公开(公告)号：DK1339695T3

公开(公告)日：2006-07-31

申请号：DK01273519

申请日：2001-11-30

Applicant: ABBOTT LAB

Inventor： CLAIBORNE AKIYO K ,  GWALTNEY STEPHEN L II ,  LI TOMGMEI ,  MANTEI ROBERT A ,  ROCKWAY TODD W ,  TONG YUNSONG ,  WANG GARY T ,  WANG XILU ,  WANG WEIBO ,  HASVOLD LISA A ,  LI QUN ,  LIN NAN-HORNG ,  SHAM HING L ,  SULLIVAN GERARD M ,  WANG LE

IPC: C07D233/64 ,  A61K31/4164 ,  A61K31/4178 ,  A61K31/426 ,  A61K31/4439 ,  A61K31/4709 ,  A61P35/00 ,  A61P43/00 ,  C07D233/54 ,  C07D277/20 ,  C07D277/30 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12

Abstract: Substituted imidazoles and thiazoles having the formula are useful for inhibiting farnesyltransferase. Also disclosed are farnesyltransferase-inhibiting compositions and methods of inhibiting farnesyltransferase in a patient.

公开(公告)号：CA2545055A1

公开(公告)日：2005-05-26

申请号：CA2545055

申请日：2004-11-03

Applicant: ABBOTT LAB

Inventor： SOWIN THOMAS J ,  SULLIVAN GERARD M ,  WANG LE ,  LIN NAN-HORNG ,  TONG YUNSONG ,  TAO ZHI-FU ,  PRZYTULINSKA MAGDALENNA ,  LI GAOQUAN

IPC: C07D498/08 ,  A61K31/395 ,  A61K31/4995 ,  A61P35/00 ,  C07D498/18

公开(公告)号：DK0934308T3

公开(公告)日：2004-12-06

申请号：DK97927830

申请日：1997-06-04

Applicant: ABBOTT LAB

Inventor： LIN NAN-HORNG ,  HE YUN ,  HOLLADAY MARK W ,  RYTHER KEITH ,  LI YIHONG ,  BAI HAO

IPC: A61K31/44 ,  A61K31/4427 ,  A61K31/4436 ,  A61K31/4439 ,  A61K31/445 ,  A61K31/4545 ,  A61K31/465 ,  A61K31/4709 ,  A61K31/497 ,  A61K31/501 ,  A61K31/505 ,  A61K31/506 ,  A61P25/00 ,  A61P43/00 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D407/14 ,  C07D409/14

Abstract: Novel 3-pyridyloxymethyl heterocyclic ether compounds of the formula: or the pharmaceutically-acceptable salts or prodrugs thereof are selective and potent ligands at neuronal nicotinic cholinergic channel receptors, and are effective in controlling synaptic transmission.

公开(公告)号：CA2517885A1

公开(公告)日：2004-09-23

申请号：CA2517885

申请日：2004-03-04

Applicant: ABBOTT LAB

Inventor： SHAM HING ,  LIN NAN-HORNG ,  CLAIBORNE AKIYO K ,  LI GAOQUAN ,  TAO ZHI-FU ,  TONG YUNSONG ,  SOWIN TOM

IPC: A61P35/00 ,  C07D231/54 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/10 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/14 ,  C07D417/14 ,  C07D521/00 ,  A61K31/416 ,  C07D403/14 ,  C07D417/12

Abstract: Compounds having the formula (I) (I), are useful for inhibiting protein kinases. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.

公开(公告)号：AT262519T

公开(公告)日：2004-04-15

申请号：AT98964167

申请日：1998-12-18

Applicant: ABBOTT LAB

Inventor： HOLLADAY MARK W ,  ABREO MELWYN A ,  GUNN DAVID E ,  LIN NAN-HORNG ,  GARVEY DAVID S ,  RYTHER KEITH ,  LEBOLD SUZANNE A ,  ELLIOTT RICHARD L ,  HE YUN ,  WASIAK JAMES T ,  BAI HAO ,  DART MICHAEL J ,  EHRLICH PAUL P ,  LI YIHONG ,  KINCAID JOHN F ,  SCHKERYANTZ JEFFREY M ,  LYNCH JOHN K

IPC: A61K31/427 ,  A61K31/4427 ,  A61K31/4439 ,  A61K31/4545 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/497 ,  A61K31/501 ,  A61K31/506 ,  A61P25/00 ,  A61P25/22 ,  A61P25/28 ,  A61P25/30 ,  A61P43/00 ,  C07D401/12 ,  C07D403/12 ,  C07D417/12 ,  C07D455/02 ,  C07D487/04 ,  A61K31/40 ,  A61K31/425 ,  A61K31/44

公开(公告)号：BR0112028A

公开(公告)日：2004-02-17

申请号：BR0112028

申请日：2001-11-30

Applicant: ABBOTT LAB

Inventor： CLAIBORNE AKIYO K ,  GWALTNEY STEPHEN L II ,  HASVOLD LISA A ,  LI QUN ,  LI TOMGMEI ,  LIN NAN-HORNG ,  MANTEI ROBERT A ,  ROCKWAY TODD W ,  SHAM HING L ,  SULLIVAN GERARD M ,  TONG YUNSONG ,  WANG GARY T ,  WANG LE ,  WANG XILU ,  WANG WEIBO

IPC: A61K31/4164 ,  A61K31/4178 ,  A61K31/426 ,  A61K31/4439 ,  A61K31/4709 ,  A61P35/00 ,  A61P43/00 ,  C07D233/54 ,  C07D233/64 ,  C07D277/20 ,  C07D277/30 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12

Abstract: Substituted imidazoles and thiazoles having the formula are useful for inhibiting farnesyltransferase. Also disclosed are farnesyltransferase-inhibiting compositions and methods of inhibiting farnesyltransferase in a patient.

公开(公告)号：DK0970083T3

公开(公告)日：2003-08-11

申请号：DK98907359

申请日：1998-02-05

Applicant: ABBOTT LAB

Inventor： WASICAK JAMES T ,  GARVEY DAVID S ,  HOLLADAY MARK W ,  RYTHER KEITH B ,  LIN NAN-HORNG

IPC: A61P25/04 ,  A61K31/422 ,  A61K31/4439 ,  A61K31/4725 ,  A61P25/00 ,  A61P43/00 ,  C07D487/04 ,  A61K31/44

Abstract: 7a-Substituted hexahydro-1H-pyrrolizine compounds having the formula wherein A is a defined heterocycle moiety, pharmaceutical compositions of these compounds, and use of said compositions to selectively control synaptic transmission in mammals.

公开(公告)号：NO20032471A

公开(公告)日：2003-07-25

申请号：NO20032471

申请日：2003-05-30

Applicant: ABBOTT LAB

Inventor： CLAIBORNE AKIYO K ,  GWALTNEY II STEPHEN L ,  HASVOLD LISA A ,  LI QUN ,  LI TOMGMEI ,  LIN NAN-HORNG ,  MANTEI ROBERT A ,  ROCKWAY TODD W ,  SHAM HING L ,  SULLIVAN GERARD M ,  TONG YUNSONG ,  WANG GARY T ,  WANG LE ,  WANG XILU ,  WANG WEIBO

IPC: A61K31/4164 ,  A61K31/4178 ,  A61K31/426 ,  A61K31/4439 ,  A61K31/4709 ,  A61P35/00 ,  A61P43/00 ,  C07D233/54 ,  C07D233/64 ,  C07D277/20 ,  C07D277/30 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12

CPC classification number: C07D233/64 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12

Abstract: Substituted imidazoles and thiazoles having the formula are useful for inhibiting farnesyltransferase. Also disclosed are farnesyltransferase-inhibiting compositions and methods of inhibiting farnesyltransferase in a patient.

公开(公告)号：DK0950057T3

公开(公告)日：2003-03-10

申请号：DK97952392

申请日：1997-12-10

Applicant: ABBOTT LAB

Inventor： HOLLADAY MARK W ,  ARNERIC STEPHEN P ,  BAI HAO ,  DART MICHAEL J ,  LYNCH JOHN K ,  OR YAT SUN ,  RYTHER KEITH B ,  SULLIVAN JAMES P ,  WASICAK JAMES T ,  EHRLICH PAUL P ,  LIN NAN-HORNG

IPC: A61P25/04 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/4439 ,  A61K31/485 ,  A61P25/28 ,  A61P29/00 ,  C07D205/04 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  A61K31/44

Abstract: The present invention relates to a method of controlling pain in mammals, including humans, comprising administering to a mammal or patient in need of treatment thereof selected compounds of formula (I) or a pharmaceutically acceptable salt thereof. The invention further relates to selected (R) and (S) compounds of formula (I) which are useful as analgesics as well as neuronal cell death preventors and anti-inflammatories.

公开(公告)号：DE69617701T2

公开(公告)日：2002-10-17

申请号：DE69617701

申请日：1996-05-28

Applicant: ABBOTT LAB

Inventor： HOLLADAY W ,  LIN NAN-HORNG ,  RYTHER B ,  HE YUN

IPC: A61K31/00 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/4439 ,  A61P25/00 ,  A61P25/04 ,  C07D401/12 ,  C07D403/12 ,  C07D417/12

Abstract: Novel 3-pyridyloxymethyl heterocyclic ether compounds having formula (I), wherein * is a chiral center and n, X, R , R , A andB are specifically defined, which are useful in controlling chemical synaptic transmission; therapeutically-effective pharmaceutical compositions therof; and use of said compositions to selectively control synaptic transmission in mammals.