公开(公告)号：CO2021005884A2

公开(公告)日：2021-05-20

申请号：CO2021005884

申请日：2021-05-05

Applicant: VERTEX PHARMA

Inventor： BLIGH CAVAN MCKEON ,  BRODNEY MICHAEL AARON ,  ECCLES MARY ELIZABETH ,  GAGNON KEVIN JAMES ,  HOOD SARAH CAROL ,  HUSSEY JOSHUA KENNEDY ,  LOOKER ADAM ,  MAXWELL JOHN PATRICK ,  MEDEK ALES ,  NAVAMAL METTACHIT ,  RODAY SETU ,  ROEPER STEFANIE ,  SAWANT RUPA ,  SHI YI ,  TANG QING ,  WALDO MICHAEL ,  BANDARAGE UPUL KEERTHI ,  BOUCHER DIANE M ,  BOYD MICHAEL JOHN ,  DAMAGNEZ VERONIQUE ,  DEWEY FANNING LEV TYLER ,  FIMOGNARI JR ROBERT FRANCIS ,  GARCIA BARRANTES PEDRO M ,  GIROUX SIMON ,  GREY JR RONALD LEE ,  HALL AMY BETH ,  HURLEY DENNIS JAMES ,  JOHNSON JR MAC ARTHUR ,  JONES PETER ,  KESAVAN SARATHY ,  NUHANT PHILIPPE MARCEL ,  SWETT REBECCA JANE ,  TAPLEY TIMOTHY LEWIS ,  THOMSON STEPHEN A ,  XU JINWANG ,  MAXWELL BRAD D ,  COTTRELL KEVIN MICHAEL

IPC: A61P1/16 ,  A61K31/4162 ,  A61K31/4178 ,  A61K31/4196 ,  A61K31/427 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/496 ,  A61K31/4985 ,  A61K31/5377 ,  A61P11/00 ,  C07D471/14 ,  C07D487/04 ,  C07D487/14 ,  C07D519/00

Abstract: Nuevos compuestos, composiciones y métodos para usar y preparar los mismos, los cuales pueden ser útiles para tratar la deficiencia de alfa-1 antitripsina (AATD).

公开(公告)号：AU2018375186A1

公开(公告)日：2020-06-18

申请号：AU2018375186

申请日：2018-11-30

Applicant: VERTEX PHARMA

Inventor： LEMERCIER LEWANDOWSKI BERENICE ,  LEWIS ROBERT ,  LOOKER ADAM ,  MORGAN ADAM ,  ROEPER STEFANIE ,  RYAN MICHAEL ,  SOLSONA ROCABERT JUAN ,  WILDE NATHAN

IPC: C07D215/56 ,  C07B59/00 ,  C07C33/18 ,  C07C69/96

Abstract: The disclosure provides processes for synthesizing compounds for use as CFTR modulators.

公开(公告)号：UY38403A

公开(公告)日：2020-04-30

申请号：UY38403

申请日：2019-10-07

Applicant: VERTEX PHARMA

Inventor： JONES PETER ,  NUHANT PHILIPPE MARCEL ,  BANDARAGE UPUL KEERTHI ,  BLIGH CAVAN MCKEON ,  BOUCHER DIANE M ,  DEWEY FANNING LEV TYLER ,  ECCLES MARY ELIZABETH ,  FIMOGNARI JR ROBERT FRANCIS ,  GAGNON KEVIN JAMES ,  BOYD MICHAEL JOHN ,  GARCÍA BARRANTES PEDRO M ,  GIROUX SIMON ,  GREY JR RONALD LEE ,  HALL AMY BETH ,  HOOD SARAH CAROL ,  HURLEY DENNIS JAMES ,  HUSSEY JOSHUA KENNEDY ,  JOHNSON JR ,  KESAVAN SARATHY ,  LOOKER ADAM ,  MAXWELL BRAD D ,  MAXWELL JOHN PATRICK ,  MEDEK ALES ,  NAVAMAL METTACHIT ,  RODAY SETU ,  ROEPER STEFANIE ,  SAWANT RUPA ,  SHI YI ,  SWETT REBECCA JANE ,  TANG QING ,  TAPLEY TIMOTHY LEWIS ,  THOMSON STEPHEN A ,  WALDO MICHAEL ,  XU JINWANG ,  DAMAGNEZ VERONIQUE ,  BRODNEY MICHAEL AARON

IPC: A61P1/16 ,  A61K31/4162 ,  A61K31/437 ,  A61K31/497 ,  A61P11/00 ,  C07D471/14 ,  C07D487/04 ,  C07D487/14 ,  C07F5/04

Abstract: Nuevos compuestos, composiciones y métodos de uso y preparación de los mismos, que pueden ser útiles para el tratamiento de la deficiencia de alfa-1 antitripsina (AATD).

公开(公告)号：CA3082444A1

公开(公告)日：2019-06-06

申请号：CA3082444

申请日：2018-11-30

Applicant: VERTEX PHARMA

Inventor： LEMERCIER LEWANDOWSKI BERENICE ,  LEWIS ROBERT ,  LOOKER ADAM ,  MORGAN ADAM ,  ROEPER STEFANIE ,  RYAN MICHAEL ,  SOLSONA ROCABERT JUAN GABRIEL ,  WILDE NATHAN

IPC: C07D215/56 ,  C07B59/00 ,  C07C33/18 ,  C07C69/96

Abstract: The disclosure provides processes for synthesizing compounds for use as CFTR modulators.

公开(公告)号：AU2012335714B2

公开(公告)日：2017-04-13

申请号：AU2012335714

申请日：2012-11-08

Applicant: VERTEX PHARMA

Inventor： LOOKER ADAM ,  LITTLER BENJAMIN JOSEPH ,  CHOUDHURY ANUSUYA ,  HARRISON CRISTIAN L ,  VELURI RAVIKANTH ,  RYAN MICHAEL P ,  JIANG LICONG ,  LUSS-LUSIS EDUARD

IPC: C07D405/12 ,  A61K31/405 ,  A61K31/553 ,  A61P1/00 ,  A61P3/00 ,  A61P11/00 ,  A61P25/00 ,  A61P27/00 ,  A61P35/00 ,  C07D405/14 ,  C07D498/04

Abstract: Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator ("CFTR"). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.

公开(公告)号：NZ620027A

公开(公告)日：2015-05-29

申请号：NZ62002708

申请日：2008-09-15

Applicant: VERTEX PHARMA

Inventor： FENG YUSHI ,  LOOKER ADAM ,  ZHANG YUEGANG ,  DEMATTEI JOHN ,  MUDUNURI PRAVEEN ,  ROEPER STEFANIE ,  HARRISON CRISTIAN

IPC: A61K31/47 ,  A61P3/00 ,  A61P3/10 ,  A61P25/28 ,  A61P27/02 ,  A61P35/00 ,  C07D215/233

Abstract: Disclosed is a compound selected from N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide (Compound 1) 2-methylbutyric acid. Also disclosed is a method of making the crystalline forms, pharmaceutical compositions and kits comprising the crystalline forms and the use of the crystalline forms for the manufacture of a medicament for the for treating or lessening the severity of a disease in a patient, wherein said disease is selected from cystic fibrosis, hereditary emphysema, hereditary hemochromatosis, coagulation-fibrinolysis deficiencies, lipid processing deficiencies, lysosomal storage diseases, neurodegenerative diseases, polyglutamine neurological disorders, spongiform encephalopathies, COPD, dry-eye disease, and Sjogren’s disease .

公开(公告)号：ZA201400049B

公开(公告)日：2015-04-29

申请号：ZA201400049

申请日：2014-01-06

Applicant: VERTEX PHARMA

Inventor： TANOIRY GERALD J ,  JUNG YOUNG CHUN ,  MAGDZIAK DEREK ,  LOOKER ADAM ,  KLINE BILLIE J ,  JURCIK VACLAV ,  DOMINGUEZ OLMO BEATRIZ

Abstract: The present invention relates to processes and intermediates for the preparation of compounds useful as inhibitors of Janus kinases (JAK).

公开(公告)号：CA2557645C

公开(公告)日：2013-09-24

申请号：CA2557645

申请日：2005-02-28

Applicant: VERTEX PHARMA

Inventor： CHARRIER JEAN-DAMIEN ,  DURRANT STEVEN ,  MORTIMORE MICHAEL ,  O'DONNELL MICHAEL ,  RUTHERFORD ALISTAIR ,  RAMAYA SHARN ,  STUDLEY JOHN R ,  TRUDEAU MARTIN ,  LOOKER ADAM

IPC: C07D405/12 ,  A01N1/02 ,  A61K38/04 ,  A61K38/06 ,  C07D207/16 ,  C07D209/52 ,  C07D401/12 ,  C07D401/14 ,  C07D417/06 ,  C07D417/12 ,  C07K5/02 ,  C07K5/04 ,  C07K5/062 ,  C07K5/083

Abstract: The present invention provides a compound of formula (I): wherein the variables are as defined herein. The present invention also provides processes for preparing the compounds of formula (I), and intermediates thereof, pharmaceutical compositions comprising those compounds, and methods of using the compounds and compositions.

公开(公告)号：MX2010002974A

公开(公告)日：2010-07-29

申请号：MX2010002974

申请日：2008-09-15

Applicant: VERTEX PHARMA

Inventor： DEMATTEI JOHN ,  HARRISON CRISTIAN ,  FENG YUSHI ,  LOOKER ADAM ,  MUDUNURI PRAVEEN ,  ROEPER STEFANIE ,  ZHANG YUEGANG

IPC: A61K31/47 ,  A61P3/00 ,  A61P3/10 ,  A61P25/28 ,  A61P27/02 ,  A61P35/00 ,  C07D215/233

Abstract: Se describen en la presente formas sólidas de N- [2,4-bis (1,1-dimetiletil) -5-hidroxiferxil] -1,4-dihidro-4-oxoquinolin-3-c arboxamida, entre las que se incluyen las formas cristalinas de la misma.

公开(公告)号：NO20076307L

公开(公告)日：2007-12-07

申请号：NO20076307

申请日：2007-12-07

Applicant: VERTEX PHARMA

Inventor： SNOONIAN JOHN R ,  LOOKER ADAM ,  ANSELL GRAHAM ,  BLYTHE TODD A ,  JONES ANDREW D ,  LITTLER BENJAMIN ,  NYCE PHILIP L

IPC: C07C275/42 ,  C07C271/34 ,  C07D307/16 ,  C07D413/12

Abstract: The present invention relates to processes for preparing biaryl ureas derivatives and analogs thereof. The invention also provides compounds useful as intermediates in the processes of the present invention. The process is useful for preparing compounds that inhibit IMPDH.