公开(公告)号：DE59604806D1

公开(公告)日：2000-04-27

申请号：DE59604806

申请日：1996-12-11

Applicant: BASF AG

Inventor： SCHADE CHRISTIAN ,  WEKEL HANS-ULRICH ,  SANNER AXEL ,  SPERLING KARIN

IPC: A61K47/32 ,  A61K8/72 ,  A61K8/81 ,  A61K9/10 ,  A61K31/74 ,  A61Q19/00 ,  C08F220/04 ,  C08F222/00 ,  C08F222/02 ,  C08F222/04 ,  C08F290/06 ,  C09K3/00 ,  C09K23/00 ,  C09K23/52

Abstract: PCT No. PCT/EP96/05522 Sec. 371 Date Jun. 2, 1998 Sec. 102(e) Date Jun. 2, 1998 PCT Filed Dec. 11, 1996 PCT Pub. No. WO97/21744 PCT Pub. Date Jun. 19, 1997The disclosure relates to a copolymer obtainable by radically initiated polymerization of the following: A) 70-99.9 wt. % an olefinically unsaturated C3-C5 monocarboxylic acid, an olefinically unsaturated C4-C8 dicarboxylic acid or its anhydride, or a mixture of such carboxylic acids; with B) 0.1-30 wt. % one or more multiply olefinically unsaturated carboxylic acid derivatives of formula (I)Z-Y-(CHR3-CH2-X)n-R4(I)in which Z is a vinyl or allyl group or structure (a), R1, R2 are hydrogen or methyl, R3 is hydrogen, methyl or ethyl, R4 is a singly or multiply olefinically unsaturated alkenyl or cycloalkenyl group or a singly or doubly olefinically unsaturated arylalkylene group, X is oxygen or NH, Y is oxygen, NH or N-alkyl, n is a number between 0 and 50; and C) 0-29.9 wt. % other copolymerizable monomers. The proposed copolymer can be used as a thickener or dispergent for aqueous systems.

公开(公告)号：DE19843903A1

公开(公告)日：2000-03-30

申请号：DE19843903

申请日：1998-09-24

Applicant: BASF AG

Inventor： KOTHRADE STEPHAN ,  BERNDL GUNTHER ,  SANNER AXEL ,  SIMON DIRK

IPC: A61K9/20 ,  A61K9/22

Abstract: A solid dosage form contains a copolymer of an N-vinyl-lactam and methyl methacrylate, having a limited water uptake, as polymeric binder. A solid dosage form comprises least one polymeric binder, at least one active agent (A) and optionally conventional additives, where the binder is a copolymer of at least one N-vinyl-lactam of formula (I) (10-60 wt. %) with methyl methacrylate (40-90 wt. %), having a water uptake on swelling of less than 50 wt. % (based on the weight of the binder). n = 1-3. An Independent claim is included for the preparation of the dosage form, by mixing the components (directly or after preliminary melting) and shaping the obtained plastic mixture into the required dosage form.

公开(公告)号：AU5853499A

公开(公告)日：2000-03-14

申请号：AU5853499

申请日：1999-08-19

Applicant: BASF AG

Inventor： KIM SON NGUYEN ,  SANNER AXEL ,  SCHEHLMANN VOLKER

IPC: A61K8/72 ,  A61K8/00 ,  A61K8/06 ,  A61K8/31 ,  A61K8/34 ,  A61K8/42 ,  A61K8/81 ,  A61K8/89 ,  A61K8/891 ,  A61Q5/00 ,  A61Q5/02 ,  A61Q5/06 ,  C08F2/44 ,  C08F8/00 ,  C08F220/10 ,  C08F220/18 ,  C08F220/54 ,  C08F226/06 ,  A61K7/06

Abstract: Cationic polymers are obtainable by free-radical copolymerization, ofa) from 50 to 70% by weight of one or more monomers of the formula IX=O, NR ,R =H, C1-C8-alkyl,R =tert-butyl,(b) from 5 to 45% by weight of one or more monomers of the formula IIwhere n=1 to 3,(c) from 5 to 40% by weight of a monoethylenically unsaturated monomer having at least one amine-containing group,(d) from 0 to 5% by weight of a polyalkylene oxide-containing silicone derivative,where up to 40% by weight, based on (a), (b), (c) and (d), of the monomer (a) can be replaced by a monomer of the formula I where R =C2-C22-alkyl.

公开(公告)号：DE59309876D1

公开(公告)日：1999-12-23

申请号：DE59309876

申请日：1993-08-04

Applicant: BASF AG

Inventor： GRABOWSKI SVEN ,  SANNER AXEL ,  ROSENBERG JOERG

IPC: A01N25/10 ,  A01N25/12 ,  A61K9/14 ,  A61K9/20 ,  A61K9/22 ,  A61K9/26

Abstract: Preparations in solid particle form containing active compounds, obtainable by intimate mixing of the active compound with a water-soluble melt of a) 10 to 90% by weight of a water-soluble polymer A of a viscosity Va of 1,000 to 120,000 cps and b) 10 to 90% by weight of a water-soluble polymer B of a viscosity Vb of 1 to 500 cps as a carrier substance, the viscosities Va and Vb being those of a 2% strength by weight aqueous solution at 20@C, measured by the capillary method ASTM D 2363-72 (European Pharmacopoeia, Vol. III, p. 37), and processing of the melt with shaping to give the particles.

公开(公告)号：DE59603219D1

公开(公告)日：1999-11-04

申请号：DE59603219

申请日：1996-11-04

Applicant: BASF AG

Inventor： NGUYEN KIM SON ,  SANNER AXEL ,  HOESSEL PETER

IPC: A61K8/72 ,  A61K8/02 ,  A61K8/06 ,  A61K8/64 ,  A61K8/85 ,  A61K8/87 ,  A61K8/91 ,  A61Q5/06 ,  C08G18/00 ,  C08G18/08 ,  C08G18/10 ,  C08G18/12 ,  C08G18/64 ,  C08G18/66 ,  A61K7/06

Abstract: Water-soluble or -dispersible graft polymers (I) and their salts are claimed. The polymers are from a water-soluble or -dispersible polyurethane prepolymer (A) with terminal NCO groups, and a protein (B) with free amino groups. Also claimed are (1) a process for preparing (I) by reacting (A) with (B); and (2) a hair-treatment agent containing (I), especially in the form of a hair spray. Pref. (I) is produced from (a) a compound with at least 2 active H atoms, (b) a compound with at least 2 active H atoms and at least 1 acid, tertiary amine or ionogenic or ionic group, and (c) a diisocyanate. The equivalent ratio (NCO):(active H) = >1:1 to 1.2:1. (b) is preferably a carboxylate and/or sulphonate group or a group containing nitrogen, especially dimethylolpropanoic acid. (a) contains a polyester diol and/or a silicone. (B) is casein or its hydrolysate.

公开(公告)号：BR9712152A

公开(公告)日：1999-08-31

申请号：BR9712152

申请日：1997-09-29

Applicant: BASF AG

Inventor： NIESSENER MANFRED ,  NILZ CLAUDIA ,  HOSSEL PETER ,  KOTHRADE STEPHAN ,  SANNER AXEL

IPC: A61K8/00 ,  A61K8/36 ,  A61K8/42 ,  A61K8/49 ,  A61K8/72 ,  A61K8/81 ,  A61K8/898 ,  A61Q5/00 ,  A61Q5/02 ,  A61Q5/04 ,  A61Q5/10 ,  A61Q5/12 ,  A61Q11/00 ,  A61Q19/00 ,  C08F226/02 ,  C08F226/06 ,  A61K7/06 ,  A61K7/48

Abstract: A cosmetic composition comprising water-soluble copolymer, which as characteristic structural elements comprisesa) vinylcarboxamide units of the general formula IwhereR1 and R2 independently of one another are H, alkyl, cycloalkyl, aryl or aralkyl, andb) units of the general formula IIwhereA is a chemical bond or an alkylene group,the radicals R3 independently of one another are H, alkyl, cycloalkyl, aryl or aralkyl, or together with the nitrogen atom to which they are bonded, form an unsubstituted, mono- or polysubstituted, five- to seven-membered, heterocyclic, aromatic or nonaromatic ring, which if appropriate contains one or two further heteroatoms, selected from among O, N and S, it being possible for the heterocyclic ring to be fused to a further five- or six-membered, aromatic or nonaromatic ring,R4 is H, alkyl or aralkyl.

公开(公告)号：CA2311308A1

公开(公告)日：1999-06-10

申请号：CA2311308

申请日：1998-11-30

Applicant: BASF AG

Inventor： ERNST ANDREAS ,  MEFFERT HELMUT ,  SANNER AXEL ,  KOTHRADE STEPHAN ,  BERNDL GUNTHER

IPC: A61K47/32 ,  A23K20/10 ,  A23K40/10 ,  A23K40/20 ,  A23L27/00 ,  A23L33/10 ,  A61K9/16 ,  A61K9/20 ,  A61K9/22 ,  A61K31/277 ,  A61K31/421 ,  A61K47/30

Abstract: The invention relates to a method for producing solid dosing forms by mixing at least one polymeric binding agent, at least one active substance, and optional common additives while producing a plastic mixture and during shaping, whereby a copolymer from a N-vinyl lactam and from an copolymerizable monomer with a hydrophobic radical is used as a polymeric binding agent. Dosing forms which slowly release the active substance are obtained in a simple and economical manner.

公开(公告)号：PL329911A1

公开(公告)日：1999-06-07

申请号：PL32991198

申请日：1998-11-26

Applicant: BASF AG

Inventor： DIEING REINHOLD ,  FAUL DIETER ,  RAUBENHEIMER HANS-JUERGEN ,  SANNER AXEL

IPC: A61K8/72 ,  A61K8/00 ,  A61K8/02 ,  A61K8/81 ,  A61Q5/06 ,  A61Q11/00 ,  A61Q19/10 ,  C08F2/44 ,  C08F8/12 ,  C08F8/14 ,  C08F216/18 ,  C08F222/06 ,  C08F261/06 ,  C08F267/04 ,  C08F269/00

公开(公告)号：NZ302243A

公开(公告)日：1999-01-28

申请号：NZ30224396

申请日：1996-02-01

Applicant: BASF AG

Inventor： GRABOWSKI SVEN ,  BREITENBACH JORG ,  ROSENBERG JOERG ,  SANNER AXEL

IPC: A61K9/22 ,  A61K9/20 ,  A61K47/48

Abstract: PCT No. PCT/EP96/00417 Sec. 371 Date Jul. 30, 1997 Sec. 102(e) Date Jul. 30, 1997 PCT Filed Feb. 1, 1996 PCT Pub. No. WO96/25151 PCT Pub. Date Aug. 22, 1996Solid preparations are obtainable by melt extrusion of A) at least one active compound, B) a mixture of B1) from 10 to 90% by weight of a water-soluble, thermoplastic polymer, and B2) from 10 to 90% by weight of a low-substituted hydroxypropylcellulose, and C) from 0 to 50% by weight, based on the total amount of the preparation, of customary pharmaceutical auxiliaries.

公开(公告)号：DE59407308D1

公开(公告)日：1998-12-24

申请号：DE59407308

申请日：1994-07-05

Applicant: BASF AG

Inventor： SCHADE CHRISTIAN ,  WESTENFELDER HORST ,  SPERLING-VIETMEIER KARIN ,  SANNER AXEL ,  WEKEL HANS-ULRICH

IPC: A61K47/30 ,  A61K8/06 ,  A61K8/72 ,  A61K8/81 ,  A61K9/113 ,  A61K47/32 ,  C08F2/08 ,  C08F20/04 ,  C08F20/06 ,  C08F220/00 ,  C08F220/06 ,  C08F220/08 ,  C08F222/00 ,  C08K3/20 ,  C09K23/00 ,  C09K23/52 ,  A61K7/48

Abstract: The use of crosslinked copolymers obtainable by precipitation polymerization of monomer mixtures comprising(a) monoethylenically unsaturated C3-C8-carboxylic acids, their anhydrides or mixtures of said carboxylic acids and anhydrides,(b) compounds with at least 2 non-conjugated ethylenic double bonds in the molecule as crosslinkers and, where appropriate,(c) other monoethylenically unsaturated monomers which are copolymerizable with monomers (a) and (b),in the presence of free-radical polymerization initiators and from 0.1 to 20% by weight, based on the monomers used, of saturated, nonionic surface-active compounds, as stabilizer in oil-in-water emulsions in amounts of from 0.01 to 5% of the weight of the emulsions, and cosmetic and pharmaceutical formulations based on oil-in-water emulsions which contain said precipitation polymers.