公开(公告)号：LT3091011T

公开(公告)日：2018-04-10

申请号：LT16155334

申请日：2007-04-09

Applicant: VERTEX PHARMA

Inventor： RUAH SARA S HADIDA ,  GROOTENHUIS PETER D J ,  VAN GOOR FREDRICK ,  ZHOU JINGLAN ,  BEAR BRIAN ,  MILLER MARK T ,  MCCARTNEY JASON ,  NUMA MEHDI MICHEL JAMEL ,  YANG XIAOQING

IPC: C07D405/12 ,  A61K31/404 ,  A61P31/00 ,  C07D403/12 ,  C07D405/14 ,  C07D471/04 ,  C07D487/04

公开(公告)号：LT2489659T

公开(公告)日：2018-03-26

申请号：LT12152224

申请日：2005-06-24

Applicant: VERTEX PHARMA

Inventor： HADIDA RUAH SARAH S ,  HAZLEWOOD ANNA R ,  GROOTENHUIS PETER D J ,  VAN GOOR FREDRICK F ,  SINGH ASHVANI K ,  ZHOU JINGLAN ,  MCCARTNEY JASON

IPC: C07D215/56 ,  A61K31/47 ,  A61P11/08 ,  A61P29/00 ,  A61P31/00

公开(公告)号：PL2502911T3

公开(公告)日：2017-09-29

申请号：PL12152225

申请日：2005-06-24

Applicant: VERTEX PHARMA

Inventor： HADIDA RUAH SARAH S ,  HAZLEWOOD ANNA R ,  GROOTENHUIS PETER D J ,  VAN GOOR FREDRICK F ,  SINGH ASHVANI K ,  ZHOU JINGLAN ,  MCCARTNEY JASON

IPC: C07D401/12 ,  A61K31/47 ,  A61K31/4709 ,  A61P25/00 ,  A61P31/00 ,  A61P35/00 ,  C07C215/76 ,  C07D209/08 ,  C07D209/12 ,  C07D209/14 ,  C07D209/18 ,  C07D215/56 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12

公开(公告)号：LT2502911T

公开(公告)日：2017-09-11

申请号：LT12152225

申请日：2005-06-24

Applicant: VERTEX PHARMA

Inventor： HADIDA RUAH SARAH S ,  HAZLEWOOD ANNA R ,  GROOTENHUIS PETER D J ,  VAN GOOR FREDRICK F ,  SINGH ASHVANI K ,  ZHOU JINGLAN ,  MCCARTNEY JASON

IPC: C07D401/12 ,  A61K31/47 ,  A61K31/4709 ,  A61P25/00 ,  A61P31/00 ,  A61P35/00 ,  C07C215/76 ,  C07D209/08 ,  C07D209/12 ,  C07D209/14 ,  C07D209/18 ,  C07D215/56 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12

公开(公告)号：MA41051A

公开(公告)日：2017-08-16

申请号：MA41051

申请日：2015-10-06

Applicant: VERTEX PHARMA

Inventor： ANDERSON COREY ,  ARUMUGAM VIJAYALAKSMI ,  BEAR BRIAN RICHARD ,  BINCH HAYLEY MARIE ,  CLEMENS JEREMY J ,  CLEVELAND THOMAS ,  CONROY ERICA ,  COON TIMOTHY RICHARD ,  FRIEMAN BRYAN A ,  GROOTENHUIS PETER DIEDERIK JAN ,  GROSS RAYMOND STANLEY ,  HADIDA-RUAH SARA SABINA ,  JOSHI PRAMOD VIRUPAX ,  KHATUYA HARIPADA ,  KRENITSKY PAUL JOHN ,  LIN CHUN-CHIEH ,  MARELIUS GULIN ERDOGAN ,  MCCARTNEY JASON ,  MELILLO VITO ,  MILLER MARK THOMAS ,  NICHOLLS GEORGIA MCGAUGHEY ,  PIERRE FABRICE JEAN DENIS ,  SILINA ALINA ,  TERMIN ANDREAS P ,  UY JOHNNY ,  ZHOU JINGLAN

IPC: A01N41/06 ,  A61K31/18 ,  C07D209/18 ,  C07D209/49 ,  C07D213/64 ,  C07D213/73 ,  C07D231/20 ,  C07D235/24 ,  C07D239/34 ,  C07D401/04 ,  C07D403/10 ,  C07D403/12 ,  C07D407/12 ,  C07D413/14

Abstract: La présente invention concerne un composé de formule (i): (i) ou un sel pharmaceutiquement acceptable de celui-ci, où r1, r2, r3, w, x, y, z, n, o, p et q sont tels que définis dans la description, lequel composé est utile pour le traitement de maladies médiées par le cftr, telles que la mucoviscidose. La présente invention concerne également des compositions pharmaceutiques, une méthode de traitement et des kits correspondants.

公开(公告)号：JOP20190042A1

公开(公告)日：2017-06-16

申请号：JOP20190042

申请日：2019-03-11

Applicant: VERTEX PHARMA

Inventor： ABELA ALEXANDER RUSSELL ,  BAEK MINSON ,  ZHANG BEILI ,  UY JOHNNY ,  ZHOU JINGLAN ,  JOSHI PRAMOD VIRUPAX ,  SIESEL DAVID ANDREW ,  BUSCH BRETT BRADLEY ,  GROOTENHUIS PETER ,  VAN GOOR FREDRICK ,  KESHAVARZ-SHOKRI ALI ,  MELILLO VITO ,  HUGHES ROBERT M ,  ANDERSON COREY ,  ALCACIO TIMOTHY ,  PARASELLI PRASUNA ,  KHATUYA HARIPADA ,  FRIEMAN BRYAN A ,  CLEVELAND THOMAS ,  PIERRE FABRICE JEAN DENIS ,  KRENITSKY PAUL JOHN ,  MCCARTNEY JASON ,  TERMIN ANDREAS P ,  MCAULEY-AOKI RACHEL ,  MILLER MARK THOMAS ,  HADIDA RUAH SARA SABINA

Abstract: ( I )، يتمالكشفعنمركباتلهاالصيغة ( I )،أملاحمقبولةصيدليًامنها،مشتقاتمعالجةبالديوتيريوممنأيٍمماسبق،ونواتجأيضلأيٍمماسبق. كمايتمالكشفعنتركيباتصيدليةتشتملعليها،طرقلعلاجالتليفالكيسيباستخدامها،وطرقلتصنيعها.

公开(公告)号：NZ719598A

公开(公告)日：2017-03-31

申请号：NZ71959808

申请日：2008-11-12

Applicant: VERTEX PHARMA

Inventor： RUAH SARA HADIDA S ,  MILLER MARK T ,  NUMA MEHDI MICHEL DJAMEL ,  ZHOU JINGLAN ,  VAN GOOR FREDRICK ,  GROOTENHUIS PETER D J ,  MCCARTNEY JASON ,  BEAR BRIAN

IPC: C07D405/12 ,  A61K31/404 ,  A61P3/00 ,  A61P25/00

Abstract: Disclosed herein is a use of an indol-cyclopropanecarboxamide derivative represented by structural formula shown herein in the manufacture of a medicament for treating a condition, disease, or disorder in a patient implicated by ABC transporter activity. Said compound is a modulator of ATP-Binding Cassette (’ABC’) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) and is also suitable for treating a condition, disease, or disorder selected from cystic fibrosis, hereditary emphysema, hereditary hemochromatosis, coagulation-fibrinolysis deficiencies, lipid processing deficiencies, lysosomal storage diseases, neurodegenerative diseases, polyglutamine neurological disorders, spongiform encephalopathies, chronic obstructive pulmonary disease (COPD), dry-eye disease, and Sjögren’s disease.

公开(公告)号：CA2856037C

公开(公告)日：2017-03-07

申请号：CA2856037

申请日：2006-12-28

Applicant: VERTEX PHARMA

Inventor： RUAH SARA S HADIDA ,  MILLER MARK T ,  BEAR BRIAN ,  MCCARTNEY JASON ,  GROOTENHUIS PETER D J

IPC: C07C237/24 ,  A61K31/00 ,  C07C311/46 ,  C07D207/12 ,  C07D307/79 ,  C07D317/60 ,  C07D319/18 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D498/04

Abstract: A compound of formula (I): (see formula I) or a pharmaceutically acceptable salt thereof, a pharmaceutical composition comprising a compound according to formula (I) and a pharmaceutically acceptable carrier, a kit for use in measuring the activity of an ABC transporter or a fragment thereof in a biological sample in vitro or in vivo, comprising a composition comprising the compound of formula (I) and instructions for a) contacting the composition with the biological sample and b) measuring activity of said ABC transporter or a fragment thereof, and use of an effective amount of the compound of formula (I) or the pharmaceutically acceptable salt thereof for treating or lessening the severity of a disease in a patient need thereof.

公开(公告)号：HUE028983T2

公开(公告)日：2017-01-30

申请号：HUE11720264

申请日：2011-05-06

Applicant: VERTEX PHARMA

Inventor： HADIDA-RUAH SARA SABINA ,  KALLEL EDWARD ADAM ,  MILLER MARK THOMAS ,  PONTILLO JOSEPH ,  ANDERSON COREY ,  NUMA MEHDI ,  FRIEMAN BRYAN A ,  BEAR BRIAN RICHARD ,  ARUMUGAM VIJAYALAKSMI ,  HILGRAF NICOLE ,  MCCARTNEY JASON ,  GROOTENHUIS PETER DIEDERIK JAN ,  JOHNSON JAMES PHILIP

IPC: A61P25/04

公开(公告)号：SI2670752T1

公开(公告)日：2016-10-28

申请号：SI201230587

申请日：2012-02-02

Applicant: VERTEX PHARMA

Inventor： HADIDA RUAH SARA S ,  KALLEL EDWARD ADAM ,  MILLER MARK THOMAS ,  ARUMUGAM VIJAYALAKSMI ,  MCCARTNEY JASON ,  ANDERSON COREY ,  GROOTENHUIS PETER DIEDERIK JAN ,  JIANG LICONG

IPC: C07D471/00 ,  A61K31/00 ,  A61P25/00