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    2-피롤리돈기를 포함하는 옥사졸리디논 유도체 또는 이의 약학적으로 허용 가능한 염 및 이들의 제조방법
    41.
    发明公开
    2-피롤리돈기를 포함하는 옥사졸리디논 유도체 또는 이의 약학적으로 허용 가능한 염 및 이들의 제조방법 有权
    含有2-吡咯烷酮基或其药学上可接受的盐的氧杂环丁酮衍生物及其制备方法

    公开(公告)号：KR1020120056078A

    公开(公告)日：2012-06-01

    申请号：KR1020100117602

    申请日：2010-11-24

    Applicant: 한국과학기술연구원

    Inventor： 금교창 ,  김은경 ,  배애님 ,  김유승 ,  강순방 ,  서선희 ,  바타라이디팍

    IPC: C07D413/10 ,  A61K31/422 ,  A61P31/04

    CPC classification number: Y02A50/473 ,  Y02A50/481

    Abstract: PURPOSE: An antibacterial composition containing novel oxazolidinone derivative is provided to ensure antibacterial activity against gram positive bacteria. CONSTITUTION: A novel oxazolidinone derivative with antibacterial activity is denoted by chemical formula 1. A method for preparing the compound of chemical formula 1 or the salt thereof comprises: a step of reacting an amine group of a compound of chemical formula 2 with a compound of chemical formula 3 or 4; and a step of substituting a hydroxyl group of an oxazolidinone derivative or a pharmaceutically acceptable salt thereof with a halogen group or methoxy group. An antibacterial composition contains the oxazolidinone derivative of chemical formula 1 or a salt thereof as an active ingredient.

    Abstract translation: 目的：提供含有新恶唑烷酮衍生物的抗菌组合物，以确保对革兰氏阳性菌的抗菌活性。 构成：具有抗菌活性的新型恶唑烷酮衍生物由化学式1表示。化学式1化合物或其盐的制备方法包括：使化学式2的化合物的胺基与 化学式3或4; 以及将恶唑烷酮衍生物或其药学上可接受的盐的羟基与卤素基或甲氧基取代的步骤。 抗菌组合物含有化学式1的恶唑烷酮衍生物或其盐作为活性成分。

    1,6-이치환-3-아미노-4,5,6,7-테트라하이드로-1Ｈ-피라졸로［3,4-ｃ］피리딘-7-온 화합물 및 이 화합물의 제조방법
    42.
    发明公开
    1,6-이치환-3-아미노-4,5,6,7-테트라하이드로-1Ｈ-피라졸로［3,4-ｃ］피리딘-7-온 화합물 및 이 화합물의 제조방법 有权
    新的1,6-二异丙基氨基-4,5,6,7-四氢-1H-吡唑并[3,4-C]吡啶-7-酮化合物及其制备方法

    公开(公告)号：KR1020110139988A

    公开(公告)日：2011-12-30

    申请号：KR1020100060138

    申请日：2010-06-24

    Applicant: 한국과학기술연구원

    Inventor： 남길수 ,  배애님 ,  최경일 ,  추현아 ,  와니 ,  서선희

    IPC: C07D471/04 ,  C07D403/02 ,  A61K31/437 ,  A61P35/00

    CPC classification number: C07D471/04

    Abstract: PURPOSE: A novel 1,6-disubstituted-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-7-one is provided to suppress cancer cells. CONSTITUTION: A 1,6-disubstituted-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-7-one compound is denoted by chemical formula 1. A pharmaceutical composition for anticancer contains the compound of chemical formula 1 or pharmaceutically acceptable salt thereof as an active ingredient. A method for preparing the compound of chemical formula 1 comprises a step of alkylating 3-amino compounds of chemical formula 2 with haloalkylcarbonyl piperazine of chemical formula 3 by alkylating.

    Abstract translation: 目的：提供新颖的1,6-二取代-4,5,6,7-四氢-1H-吡唑并[3,4-c]吡啶-7-酮以抑制癌细胞。 构成：1,6-二取代-4,5,6,7-四氢-1H-吡唑并[3,4-c]吡啶-7-酮化合物由化学式1表示。用于抗癌的药物组合物含有化合物 的化学式1或其药学上可接受的盐作为活性成分。 制备化学式1的化合物的方法包括通过烷基化将化学式2的3-氨基化合物与化学式3的卤代烷基羰基哌嗪烷基化的步骤。

    3,6-이치환-4,5,6,7-테트라하이드로-1Ｈ-피라졸로［3,4-ｃ］피리딘-7-온 화합물과 이 화합물의 제조방법
    43.
    发明公开
    3,6-이치환-4,5,6,7-테트라하이드로-1Ｈ-피라졸로［3,4-ｃ］피리딘-7-온 화합물과 이 화합물의 제조방법 有权
    新的3,6-取代-4,5,6,7-四氢-1H-吡唑并[3,4-C]吡啶-7-酮化合物及其制备方法

    公开(公告)号：KR1020110121868A

    公开(公告)日：2011-11-09

    申请号：KR1020100041360

    申请日：2010-05-03

    Applicant: 한국과학기술연구원 ,  서울대학교산학협력단

    Inventor： 남길수 ,  배애님 ,  최경일 ,  와니 ,  서선희 ,  추현아

    IPC: C07D471/02 ,  C07D487/04 ,  A61P35/00 ,  A61K31/437

    Abstract: PURPOSE: A novel 3,6-disubstituted-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridin-7-one compound is provided to suppress cancer cell and to be used as an anticancer agent. CONSTITUTION: A 3,6-disubstituted-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridin-7-one is denoted by chemical formula 1. A pharmaceutical composition for anticancer contains the compound of chemical formula 1 as an active ingredient. A method for preparing the compound of chemical formula 1 comprises: a step of performing acrylation of 3-amino compound of chemical formula 2 with acyl halide compound of chemical formula 3 to prepare 3-haloacylcarbamoyl compound of chemical formula 4; and a step of substituting 3-haloacylcarbamoyl compound of chemical formula 4 with amine compounds of chemical formula 5.

    Abstract translation: 目的：提供新的3,6-二取代-4,5,6,7-四氢-1H-吡唑并[3,4-c]吡啶-7-酮化合物以抑制癌细胞并用作抗癌剂 。 构成：3,6-二取代-4,5,6,7-四氢-1H-吡唑并[3,4-c]吡啶-7-酮由化学式1表示。用于抗癌的药物组合物含有 化学式1为活性成分。 制备化学式1化合物的方法包括：用化学式3的酰卤化合物进行化学式2的3-氨基化合物的丙烯酸化以制备化学式4的3-卤代酰基氨基甲酰基化合物的步骤; 和用化学式5的胺化合物代替化学式4的3-卤代酰基氨基甲酰基化合物的步骤。

    1,6-디옥세케인 화합물과 이의 제조방법
    45.
    发明公开
    1,6-디옥세케인 화합물과 이의 제조방법 失效
    1,6-二氧化物及其制备方法

    公开(公告)号：KR1020100134977A

    公开(公告)日：2010-12-24

    申请号：KR1020090053364

    申请日：2009-06-16

    Applicant: 한국과학기술연구원

    Inventor： 조용서 ,  김유승 ,  민선준 ,  이재균 ,  배애님 ,  추현아 ,  울라프,푼나레디

    IPC: C07D493/04 ,  C07D493/02

    Abstract: PURPOSE: A method for preparing 1,6-dioxecane compound is provided to enlarge other ring by Diels-Alder reaction and to use as an intermediate. CONSTITUTION: A 1,6-Dioxecanes compound is denoted by chemical formula 1. The 1,6-Dioxecanes compound is prepared by Prins reaction of alcohol compound of chemical formula 2 and aldehyde compound of chemical formula 3. A tetrahydrofuran is used as a reaction catalyst. The reaction temperature is -78 to 30°C.

    Abstract translation: 目的：提供1,1-二氧化合物的制备方法，以通过狄尔斯 - 阿尔德反应扩大其它环并用作中间体。 构成：1,6-二氧癸烷化合物由化学式1表示。1,6-二氧癸烷化合物通过化学式2的醇化合物与化学式3的醛化合物的Prins反应制备。使用四氢呋喃作为反应 催化剂。 反应温度为-78〜30℃。

    1-(2-하이드록시페닐)부타-2-엔-1-온 또는 크로만-4-온 유도체의 제조방법
    48.
    发明授权
    1-(2-하이드록시페닐)부타-2-엔-1-온 또는 크로만-4-온 유도체의 제조방법 失效
    制备1-2-羟基苯基丁-2-烯-1-酮和色甘酸-4-酮的方法

    公开(公告)号：KR100935016B1

    公开(公告)日：2010-01-06

    申请号：KR1020080013153

    申请日：2008-02-13

    Applicant: 한국과학기술연구원

    Inventor： 조용서 ,  김유승 ,  이재균 ,  배애님 ,  추현아 ,  박지연

    IPC: C07D311/26 ,  C07D311/22 ,  C07D311/28

    Abstract: 본 발명은 1-(2-하이드록시페닐)부타-2-엔-1-온 또는 크로만-4-온 유도체의 제조방법에 관한 것으로서, 더욱 상세하게는 2-에티이닐페놀 유도체를 루이스산 촉매 존재 하에서 알데하이드 화합물과 반응시켜 하기 화학식 1로 표시되는 1-(2-하이드록시페닐)부타-2-엔-1-온 유도체 또는 하기 화학식 2로 표시되는 크로만-4-온 유도체를 제조하는 방법에 관한 것이다.


    상기 화학식 1 또는 2에서, R
    1 및 R
    2 는 각각 발명의 상세한 설명에서 정의한 바와 같다.
    1-(2-하이드록시페닐)부타-2-엔-1-온, 크로만-4-온, 루이스산

    중추신경계 질환 치료제로 유효한Ｎ-벤질-Ｎ-(2-디메틸아미노-에틸)-벤젠술폰아미드 화합물
    50.
    发明授权
    중추신경계 질환 치료제로 유효한Ｎ-벤질-Ｎ-(2-디메틸아미노-에틸)-벤젠술폰아미드 화합물 失效
    使用N-苄基-N-（2-二甲基氨基 - 乙基）苯并呋喃衍生物治疗CNS病症

    公开(公告)号：KR100843351B1

    公开(公告)日：2008-07-03

    申请号：KR1020070009626

    申请日：2007-01-30

    Applicant: 한국과학기술연구원 ,  주식회사 디비하이텍

    Inventor： 배애님 ,  조용서 ,  추현아 ,  김혜정 ,  고훈영 ,  박우규 ,  공재양 ,  채명윤 ,  조인선 ,  황봉운 ,  이동하

    IPC: A61K31/63 ,  A61P25/00

    CPC classification number: A61K31/18

    Abstract: An N-benzyl-N-(2-dimethylamino-ethyl)benzenesulfonamide compound is provided to show selective antagonistic activity on serotonin 5-HT2a or 5-HT2c receptor and have selective serotonin reuptake inhibitor(SSRI) activity, thereby being used for a pharmaceutical composition for treating and preventing central nervous system diseases. A pharmaceutical composition for treating and preventing diseases such as anxiety, depression, stroke, obsessive neurosis, psychosis, schizophrenia, suicidal tendency, sleep disorders, appetite disorders, withdrawal symptoms caused by drug abuse, and migraine comprises an N-benzyl-N-(2-dimethylamino-ethyl)benzenesulfonamide compound represented by a formula(1) or a pharmaceutically acceptable salt thereof. In the formula(1), R is H, halogen, hydroxy, C1-10 alkyl, C1-10 alkoxy, C1-10 haloalkyl, C1-10 haloalkoxy, C1-10 acyl, phenyl or phenyloxy, provided that a benzen-ring of the phenyl or the phenyloxy may be substituted by H, halogen, cyano, C1-10 alkyl or C1-10 alkoxy.

    Abstract translation: 提供N-苄基-N-（2-二甲基氨基 - 乙基）苯磺酰胺化合物以显示对5-羟色胺5-HT2a或5-HT2c受体的选择性拮抗活性，并且具有选择性5-羟色胺再摄取抑制剂（SSRI）活性，从而用于药物 用于治疗和预防中枢神经系统疾病的组合物。 用于治疗和预防诸如焦虑，抑郁，中风，强迫神经症，精神病，精神分裂症，自杀倾向，睡眠障碍，食欲障碍，药物滥用引起的戒断症状和偏头痛等疾病的药物组合物包含N-苄基-N-（ 2-二甲基氨基 - 乙基）苯磺酰胺化合物或其药学上可接受的盐。 在式（1）中，R为H，卤素，羟基，C 1-10烷基，C 1-10烷氧基，C 1-10卤代烷基，C 1-10卤代烷氧基，C 1-10酰基，苯基或苯氧基，条件是苯环 的苯基或苯氧基可以被H，卤素，氰基，C 1-10烷基或C 1-10烷氧基取代。

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