公开(公告)号：NO20084007A

公开(公告)日：2008-10-07

申请号：NO20084007

申请日：2008-09-19

Applicant: VERTEX PHARMA

Inventor： MAKINGS LEWIS R ,  BLANCO MIGUEL GARCIA-GUZMAN ,  NAKATANI AKIKO ,  DRUTU IOANA ,  BERGERON DANIELE M ,  TERMIN ANDREAS P ,  RAFFAI GABRIEL ,  SILINA ALINA ,  HURLEY DENNIS J

IPC: C07D471/10 ,  C07D519/00

CPC classification number: C07D471/10

公开(公告)号：CA2642649A1

公开(公告)日：2007-09-07

申请号：CA2642649

申请日：2007-02-22

Applicant: VERTEX PHARMA

Inventor： TERMIN ANDREAS P ,  BERGERON DANIELE M ,  HURLEY DENNIS J ,  DRUTU IOANA ,  RAFFAI GABRIEL ,  MAKINGS LEWIS R ,  GARCIA-GUZMAN BLANCO MIGUEL ,  SILINA ALINA ,  NAKATANI AKIKO

IPC: C07D471/10 ,  A61K31/438 ,  A61K31/46 ,  A61K31/4747 ,  A61P25/00 ,  C07D519/00

Abstract: The present invention relates to modulators of muscarinic receptors of formula (I). The present invention also provides impositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.

公开(公告)号：NO20061845L

公开(公告)日：2006-06-26

申请号：NO20061845

申请日：2006-04-26

Applicant: VERTEX PHARMA

Inventor： MAKINGS LEWIS R ,  GROOTENHUIS PETER D J ,  BLANCO MIGUEL GARCIA-GUZMAN ,  BERGERON DANIELE ,  HURLEY DENNIS JAMES ,  NAKATANI AKIKO ,  DISEPIO DANIEL ,  RAFFAI GABRIEL

IPC: A61K31/495 ,  A61K31/496 ,  C07D295/02 ,  C07D295/033 ,  C07D295/073 ,  C07D295/096 ,  C07D295/135 ,  C07D295/155 ,  C07D309/14 ,  C07D451/02 ,  C07D451/04 ,  C07D493/08

Abstract: The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.

公开(公告)号：NO20061543A

公开(公告)日：2006-06-06

申请号：NO20061543

申请日：2006-04-05

Applicant: VERTEX PHARMA

Inventor： MILLER MARK T ,  RUAH SARA S HADIDA ,  SINGH ASHAVINI K ,  CLEVELAND THOMAS ,  MAKINGS LEWIS R ,  HAMILTON MATTHEW ,  GROOTENHUIS PETER D J

IPC: C07D263/48 ,  A61K31/426 ,  A61K31/427 ,  A61P43/00 ,  C07D277/46 ,  C07D277/82 ,  C07D417/02 ,  C07D417/04 ,  C07D417/06 ,  C07D417/12

CPC classification number: A61K31/426 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/5377 ,  C07D263/48 ,  C07D277/46 ,  C07D277/82 ,  C07D295/15 ,  C07D417/04 ,  C07D417/06 ,  C07D417/12 ,  G01N33/5076

公开(公告)号：AU2005249494A1

公开(公告)日：2005-12-15

申请号：AU2005249494

申请日：2005-05-31

Applicant: VERTEX PHARMA

Inventor： BLANCO MIGUEL GARCIA-GUZMAN ,  NAKATANI AKIKO ,  BERGERON DANIELE M ,  HURLEY DENNIS J ,  MAKINGS LEWIS R

IPC: A61K31/454 ,  A61K31/496 ,  A61K31/506 ,  C07D213/74 ,  C07D213/82 ,  C07D213/85 ,  C07D237/24 ,  C07D239/42 ,  C07D241/20 ,  C07D241/24 ,  C07D401/04 ,  C07D451/04

Abstract: The present invention relates to substituted piperazine compounds that are useful modulators of muscarinic receptors. The present invention also provides compositions comprising such compounds, and methods for treating muscarinic receptor mediated diseases.

公开(公告)号：AU2004297241A1

公开(公告)日：2005-06-23

申请号：AU2004297241

申请日：2004-12-07

Applicant: VERTEX PHARMA

Inventor： MAKINGS LEWIS R ,  GROOTENHUIS PETER D J ,  LONDO PHILIP MARTIN ,  BLANCO MIGUEL GARCIA-GUZMAN

IPC: C07D471/04 ,  A61K31/4745 ,  C07D471/02

Abstract: The modulator compounds described herein modulate muscarinic receptors and are useful for treating muscarinic receptor mediated diseases.

公开(公告)号：AU2005309365B2

公开(公告)日：2011-10-06

申请号：AU2005309365

申请日：2005-11-29

Applicant: VERTEX PHARMA

Inventor： DAVIES ROBERT J ,  GABRIEL RAFFAI ,  AKIKO NAKATANI ,  MAKINGS LEWIS R ,  IOANA DRUTU ,  BANDARAGE UPUL K ,  CHARIFSON PAUL S ,  MIGUEL GARCIA-GUZMAN BLANCO ,  HURLEY DENNIS J ,  BERGERON DANIELE M

IPC: C07D471/00 ,  A61K31/435 ,  A61K31/439 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/4747 ,  A61P1/00 ,  A61P3/04 ,  A61P9/00 ,  A61P17/02 ,  A61P25/00 ,  A61P27/02 ,  A61P43/00

Abstract: The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.

公开(公告)号：ZA200807236B

公开(公告)日：2009-08-26

申请号：ZA200807236

申请日：2008-08-21

Applicant: VERTEX PHARMA

Inventor： MAKINGS LEWIS R ,  MIGUEL GARCIA-GUZMAN BLANCO ,  HURLEY DENNIS J ,  IOANA DRUTU ,  GABRIEL RAFFAI ,  BERGERON DANIELE M ,  AKIKO NAKATANI ,  TERMIN ANDREAS P ,  ALINA SILINA

IPC: A61K20090101 ,  A61P20090101 ,  C07D20090101

公开(公告)号：ZA200806028B

公开(公告)日：2009-04-29

申请号：ZA200806028

申请日：2008-07-10

Applicant: VERTEX PHARMA

Inventor： MAKINGS LEWIS R ,  MIGUEL GARCIA-GUZMAN BLANCO ,  HURLEY DENNIS J ,  IOANA DRUTU ,  GABRIEL RAFFAI ,  BERGERON DANIELE M ,  AKIKO NAKATANI ,  TERMIN ANDREAS P ,  ALINA SILINA

IPC: A61K20090101 ,  A61P20090101 ,  C07D20090101

Abstract: The present invention relates to spiro compounds of formula XX as modulators of muscarinic receptors, wherein R1, R2, R3, Z1, Z2, L, G, n, m, t and p are defined herein. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.

公开(公告)号：ZA200701397B

公开(公告)日：2009-04-29

申请号：ZA200701397

申请日：2007-02-16

Applicant: VERTEX PHARMA

Inventor： MAKINGS LEWIS R ,  HURLEY DENIS J ,  GABRIEL RAFFAI ,  AKIKO NAKATANI ,  ALINA SILINA ,  MIGUEL GARCIA-GUZMAN BLANCO ,  LOANA DRUTU ,  BERGERON DANIELE M ,  TERMIN ANDREAS P

IPC: A61K20090101 ,  A61P20090101 ,  C07D20090101

Abstract: The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith or treating muscarinic receptor mediated diseases.