公开(公告)号：AT235891T

公开(公告)日：2003-04-15

申请号：AT99966909

申请日：1999-11-30

Applicant: BASF AG

Inventor： BERNDL GUNTHER ,  KOTHRADE STEPHAN ,  KESSLER THOMAS ,  LANGE ARMIN ,  HOFMANN JUERGEN ,  REINHOLD ULRICH

IPC: A61J3/10 ,  A61K9/16 ,  A61K9/20 ,  B29C47/42

公开(公告)号：DK0857062T3

公开(公告)日：2002-07-15

申请号：DK96937214

申请日：1996-10-23

Applicant: BASF AG

Inventor： BREITENBACH JOERG ,  AXEL PAUL HAERTL ,  HOFMANN JUERGEN ,  ROSENBERG JOERG ,  SCHIESSL MICHAEL ,  HANS DIETER ZETTLER

IPC: A61J3/10 ,  A61K9/20 ,  A61K9/24 ,  A61K9/28 ,  A61K31/07 ,  A61K31/167 ,  A61K31/192 ,  A61K31/277 ,  A61K31/355 ,  A61K31/375 ,  A61K31/401 ,  A61K31/4422 ,  A61K31/52 ,  A61K31/522 ,  A61K31/60

Abstract: PCT No. PCT/EP96/04601 Sec. 371 Date Apr. 15, 1998 Sec. 102(e) Date Apr. 15, 1998 PCT Filed Oct. 23, 1996 PCT Pub. No. WO97/15293 PCT Pub. Date May 1, 1997The present invention relates to a process for producing multilayer, solid drug forms for oral or rectal administration, which comprises coextrusion of at least two compositions which in each case comprise a thermoplastic, pharmacologically acceptable polymeric binder which is soluble or swellable in a physiological environment, and at least one of which contains a pharmaceutical active ingredient, and shaping the coextruded multilayer material to the required drug form.

公开(公告)号：DE19955861A1

公开(公告)日：2001-05-23

申请号：DE19955861

申请日：1999-11-20

Applicant: BASF AG

Inventor： HEIDE WILFRIED ,  WICKEL STEFAN ,  DANIEL THOMAS ,  NILGES JOACHIM ,  HOFMANN JUERGEN

IPC: B01J14/00 ,  B01J19/00 ,  B01J19/20 ,  C08F2/01 ,  C08F2/10 ,  C08F220/00 ,  C08F220/06 ,  C08F220/56

Abstract: In a process for the continuous production of crosslinked, finely-divided gel polymers by co polymerisation of water-soluble mono-unsaturated monomers and poly-unsaturated comonomers in a multi-screw mixer-kneader, at least 5% of the heat of reaction is removed by evaporation of water, at least 25% with the product and the rest by cooling the reactor. A process for the continuous production of crosslinked, finely-divided gel polymers (I) involves the co polymerisation of (a) water-soluble mono-unsaturated monomers, (b) 0.001-5 mol% (based on a) monomers with at least two ethylenic double bonds and (c) 0-20 mol% water-insoluble mono-unsaturated monomers in 20-80 wt% aqueous solution in presence of initiators at 0-140 deg C, by feeding the monomer solution with the initiator and inert gas into a mixer-kneader with at least two parallel rotating shafts fitted with several kneading and transporting elements to move the materials through the mixer. In this process, at least 5% of the heat of reaction is removed by evaporation of water from the reaction mixture, at least 25% is removed with the product and the rest is removed by cooling the reactor walls.

公开(公告)号：BR9608052A

公开(公告)日：1999-02-17

申请号：BR9608052

申请日：1996-03-28

Applicant: BASF AG

Inventor： KOPIETZ MICHAEL ,  GOETZ WALTER ,  HORLE HELMUT ,  HOFMANN JUERGEN

IPC: C08G69/26 ,  C08G69/04 ,  C08G69/28 ,  C08G73/10 ,  G03F7/004 ,  G03F7/038 ,  G11B5/48 ,  G11B21/00 ,  H05K1/05

Abstract: A polymer based on a dicarboxylic acid and a diamine is prepared by polycondensation in an extruder, by(a) heating a mixture of a dicarboxylic acid having from 4 to 12 carbon atoms and a diamine having from 4 to 12 carbon atoms, which mixture is solid at room temperature and has a residual moisture content of less than 5% by weight, to a temperature in the range from 150 to 400° C. under autogenous pressure in a contrarotating twin-screw extruder to give a product A,(b) feeding the product A to a corotating twin-screw extruder, with the product A being exposed to a temperature in the range from 150 to 400° C. and residual water present and also water from the polycondensation being removed through the degassing openings, to give a product B, with the proviso that the corotating twin-screw extruder has at least two segments having different pressures.

公开(公告)号：DE59309132D1

公开(公告)日：1998-12-24

申请号：DE59309132

申请日：1993-05-14

Applicant: BASF AG

Inventor： HESSE ANTON DR ,  HOFMANN JUERGEN ,  HECKMANN WALTER DR ,  WARZELHAN VOLKER DR

IPC: C08L63/10 ,  C08L67/06 ,  C08L75/14 ,  C08L75/16

Abstract: The invention relates to a process for the preparation of a curable moulding composition based on a dispersion of a finely divided ethylene polymer in an unsaturated polyester resin. A melt of the ethylene polymer is distributed uniformly in a melt of an unsaturated polyester in an extruder or stirred reactor.

公开(公告)号：AT174361T

公开(公告)日：1998-12-15

申请号：AT96909142

申请日：1996-03-28

Applicant: BASF AG

Inventor： GOETZ WALTER ,  HOFMANN JUERGEN ,  KOPIETZ MICHAEL ,  HORLE HELMUT

IPC: C08G69/26 ,  C08G69/04 ,  C08G69/28 ,  C08G73/10 ,  G03F7/004 ,  G03F7/038 ,  G11B5/48 ,  G11B21/00 ,  H05K1/05

Abstract: A polymer based on a dicarboxylic acid and a diamine is prepared by polycondensation in an extruder, by(a) heating a mixture of a dicarboxylic acid having from 4 to 12 carbon atoms and a diamine having from 4 to 12 carbon atoms, which mixture is solid at room temperature and has a residual moisture content of less than 5% by weight, to a temperature in the range from 150 to 400° C. under autogenous pressure in a contrarotating twin-screw extruder to give a product A,(b) feeding the product A to a corotating twin-screw extruder, with the product A being exposed to a temperature in the range from 150 to 400° C. and residual water present and also water from the polycondensation being removed through the degassing openings, to give a product B, with the proviso that the corotating twin-screw extruder has at least two segments having different pressures.

公开(公告)号：DE59600363D1

公开(公告)日：1998-08-27

申请号：DE59600363

申请日：1996-01-08

Applicant: BASF AG

Inventor： WARZELHAN VOLKER ,  KRONER MATTHIAS ,  HOFMANN JUERGEN ,  SEELIGER URSULA ,  YAMAMOTO MOTONORI ,  BAUER PETER

IPC: A01G9/10 ,  B65D65/46 ,  C08G69/40 ,  C08G69/44 ,  C08G69/48 ,  C08G73/04 ,  C08J9/00 ,  C08L3/02 ,  C08L77/12 ,  C08L101/16 ,  C09J177/12

Abstract: PCT No. PCT/EP96/00067 Sec. 371 Date Jul. 3, 1997 Sec. 102(e) Date Jul. 3, 1997 PCT Filed Jan. 8, 1996 PCT Pub. No. WO96/21692 PCT Pub. Date Jul. 18, 1996Biodegradable polyesteramides as defined in the specification obtained by reacting a mixture consisting essentially of (a1) from 95 to 99.9% by weight of a polyesteramide, (a2) from 0.1 to 5% by weight of a divinyl ether, and (a3) from 0 to 5 mol % of compound D as defined in the specification, and other biodegradable polymers and thermoplastic molding compositions, processes for the preparation thereof, the use thereof for producing biodegradable moldings, and adhesives, biodegradable moldings obtained from the polymers and molding compositions according to the invention.

公开(公告)号：ES2117890T3

公开(公告)日：1998-08-16

申请号：ES96104389

申请日：1996-03-20

Applicant: BASF AG

Inventor： GUENTHERBERG NORBERT ,  HOFMANN JUERGEN ,  OHLIG HILMAR ,  MAILAHN ELMAR ,  BUS KLAUS ,  CZAUDERNA BERNHARD

IPC: C08J5/18 ,  B29B7/48 ,  B29B7/58 ,  B29C47/40 ,  B29C48/76 ,  C08J3/20 ,  C08J3/205 ,  C08L25/04 ,  C08L27/06 ,  C08L33/04 ,  C08L33/12 ,  C08L51/00 ,  C08L51/04 ,  C08L55/02 ,  D01F6/00 ,  B29C47/76

Abstract: The prepn. of deep draw-modified thermoplastics (T) is by mechanical dewatering of a wet elastomer component (A) contg. up to 50 wt.% residual water and mixing dewatered (A) with a thermoplastic polymer (B) in a screw - by adding (A) to a twin-screw extruder with rotating screws. This extruder contains the following sections (in the direction of flow) : (1) feed for adding (A) to the extruder ; (2) at least one crusher for dewatering (A) that contains one or more barriers each with an opening through which at least some of the water passes as a liq. ; (3) at least one section to which molten (B) is added ; (4) one or more sections with mixing, kneading and / or plasticising devices ; (5) at least one degassing section with one or more gas outlets through which the rest of the water is removed as steam ; and (6) an exit zone. Deep draw-modified moulding materials prepd. by this process are also claimed.

公开(公告)号：DE59600302D1

公开(公告)日：1998-08-06

申请号：DE59600302

申请日：1996-03-20

Applicant: BASF AG

Inventor： GUENTHERBERG NORBERT ,  HOFMANN JUERGEN ,  OHLIG HILMAR ,  MAILAHN ELMAR ,  BUS KLAUS ,  CZAUDERNA BERNHARD ,  GRABOWSKI SVEN

IPC: C08J5/18 ,  B29B7/48 ,  B29B7/58 ,  B29C47/40 ,  B29C48/76 ,  C08J3/20 ,  C08J3/205 ,  C08L25/04 ,  C08L27/06 ,  C08L33/04 ,  C08L33/12 ,  C08L51/00 ,  C08L51/04 ,  C08L55/02 ,  D01F6/00 ,  B29C47/76

Abstract: The prepn. of deep draw-modified thermoplastics (T) is by mechanical dewatering of a wet elastomer component (A) contg. up to 50 wt.% residual water and mixing dewatered (A) with a thermoplastic polymer (B) in a screw - by adding (A) to a twin-screw extruder with rotating screws. This extruder contains the following sections (in the direction of flow) : (1) feed for adding (A) to the extruder ; (2) at least one crusher for dewatering (A) that contains one or more barriers each with an opening through which at least some of the water passes as a liq. ; (3) at least one section to which molten (B) is added ; (4) one or more sections with mixing, kneading and / or plasticising devices ; (5) at least one degassing section with one or more gas outlets through which the rest of the water is removed as steam ; and (6) an exit zone. Deep draw-modified moulding materials prepd. by this process are also claimed.

公开(公告)号：NO981793L

公开(公告)日：1998-04-22

申请号：NO981793

申请日：1998-04-22

Applicant: BASF AG

Inventor： BREITENBACH JUERG ,  HORTL AXEL PAUL ,  HOFMANN JUERGEN ,  ROSENBERG JOERG ,  SCHIESSL MICHAEL ,  ZETTLER HANS DIETER

IPC: A61J3/10 ,  A61K9/20 ,  A61K9/24 ,  A61K9/28 ,  A61K31/07 ,  A61K31/167 ,  A61K31/192 ,  A61K31/277 ,  A61K31/355 ,  A61K31/375 ,  A61K31/401 ,  A61K31/4422 ,  A61K31/52 ,  A61K31/522 ,  A61K31/60 ,  A61K9/02

Abstract: PCT No. PCT/EP96/04601 Sec. 371 Date Apr. 15, 1998 Sec. 102(e) Date Apr. 15, 1998 PCT Filed Oct. 23, 1996 PCT Pub. No. WO97/15293 PCT Pub. Date May 1, 1997The present invention relates to a process for producing multilayer, solid drug forms for oral or rectal administration, which comprises coextrusion of at least two compositions which in each case comprise a thermoplastic, pharmacologically acceptable polymeric binder which is soluble or swellable in a physiological environment, and at least one of which contains a pharmaceutical active ingredient, and shaping the coextruded multilayer material to the required drug form.