136181A
公开(公告)日：2008-08-29
申请号：MYPI20014939
申请日：2001-10-24
Applicant: ABBOTT LAB
Inventor： CLAIBORNE AKIYO K , SULLIVAN GERARD M , TONG YUNSONG , WANG GARY T , WANG LE , WANG XILU , WANG WEIBO , GWALTNEY STEPHEN L II , HASVOLD LISA A , LI QUN , LI TONGMEI , LIN NAN-HORNG , MANTEI ROBERT A , ROCKWAY TODD W , SHAM HING L
IPC: A61K31/4164 , A61K31/4178 , A61K31/426 , A61K31/4439 , A61K31/4709 , A61P35/00 , A61P43/00 , C07D233/54 , C07D233/64 , C07D277/20 , C07D277/30 , C07D401/12 , C07D405/12 , C07D409/12
Abstract: SUBSTITUTED IMIDAZOLES AND THIAZOLES HAVING THE FORMULA I ARE USEFUL FOR INHIBITING FARNESYLTRANSFERASE.ALSO DISCLOSED ARE FARNESYLTRANSFERASE-INHIBITING COMPOSITIONS AND METHODS OF INHIBITING FARNESYLTRANSFERASE IN A PATIENT .
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公开(公告)号：DK1339695T3
公开(公告)日：2006-07-31
申请号：DK01273519
申请日：2001-11-30
Applicant: ABBOTT LAB
Inventor： CLAIBORNE AKIYO K , GWALTNEY STEPHEN L II , LI TOMGMEI , MANTEI ROBERT A , ROCKWAY TODD W , TONG YUNSONG , WANG GARY T , WANG XILU , WANG WEIBO , HASVOLD LISA A , LI QUN , LIN NAN-HORNG , SHAM HING L , SULLIVAN GERARD M , WANG LE
IPC: C07D233/64 , A61K31/4164 , A61K31/4178 , A61K31/426 , A61K31/4439 , A61K31/4709 , A61P35/00 , A61P43/00 , C07D233/54 , C07D277/20 , C07D277/30 , C07D401/12 , C07D405/12 , C07D409/12
Abstract: Substituted imidazoles and thiazoles having the formula are useful for inhibiting farnesyltransferase. Also disclosed are farnesyltransferase-inhibiting compositions and methods of inhibiting farnesyltransferase in a patient.
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公开(公告)号：BR0112028A
公开(公告)日：2004-02-17
申请号：BR0112028
申请日：2001-11-30
Applicant: ABBOTT LAB
Inventor： CLAIBORNE AKIYO K , GWALTNEY STEPHEN L II , HASVOLD LISA A , LI QUN , LI TOMGMEI , LIN NAN-HORNG , MANTEI ROBERT A , ROCKWAY TODD W , SHAM HING L , SULLIVAN GERARD M , TONG YUNSONG , WANG GARY T , WANG LE , WANG XILU , WANG WEIBO
IPC: A61K31/4164 , A61K31/4178 , A61K31/426 , A61K31/4439 , A61K31/4709 , A61P35/00 , A61P43/00 , C07D233/54 , C07D233/64 , C07D277/20 , C07D277/30 , C07D401/12 , C07D405/12 , C07D409/12
Abstract: Substituted imidazoles and thiazoles having the formula are useful for inhibiting farnesyltransferase. Also disclosed are farnesyltransferase-inhibiting compositions and methods of inhibiting farnesyltransferase in a patient.
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公开(公告)号：NO20032471A
公开(公告)日：2003-07-25
申请号：NO20032471
申请日：2003-05-30
Applicant: ABBOTT LAB
Inventor： CLAIBORNE AKIYO K , GWALTNEY II STEPHEN L , HASVOLD LISA A , LI QUN , LI TOMGMEI , LIN NAN-HORNG , MANTEI ROBERT A , ROCKWAY TODD W , SHAM HING L , SULLIVAN GERARD M , TONG YUNSONG , WANG GARY T , WANG LE , WANG XILU , WANG WEIBO
IPC: A61K31/4164 , A61K31/4178 , A61K31/426 , A61K31/4439 , A61K31/4709 , A61P35/00 , A61P43/00 , C07D233/54 , C07D233/64 , C07D277/20 , C07D277/30 , C07D401/12 , C07D405/12 , C07D409/12
CPC classification number: C07D233/64 , C07D401/12 , C07D405/12 , C07D409/12
Abstract: Substituted imidazoles and thiazoles having the formula are useful for inhibiting farnesyltransferase. Also disclosed are farnesyltransferase-inhibiting compositions and methods of inhibiting farnesyltransferase in a patient.
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Patent Agency Ranking16.发明专利
公开(公告)号：CA2744711C
公开(公告)日：2017-06-27
申请号：CA2744711
申请日：2009-12-04
Applicant: ABBOTT LAB
Inventor： BRUNCKO MILAN , DING HONG , DOHERTY GEORGE A , ELMORE STEVEN W , HASVOLD LISA , HEXAMER LAURA , KUNZER AARON R , MANTEI ROBERT A , MCCLELLAN WILLIAM J , PARK CHANG H , PARK CHEOL-MIN , PETROS ANDREW M , SONG XIAOHONG , SOUERS ANDREW J , SULLIVAN GERARD M , TAO ZHI-FU , WANG GARY T , WANG LE , WANG XILU , WENDT MICHAEL D
IPC: C07D405/12 , A61K31/404 , A61P35/00 , C07D209/32 , C07D211/96 , C07D213/64 , C07D215/20 , C07D217/16 , C07D235/26 , C07D249/04 , C07D295/125 , C07D295/14 , C07D309/14 , C07D401/12
Abstract: Disclosed are compounds of formula (I) which inhibit the activity of anti-apoptotic BcI -2 or BcI -xL proteins, compositions containing the compounds and methods of treating diseases during which are expressed anti -aooptotic Bcl-2 protein.
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公开(公告)号：CR20120346A
公开(公告)日：2012-09-03
申请号：CR20120346
申请日：2012-06-25
Applicant: ABBOTT LAB
Inventor： BRUNCKO MILAN , DING HONG , DOHERTY GEORGE A , ELMORE STEVEN W , HASVOLD LISA , HEXAMER LAURA , KUNZER AARON , MANTEI ROBERT A , MCCLELLAN WILLIAM J , PETROS ANDREW M , SOUERS ANDREW J , SULLIVAN GERARD M , TAO ZHI-FU , WANG GARY T , WANG LE , WANG XILU , WENDT MICHAEL D , HANSEN TODD M , SONG XIAOHONG , PARK CHANG H , PARK CHEOL-MIN
IPC: C07D405/12 , A61K31/404 , A61P35/00 , C07D209/32 , C07D211/96 , C07D213/64 , C07D215/20 , C07D217/16 , C07D231/56 , C07D235/26 , C07D249/04 , C07D295/125 , C07D295/14 , C07D309/14 , C07D401/12 , C07D405/14
Abstract: Compuestos que inhiben la actividad de las proteínas anti-apoptóticas Bcl-2 o Bcl-XL, composiciones que contienen dichos compuestos y métodos para tratar enfermedades durante las cuales se expresa la proteína anti-apoptótica Bcl-2.
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公开(公告)号：ECSP12012017A
公开(公告)日：2012-08-31
申请号：ECSP12012017
申请日：2012-07-03
Applicant: ABBOTT LAB
Inventor： HASVOLD LISA A , SULLIVAN GERARD M , WANG GARY , WANG XILU , MANTEI ROBERT A , ELMORE STEVEN W , SOUERS ANDREW J , BRUNCKO MILAN , SONG XIAOHONG , WANG LE , KUNZER AARON R , PARK CHEOL-MIN , WENDT MICHAEL D , TAO ZHI-FU , DING HONG , HEXAMER LAURA , MCCLELLAN WILLIAM J , PARK CHANG H , PETROS ANDREW M , HANSEN TODD M , DOHERTY GEORGE A
IPC: C07D405/12 , A61K31/404 , A61P35/00 , C07D209/32 , C07D213/64 , C07D215/20 , C07D217/16 , C07D231/56 , C07D235/26 , C07D249/04 , C07D295/125 , C07D295/14 , C07D309/14 , C07D401/12 , C07D405/14
Abstract: Compuestos que inhiben la actividad de las proteínas anti-apoptóticas Bcl-2 o Bcl-XL, composiciones que contienen dichos compuestos y métodos para tratar enfermedades durante las cuales se expresa la proteína anti-apoptótica Bcl-2.
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19.发明专利
公开(公告)号：MX2012006391A
公开(公告)日：2012-06-19
申请号：MX2012006391
申请日：2010-06-01
Applicant: ABBOTT LAB
Inventor： WANG GARY T , HEXAMER LAURA , SULLIVAN GERARD M , WANG LE , TAO ZHI-FU , BRUNCKO MILAN , WENDT MICHAEL D , DAI YUJIA , DING HONG , ELMORE STEVEN W , MCCELLAN WILLIAM J , HANSEN TODD M , SOUERS ANDREW J , SONG XIAOHONG , PARK CHEOL-MIN , MANTEI ROBERT A , DOHERTY GEORGE A , HASVOLD LISA , PARK CHANG H , PETROS ANDREW M , KUNZER AARON
IPC: C07D209/08 , C07D211/58 , C07D213/74 , C07D213/84 , C07D231/56 , C07D235/06 , C07D277/24 , C07D309/04 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/12 , C07D417/12 , C07D471/04
Abstract: Se describen los compuestos que inhiben la actividad de las proteínas anti-apoptóticas BcI-2, las composiciones que contienen los compuestos, y los métodos para tratar las enfermedades durante las cuales se expresa la proteína anti-apoptótica Bcl-2.
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20.发明专利
公开(公告)号：MX2012005162A
公开(公告)日：2012-06-01
申请号：MX2012005162
申请日：2010-10-18
Applicant: ABBOTT LAB
Inventor： ERICKSON SCOTT A , KAWAI MEGUMI , SHEPPARD GEORGE S , FIDANZE STEVE D , WANG GARY T , CLARK RICHARD F , MANTEI ROBERT A , BA-MAUNG NWE Y , SORENSON BRYAN K
IPC: C07D471/04 , A61K31/437 , A61P35/00
Abstract: Se describen los compuestos que inhiben las proteínas cinasas, las composiciones que contienen los compuestos y los métodos para tratar las enfermedades al usar los compuestos de fórmula (I).
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