公开(公告)号：AT39694T

公开(公告)日：1989-01-15

申请号：AT85108319

申请日：1985-07-05

Applicant: BASF AG

Inventor： GEISS KARL-HEINZ DR ,  SCHMIED BERNHARD DR ,  RASCHACK MANFRED DR ,  LEHMANN HANS-DIETER PROF DR ,  GRIES JOSEF DR ,  RUEBSAMEN KLAUS DR

IPC: A61K31/50 ,  A61K31/55 ,  A61P1/04 ,  A61P7/02 ,  A61P9/04 ,  A61P9/12 ,  C07D237/00 ,  C07D403/04 ,  C07D403/10

公开(公告)号：DE3642331A1

公开(公告)日：1988-06-23

申请号：DE3642331

申请日：1986-12-11

Applicant: BASF AG

Inventor： SEITZ WERNER DR ,  UNGER LILIANE DR ,  RASCHACK MANFRED DR ,  BALDINGER VERENA DR ,  RUEBSAMEN KLAUS DR ,  GRIES JOSEF DR

IPC: A61K31/275 ,  A61K31/335 ,  A61K31/357 ,  A61K31/36 ,  A61P1/04 ,  A61P3/00 ,  A61P9/00 ,  A61P11/00 ,  A61P43/00 ,  C07C67/00 ,  C07C253/00 ,  C07C253/30 ,  C07C255/32 ,  C07C255/33 ,  C07C255/35 ,  C07C255/37 ,  C07C255/42 ,  C07C255/53 ,  C07C255/58 ,  C07D317/50 ,  C07D317/60 ,  C07D319/08 ,  C07D319/18 ,  C07D321/00 ,  C07C121/75 ,  C07C121/66

Abstract: Basic-substituted phenylacetonitriles of the formula I … … in which… R to R and n have the meaning given in the description, are suitable for combating diseases.

公开(公告)号：DE3268963D1

公开(公告)日：1986-03-20

申请号：DE3268963

申请日：1982-09-09

Applicant: BASF AG

Inventor： FRANKE ALBRECHT DR ,  MUELLER JOSEF DR ,  LIETZ HELMUT ,  WIERSDORFF WALTER-WIELANT DR ,  HEGE HANS-GUENTHER DR ,  MUELLER CLAUS D DR ,  GRIES JOSEF DR ,  LENKE DIETER DR ,  VON PHILIPSBORN GERDA DR ,  RASCHACK MANFRED DR

IPC: A61K31/13 ,  A61K31/445 ,  A61K31/495 ,  C07C45/62 ,  C07C45/71 ,  C07C45/73 ,  C07C45/74 ,  C07C49/83 ,  C07C49/835 ,  C07C49/84 ,  C07D211/46 ,  C07D211/52 ,  C07D295/08 ,  C07D295/092 ,  C07D303/22 ,  C07D303/24 ,  C07C93/06 ,  C07C149/24 ,  C07C93/14

Abstract: Novel aminopropanol derivatives of 2-hydroxy- beta -phenyl-propiophenones and their physiologically acceptable acid addition compounds, processes for their preparation and therapeutic agents which contain these derivatives and are useful as antiarrhythmic drugs.

公开(公告)号：DE3344755A1

公开(公告)日：1985-06-20

申请号：DE3344755

申请日：1983-12-10

Applicant: BASF AG

Inventor： RASCHACK MANFRED DR ,  KREISKOTT HORST PROF DR ,  SEITZ WERNER DR

IPC: C07B57/00 ,  A61K20060101 ,  A61K31/275 ,  A61P9/00 ,  C07B31/00 ,  C07C20060101 ,  C07C67/00 ,  C07C253/00 ,  C07C255/32 ,  C07C255/42 ,  C07C255/58 ,  C07D20060101 ,  C07C121/66

Abstract: 1,7-diphenyl-3-methylaza-7-cyano-8-methylnonane and its antipodes and salts are used for the treatment of diseases.

公开(公告)号：DE3260265D1

公开(公告)日：1984-07-26

申请号：DE3260265

申请日：1982-03-19

Applicant: BASF AG

Inventor： BINNIG FRITZ DR ,  MUELLER CLAUS D DR ,  RASCHACK MANFRED DR ,  VON PHILIPSBORN GERDA DR

IPC: A61K31/435 ,  A61K31/445 ,  A61P9/00 ,  A61P9/06 ,  C07D221/00 ,  C07D471/08

Abstract: Bispidine derivatives of the formula I I where R is hydrogen or amino, and their salts with physiologically tolerated acids. The compounds have antiarrhythmic properties.

公开(公告)号：DE3144150A1

公开(公告)日：1982-12-09

申请号：DE3144150

申请日：1981-11-06

Applicant: BASF AG

Inventor： DENGEL FERDINAND DIPL CHEM DR ,  EHRMANN OSKAR DIPL CHEM DR ,  FRANK WOLFRAM DR ,  FRIEDRICH LUDWIG DR ,  GRIES JOSEF DR ,  KRETZSCHMAR ROLF PROF DR MED ,  KURBJUWEIT HANS-GEORG DR ,  MUELLER CLAUS D DR MED ,  RASCHACK MANFRED DR ,  SEITZ WERNER DIPL CHEM DR ,  TREIBER HANS JOERG DR ,  WUPPERMANN DIRK DR MED ,  ZIMMERMANN FRANK DR MED

IPC: C07C255/42 ,  A61K31/275 ,  A61K31/277 ,  A61K31/335 ,  A61P9/06 ,  A61P9/10 ,  A61P37/08 ,  C07C253/30 ,  C07C255/32 ,  C07C255/53 ,  C07C255/58 ,  C07D317/06 ,  C07D317/58 ,  C07D317/60 ,  C07D319/02 ,  C07D319/08 ,  C07D319/18 ,  C07C121/78

公开(公告)号：DE3112055A1

公开(公告)日：1982-10-07

申请号：DE3112055

申请日：1981-03-27

Applicant: BASF AG

Inventor： BINNIG FRITZ DIPL CHEM DR ,  MUELLER CLAUS D DR MED VET ,  RASCHACK MANFRED DR ,  PHILIPSBORN GERDA VON DR MED

IPC: A61K31/435 ,  A61K31/445 ,  A61P9/00 ,  A61P9/06 ,  C07D221/00 ,  C07D471/08

Abstract: Bispidine derivatives of the formula I I where R is hydrogen or amino, and their salts with physiologically tolerated acids. The compounds have antiarrhythmic properties.

公开(公告)号：DE2841044A1

公开(公告)日：1980-04-03

申请号：DE2841044

申请日：1978-09-21

Applicant: BASF AG

Inventor： ALBRECHT HANS PETER DIPL CHEM ,  PHILIPSBORN GERDA VON DR MED ,  RASCHACK MANFRED DR ,  SIEBENEICK HANS

IPC: C07J53/00 ,  C07J19/00 ,  A61K31/585

Abstract: Bufadienolide derivs. of formula (I) are new. (I) can be prepd. by the addition of methylene to scillarenin or to 3-epi-scillarenin and then opt. oxidising and again reducing the cpds. obtd. (I) have positive inotropic and cardiovascular properties. (I) are esp. suitable in the prepn. of 4,5-methanolbufadienolide rhamnosides which are more effective cardiac glycosides with an increased therapeutic breadth compared to previously used cpds..

公开(公告)号：DE2744248A1

公开(公告)日：1979-04-12

申请号：DE2744248

申请日：1977-10-01

Applicant: BASF AG

Inventor： BINNIG FRITZ DIPL CHEM DR ,  RASCHACK MANFRED DR

IPC: A61K31/395 ,  A61K45/06 ,  A61K31/495

Abstract: Mixt. comprises a bispidine derivs. of formula (I) and a calcium antagonist (II) or their physiologically acceptable salts. Ratio (I):(II) is 1-50:2-1. (R1-R4 are H, F, Cl, OH, lower alkyl, lower alkoxy, CF3 or NO2; R5 and R6 are H or Ph). Compsns are used as antiarrhythmic and coronary therapeutic agents. (II) counteract the hypertensive side-effects of (I).

公开(公告)号：CZ290684B6

公开(公告)日：2002-09-11

申请号：CZ287396

申请日：1995-03-23

Applicant: BASF AG

Inventor： BAUMANN ERNST DR ,  VOGELBACHER UWE JOSEF DR ,  RHEINHEIMER JOACHIM DR ,  KLINGE DAGMAR DR ,  RIECHERS HARTMUT DR ,  KROGER BURKHARD DR ,  BIALOJAN SIEGFRIED DR ,  BOLLSCHWEILER CLAUS DR ,  WERNER VOLFGANG DR ,  UNGER LILIANE DR ,  RASCHACK MANFRED DR

IPC: C07D251/26 ,  A61K31/00 ,  A61K31/505 ,  A61K31/506 ,  A61K31/53 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P11/08 ,  A61P13/02 ,  A61P15/00 ,  A61P25/04 ,  A61P39/02 ,  C07D239/26 ,  C07D239/34 ,  C07D239/38 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12

Abstract: The present invention relates to the use of carboxylic acid derivatives of the general formula I for preparing medicament i.e. endothelin receptor antagonists. The medicament can be used for treating hypertension, renal insufficiency, and restenosis after angioplasty.