公开(公告)号：HRP20181740T1

公开(公告)日：2018-12-28

申请号：HRP20181740

申请日：2018-10-23

Applicant: VERTEX PHARMA

Inventor： VERWIJS MARINUS JACOBUS ,  KARKARE RADHIKA ,  MOORE MICHAEL DOUGLAS

IPC: A61K9/20 ,  A61K31/443 ,  A61K31/47 ,  A61K45/06

公开(公告)号：AU2016216569B2

公开(公告)日：2018-01-25

申请号：AU2016216569

申请日：2016-08-16

Applicant: VERTEX PHARMA

Inventor： ROWE WILLIAM ,  HURTER PATRICIA ,  YOUNG CHRISTOPHER ,  DINEHART KIRK ,  OVERHOFF KIRK ,  GROOTENHUIS PETER D J ,  BOTFIELD MARTYN ,  GROSSI ALFREDO ,  VERWIJS MARINUS JACOBUS

IPC: A61K47/32

Abstract: The present invention relates to pharmaceutical compositions comprising a solid dispersion of N-[2,4-Bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3 carboxamide, methods of manufacturing pharmaceutical compositions of the present invention, and methods of administering pharmaceutical compositions of the present invention.

公开(公告)号：SG10201703452PA

公开(公告)日：2017-06-29

申请号：SG10201703452P

申请日：2013-11-01

Applicant: VERTEX PHARMA

Inventor： VERWIJS MARINUS JACOBUS ,  KARKARE RADHIKA ,  MOORE MICHAEL DOUGLAS

Abstract: Pharmaceutical compositions comprising 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid (Compound 1) in Form I and a solid dispersion comprising substantially amorphous N-(5-hydroxy-2,4-ditert-butyl-phenyl)-4-oxo-1H-quinoline-3-carboxamide (Compound 2), methods of treating, lessening the severity of, or symptomatically treating CFTR mediated diseases, such as cystic fibrosis, methods of manufacturing, methods of administering, and kits thereof are disclosed.

公开(公告)号：AU2011242457A1

公开(公告)日：2012-11-08

申请号：AU2011242457

申请日：2011-04-22

Applicant: VERTEX PHARMA

Inventor： VAN GOOR FREDRICK F ,  ALARGOVA ROSSITZA GUEORGUIEVA ,  ALCACIO TIM EDWARD ,  BINCH HAYLEY MARIE ,  BOTFIELD MARTYN CURTIS ,  FANNING LEV TYLER DEWEY ,  GROOTENHUIS PETER DIEDERIK JAN ,  HURLEY DENNIS JAMES ,  KADIYALA IRINA NIKOLAEVNA ,  KAUSHIK RITU ROHIT ,  KESHAVARZ-SHOKRI ALI ,  KRAWIEC MARIUSZ ,  LEE ELAINE CHUNGMIN ,  LUISI BRIAN ,  MEDEK ALES ,  NUMA MEHDI ,  SHETH URVI JAGDISHBHAI ,  SILINA ALINA ,  VERWIJS MARINUS JACOBUS ,  YANG XIAOQING ,  YOUNG CHRISTOPHER RYAN ,  ZAMAN NOREEN TASNEEM ,  ZHANG BEILI ,  ZHANG YUEGANG ,  ZLOKARNIK GREGOR

IPC: A61K31/4704 ,  A61K31/404 ,  A61K31/443

Abstract: The present invention relates to pharmaceutical compositions comprising a compound of Formula I in combination with one or both of a Compound of Formula II and/or a Compound of Formula III. The invention also relates to solid forms and to pharmaceutical formulations thereof, and to methods of using such compositions in the treatment of CFTR mediated diseases, particularly cystic fibrosis.(Formula I), (Formula II), (Formula III).

公开(公告)号：ZA201101097B

公开(公告)日：2012-05-30

申请号：ZA201101097

申请日：2011-02-10

Applicant: VERTEX PHARMA

Inventor： ROWE WILLIAM ,  HURTER PATRICIA ,  YOUNG CHRISTOPHER ,  DINEHART KIRK ,  VERWIJS MARINUS JACOBUS ,  OVERHOFF KIRK ,  GROOTENHUIS PETER D J ,  BOTFIELD MARTYN C ,  GROSSI ALFREDO

IPC: A61K20060101

Abstract: The present invention relates to pharmaceutical compositions comprising a solid dispersion of N-[2,4-Bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide, methods of manufacturing pharmaceutical compositions of the present invention, and methods of administering pharmaceutical compositions of the present invention.

公开(公告)号：MX2012001939A

公开(公告)日：2012-03-29

申请号：MX2012001939

申请日：2010-02-18

Applicant: VERTEX PHARMA

Inventor： GROOTENHUIS PETER D J ,  ZLOKARNIK GREGOR ,  HURTER PATRICIA ,  GROSSI ALFREDO ,  ROWE WILLIAM ,  DINEHART KIRK ,  OVERHOFF KIRK ,  BOTFIELD MARTYN ,  VERWIJS MARINUS JACOBUS ,  GOOR FREDRICK F VAN ,  YOUNG CHRISTOPHER R

IPC: A61K47/32 ,  A61K9/14 ,  A61K31/47 ,  A61P19/00 ,  A61P19/10 ,  A61P43/00

Abstract: La presente invención se relaciona con composiciones farmacéuticas que comprenden una dispersión sólida de N-[2,4-Bis(1,1-dimetiletil)-5-hidroxifenil]-1,4-dihidro-4-oxoquin olina-3-carboxamida, los métodos para elaborar las composiciones farmacéuticas de la presente invención, y los métodos para administrar las composiciones farmacéuticas de la presente invención.

公开(公告)号：AU2009282419A1

公开(公告)日：2010-02-18

申请号：AU2009282419

申请日：2009-08-13

Applicant: VERTEX PHARMA

Inventor： ROWE WILLIAM ,  HURTER PATRICIA ,  YOUNG CHRISTOPHER ,  DINEHART KIRK ,  VERWIJS MARINUS JACOBUS ,  OVERHOFF KIRK ,  GROOTENHUIS PETER D J ,  BOTFIELD MARTYN ,  GROSSI ALFREDO

IPC: A61K47/32

Abstract: The present invention relates to pharmaceutical compositions comprising a solid dispersion of N-[2,4-Bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide, methods of manufacturing pharmaceutical compositions of the present invention, and methods of administering pharmaceutical compositions of the present invention.

公开(公告)号：PL3470063T3

公开(公告)日：2025-04-14

申请号：PL18192504

申请日：2013-11-01

Applicant: VERTEX PHARMA

Inventor： VERWIJS MARINUS JACOBUS ,  KARKARE RADHIKA ,  MOORE MICHAEL DOUGLAS

IPC: A61P11/00 ,  A61K9/20 ,  A61K31/443 ,  A61K31/47 ,  A61K45/06

公开(公告)号：HRP20250100T1

公开(公告)日：2025-03-28

申请号：HRP20250100

申请日：2013-11-01

Applicant: VERTEX PHARMA

Inventor： VERWIJS MARINUS JACOBUS ,  KARKARE RADHIKA ,  MOORE MICHAEL DOUGLAS

IPC: A61P11/00 ,  A61K9/20 ,  A61K31/443 ,  A61K31/47 ,  A61K45/06

公开(公告)号：HUE053357T2

公开(公告)日：2021-06-28

申请号：HUE17204189

申请日：2009-08-13

Applicant: VERTEX PHARMA

Inventor： ROWE WILLIAM ,  HURTER PATRICIA ,  YOUNG CHRISTOPHER ,  DINEHART KIRK ,  VERWIJS MARINUS JACOBUS ,  OVERHOFF KIRK ,  GROOTENHUIS PETER D J ,  BOTFIELD MARTYN ,  GROSSI ALFREDO

IPC: A61K9/16 ,  A61K9/20 ,  A61K9/28 ,  A61K31/47