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公开(公告)号：AU2003222055A1
公开(公告)日：2003-10-08
申请号：AU2003222055
申请日：2003-03-21
Applicant: ABBOTT LAB
Inventor： HIRST GAVIN C , ARNOLD LEE D , BURCHAT ANDREW , WISHART NEIL , CALDERWOOD DAVID , WADA CAROL K , MICHAELIDES MICHAEL R , JI ZHIQIN , MUCKEY MELANIE
IPC: A61K31/519 , A61P1/04 , A61P1/16 , A61P3/10 , A61P5/14 , A61P7/00 , A61P7/06 , A61P9/00 , A61P9/10 , A61P9/12 , A61P11/00 , A61P11/06 , A61P13/12 , A61P15/08 , A61P17/02 , A61P17/06 , A61P19/02 , A61P27/02 , A61P27/06 , A61P29/00 , A61P31/04 , A61P31/12 , A61P31/18 , A61P31/22 , A61P33/02 , A61P35/00 , A61P35/02 , A61P37/02 , A61P37/06 , A61P43/00 , C07D413/04 , C07D487/04 , C07D491/04 , C07D491/048 , C07D498/04 , C07D491/00 , C07D487/02 , C07D473/00 , C07D471/00 , C07D487/00
Abstract: The present application is directed to pyrazolopyrimidine and furopyrimnidine analogs of the formula (I) wherein the substituents are as defined herein, which are useful as kinase inhibitors.
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公开(公告)号：AU2003220437A1
公开(公告)日：2003-10-08
申请号：AU2003220437
申请日：2003-03-20
Applicant: ABBOTT LAB
Inventor： FREY ROBIN R , GUO YAN , JI ZHIQIN , CURTIN MICHAEL , MICHAELIDES MICHAEL R , DAI YUJIA , DAVIDSEN STEVEN K
IPC: C07D495/04 , A61K31/519 , A61P1/04 , A61P3/10 , A61P5/14 , A61P7/10 , A61P9/10 , A61P9/12 , A61P11/00 , A61P17/06 , A61P19/02 , A61P21/04 , A61P25/00 , A61P29/00 , A61P35/00 , A61P35/02 , A61P37/06 , A61P43/00 , C07D498/02 , C07D513/04
Abstract: Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
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公开(公告)号：CA2477651A1
公开(公告)日：2003-10-02
申请号：CA2477651
申请日：2003-03-21
Applicant: ABBOTT LAB
Inventor： BURCHAT ANDREW , ARNOLD LEE D , WADA CAROL K , HIRST GAVIN C , WISHART NEIL , CALDERWOOD DAVID , MICHAELIDES MICHAEL R , MUCKEY MELANIE , JI ZHIQIN
IPC: A61K31/519 , A61P1/04 , A61P1/16 , A61P3/10 , A61P5/14 , A61P7/00 , A61P7/06 , A61P9/00 , A61P9/10 , A61P9/12 , A61P11/00 , A61P11/06 , A61P13/12 , A61P15/08 , A61P17/02 , A61P17/06 , A61P19/02 , A61P27/02 , A61P27/06 , A61P29/00 , A61P31/04 , A61P31/12 , A61P31/18 , A61P31/22 , A61P33/02 , A61P35/00 , A61P35/02 , A61P37/02 , A61P37/06 , A61P43/00 , C07D413/04 , C07D487/04 , C07D491/04 , C07D491/048 , C07D498/04 , C07D473/00 , C07D491/00
Abstract: The present application is directed to pyrazolopyrimidine and furopyrimidine analogs of the formula (I), wherein the substituents are as defined herein, which are useful as kinase inhibitors.
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公开(公告)号：AU4340202A
公开(公告)日：2002-06-18
申请号：AU4340202
申请日：2001-10-26
Applicant: ABBOTT LAB
Inventor： CURTIN MICHAEL L , DAI YUJIA , DAVIDSEN STEVEN K , FREY ROBIN R , GUO YAN , HEYMAN HOWARD R , HOLMS JAMES H , JI ZHIQIN , MICHAELIDES MICHAEL R , VASUDEVAN ANIL , WADA CAROL K
IPC: C07C45/29 , C07C45/30 , C07C45/45 , C07C45/51 , C07C45/67 , C07C47/277 , C07C49/255 , C07C59/90 , C07C69/716 , C07C235/14 , C07C235/16 , C07C235/20 , C07C235/74 , C07C235/80 , C07C243/38 , C07C255/54 , C07C255/60 , C07C311/19 , C07C317/32 , C07C317/44 , C07C323/41 , C07C323/60 , C07D209/08 , C07D209/42 , C07D213/30 , C07D213/40 , C07D213/75 , C07D215/38 , C07D231/40 , C07D235/06 , C07D257/04 , C07D263/14 , C07D263/32 , C07D263/58 , C07D271/10 , C07D277/46 , C07D277/56 , C07D277/74 , C07D277/82 , C07D285/08 , C07D295/112 , C07D307/68 , C07D307/85 , C07D317/58 , C07D317/66 , C07D317/68 , C07D413/04 , C07D413/12 , C07D417/04 , C07D491/10
Abstract: Substituted trifluoromethyl ketones, ketooxazoles, ketoamides, ketoesters, and diketones having the formula or therapeutically acceptable salts thereof, are histone deacetylase (HDAC) inhibitors. Preparation of the compounds, compositions containing the compounds, and treatment of diseases using the compounds are disclosed.
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25.发明专利
公开(公告)号：CA2608974C
公开(公告)日：2014-03-18
申请号：CA2608974
申请日：2006-05-16
Applicant: ABBOTT LAB
Inventor： GRACIAS VIJAYA J , ABAD-ZAPATERO CELERINO , DJURIC STEVAN W , JI ZHIQIN , MICHAELIDES MICHAEL R , STEWART KENT D , ZANZE IRINI
IPC: C07D487/04 , A61K31/551 , A61P35/00
Abstract: Compounds having the Formula (I) are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
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Patent Agency Ranking
公开(公告)号：CA2526430C
公开(公告)日：2012-07-10
申请号：CA2526430
申请日：2004-05-21
Applicant: ABBOTT LAB
Inventor： DAI YUJIA , DAVIDSEN STEVEN K , ERICSSON ANNA M , HARTANDI KRESNA , JI ZHIQIN , MICHAELIDES MICHAEL R
IPC: C07D231/56 , A61K31/416 , A61K31/42 , A61K31/423 , A61K31/428 , A61K31/4709 , A61P35/00 , C07D261/20 , C07D275/04 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D409/04 , C07D413/02
Abstract: Compounds having the formula (I) are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
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公开(公告)号：DK1638941T3
公开(公告)日：2010-10-11
申请号：DK04776083
申请日：2004-05-21
Applicant: ABBOTT LAB
Inventor： DAI YUJIA , DAVIDSEN STEVEN K , ERICSSON ANNA M , HARTANDI KRESNA , JI ZHIQIN , MICHAELIDES MICHAEL R
IPC: C07D231/56 , A61K31/416 , A61K31/42 , A61K31/423 , A61K31/428 , A61K31/4709 , A61P35/00 , C07D261/20 , C07D275/04 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D409/04 , C07D413/02
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公开(公告)号：CA2479363A1
公开(公告)日：2003-10-02
申请号：CA2479363
申请日：2003-03-20
Applicant: ABBOTT LAB
Inventor： FREY ROBIN R , JI ZHIQIN , MICHAELIDES MICHAEL R , DAVIDSEN STEVEN K , GUO YAN , CURTIN MICHAEL , DAI YUJIA
IPC: C07D495/04 , A61K31/519 , A61P1/04 , A61P3/10 , A61P5/14 , A61P7/10 , A61P9/10 , A61P9/12 , A61P11/00 , A61P17/06 , A61P19/02 , A61P21/04 , A61P25/00 , A61P29/00 , A61P35/00 , A61P35/02 , A61P37/06 , A61P43/00 , C07D498/02 , C07D513/04
Abstract: Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compound s, compositions containing the compounds, and methods of treatment using the compounds.
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公开(公告)号：ES2398074T3
公开(公告)日：2013-03-13
申请号：ES10164213
申请日：2004-05-21
Applicant: ABBOTT LAB
Inventor： DAI YUJIA , DAVIDSEN STEVEN , ERICSSON ANNA , HARTANDI KRESNA , JI ZHIQIN , MICHAELIDES MICHAEL
IPC: C07D231/56 , A61K31/416 , A61K31/42 , A61K31/423 , A61K31/428 , A61K31/4709 , A61P35/00 , C07D261/20 , C07D275/04 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D409/04 , C07D413/02
Abstract: El compuesto de fórmula (II) o una sal terapéuticamente aceptable del mismo, en la que X se selecciona entre el grupo que consiste en O y S; R1 y R2 se seleccionan independientemente entre el grupo que consiste en hidrógeno, alcoxi, alcoxialcoxi,alcoxialquilo, alquilo, ariloxi, ariloxialquilo, halo, haloalcoxi, haloalquilo, heterociclilo, heterociclilalquenilo,heterociclilalcoxi, heterociclilalquilo, heterocicliloxialquilo, hidroxi, hidroxialcoxi, hidroxialquilo, (NRaRb)alcoxi,(NRaRb)alquenilo, (NRaRb)alquilo, (NRaRb)carbonilalquenilo y (NRaRb)carbonilalquilo;R3 y R4 se seleccionan independientemente entre el grupo que consiste en hidrógeno, alcoxi, alquilo, halo,haloalcoxi, haloalquilo e hidroxi; L se selecciona entre el grupo que consiste en (CH2)mN(R7)C(O)N(R8)(CH2)n y CH2C(O)NR7, en la que m y nson independientemente 0 ó 1, y en la que cada grupo se dibuja con su extremo izquierdo unido al anillosustituido con R3 y R4.
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公开(公告)号：AT540951T
公开(公告)日：2012-01-15
申请号：AT06759877
申请日：2006-05-16
Applicant: ABBOTT LAB
Inventor： GRACIAS VIJAYA , ABAD-ZAPATERO CELERINO , DJURIC STEVAN , JI ZHIQIN , MICHAELIDES MICHAEL , STEWART KENT , ZANZE IRINI
IPC: C07D487/04 , A61K31/551
Abstract: Compounds having the Formula (I) are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
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