公开(公告)号：DK1272500T3

公开(公告)日：2005-09-05

申请号：DK00942860

申请日：2000-06-15

Applicant: ABBOTT LAB

Inventor： KU YI-YIN ,  COOPER ARTHUR J ,  HAIGHT ANTHONY R ,  RASMUSSEN MICHAEL ,  TIEN JIEN-HEH J ,  STONER ERIC J ,  PETERSON MATTHEW J ,  CINK RUSSELL D ,  DESHPANDE MAHENDRA N ,  GRIEME TIM ,  HILL DAVID R ,  HSU MARGARET CHI-PING ,  KING STEVEN A ,  LEANNA MARVIN R ,  LEE ELAINE C ,  MCLAUGHLIN MAUREEN A ,  MORTON HOWARD E ,  NAPIER JAMES J ,  PLATA DANIEL J ,  RAJE PRASAD S ,  RILEY DAVID ,  WITTENBERGER STEVEN J

IPC: A61K31/70 ,  A61P31/04 ,  C07H17/08

公开(公告)号：HK1053659A1

公开(公告)日：2003-10-31

申请号：HK03104301

申请日：2003-06-16

Applicant: ABBOTT LAB

Inventor： STONER ERIC J ,  PETERSON MATTHEW J ,  KU YI-YIN ,  CINK RUSSELL D ,  COOPER ARTHUR J ,  DESHPANDE MAHENDRA N ,  GRIEME TIM ,  HAIGHT ANTHONY R ,  HILL DAVID R ,  HSU MARGARET CHI-PING ,  KING STEVEN A ,  LEANNA MARVIN R ,  LEE ELAINE C ,  MCLAUGHLIN MAUREEN A ,  MORTON HOWARD E ,  NAPIER JAMES J ,  PLATA DANIEL J ,  RAJE PRASAD S ,  RASMUSSEN MICHAEL ,  RILEY DAVID ,  TIEN JIEN-HEH J ,  WITTENBERGER STEVEN J

IPC: A61P31/04 ,  C07B61/00 ,  C07H1/00 ,  C07H17/08 ,  C07H ,  A61K ,  A61P

Abstract: In one aspect, the invention relates to a process for preparing 6-O-substituted erythromycin derivatives comprising reacting 2'-substituted and optionally 4''-substituted 9-oxime erythromycin derivatives with an alkylating agent in the presence of a palladium catalyst and phosphine. In another aspect, the invention relates to processes for preparing 6-O-substituted erythromycin ketolides using the palladium-catalyzed alkylation reaction.

公开(公告)号：BRPI0714945A2

公开(公告)日：2013-05-21

申请号：BRPI0714945

申请日：2007-07-24

Applicant: ABBOTT LAB

Inventor： VISWANATH SHEKHAR ,  BARTELT LARRY ,  LEANNA ROBERT ,  RASMUSSEN MICHAEL ,  DHAON MADHUP ,  HENRY RODGER ,  BORCHARDT THOMAS ,  CHEN SHUANG ,  ZHANG GEOFF

IPC: C07D498/18 ,  A61K31/395 ,  A61K31/4353 ,  A61P37/06

Abstract: A process for preparing a crystalline form of a rapamycin analog, which process comprises: combining the rapamycin analog with at least one organic medium to form a mixture that is saturated with the rapamycin analog; incubating the saturated mixture until the rapamycin analog crystallizes; and recovering the crystalline rapamycin analog from the organic medium.

公开(公告)号：ZA200900740B

公开(公告)日：2010-05-26

申请号：ZA200900740

申请日：2007-07-24

Applicant: ABBOTT LAB

Inventor： VISWANATH SHEKHAR ,  BARTELT LARRY ,  LEANNA ROBERT ,  RASMUSSEN MICHAEL ,  DHAON MADHUP ,  HENRY RODGER ,  BORCHARDT THOMAS ,  CHEN SHUANG ,  ZHANG GEOFF

IPC: A61K20100101 ,  A61P20100101 ,  C07D20100101

公开(公告)号：MX2009001067A

公开(公告)日：2009-06-17

申请号：MX2009001067

申请日：2007-07-24

Applicant: ABBOTT LAB

Inventor： BORCHARDT THOMAS ,  HENRY RODGER ,  DHAON MADHUP ,  VISWANATH SHEKHAR ,  BARTELT LARRY ,  LEANNA ROBERT ,  RASMUSSEN MICHAEL ,  CHEN SHUANG ,  ZHANG GEOFF

IPC: C07D498/18 ,  A61K31/395 ,  A61K31/4353 ,  A61P37/06

Abstract: Una composición de análogo de rapamicina incluye una forma cristalina de un análogo de rapamicina. El cristal puede ser un hidrato, dehidrato, solvato, o desolvato. El análogo de rapamicina puede tener una estructura de la Fórmula (I), el cual es opcionalmente un profármaco, sal, derivado, o combinación de los mismos: Fórmula (I).

公开(公告)号：AU2007276837A1

公开(公告)日：2008-01-31

申请号：AU2007276837

申请日：2007-07-24

Applicant: ABBOTT LAB

Inventor： ZHANG GEOFF ,  BORCHARDT THOMAS ,  VISWANATH SHEKHAR ,  RASMUSSEN MICHAEL ,  CHEN SHUANG ,  DHAON MADHUP ,  HENRY RODGER ,  BARTELT LARRY ,  LEANNA ROBERT

IPC: C07D498/18 ,  A61K31/395 ,  A61K31/4353 ,  A61P37/06

Abstract: A process for preparing a crystalline form of a rapamycin analog, which process comprises: combining the rapamycin analog with at least one organic medium to form a mixture that is saturated with the rapamycin analog; incubating the saturated mixture until the rapamycin analog crystallizes; and recovering the crystalline rapamycin analog from the organic medium.

公开(公告)号：DE60019976D1

公开(公告)日：2005-06-09

申请号：DE60019976

申请日：2000-06-15

Applicant: ABBOTT LAB

Inventor： STONER ERIC J ,  PETERSON MATTHEW J ,  KU YI-YIN ,  CINK RUSSELL D ,  COOPER ARTHUR J ,  DESHPANDE MAHENDRA N ,  GRIEME TIM ,  HAIGHT ANTHONY R ,  HILL DAVID R ,  HSU CHI-PING ,  KING STEVEN A ,  LEANNA MARVIN R ,  LEE ELAINE C ,  MCLAUGHLIN MAUREEN A ,  MORTON HOWARD E ,  NAPIER JAMES J ,  PLATA DANIEL J ,  RAJE PRASAD S ,  RASMUSSEN MICHAEL ,  RILEY DAVID ,  TIEN ,  WITTENBERGER

IPC: A61P31/04 ,  C07B61/00 ,  C07H1/00 ,  C07H17/08 ,  A61K31/70

Abstract: In one aspect, the invention relates to a process for preparing 6-O-substituted erythromycin derivatives comprising reacting 2'-substituted and optionally 4''-substituted 9-oxime erythromycin derivatives with an alkylating agent in the presence of a palladium catalyst and phosphine. In another aspect, the invention relates to processes for preparing 6-O-substituted erythromycin ketolides using the palladium-catalyzed alkylation reaction.