公开(公告)号：CA2398848A1

公开(公告)日：2001-08-30

申请号：CA2398848

申请日：2001-02-23

Applicant: ABBOTT LAB

Inventor： OR YAT SUN ,  YONG HONG ,  ZHANG SOUMING ,  MA ZHENKUN ,  NEMOTO PETER A

IPC: C07H17/08 ,  A61K31/335 ,  A61K31/7048 ,  A61P31/04

Abstract: Published without an

公开(公告)号：CA2594098C

公开(公告)日：2014-04-01

申请号：CA2594098

申请日：2006-01-05

Applicant: ABBOTT LAB

Inventor： PATEL JYOTI R ,  SHUAI QI ,  LINK JAMES T ,  ROHDE JEFFREY J ,  DINGES JURGEN ,  SORENSEN BRYAN K ,  WINN MARTIN ,  YONG HONG ,  YEH VINCE S

IPC: C07C235/14 ,  A61K31/4402 ,  A61P3/10 ,  C07C317/16 ,  C07C323/41 ,  C07D207/48 ,  C07D213/64 ,  C07D233/54 ,  C07D257/04 ,  C07D261/08

Abstract: The present invention relates to compounds which are inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme. The present invention further relates to the use of inhibitors of 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme for the treatment of non-insulin dependent type 2 diabetes, insulin resistance, obesity, lipid disorders, metabolic syndrome and other diseases and conditions that are mediated by excessive glucocorticoid action.

公开(公告)号：AT555081T

公开(公告)日：2012-05-15

申请号：AT06717418

申请日：2006-01-05

Applicant: ABBOTT LAB

Inventor： PATEL JYOTI ,  SHUAI QI ,  LINK JAMES ,  ROHDE JEFFREY ,  DINGES JURGEN ,  SORENSEN BRYAN ,  WINN MARTIN ,  YONG HONG ,  YEH VINCE

IPC: C07C235/14 ,  C07C317/16 ,  C07C323/41 ,  C07D207/48 ,  C07D213/64 ,  C07D233/54 ,  C07D257/04 ,  C07D261/08

Abstract: The present invention relates to compounds which are inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme. The present invention further relates to the use of inhibitors of 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme for the treatment of non-insulin dependent type 2 diabetes, insulin resistance, obesity, lipid disorders, metabolic syndrome and other diseases and conditions that are mediated by excessive glucocorticoid action.

公开(公告)号：NZ565461A

公开(公告)日：2011-08-26

申请号：NZ56546106

申请日：2006-08-25

Applicant: ABBOTT LAB

Inventor： PEI ZHONGHUA ,  VON GELDERN THOMAS ,  MADAR DAVID J ,  LI XIAOFENG ,  BASHA FATIMA ,  YONG HONG ,  LONGENECKER KENTON L ,  BACKES BRADLEY J ,  JUDD ANDREW S ,  MULHERN MATHEW M ,  STEWART KENT D

IPC: C07D317/64 ,  A61K31/137 ,  C07C211/40 ,  C07C211/54 ,  C07C211/62 ,  C07D213/38 ,  C07D213/68 ,  C07D487/04

Abstract: Disclosed is a cyclohexyl amine of formula (Ia) or a pharmaceutically acceptable salt thereof, wherein m is 4; Ar 1 is aryl, R1 is hydrogen, and R2 and R3 are defined in the specification for treating diabetes, type II diabetes, hyperglycemia, metabolic syndrome, hyperinsulinemia, or obesitycardiovascular disease, atherosclerosis, cerebrovascular diseases, diseases and disorders of the central nervous system, schizophrenia, anxiety, bipolar disease, depression, insomnia, cognitive disorders, gastrointestinal diseases and disorders, cancer, inflammation and inflammatory diseases, respiratory diseases and disorders, musculo-skeletal disorders, osteoporosis, menopausal symptoms, periodontal diseases and gingivitis.

公开(公告)号：BRPI0606256A2

公开(公告)日：2009-06-09

申请号：BRPI0606256

申请日：2006-01-05

Applicant: ABBOTT LAB

Inventor： PATEL JYOTI R ,  SHUAI QI ,  LINK JAMES T ,  ROHDE JEFFREY J ,  DINGES JURGEN ,  SORENSEN BRYAN K ,  WINN MARTIN ,  YONG HONG ,  YEH VINCE S

IPC: C07C235/14 ,  A61K31/4402 ,  A61P3/10 ,  C07C233/54 ,  C07C257/04 ,  C07C317/16 ,  C07C323/41 ,  C07D207/48 ,  C07D213/64 ,  C07D261/08

Abstract: The present invention relates to compounds which are inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme. The present invention further relates to the use of inhibitors of 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme for the treatment of non-insulin dependent type 2 diabetes, insulin resistance, obesity, lipid disorders, metabolic syndrome and other diseases and conditions that are mediated by excessive glucocorticoid action.

公开(公告)号：DE60315336T2

公开(公告)日：2008-05-08

申请号：DE60315336

申请日：2003-09-15

Applicant: ABBOTT LAB

Inventor： MADAR DAVID ,  PEI ZHONGHUA ,  PIREH DAISY ,  DJURIC STEVAN W ,  WIEDEMAN PAUL E ,  YONG HONG ,  MICHMERHUIZEN MELISSA J ,  KOPECKA HANA ,  LI XIAOFENG ,  LONGENECKER KENTON ,  SHAM HING L ,  STEWART KENT D ,  SZCZEPANKIEWICZ BRUCE G

IPC: C07D207/00 ,  A61P37/02 ,  C07D207/16 ,  C07D207/26 ,  C07D207/27 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D417/12

Abstract: The present invention relates to compounds of formula I which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, Syndrome X, hyperinsulinemia, obesity, atherosclerosis, and various immunomodulatory diseases. Or pharmaceutically acceptable salts or prodrugs thereof, wherein X,R,R ,R and R have the definitions given in the description.

公开(公告)号：NZ538567A

公开(公告)日：2007-04-27

申请号：NZ53856703

申请日：2003-09-15

Applicant: ABBOTT LAB

Inventor： MADAR DAVID ,  PEI ZHONGHUA ,  PIREH DAISY ,  DJURIC STEVAN W ,  WIEDEMAN PAUL E ,  YONG HONG ,  FEENSTRA MELISSA J ,  KOPECKA HANA ,  LI XIAOFENG ,  LONGENECKER KENTON ,  SHAM HING L ,  STEWART KENT D ,  SZCZEPANKIEWICZ BRUCE G

IPC: A61P37/02 ,  C07D207/16 ,  C07D207/26 ,  C07D207/27 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D417/12 ,  A61K31/401 ,  A61K31/506 ,  A61K31/4439

Abstract: Compounds of formula (I), pharmaceutically acceptable salts and prodrugs thereof which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, Syndrome X, hyperinsulinemia, obesity, atherosclerosis, and various immunomodulatory diseases are disclosed, wherein X, R, R1, R2 and R3 have the definitions given in the description.

公开(公告)号：CA2617495A1

公开(公告)日：2007-03-08

申请号：CA2617495

申请日：2006-08-25

Applicant: ABBOTT LAB

Inventor： PEI ZHONGHUA ,  VON GELDERN THOMAS ,  MADAR DAVID J ,  LONGENECKER KENTON L ,  STEWART KENT D ,  LI XIAOFENG ,  YONG HONG ,  BACKES BRADLEY J ,  MULHERN MATHEW M ,  BASHA FATIMA ,  JUDD ANDREW S

IPC: C07C211/40 ,  A61K31/137 ,  C07C211/54 ,  C07C211/62 ,  C07D213/38 ,  C07D213/68 ,  C07D317/64 ,  C07D487/04

Abstract: The present invention relates to compounds, which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II, as well as hyperglycemia, metabolic syndrome, hyperinsulinemia, obesity, atherosclerosis, various immunomodulatory diseases, and other diseases.

公开(公告)号：DE60115851T2

公开(公告)日：2006-08-10

申请号：DE60115851

申请日：2001-02-23

Applicant: ABBOTT LAB

Inventor： MA ZHENKUN ,  NEMOTO A ,  ZHANG SOUMING ,  YONG HONG ,  OR SUN

IPC: C07H17/08 ,  A61K31/335 ,  A61K31/7048 ,  A61P31/04

公开(公告)号：DK1259923T3

公开(公告)日：2006-05-01

申请号：DK01920147

申请日：2001-02-23

Applicant: ABBOTT LAB

Inventor： MA ZHENKUN ,  YONG HONG ,  NEMOTO PETER A ,  ZHANG SOUMING ,  OR YAT SUN

IPC: C07H17/08 ,  A61K31/335 ,  A61K31/7048 ,  A61P31/04