公开(公告)号：CA2483220A1

公开(公告)日：2003-11-06

申请号：CA2483220

申请日：2003-04-23

Applicant: ABBOTT LAB

Inventor： FLORJANCIC ALAN S ,  DJURIC STEVAN ,  MA ZHENKUN ,  GU YUGUI ,  YONG HONG

IPC: A61K31/7048 ,  A61P31/04 ,  C07H17/08 ,  C07D407/12

Abstract: Antibacterial compounds having formula (I) and formula (II), and salts, prodrugs, and salts of prodrugs thereof, processes for making the compounds and intermediates employed in the processes, compositions containing the compounds, and methods for prophylaxis or treatment of bacterial infections in a fish or a mammal using the compounds are disclosed.

公开(公告)号：BRPI0615102A2

公开(公告)日：2011-05-03

申请号：BRPI0615102

申请日：2006-08-25

Applicant: ABBOTT LAB

Inventor： PEI ZHONGHUA ,  GELDERN THOMAS VON ,  MADAR DAVID J ,  LI XIAOFENG ,  BASHA FATIMA ,  YONG HONG ,  LONGENECKER KENTON L ,  BACKES BRADLEY J ,  JUDD ANDREW S ,  MULHERN MATHEW M ,  STEWART KENT D

IPC: C07C211/40 ,  A61K31/137 ,  C07C211/54 ,  C07C211/62 ,  C07D213/38 ,  C07D213/68 ,  C07D317/64 ,  C07D487/04

Abstract: The present invention relates to compounds, which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II, as well as hyperglycemia, metabolic syndrome, hyperinsulinemia, obesity, atherosclerosis, various immunomodulatory diseases, and other diseases.

公开(公告)号：ZA200705468B

公开(公告)日：2010-03-31

申请号：ZA200705468

申请日：2007-07-04

Applicant: ABBOTT LAB

Inventor： ROHDE JEFFREY J ,  LINK JAMES T ,  DINGES JURGEN ,  YONG HONG ,  KURUKULASURIYA RAVI ,  SHUAI QI ,  PATEL JYOTI R ,  SORENSEN BRYAN K ,  YEH VINCE S

IPC: A61K20100101 ,  A61P20100101 ,  C07C20100101 ,  C07D20100101

Abstract: The present invention relates to compounds that are inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme. The present invention further relates to the use of inhibitors of 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme for the treatment of non-insulin dependent type 2 diabetes, insulin resistance, obesity, lipid disorders, metabolic syndrome and other diseases and conditions that are mediated by excessive glucocorticoid action.

公开(公告)号：BRPI0606228A2

公开(公告)日：2009-06-09

申请号：BRPI0606228

申请日：2006-01-05

Applicant: ABBOTT LAB

Inventor： ROHDE JEFFREY J ,  LINK JAMES T ,  PATEL JYOTI R ,  DINGES JURGEN ,  SORENSEN BRYAN K ,  YONG HONG ,  SHUAI QI

IPC: C07C233/63 ,  A61K31/165 ,  A61K31/381 ,  A61K31/415 ,  A61K31/42 ,  A61K31/4409 ,  A61P3/04 ,  C07D213/56 ,  C07D231/12 ,  C07D261/08 ,  C07D333/24

Abstract: The present invention relates to compounds that are inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme. The present invention further relates to the use of inhibitors of 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme for the treatment of non-insulin dependent type 2 diabetes, insulin resistance, obesity, lipid disorders, metabolic syndrome and other diseases and conditions that are mediated by excessive glucocorticoid action.

公开(公告)号：HK1117138A1

公开(公告)日：2009-01-09

申请号：HK08104526

申请日：2008-04-23

Applicant: ABBOTT LAB

Inventor： PATEL JYOTI R ,  SHUAI QI ,  LINK JAMES T ,  ROHDE JEFFREY J ,  DINGES JURGEN ,  SORENSEN BRYAN K ,  WINN MARTIN ,  YONG HONG ,  YEH VINCE S

IPC: A61K20060101 ,  A61P20060101 ,  C07C20060101 ,  C07D20060101

Abstract: The present invention relates to compounds which are inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme. The present invention further relates to the use of inhibitors of 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme for the treatment of non-insulin dependent type 2 diabetes, insulin resistance, obesity, lipid disorders, metabolic syndrome and other diseases and conditions that are mediated by excessive glucocorticoid action.

公开(公告)号：DK1560811T3

公开(公告)日：2007-12-10

申请号：DK03774478

申请日：2003-09-15

Applicant: ABBOTT LAB

Inventor： MADAR DAVID ,  PEI ZHONGHUA ,  PIREH DAISY ,  DJURIC STEVAN W ,  WIEDEMAN PAUL E ,  YONG HONG ,  MICHMERHUIZEN MELISSA J ,  KOPECKA HANA ,  LI XIAOFENG ,  LONGENECKER KENTON ,  SHAM HING L ,  STEWART KENT D ,  SZCZEPANKIEWICZ BRUCE G

IPC: C07D207/00 ,  A61P37/02 ,  C07D207/16 ,  C07D207/26 ,  C07D207/27 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D417/12

Abstract: The present invention relates to compounds of formula I which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, Syndrome X, hyperinsulinemia, obesity, atherosclerosis, and various immunomodulatory diseases. Or pharmaceutically acceptable salts or prodrugs thereof, wherein X,R,R ,R and R have the definitions given in the description.

公开(公告)号：PT1560811E

公开(公告)日：2007-11-14

申请号：PT03774478

申请日：2003-09-15

Applicant: ABBOTT LAB

Inventor： STEWART KENT D ,  SHAM HING L ,  MADAR DAVID ,  PEI ZHONGHUA ,  PIREH DAISY ,  DJURIC STEVAN W ,  WIEDEMAN PAUL E ,  YONG HONG ,  MICHMERHUIZEN MELISSA J ,  KOPECKA HANA ,  LI XIAOFENG ,  LONGENECKER KENTON ,  SZCZEPANKIEWICZ BRUCE G

IPC: C07D207/00 ,  A61P37/02 ,  C07D207/16 ,  C07D207/26 ,  C07D207/27 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D417/12

公开(公告)号：MX2007008239A

公开(公告)日：2007-08-17

申请号：MX2007008239

申请日：2006-01-05

Applicant: ABBOTT LAB

Inventor： YONG HONG ,  LINK JAMES T ,  ROHDE JEFFREY J ,  PATEL JYOTI R ,  SHUAI QI ,  DINGES JURGEN ,  SORENSEN BRYAN K ,  YEH VINCE S ,  KURUKULASURIYA RAVI

IPC: C07C233/63 ,  A61K31/165 ,  A61K31/381 ,  A61K31/415 ,  A61K31/42 ,  A61K31/4409 ,  A61P3/04 ,  A61P3/10 ,  C07D213/56 ,  C07D231/12 ,  C07D261/08 ,  C07D333/24

Abstract: La presente invencion se refiere a compuestos que son inhibidores de la enzima 11-beta-hidroxiesteroide deshidrogenasa Tipo I. La presente invencion ademas se refiere al uso de inhibidores de la enzima 11-beta-hidroxiesteroide deshidrogenasa Tipo I para el tratamiento de la diabetes tipo 2 no-insulina dependiente, resistencia a la insulina, obesidad, trastornos de lipidos, sindrome metabolico y otras enfermedades y condiciones que son mediadas por la accion excesiva de glucocorticoides.

公开(公告)号：AT368647T

公开(公告)日：2007-08-15

申请号：AT03774478

申请日：2003-09-15

Applicant: ABBOTT LAB

Inventor： MADAR DAVID ,  PEI ZHONGHUA ,  PIREH DAISY ,  DJURIC STEVAN ,  WIEDEMAN PAUL ,  YONG HONG ,  MICHMERHUIZEN MELISSA ,  KOPECKA HANA ,  LI XIAOFENG ,  LONGENECKER KENTON ,  SHAM HING ,  STEWART KENT ,  SZCZEPANKIEWICZ BRUCE

IPC: C07D207/00 ,  A61P37/02 ,  C07D207/16 ,  C07D207/26 ,  C07D207/27 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D417/12

Abstract: The present invention relates to compounds of formula I which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, Syndrome X, hyperinsulinemia, obesity, atherosclerosis, and various immunomodulatory diseases. Or pharmaceutically acceptable salts or prodrugs thereof, wherein X,R,R ,R and R have the definitions given in the description.

公开(公告)号：AU2003282800A1

公开(公告)日：2004-04-08

申请号：AU2003282800

申请日：2003-09-15

Applicant: ABBOTT LAB

Inventor： SZCZEPANKIEWICZ BRUCE G ,  MADAR DAVID ,  PEI ZHONGHUA ,  PIREH DAISY ,  DJURIC STEVAN W ,  WIEDEMAN PAUL E ,  YONG HONG ,  FEENSTRA MELISSA J ,  KOPECKA HANA ,  LI XIAOFENG ,  LONGENECKER KENTON ,  SHAM HING L ,  STEWART KENT D

IPC: A61P37/02 ,  C07D207/16 ,  C07D207/26 ,  C07D207/27 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D417/12 ,  C07D207/00

Abstract: The present invention relates to compounds of formula I which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, Syndrome X, hyperinsulinemia, obesity, atherosclerosis, and various immunomodulatory diseases. Or pharmaceutically acceptable salts or prodrugs thereof, wherein X,R,R ,R and R have the definitions given in the description.