公开(公告)号：NZ592569A

公开(公告)日：2012-05-25

申请号：NZ59256909

申请日：2009-10-20

Applicant: VERTEX PHARMA

Inventor： LAUFFER DAVID ,  LI PAN ,  MCGINTY KIRA ,  RONKIN STEVEN ,  TANG QING ,  GRILLOT ANNE-LAURE ,  WAAL NATHAN

IPC: C07D401/04 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D451/06

Abstract: Disclosed are tetrazole piperazine compounds represented by general formula (I), or pharmaceutically acceptable salts thereof, wherein RA is a phenyl or 5-9 membered heteroaryl. The compounds are used to treat a proliferative disorder such as cancer.

公开(公告)号：CL2011001152A1

公开(公告)日：2012-02-24

申请号：CL2011001152

申请日：2011-05-18

Applicant: VERTEX PHARMA

Inventor： LAUFFER DAVID ,  LI PAN ,  SHANNON DEAN ,  LIANG JIANGLIN

IPC: A61K31/433 ,  A61P35/04 ,  C07D513/14

Abstract: Compuesto cristalino 6-((s)-1-(6-(1-metil-1h-pirazol-4-il)-[1,2,4]triazolo[3,4-b][1,3,4]tiadiazol-3-il)etil)quinolina, inhibidor de la proteina kinasa c-met; composición farmacéutica; y método para tratar o disminuir la gravedad de un trastorno proliferativo tal como cáncer metastásico de colon, mama y hepático, entre otros.

公开(公告)号：PL1730146T3

公开(公告)日：2011-10-31

申请号：PL05756052

申请日：2005-03-30

Applicant: VERTEX PHARMA

Inventor： SALITURO FRANCESCO ,  FARMER LUC ,  BETHIEL RANDY ,  HARRINGTON EDMUND ,  GREEN JEREMY ,  COURT JOHN ,  COME JON ,  LAUFFER DAVID ,  ARONOV ALEX ,  BINCH HAYLEY ,  BOYALL DEAN ,  CHARRIER JEAN-DAMIEN ,  EVERITT SIMON ,  FRAYSSE DAMIEN ,  MORTIMORE MICHAEL ,  PIERARD FRANCOISE ,  ROBINSON DANIEL ,  PINDER JOANNE ,  WANG TIANSHENG ,  PIERCE ALBERT ,  WANG JIAN

IPC: C07D471/04 ,  C07D519/00

公开(公告)号：CA2762190A1

公开(公告)日：2010-12-02

申请号：CA2762190

申请日：2010-05-27

Applicant: VERTEX PHARMA

Inventor： LAUFFER DAVID ,  LI PAN ,  MCGINTY KIRA

IPC: C07D513/04 ,  A61K31/47 ,  A61P35/00

Abstract: The present invention relates to compounds of formula (I), which is useful in the inhibition of c-Met protein kinase. The invention also provides pharmaceutically acceptable compositions comprising compounds of formula (I) and methods of using the compositions in the treatment of proliferative disorders.

公开(公告)号：AU2009316756A1

公开(公告)日：2010-05-27

申请号：AU2009316756

申请日：2009-11-18

Applicant: VERTEX PHARMA

Inventor： LAUFFER DAVID ,  LI PAN ,  SHANNON DEAN ,  LIANG JIANGLIN

IPC: C07D513/04 ,  A61K31/433

Abstract: The present invention relates to compound 1, which is useful in the inhibition of c-Met protein kinase. The invention also provides pharmaceutically acceptable compositions comprising Compound 1 and methods of using the compositions in the treatment of proliferative disorders.

公开(公告)号：BRPI0509369A

公开(公告)日：2007-09-11

申请号：BRPI0509369

申请日：2005-03-30

Applicant: VERTEX PHARMA

Inventor： SALITURO FRANCESCO G ,  FARMER LUC ,  BETHIEL RANDY ,  HARRINGTON EDMUND ,  COME JON ,  LAUFFER DAVID ,  ARONOV ALEX ,  BINCH HAYLEY ,  BOYALL DEAN ,  EVERITT SIMON ,  FRAYSSE DAMIEN ,  MORTIMORE MICHAEL ,  PIERARD FRANCOISE ,  ROBINSON DANIEL ,  CHARRIER JEAN-DAMIEN ,  WANG JIAN ,  PINDER JOANNE ,  WANG TIANSHENG ,  PIERCE ALBERT ,  GREEN JEREMY

IPC: C07D471/04 ,  C07D519/00

Abstract: The present invention relates to compounds of formula (I), which are inhibitors of protein kinases. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.

公开(公告)号：AU2006320580A1

公开(公告)日：2007-06-07

申请号：AU2006320580

申请日：2006-11-30

Applicant: VERTEX PHARMA

Inventor： STEWART MICHELLE ,  ARONOV ALEXANDER ,  LI PAN ,  DEININGER DAVID ,  LAUFFER DAVID ,  STAMOS DEAN ,  MCGINTY KIRA ,  COME JON

IPC: C07D513/04 ,  A61K31/433 ,  A61P35/00 ,  C07D487/04 ,  C07D519/00

Abstract: The present invention provides compounds useful as inhibitors of c-Met tyrosine kinase. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various proliferative disorders.

公开(公告)号：AU2005228904A1

公开(公告)日：2005-10-13

申请号：AU2005228904

申请日：2005-03-30

Applicant: VERTEX PHARMA

Inventor： COURT JOHN ,  ROBINSON DANIEL ,  CHARRIER JEAN-DAMIEN ,  FRAYSSE DAMIEN ,  MORTIMORE MICHAEL ,  LAUFFER DAVID ,  BETHIEL RANDY ,  FARMER LUC ,  HARRINGTON EDMUND ,  COME JON ,  GREEN JEREMY ,  EVERITT SIMON ,  BINCH HAYLEY ,  SALITURO FRANCESCO ,  PIERARD FRANCOISE ,  ARONOV ALEX ,  BOYALL DEAN

IPC: C07D471/04 ,  C07D519/00

Abstract: The present invention relates to compounds of formula (I), which are inhibitors of protein kinases. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.

公开(公告)号：CA2444598A1

公开(公告)日：2003-10-31

申请号：CA2444598

申请日：2002-04-19

Applicant: FORSTER CORNELIA ,  CAO JINGRONG ,  VERTEX PHARMA ,  LAUFFER DAVID ,  WANNAMAKER MARION ,  METZ NATALIE ,  TOMLINSON RONALD ,  PIERCE ALBERT ,  DAVIES ROBERT ,  CHOQUETTE DEBBIE

Inventor： FORSTER CORNELIA ,  CAO JINGRONG ,  LAUFFER DAVID ,  WANNAMAKER MARION ,  METZ NATALIE ,  TOMLINSON RONALD ,  PIERCE ALBERT ,  DAVIES ROBERT ,  CHOQUETTE DEBBIE

IPC: C07D487/04 ,  A61K31/519 ,  A61K31/55 ,  A61K31/59 ,  A61K45/00 ,  A61P3/10 ,  A61P9/00 ,  A61P9/10 ,  A61P9/12 ,  A61P9/14 ,  A61P11/06 ,  A61P15/10 ,  A61P17/14 ,  A61P25/00 ,  A61P25/08 ,  A61P25/14 ,  A61P25/16 ,  A61P25/18 ,  A61P25/28 ,  A61P27/06 ,  A61P29/00 ,  A61P31/18 ,  A61P35/04 ,  A61P37/06 ,  A61P41/00 ,  A61P43/00 ,  C07D471/14 ,  C07D487/14 ,  C07D495/04 ,  C07D498/14 ,  C07D513/14

Abstract: The present invention provides compounds of formula I:or a pharmaceutically acceptable derivative thereof, wherein X is oxygen or sulfur; Y is -S-, -O- or -NR1-; and R2, R3, and R4 are as described in the specification. These compounds are inhibitors of protein kinase, particularly inhibitors of GSK-3 mammalian protein kinase. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatement and prevention of various disorders, such as diabetes and Alzheimer's disease.

公开(公告)号：HU0301391A2

公开(公告)日：2003-08-28

申请号：HU0301391

申请日：2001-02-09

Applicant: VERTEX PHARMA

Inventor： LAUFFER DAVID ,  MULLICAN MICHAEL ,  TOMLINSON RONALD

IPC: A61K31/40 ,  A61K31/4025 ,  A61K31/427 ,  A61K31/4523 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/4995 ,  A61K31/506 ,  A61K38/22 ,  A61K38/27 ,  A61P19/04 ,  A61P21/00 ,  A61P21/04 ,  A61P25/00 ,  A61P25/02 ,  A61P25/04 ,  A61P25/14 ,  A61P25/16 ,  A61P25/28 ,  A61P29/00 ,  C07D20060101 ,  C07D205/04 ,  C07D207/16 ,  C07D209/52 ,  C07D211/26 ,  C07D211/60 ,  C07D211/62 ,  C07D211/78 ,  C07D277/06 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D409/14 ,  C07D417/06 ,  C07D417/12 ,  C07D487/08

Abstract: The present invention relates to piperazine and piperidine derivatives, which are especially useful for treating or preventing neuronal damage, particularly damage associated with neurological diseases. These compounds are also useful for stimulating nerve growth. The invention also provides compositions comprising the compounds of the present invention and methods of utilizing those compositions for treating or preventing neuronal damage or for stimulating nerve growth.