公开(公告)号：MX2010012260A

公开(公告)日：2010-11-30

申请号：MX2010012260

申请日：2008-12-11

Applicant: ABBOTT LAB

Inventor： MICHAELIDES MICHAEL R ,  JI ZHIQIN

IPC: C07D487/04 ,  A61K31/53 ,  A61P35/00

Abstract: Se describen compuestos que inhiben Aurora-cinasas, composiciones que contienen los compuestos y métodos para tratar enfermedades utilizando los compuestos. Una modalidad de esta invención, por lo tanto, se refiere a compuestos que inhiben Aurora-cinasas, los compuestos teniendo la Fórmula I y sales terapéuticamente aceptables de los mismos.

公开(公告)号：CA2723127A1

公开(公告)日：2009-11-12

申请号：CA2723127

申请日：2008-12-11

Applicant: ABBOTT LAB

Inventor： MICHAELIDES MICHAEL R ,  JI ZHIQIN

IPC: C07D487/04 ,  A61K31/53 ,  A61P35/00

Abstract: Compounds that inhibit Aurora-kinases, compositions containing the compounds and methods of treating diseases using the compounds are disclosed. One embodiment of this invention, therefore, pertains to compounds that inhibit Aurora-kinases, the compounds having formula I and therapeutically acceptable salts thereof.

公开(公告)号：DK1648905T3

公开(公告)日：2009-03-30

申请号：DK04779180

申请日：2004-07-26

Applicant: ABBOTT LAB

Inventor： BETSCHMANN PATRICK ,  BURCHAT ANDREW F ,  CALDERWOOD DAVID J ,  CURTIN MICHAEL L ,  DAVIDSEN STEVEN K ,  DAVIS HEATHER M ,  FREY ROBIN R ,  HEYMAN HOWARD R ,  HIRST GAVIN C ,  HRNCIAR PETER ,  MICHAELIDES MICHAEL R ,  MUCKEY MELANIE A ,  RAFFERTY PAUL ,  WADA CAROL K

IPC: C07D495/04 ,  A61K31/4355 ,  A61K31/4365 ,  A61P35/00 ,  C07D491/04 ,  C07D498/04

Abstract: Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.

公开(公告)号：CA2690619A1

公开(公告)日：2009-01-22

申请号：CA2690619

申请日：2008-07-16

Applicant: ABBOTT LAB

Inventor： DAI YUJIA ,  ZHIQIN JI ,  MICHAELIDES MICHAEL R

IPC: C07D231/56 ,  A61K31/416 ,  A61K31/423 ,  A61K31/428 ,  A61P35/00 ,  C07D261/20 ,  C07D275/04

Abstract: Compounds that inhibit Aurora-kinases, compositions containing the compounds and methods of treating diseases using the compounds are disclosed.

公开(公告)号：CA2631664A1

公开(公告)日：2007-06-14

申请号：CA2631664

申请日：2006-12-08

Applicant: ABBOTT LAB

Inventor： DAI YUJIA ,  STEINMAN DOUGLAS H ,  CURTIN MICHAEL L ,  FREY ROBIN R ,  MCCLELLAN WILLIAM J ,  MICHAELIDES MICHAEL R ,  HOLMS JAMES H

IPC: C07D487/04 ,  A61K31/519 ,  A61P35/00 ,  C07D495/04

Abstract: Compounds that inhibit protein kinases, compositions containing the compounds and methods of treating cancer using the compounds are disclosed.

公开(公告)号：MXPA05012596A

公开(公告)日：2006-02-22

申请号：MXPA05012596

申请日：2004-05-21

Applicant: ABBOTT LAB

Inventor： MICHAELIDES MICHAEL R

IPC: A61K31/416 ,  A61K31/42 ,  A61K31/423 ,  A61K31/428 ,  A61K31/4709 ,  A61P35/00 ,  C07D231/56 ,  C07D261/20 ,  C07D275/04 ,  C07D401/04 ,  C07D401/12 ,  C07D403/04 ,  C07D403/12 ,  C07D405/12 ,  C07D409/04 ,  C07D413/02

Abstract: Los compuestos que tienen la formula (I) son utiles para inhibir las tirosina-quinasas de proteina. La presente invencion describe tambien metodos para formar los compuestos; composiciones que contienen los compuestos, y metodos de tratamiento que usan los compuestos.

公开(公告)号：CA2560691A1

公开(公告)日：2005-10-13

申请号：CA2560691

申请日：2005-03-24

Applicant: MAKOTO AOYAMA ,  ABBOTT LAB

Inventor： WADA CAROL K ,  STEINMAN DOUGLAS H ,  RAFFERTY PAUL ,  MAKOTO AOYAMA ,  XIA ZHIREN ,  MICHAELIDES MICHAEL R ,  MUCKEY MELANIE A ,  DINGES JUERGEN ,  HOLMS JAMES H ,  ZHANG HENRY Q ,  AKRITOPOULOU-ZANZE IRINI ,  DIXON RICHARD W ,  DJURIC STEVAN W ,  ERICSSON ANNA M ,  FISCHER KIMBA ,  GRACIAS VIJAYA J ,  ARNOLD LEE D ,  GASIECKI ALAN F

IPC: C07D409/04 ,  A61K31/416 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/496 ,  A61K31/506 ,  A61K31/5377 ,  A61P35/00 ,  A61P37/00 ,  C07D231/54 ,  C07D409/14 ,  C07D413/14 ,  C07D491/04 ,  C07D495/04

Abstract: Compounds of the present invention are useful for inhibiting protein tyrosin e kinases. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.

公开(公告)号：ES2193158T3

公开(公告)日：2003-11-01

申请号：ES94912799

申请日：1994-03-18

Applicant: ABBOTT LAB

Inventor： MICHAELIDES MICHAEL R ,  HONG YUFENG

IPC: A61K31/435 ,  A61P1/08 ,  A61P9/00 ,  A61P25/00 ,  A61P25/18 ,  A61P25/24 ,  A61P25/26 ,  A61P25/28 ,  A61P39/02 ,  C07D491/04 ,  C07D491/048 ,  C07D495/04 ,  C07D498/04 ,  C07D513/04 ,  A61K31/47

Abstract: A tetracyclic compound of the formula: wherein A and the atoms to which it is attached and the optional double bond represent a mono- or di-heterocyclic ring selected from: wherein R1, R2, R3, R4 and X are specifically defined, which compounds are useful in the treatment of dopamine-related neurological, psychological and cardiovascular disorders as well as in the treatment of substance abuse and other addictive behavior disorders, cognitive impairment and attention deficit disorder.

公开(公告)号：AU2003222055A1

公开(公告)日：2003-10-08

申请号：AU2003222055

申请日：2003-03-21

Applicant: ABBOTT LAB

Inventor： HIRST GAVIN C ,  ARNOLD LEE D ,  BURCHAT ANDREW ,  WISHART NEIL ,  CALDERWOOD DAVID ,  WADA CAROL K ,  MICHAELIDES MICHAEL R ,  JI ZHIQIN ,  MUCKEY MELANIE

IPC: A61K31/519 ,  A61P1/04 ,  A61P1/16 ,  A61P3/10 ,  A61P5/14 ,  A61P7/00 ,  A61P7/06 ,  A61P9/00 ,  A61P9/10 ,  A61P9/12 ,  A61P11/00 ,  A61P11/06 ,  A61P13/12 ,  A61P15/08 ,  A61P17/02 ,  A61P17/06 ,  A61P19/02 ,  A61P27/02 ,  A61P27/06 ,  A61P29/00 ,  A61P31/04 ,  A61P31/12 ,  A61P31/18 ,  A61P31/22 ,  A61P33/02 ,  A61P35/00 ,  A61P35/02 ,  A61P37/02 ,  A61P37/06 ,  A61P43/00 ,  C07D413/04 ,  C07D487/04 ,  C07D491/04 ,  C07D491/048 ,  C07D498/04 ,  C07D491/00 ,  C07D487/02 ,  C07D473/00 ,  C07D471/00 ,  C07D487/00

Abstract: The present application is directed to pyrazolopyrimidine and furopyrimnidine analogs of the formula (I) wherein the substituents are as defined herein, which are useful as kinase inhibitors.

公开(公告)号：AU2003220437A1

公开(公告)日：2003-10-08

申请号：AU2003220437

申请日：2003-03-20

Applicant: ABBOTT LAB

Inventor： FREY ROBIN R ,  GUO YAN ,  JI ZHIQIN ,  CURTIN MICHAEL ,  MICHAELIDES MICHAEL R ,  DAI YUJIA ,  DAVIDSEN STEVEN K

IPC: C07D495/04 ,  A61K31/519 ,  A61P1/04 ,  A61P3/10 ,  A61P5/14 ,  A61P7/10 ,  A61P9/10 ,  A61P9/12 ,  A61P11/00 ,  A61P17/06 ,  A61P19/02 ,  A61P21/04 ,  A61P25/00 ,  A61P29/00 ,  A61P35/00 ,  A61P35/02 ,  A61P37/06 ,  A61P43/00 ,  C07D498/02 ,  C07D513/04

Abstract: Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.