公开(公告)号：AU652433B2

公开(公告)日：1994-08-25

申请号：AU1434292

申请日：1992-02-14

Applicant: ABBOTT LAB

Inventor： SUMMERS JAMES B ,  SHEPPARD GEORGE S ,  PHILLIPS JAMES G ,  PIREH DAISY ,  STEINMAN DOUGLAS H ,  MAY PAUL D ,  GUINN DENISE E ,  HEYMAN H ROBIN ,  CARRERA GEORGE M JR ,  DAVIDSEN STEVEN K

IPC: A61K31/44 ,  A61K31/4427 ,  A61K31/4433 ,  A61P7/02 ,  A61P11/00 ,  A61P29/00 ,  C07D401/14 ,  C07D403/14 ,  C07D409/14 ,  C07D417/14

Abstract: Indole compounds substituted at the 1- or 3-position by a (pyrid-3-yl)thiazolid-4-yl)alkyl-, (pyrid-3-yl)thiazolid-4-oyl)-, (pyrid-3-yl)dithiolan-4-yl)alkyl- or (pyrid-3-yl)dithiolan-4-oyl)- group are potent inhibitors of PAF and are useful in the treatment of PAF-related disorders including septic shock, respiratory distress syndrome, acute inflammation, delayed cellular immunity, parturtition, fetal lung maturation, and cellular differentiation.

公开(公告)号：DE60315336T2

公开(公告)日：2008-05-08

申请号：DE60315336

申请日：2003-09-15

Applicant: ABBOTT LAB

Inventor： MADAR DAVID ,  PEI ZHONGHUA ,  PIREH DAISY ,  DJURIC STEVAN W ,  WIEDEMAN PAUL E ,  YONG HONG ,  MICHMERHUIZEN MELISSA J ,  KOPECKA HANA ,  LI XIAOFENG ,  LONGENECKER KENTON ,  SHAM HING L ,  STEWART KENT D ,  SZCZEPANKIEWICZ BRUCE G

IPC: C07D207/00 ,  A61P37/02 ,  C07D207/16 ,  C07D207/26 ,  C07D207/27 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D417/12

Abstract: The present invention relates to compounds of formula I which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, Syndrome X, hyperinsulinemia, obesity, atherosclerosis, and various immunomodulatory diseases. Or pharmaceutically acceptable salts or prodrugs thereof, wherein X,R,R ,R and R have the definitions given in the description.

公开(公告)号：NZ538567A

公开(公告)日：2007-04-27

申请号：NZ53856703

申请日：2003-09-15

Applicant: ABBOTT LAB

Inventor： MADAR DAVID ,  PEI ZHONGHUA ,  PIREH DAISY ,  DJURIC STEVAN W ,  WIEDEMAN PAUL E ,  YONG HONG ,  FEENSTRA MELISSA J ,  KOPECKA HANA ,  LI XIAOFENG ,  LONGENECKER KENTON ,  SHAM HING L ,  STEWART KENT D ,  SZCZEPANKIEWICZ BRUCE G

IPC: A61P37/02 ,  C07D207/16 ,  C07D207/26 ,  C07D207/27 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D417/12 ,  A61K31/401 ,  A61K31/506 ,  A61K31/4439

Abstract: Compounds of formula (I), pharmaceutically acceptable salts and prodrugs thereof which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, Syndrome X, hyperinsulinemia, obesity, atherosclerosis, and various immunomodulatory diseases are disclosed, wherein X, R, R1, R2 and R3 have the definitions given in the description.

公开(公告)号：CA2768674A1

公开(公告)日：2004-04-01

申请号：CA2768674

申请日：2003-09-15

Applicant: ABBOTT LAB

Inventor： MADAR DAVID ,  PEI ZHONGHUA ,  PIREH DAISY ,  DJURIC STEVAN W ,  WIEDEMAN PAUL E ,  YONG HONG ,  FEENSTRA MELISSA J ,  KOPECKA HANA ,  LI XIAOFENG ,  LONGENECKER KENTON ,  SHAM HING L ,  STEWART KENT D ,  SZCZEPANKIEWICZ BRUCE G

IPC: C07D207/16 ,  A61K31/40 ,  A61P3/00 ,  A61P37/02 ,  C07D207/26 ,  C07D207/27 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D417/12

Abstract: The present invention relates to compounds of formula I which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, Syndrome X, hyperinsulinemia, obesity, atherosclerosis, and various immunomodulatory diseases. Or pharmaceutically acceptable salts or prodrugs thereof, wherein X,R,R ,R and R have the definitions given in the description.

公开(公告)号：DK0874863T3

公开(公告)日：2003-05-26

申请号：DK96940766

申请日：1996-11-06

Applicant: ABBOTT LAB

Inventor： OR YAT SUN ,  CHU DANIEL T ,  ELLIOTT RICHARD L ,  PIREH DAISY

IPC: A61K31/00 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61P31/00 ,  A61P31/04 ,  C07H17/08

Abstract: A compound selected from groups (I), (II), and (III), wherein A, B, V, W, X and R are specifically defined; pharmaceutical compositions thereof; a method of treating or preventing bacterial infections by administering therapeutically effective pharmaceutical compositions thereof; and a process for the preparation thereof.

公开(公告)号：DE69626040D1

公开(公告)日：2003-03-06

申请号：DE69626040

申请日：1996-11-06

Applicant: ABBOTT LAB

Inventor： OR SUN ,  CHU T ,  ELLIOTT L ,  PIREH DAISY

IPC: A61K31/00 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61P31/00 ,  A61P31/04 ,  C07H17/08

Abstract: A compound selected from groups (I), (II), and (III), wherein A, B, V, W, X and R are specifically defined; pharmaceutical compositions thereof; a method of treating or preventing bacterial infections by administering therapeutically effective pharmaceutical compositions thereof; and a process for the preparation thereof.

公开(公告)号：AT231878T

公开(公告)日：2003-02-15

申请号：AT96940766

申请日：1996-11-06

Applicant: ABBOTT LAB

Inventor： OR YAT SUN ,  CHU DANIEL T ,  ELLIOTT RICHARD L ,  PIREH DAISY

IPC: A61K31/00 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61P31/00 ,  A61P31/04 ,  C07H17/08

Abstract: A compound selected from groups (I), (II), and (III), wherein A, B, V, W, X and R are specifically defined; pharmaceutical compositions thereof; a method of treating or preventing bacterial infections by administering therapeutically effective pharmaceutical compositions thereof; and a process for the preparation thereof.

公开(公告)号：GR3030208T3

公开(公告)日：1999-08-31

申请号：GR990401293

申请日：1999-05-13

Applicant: ABBOTT LAB

Inventor： SUMMERS JAMES B ,  DAVIDSEN STEVEN K ,  HOLMS JAMES H ,  PIREH DAISY ,  HEYMAN H ROBIN ,  MARTIN MICHAEL B ,  STEINMAN DOUGLAS H ,  SHEPPARD GEORGE S ,  CARRERA GEORGE M JR

IPC: A61K31/44 ,  A61K31/4406 ,  A61K49/00 ,  A61K49/06 ,  A61P1/04 ,  A61P7/02 ,  A61P7/06 ,  A61P9/02 ,  A61P11/06 ,  A61P17/06 ,  A61P29/00 ,  A61P37/06 ,  A61P37/08 ,  A61P43/00 ,  C07B47/00 ,  C07D213/69 ,  C07D487/04 ,  C07D498/04 ,  C07D513/04 ,  C07F5/00 ,  C07F13/00

Abstract: PCT No. PCT/US92/05890 Sec. 371 Date Dec. 2, 1993 Sec. 102(e) Date Dec. 2, 1993 PCT Filed Jul. 14, 1992 PCT Pub. No. WO93/01813 PCT Pub. Date Feb. 4, 1993.Indole compounds substituted at the 3-position by a 7-carbonyl(pyridin-3-yl)pyrrolo[1,2-c]thiazole, 7-carbonyl(pyridin-3-yl)pyrrolo[1,2-c]oxazole, or 7-carbonyl(pyridin-3-yl)pyrrolo[1,2-c]pyrrole group are potent antagionists of PAF and are useful in the treatment of PAF-related disorders including asthma, shock, respiratory distress syndrome, acute inflammation, transplanted organ rejection, gastrointesinal ulceration, allergic skin diseases, delayed cellular immunity, parturition, fetal lung maturation, and cellular differentiation.

公开(公告)号：ES2131530T3

公开(公告)日：1999-08-01

申请号：ES92915895

申请日：1992-07-14

Applicant: ABBOTT LAB

Inventor： SUMMERS JAMES B ,  DAVIDSEN STEVEN K ,  HOLMS JAMES H ,  PIREH DAISY ,  HEYMAN H ROBIN ,  MARTIN MICHAEL B

IPC: A61K31/44 ,  A61K31/4406 ,  A61K49/00 ,  A61K49/06 ,  A61P1/04 ,  A61P7/02 ,  A61P7/06 ,  A61P9/02 ,  A61P11/06 ,  A61P17/06 ,  A61P29/00 ,  A61P37/06 ,  A61P37/08 ,  A61P43/00 ,  C07B47/00 ,  C07D213/69 ,  C07D487/04 ,  C07D498/04 ,  C07D513/04 ,  C07F5/00 ,  C07F13/00

Abstract: PCT No. PCT/US92/05890 Sec. 371 Date Dec. 2, 1993 Sec. 102(e) Date Dec. 2, 1993 PCT Filed Jul. 14, 1992 PCT Pub. No. WO93/01813 PCT Pub. Date Feb. 4, 1993.Indole compounds substituted at the 3-position by a 7-carbonyl(pyridin-3-yl)pyrrolo[1,2-c]thiazole, 7-carbonyl(pyridin-3-yl)pyrrolo[1,2-c]oxazole, or 7-carbonyl(pyridin-3-yl)pyrrolo[1,2-c]pyrrole group are potent antagionists of PAF and are useful in the treatment of PAF-related disorders including asthma, shock, respiratory distress syndrome, acute inflammation, transplanted organ rejection, gastrointesinal ulceration, allergic skin diseases, delayed cellular immunity, parturition, fetal lung maturation, and cellular differentiation.

公开(公告)号：MX9803694A

公开(公告)日：1998-09-30

申请号：MX9803694

申请日：1998-05-08

Applicant: ABBOTT LAB

Inventor： OR YAT SUN ,  CHU DANIEL T ,  ELLIOTT RICHARD L ,  PIREH DAISY

IPC: A61K31/00 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61P31/00 ,  A61P31/04 ,  C07H17/08

Abstract: Un compuesto seleccionado a partir de los grupos (I), (II), y (III), en donde A, B, V, W, X, y R8 se definen específicamente; composiciones farmacéuticas del mismo; un método para tratar o prevenir infecciones bacterianas mediante la administracion de composiciones farmacéuticas terapéuticamente efectivas del mismo; y un proceso para su preparacion.