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公开(公告)号：NZ510329A
公开(公告)日：2004-02-27
申请号：NZ51032996
申请日：1996-12-06
Applicant: ABBOTT LAB
Inventor： SHAM HING LEUNG , NORBECK DANIEL W , CHEN XIAOQI , EMPF DALE J , KUMAR GONDI N , COOPER ARTHUR J , HANNICK STEVEN M , OLIVER PATRICIA A , PATEL KETAN M , LIU JIH-HEHJ , TIEN JIEH-HUA , STONER ERIC J , STENGEL PETER J , PLATA DANIEL J , KOLACZKOWSKI LAWRENCE , DICKMAN DANIEL A , CONDON STEPHEN L , HERRIN THOMAS R , BETEBENNER DAVID A
IPC: A61K31/00 , C07D253/00 , A61K31/40 , A61K31/4015 , A61K31/41 , A61K31/415 , A61K31/4164 , A61K31/4166 , A61K31/4184 , A61K31/42 , A61K31/421 , A61K31/425 , A61K31/427 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/4439 , A61K31/47 , A61K31/495 , A61K31/496 , A61K31/4965 , A61K31/505 , A61K31/513 , A61K31/53 , A61K31/55 , A61K38/05 , A61K45/00 , A61P31/18 , A61P43/00 , C07C231/12 , C07C235/20 , C07C273/18 , C07C275/16 , C07D20060101 , C07D207/22 , C07D207/26 , C07D207/27 , C07D207/273 , C07D207/34 , C07D207/40 , C07D207/404 , C07D207/408 , C07D207/416 , C07D211/72 , C07D211/84 , C07D223/06 , C07D233/28 , C07D233/30 , C07D233/32 , C07D233/36 , C07D233/40 , C07D233/42 , C07D233/66 , C07D239/06 , C07D239/10 , C07D239/20 , C07D239/22 , C07D241/06 , C07D241/08 , C07D241/18 , C07D243/04 , C07D253/06 , C07D263/16 , C07D263/20 , C07D263/22 , C07D263/34 , C07D265/04 , C07D267/04 , C07D277/12 , C07D277/32 , C07D277/34 , C07D279/06 , C07D281/02 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12
Abstract: An HIV protease inhibiting compound comprising a substituent of formula I; Wherein R3 is loweralkyl, hydroxyalkyl, or cycloalkylalkyl; and R5 is selected from a) to i) Wherein n is 1, 2 or 3, m is 1, 2 or 3, m' is 1 or 2, X is O, S or NH, Y is Ch2, O, S or N(R6) wherein R6 is hydrogen, loweralkyl, cycloalkyl, cycloalkylalkyl, aryl or arylalkyl, Y" is CH2 or N(R6") wherein R6" is hydrogen, loweralkyl, cycloalkyl, cycloalkylalkyl, aryl or arylalkyl, Y' is N(R6') wherein R6' is hydrogen, loweralkyl, cycloalkyl, cycloalkylalkyl, aryl or arylalkyl, and Z is O, S or NH.
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公开(公告)号：HU222731B1
公开(公告)日：2003-09-29
申请号：HU0003305
申请日：1996-12-06
Applicant: ABBOTT LAB
Inventor： BETEBENNER DAVID A , CHEN XIAOQI , CONDON STEPHEN L , COOPER ARTHUR J , DICKMAN DANIEL A , HANNICK STEVEN M , HERRIN THOMAS R , KEMPF DALE J , KOLACZKOWSKI LAWRENCE , KUMAR GONDI N , LIU JIH-HUA , NORBECK DANIEL W , OLIVER PATRICIA A , PATEL KETAN M , PLATA DANIEL J , SHAM HING LEUNG , STENGEL PETER J , STONER ERIC J , TIEN JIEH-HEH J
IPC: A61K31/00 , C07D253/00 , A61K31/40 , A61K31/4015 , A61K31/41 , A61K31/415 , A61K31/4164 , A61K31/4166 , A61K31/4184 , A61K31/42 , A61K31/421 , A61K31/425 , A61K31/427 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/4439 , A61K31/47 , A61K31/495 , A61K31/496 , A61K31/4965 , A61K31/505 , A61K31/513 , A61K31/53 , A61K31/55 , A61K38/05 , A61K45/00 , A61P31/18 , A61P43/00 , C07C231/12 , C07C235/20 , C07C273/18 , C07C275/16 , C07D20060101 , C07D207/22 , C07D207/26 , C07D207/27 , C07D207/273 , C07D207/34 , C07D207/40 , C07D207/404 , C07D207/408 , C07D207/416 , C07D211/72 , C07D211/84 , C07D223/06 , C07D233/28 , C07D233/30 , C07D233/32 , C07D233/36 , C07D233/40 , C07D233/42 , C07D233/66 , C07D239/06 , C07D239/10 , C07D239/20 , C07D239/22 , C07D241/06 , C07D241/08 , C07D241/18 , C07D243/04 , C07D253/06 , C07D263/16 , C07D263/20 , C07D263/22 , C07D263/34 , C07D265/04 , C07D267/04 , C07D277/12 , C07D277/32 , C07D277/34 , C07D279/06 , C07D281/02 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12
Abstract: A compound comprising a substituent of the formula (II) is disclosed as an HIV protease inhibitor. Intermediates for making such compounds and processes for making such intermediates are also disclosed.
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公开(公告)号：NZ326132A
公开(公告)日：1999-11-29
申请号：NZ32613296
申请日：1996-12-06
Applicant: ABBOTT LAB
Inventor： SHAM HING LEUNG , NORBECK DANIEL W , CHEN XIAOQI , BETEBENNER DAVID A , KEMPF DALE J , HERRIN THOMAS R , KUMAR GONDI N , CONDON STEPHEN L , COOPER ARTHUR J , DICKMAN DANIEL A , HANNICK STEVEN M , KOLACZKOWSKI LAWRENCE , OLIVER PATRICIA A , PLATA DANIEL J , STENGEL PETER J , STONER ERIC J , TIEN JIEH-HUA , LIU JIH-HEH J , PATEL KETAN M
IPC: A61K31/00 , C07D253/00 , A61K31/40 , A61K31/4015 , A61K31/41 , A61K31/415 , A61K31/4164 , A61K31/4166 , A61K31/4184 , A61K31/42 , A61K31/421 , A61K31/425 , A61K31/427 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/4439 , A61K31/47 , A61K31/495 , A61K31/496 , A61K31/4965 , A61K31/505 , A61K31/513 , A61K31/53 , A61K31/55 , A61K38/05 , A61K45/00 , A61P31/18 , A61P43/00 , C07C231/12 , C07C235/20 , C07C273/18 , C07C275/16 , C07D20060101 , C07D207/22 , C07D207/26 , C07D207/27 , C07D207/273 , C07D207/34 , C07D207/40 , C07D207/404 , C07D207/408 , C07D207/416 , C07D211/72 , C07D211/84 , C07D223/06 , C07D233/28 , C07D233/30 , C07D233/32 , C07D233/36 , C07D233/40 , C07D233/42 , C07D233/66 , C07D239/06 , C07D239/10 , C07D239/20 , C07D239/22 , C07D241/06 , C07D241/08 , C07D241/18 , C07D243/04 , C07D253/06 , C07D263/16 , C07D263/20 , C07D263/22 , C07D263/34 , C07D265/04 , C07D267/04 , C07D277/12 , C07D277/32 , C07D277/34 , C07D279/06 , C07D281/02 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12
Abstract: A compound of formula (I) is disclosed as an HIV protease inhibitor. Methods and compositions for inhibiting an HIV infection are also disclosed.
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公开(公告)号：HU9901079A2
公开(公告)日：1999-09-28
申请号：HU9901079
申请日：1996-12-06
Applicant: ABBOTT LAB
Inventor： BETEBENNER DAVID A , CHEN XIAOQI , CONDON STEPHEN L , COOPER ARTHUR J , DICKMAN DANIEL A , HANNICK STEVEN M , HERRIN THOMAS R , KEMPF DALE J , KOLACZKOWSKI LAWRENCE , KUMAR GONDI N , LIU JIH-HUA , NORBECK DANIEL W , OLIVER PATRICIA A , PATEL KETAN M , PLATA DANIEL J , SHAM HING LEUNG , STENGEL PETER J , STONER ERIC J , TIEN JIEH-HEH J
IPC: A61K31/00 , A61K31/40 , A61K31/4015 , A61K31/41 , A61K31/415 , A61K31/4164 , A61K31/4166 , C07D253/00 , A61K31/4184 , A61K31/42 , A61K31/421 , A61K31/425 , A61K31/427 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/4439 , A61K31/47 , A61K31/495 , A61K31/496 , A61K31/4965 , A61K31/505 , A61K31/513 , A61K31/53 , A61K31/55 , A61K38/05 , A61K45/00 , A61P31/18 , A61P43/00 , C07C231/12 , C07C235/20 , C07C273/18 , C07C275/16 , C07D20060101 , C07D207/22 , C07D207/26 , C07D207/27 , C07D207/273 , C07D207/34 , C07D207/40 , C07D207/404 , C07D207/408 , C07D207/416 , C07D211/72 , C07D211/84 , C07D223/06 , C07D233/28 , C07D233/30 , C07D233/32 , C07D233/36 , C07D233/40 , C07D233/42 , C07D233/66 , C07D239/06 , C07D239/10 , C07D239/20 , C07D239/22 , C07D241/06 , C07D241/08 , C07D241/18 , C07D243/04 , C07D253/06 , C07D263/16 , C07D263/20 , C07D263/22 , C07D263/34 , C07D265/04 , C07D267/04 , C07D277/12 , C07D277/32 , C07D277/34 , C07D279/06 , C07D281/02 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D239/54
Abstract: A compound comprising a substituent of the formula (II) is disclosed as an HIV protease inhibitor. Intermediates for making such compounds and processes for making such intermediates are also disclosed.
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公开(公告)号：CA2238978A1
公开(公告)日：1997-06-19
申请号：CA2238978
申请日：1996-12-06
Applicant: ABBOTT LAB
Inventor： KEMPF DALE J , KOLACZKOWSKI LAWRENCE , HANNICK STEVEN M , DICKMAN DANIEL A , BETEBENNER DAVID A , SHAM HING LEUNG , COOPER ARTHUR J , LIU JIH-HUA , PLATA DANIEL J , KUMAR GONDI N , STONER ERIC J , CHEN XIAOQI , OLIVER PATRICIA A , CONDON STEPHEN L , PATEL KETAN M , TIEN JIEH-HEH J , NORBECK DANIEL W , HERRIN THOMAS R , STENGEL PETER J
IPC: C07D253/00 , A61K31/00 , A61K31/40 , A61K31/4015 , A61K31/41 , A61K31/415 , A61K31/4164 , A61K31/4166 , A61K31/4184 , A61K31/42 , A61K31/421 , A61K31/425 , A61K31/427 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/4439 , A61K31/47 , A61K31/495 , A61K31/496 , A61K31/4965 , A61K31/505 , A61K31/513 , A61K31/53 , A61K31/55 , A61K38/05 , A61K45/00 , A61P31/18 , A61P43/00 , C07C231/12 , C07C235/20 , C07C273/18 , C07C275/16 , C07D20060101 , C07D207/22 , C07D207/26 , C07D207/27 , C07D207/273 , C07D207/34 , C07D207/40 , C07D207/404 , C07D207/408 , C07D207/416 , C07D211/72 , C07D211/84 , C07D223/06 , C07D233/28 , C07D233/30 , C07D233/32 , C07D233/36 , C07D233/40 , C07D233/42 , C07D233/66 , C07D239/06 , C07D239/10 , C07D239/20 , C07D239/22 , C07D241/06 , C07D241/08 , C07D241/18 , C07D243/04 , C07D253/06 , C07D263/16 , C07D263/20 , C07D263/22 , C07D263/34 , C07D265/04 , C07D267/04 , C07D277/12 , C07D277/32 , C07D277/34 , C07D279/06 , C07D281/02 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12
Abstract: A compound of formula (I) is disclosed as an HIV protease inhibitor. Methods and compositions for inhibiting an HIV infection are also disclosed.
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Patent Agency Ranking
公开(公告)号：PT1192139E
公开(公告)日：2012-07-20
申请号：PT00942823
申请日：2000-06-15
Applicant: ABBOTT LAB
Inventor： KOLACZKOWSKI LAWRENCE , CHANG SOU-JEN , PLATA DANIEL J , STONER ERIC J , ALLEN MICHAEL S , PREMCHANDRAN RAMIYA H , KING STEVEN A , TIEN JIEN-HEH J , WITTENBERGER STEVEN J , CONDON STEPHEN , DEMATTEI JOHN J , MANNA SUKUMAR , NICHOLS PAUL J , PATEL HEMANT H , PATEL SUBHASH R
IPC: C07D215/14 , C07C33/03 , C07C43/303 , C07C47/22 , C07C57/04 , C07C68/06 , C07C69/96 , C07C269/06 , C07C271/12 , C07D215/18 , C07D401/12 , C07H17/08
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公开(公告)号：AU784291B2
公开(公告)日：2006-03-02
申请号：AU5739300
申请日：2000-06-15
Applicant: ABBOTT LAB
Inventor： ALLEN MICHAEL S , PREMCHANDRAN RAMIYA H , CHANG SOU-JEN , CONDON STEPHEN , DEMATTEI JOHN J , KING STEVEN A , KOLACZKOWSKI LAWRENCE , MANNA SUKUMAR , NICHOLS PAUL J , PATEL HEMANT H , PATEL SUBHASH R , PLATA DANIEL J , STONER ERIC J , TIEN JIEN-HEH J , WITTENBERGER STEVEN J
IPC: C07D215/14 , C07C33/03 , C07C43/303 , C07C47/22 , C07C57/04 , C07C68/06 , C07C69/96 , C07C269/06 , C07C271/12 , C07D215/18 , C07D401/12 , C07H17/08
Abstract: The invention relates to a process for preparing carbonate and carbamate compounds, which are important intermediates in the synthesis of 6-O-substituted macrolide antibiotics. The process employs metal-catalyzed coupling reactions to provide a carbonate or carbamate of formula (I) or a substrate that can be reduced to obtain the same. €ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒR 1 -CH=CHCH 2 OC(O)-X-R 2 €ƒ€ƒ€ƒ€ƒ€ƒ(I)
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公开(公告)号：DK1272500T3
公开(公告)日：2005-09-05
申请号：DK00942860
申请日：2000-06-15
Applicant: ABBOTT LAB
Inventor： KU YI-YIN , COOPER ARTHUR J , HAIGHT ANTHONY R , RASMUSSEN MICHAEL , TIEN JIEN-HEH J , STONER ERIC J , PETERSON MATTHEW J , CINK RUSSELL D , DESHPANDE MAHENDRA N , GRIEME TIM , HILL DAVID R , HSU MARGARET CHI-PING , KING STEVEN A , LEANNA MARVIN R , LEE ELAINE C , MCLAUGHLIN MAUREEN A , MORTON HOWARD E , NAPIER JAMES J , PLATA DANIEL J , RAJE PRASAD S , RILEY DAVID , WITTENBERGER STEVEN J
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公开(公告)号：AU2004201149A1
公开(公告)日：2004-04-22
申请号：AU2004201149
申请日：2004-03-18
Applicant: ABBOTT LAB
Inventor： KUMAR GONDI N , HERRIN THOMAS R , KEMPF DALE J , BETEBENNER DAVID A , CHEN XIAOQI , NORBECK DANIEL W , SHAM HING LEUNG , PATEL KETAN M , LIU JIH-HUA , TIEN JIEH-HEH J , STONER ERIC J , STENGEL PETER J , PLATA DANIEL J , OLIVER PATRICIA A , KOLACZKOWSKI LAWRENCE , HANNICK STEVEN M , DICKMAN DANIEL A , COOPER ARTHUR J , CONDON STEPHEN L
IPC: A61K31/415 , C07D207/26 , C07D207/40 , C07D233/32 , C07D239/10 , C07D239/22 , C07D241/08 , C07D263/22
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公开(公告)号：HK1053659A1
公开(公告)日：2003-10-31
申请号：HK03104301
申请日：2003-06-16
Applicant: ABBOTT LAB
Inventor： STONER ERIC J , PETERSON MATTHEW J , KU YI-YIN , CINK RUSSELL D , COOPER ARTHUR J , DESHPANDE MAHENDRA N , GRIEME TIM , HAIGHT ANTHONY R , HILL DAVID R , HSU MARGARET CHI-PING , KING STEVEN A , LEANNA MARVIN R , LEE ELAINE C , MCLAUGHLIN MAUREEN A , MORTON HOWARD E , NAPIER JAMES J , PLATA DANIEL J , RAJE PRASAD S , RASMUSSEN MICHAEL , RILEY DAVID , TIEN JIEN-HEH J , WITTENBERGER STEVEN J
Abstract: In one aspect, the invention relates to a process for preparing 6-O-substituted erythromycin derivatives comprising reacting 2'-substituted and optionally 4''-substituted 9-oxime erythromycin derivatives with an alkylating agent in the presence of a palladium catalyst and phosphine. In another aspect, the invention relates to processes for preparing 6-O-substituted erythromycin ketolides using the palladium-catalyzed alkylation reaction.
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