公开(公告)号：DE19803515A1

公开(公告)日：1999-08-05

申请号：DE19803515

申请日：1998-01-30

Applicant: BASF AG

Inventor： FRIEDRICH WOLFGANG ,  KNEUPER HEINZ-JOSEF DR ,  ELLER KARSTEN DR ,  HENNE ANDREAS DR ,  LEBKUECHER ROLF DR

IPC: B01J31/02 ,  C07B61/00 ,  C07C213/02 ,  C07C217/08 ,  C07C217/48 ,  C07C253/30 ,  C07C255/13 ,  C07C255/37 ,  C07D487/04 ,  C07D471/04

Abstract: A process for the production of beta -alkoxy-nitriles which is carried out in the presence of a basic diazabicycloalkene catalyst. Production of beta -alkoxy-nitriles which involves reaction of alpha , beta -unsaturated nitriles with mono-, di- or tri- valent alcohols in the presence of a basic diazabicycloalkene of formula (1), at (-) 20-200 degrees C. n, m = 1-6; and where the 1-4 H atoms are optionally substituted by R -R ; R -R = 1-20C alkyl, 6-20C aryl or 7-20C arylalkyl. An Independent claim is also included for a production process of a gamma -alkoxy-amine by hydrogenation of the beta -alkoxy-nitrile in the presence of a hydrogenation catalyst and the catalyst of formula (1).

公开(公告)号：DE2861089D1

公开(公告)日：1981-12-03

申请号：DE2861089

申请日：1978-06-01

Applicant: BASF AG

Inventor： LEBKUECHER ROLF DR ,  THYES MARCO DR ,  KOENIG HORST DR ,  LEHMANN HANS DIETER DR ,  GRIES JOSEF DR ,  LENKE DIETER DR ,  KUNZE JOHANNES DR

IPC: C07D237/00 ,  A61K31/50 ,  A61P7/02 ,  A61P9/12 ,  C07D237/04

Abstract: 6-(p-Acylaminophenyl)-4,5-dihydropyridaz-3-ones of the formula I I where R1 is hydrogen or alkyl of 1 to 3 carbon atoms and R2, if R1 is hydrogen, is halogen-substituted alkyl of 3 to 6 carbon atoms or beta -haloethyl or, if R1 is alkyl of 1 to 3 carbon atoms, is halogen-substituted alkyl of 1 to 6 carbon atoms, their manufacture, and therapeutic agents which contain, as the active ingredient, a compound of the formula I, where R2 may also be halomethyl or alpha -haloethyl if R1 is hydrogen. These compounds may be used as anti-hypertensive agents and for the prophylaxis and therapy of thromboembolic disorders.

公开(公告)号：DE2446489A1

公开(公告)日：1976-04-15

申请号：DE2446489

申请日：1974-09-28

Applicant: BASF AG

Inventor： GRAEFJE HEINZ DR ,  HOFFMANN HERWIG DR ,  HUPFER LEOPOLD DR ,  LEBKUECHER ROLF DR ,  MERKEL KARL DR

IPC: C07C20060101 ,  C07C255/24 ,  C07C121/43

Abstract: The parent patent describes the prepn. of N-(2-cyanoethyl) cyclohexylamine or its ring alkyl substd. derivs. by reaction of cyclohexylamine or alkylcyclohexylamine with acrylonitrile at high temp. in the presence of catalytic quantities of acetic acid. The modification of the above process produces bis-(2-cyanoethyl)-ethylenediamine (I) from ethylenediamine. (I) is used to prepare bis-(3-aminopropyl)-ethylenediamine, an important paper-making chemical. High yields are obtd. (over 90%) compared with known processes and the reaction may be carried out at low temps.

公开(公告)号：DE59805769D1

公开(公告)日：2002-11-14

申请号：DE59805769

申请日：1998-07-22

Applicant: BASF AG

Inventor： KNEUPER DR ,  LEBKUECHER ROLF DR ,  NEUHAUSER DR ,  HENNE DR ,  BECKER DR

IPC: C07D295/02 ,  B01J23/75 ,  C07B37/04 ,  C07B61/00 ,  C07C209/26 ,  C07D295/023

公开(公告)号：DE19731745C1

公开(公告)日：1998-09-17

申请号：DE19731745

申请日：1997-07-23

Applicant: BASF AG

Inventor： KNEUPER HEINZ-JOSEF DR ,  LEBKUECHER ROLF DR ,  NEUHAUSER HORST DR ,  HENNE ANDREAS DR ,  BECKER RAINER DR

IPC: C07D295/02 ,  B01J23/75 ,  C07B37/04 ,  C07B61/00 ,  C07C209/26 ,  C07D295/023 ,  C07B43/04 ,  C07C209/24

Abstract: In the production of alkylamines (I) from amines (II) and aliphatic aldehydes (III) in the presence of hydrogen (H2) by introducing (II) and (III) into a reactor in separate streams and mixing in the stationary catalyst bed, only the (II) stream or only the (III) stream is preheated.

公开(公告)号：DE19709488A1

公开(公告)日：1998-09-10

申请号：DE19709488

申请日：1997-03-07

Applicant: BASF AG

Inventor： SIMON JOACHIM DR ,  BECKER RAINER DR ,  LEBKUECHER ROLF DR ,  NEUHAUSER HORST DR

IPC: C07D295/02 ,  B01J23/72 ,  B01J23/78 ,  B01J23/86 ,  C07B61/00 ,  C07C209/16 ,  C07C211/03 ,  C07D295/023 ,  C07D295/03 ,  C07C211/08 ,  B01J23/76

Abstract: A method for the N-alkylation of amines by reacting alcohol with (di)alkylamine in the presence of hydrogen is carried out in the presence of a catalyst based on copper and magnesium silicate, which contains 0-2 wt.% each of barium oxide, chromium (III) oxide (Cr2O3) and/or zinc oxide. Also claimed is the use of this catalyst for N-alkylation of amines.

公开(公告)号：DE19624283A1

公开(公告)日：1998-01-02

申请号：DE19624283

申请日：1996-06-18

Applicant: BASF AG

Inventor： SIMON JOACHIM DR ,  DOSTALEK ROMAN DR ,  LINGK HEINZ ,  BECKER RAINER DR ,  HENNE ANDREAS DR ,  LEBKUECHER ROLF DR ,  FREIRE ERDBRUEGGER CRISTINA DR ,  HESSE MICHAEL DR ,  KRATZ DETLEF DR

IPC: C07D295/02 ,  B01J23/72 ,  B01J37/02 ,  C07B61/00 ,  C07D295/03

Abstract: Preparation of N-substituted cyclic amines of formula (I) comprises reacting primary amines of formula R NH2 (II) with diols of formula HO-A-OH (III) in the presence of hydrogen and a catalyst containing copper obtained by impregnating an inert support with an aqueous solution of an ammine complex of a Cu compound (IV) that readily undergoes thermal decomposition, then drying and calcining to give a catalyst containing 5-50 wt.% Cu, calculated as oxide. A = alkylene or (CH2)n-ÄO-CH2)mÜr (optionally substituted by one or more R ); R , R = alkyl, alkoxyalkyl, optionally alkyl- or alkoxy-substituted cycloalkyl, cycloalkylalkyl, aryl or arylalkyl; n, m = 2-8; r = 1-3.

公开(公告)号：DE3248326A1

公开(公告)日：1984-06-28

申请号：DE3248326

申请日：1982-12-28

Applicant: BASF AG

Inventor： HERTEL OTTO DR ,  BOETTGER GUENTER DR ,  KOERNIG WOLFGANG DR ,  LEBKUECHER ROLF DR ,  WACHE HARRO DR ,  SCHANZ RUDI DR ,  SCHARF EMIL DR

IPC: C07B61/00 ,  B01J23/00 ,  C07C67/00 ,  C07C209/00 ,  C07C209/02 ,  C07C209/48 ,  C07C209/60 ,  C07C211/14 ,  C07C85/12 ,  C07C87/18 ,  C07C87/20

Abstract: Process for the preparation of polyamines by hydrogenation of mono-, bis- or tris(2-cyanoethyl)amines or mixtures thereof on a cobalt catalyst with the addition of a diamine.

公开(公告)号：DE59805686D1

公开(公告)日：2002-10-31

申请号：DE59805686

申请日：1998-11-26

Applicant: BASF AG

Inventor： FRIEDRICH WOLFGANG ,  KNEUPER HEINZ-JOSEF DR ,  ELLER KARSTEN DR ,  HENNE ANDREAS DR ,  LEBKUECHER ROLF DR

IPC: B01J31/02 ,  C07B61/00 ,  C07C213/02 ,  C07C217/08 ,  C07C217/48 ,  C07C253/30 ,  C07C255/13 ,  C07C255/37

Abstract: A process for the production of beta -alkoxy-nitriles which is carried out in the presence of a basic diazabicycloalkene catalyst. Production of beta -alkoxy-nitriles which involves reaction of alpha , beta -unsaturated nitriles with mono-, di- or tri- valent alcohols in the presence of a basic diazabicycloalkene of formula (1), at (-) 20-200 degrees C. n, m = 1-6; and where the 1-4 H atoms are optionally substituted by R -R ; R -R = 1-20C alkyl, 6-20C aryl or 7-20C arylalkyl. An Independent claim is also included for a production process of a gamma -alkoxy-amine by hydrogenation of the beta -alkoxy-nitrile in the presence of a hydrogenation catalyst and the catalyst of formula (1).

公开(公告)号：DE4437878A1

公开(公告)日：1996-04-25

申请号：DE4437878

申请日：1994-10-22

Applicant: BASF AG

Inventor： HORN PETER DR ,  JUNG LUDWIG ,  LARBIG HARALD DR ,  LEBKUECHER ROLF DR ,  LEHR GERHARD

IPC: C08G18/50 ,  C08G65/26 ,  C08G18/48 ,  C08G18/66 ,  C08G18/08 ,  C08G18/34 ,  C08G18/36

Abstract: The prodn. of polyurethane (PU) foam comprises reacting (a) polyisocyanate(s); with (b) high-mol. wt. polyol(s) with at least two reactive H atoms, comprising (B1) polyoxyalkylene-polyol(s) with an OH no. of 30-500, obtd. by alkoxylating N,N'-bis(3-aminopropyl)-ethylenediamine, tripropylene-tetramine and/or tetrapropylene-pentamine with alkene oxide(s); and opt. (c) low-mol wt. chain extenders and/or crosslinkers; in the presence of (d) blowing agents. Also claimed are polyols (b1) obtd. as above.