公开(公告)号：PT1339695E

公开(公告)日：2006-08-31

申请号：PT01273519

申请日：2001-11-30

Applicant: ABBOTT LAB

Inventor： CLAIBORNE AKIYO K ,  GWALTNEY STEPHEN L II ,  HASVOLD LISA A ,  LI QUN ,  LI TOMGMEI ,  LIN NAN-HORNG ,  MANTEI ROBERT A ,  ROCKWAY TODD W ,  SHAM HING L ,  SULLIVAN GERARD M ,  TONG YUNSONG ,  WANG GARY T ,  WANG LE ,  WANG XILU

IPC: A61K31/4164 ,  A61K31/4178 ,  A61K31/426 ,  A61K31/4439 ,  A61K31/4709 ,  A61P35/00 ,  A61P43/00 ,  C07D233/54 ,  C07D233/64 ,  C07D277/20 ,  C07D277/30 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D233/00 ,  C07D401/00 ,  C07D405/00 ,  C07D409/00

公开(公告)号：DE60118955D1

公开(公告)日：2006-05-24

申请号：DE60118955

申请日：2001-11-30

Applicant: ABBOTT LAB

Inventor： CLAIBORNE K ,  GWALTNEY L ,  HASVOLD A ,  LI QUN ,  LI TOMGMEI ,  LIN NAN-HORNG ,  MANTEI A ,  ROCKWAY W ,  SHAM L ,  SULLIVAN M ,  TONG YUNSONG ,  WANG T ,  WANG LE ,  WANG XILU ,  WANG WEIBO

IPC: C07D233/64 ,  A61K31/4164 ,  A61K31/4178 ,  A61K31/426 ,  A61K31/4439 ,  A61K31/4709 ,  A61P35/00 ,  A61P43/00 ,  C07D233/54 ,  C07D277/20 ,  C07D277/30 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12

Abstract: Substituted imidazoles and thiazoles having the formula are useful for inhibiting farnesyltransferase. Also disclosed are farnesyltransferase-inhibiting compositions and methods of inhibiting farnesyltransferase in a patient.

公开(公告)号：AT323681T

公开(公告)日：2006-05-15

申请号：AT01273519

申请日：2001-11-30

Applicant: ABBOTT LAB

Inventor： CLAIBORNE AKIYO K ,  GWALTNEY STEPHEN L II ,  HASVOLD LISA A ,  LI QUN ,  LI TOMGMEI ,  LIN NAN-HORNG ,  MANTEI ROBERT A ,  ROCKWAY TODD W ,  SHAM HING L ,  SULLIVAN GERARD M ,  TONG YUNSONG ,  WANG GARY T ,  WANG LE ,  WANG XILU ,  WANG WEIBO

IPC: A61K31/4164 ,  A61K31/4178 ,  A61K31/426 ,  A61K31/4439 ,  A61K31/4709 ,  A61P35/00 ,  A61P43/00 ,  C07D233/54 ,  C07D233/64 ,  C07D277/20 ,  C07D277/30 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12

Abstract: Substituted imidazoles and thiazoles having the formula are useful for inhibiting farnesyltransferase. Also disclosed are farnesyltransferase-inhibiting compositions and methods of inhibiting farnesyltransferase in a patient.

公开(公告)号：DK1200412T3

公开(公告)日：2004-03-22

申请号：DK00950584

申请日：2000-07-21

Applicant: ABBOTT LAB

Inventor： WANG LE ,  LI QUN ,  WOODS KEITH W ,  SHAM HING L

IPC: C07D233/64 ,  A61K31/4164 ,  A61P35/00 ,  A61P43/00 ,  C07D233/54 ,  C07D233/00

公开(公告)号：CA2494848A1

公开(公告)日：2004-02-19

申请号：CA2494848

申请日：2003-08-05

Applicant: ABBOTT LAB

Inventor： LIN NAN-HORNG ,  LI QUN ,  LI TONGMEI ,  MANTEI ROBERT A ,  LI GOAQUAN ,  SHAM HING L ,  WANG GARY T

IPC: A61P35/00 ,  C07D241/20 ,  C07D241/46 ,  C07D401/12 ,  C07D407/12 ,  A61K31/4965 ,  A61K31/497

Abstract: Compounds having the formula are useful for inhibiting protein kinases. Also disclosed are methods of making thecompounds, compositions containing the compounds, and methods of treatment using the compounds.

公开(公告)号：AT254110T

公开(公告)日：2003-11-15

申请号：AT00950584

申请日：2000-07-21

Applicant: ABBOTT LAB

Inventor： WANG LE ,  LI QUN ,  SHAM HING L ,  WOODS KEITH W

IPC: C07D233/64 ,  A61K31/4164 ,  A61P35/00 ,  A61P43/00 ,  C07D233/54

公开(公告)号：PE06872002A1

公开(公告)日：2002-08-03

申请号：PE0011982001

申请日：2001-11-29

Applicant: ABBOTT LAB

Inventor： CLAIBORNE AKIYO K ,  GWALTNEY II STEPHEN L ,  LI QUN ,  LIN NAN-HORNG ,  ROCKWAY TODD W ,  SULLIVAN GERARD M ,  WANG GARY T ,  WANG XILU ,  WANG WEIBO ,  WANG LE ,  TONG YUNSONG ,  SHAM HING L ,  MANTEI ROBERT A ,  LI TONGMEI ,  HASVOLD LISA A

IPC: A61K31/4164 ,  A61K31/4178 ,  A61K31/426 ,  A61K31/4439 ,  A61K31/4709 ,  A61P35/00 ,  A61P43/00 ,  C07D233/54 ,  C07D233/64 ,  C07D277/20 ,  C07D277/30 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D401/01

CPC classification number: C07D233/64 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12

Abstract: SE REFIERE A IMIDAZOLES Y TIAZOLES DE FORMULA I DONDE E ES UN ANILLO CARBOCICLICO AROMATICO O NO AROMATICO DE CINCO, SEIS O SIETE MIEMBROS DONDE ENTRE 0-3 ATOMOS DE CARBONO ESTAN REEMPLAZADOS POR NITROGENO; F Y G SON C Y N CON LA SALVEDAD DE QUE CUANDO UNO DE F Y G ES N EL OTRO ES C; L1 Y L2 SON ALQUENILENO, ALQUINILENO, O, NR9, C(O), S, ENTRE OTROS; X ES S, NR7; R1 ES ARILO, ARILALQUILO, HETEROCICLO, (HETEROCICLO)ALQUILO; R2 ES H, ALCOXI, ALQUILO, AMINO, AMINOALQUILO, CIANO, CIANOALQUILO, ENTRE OTROS; R3 ES ARILO, HETEROCICLO Y CICLOALQUILO; R4-R6 SON H, NR9C(O), C(N)NR9, ALCANOILO, ALQUENILO, ENTRE OTROS; R7 ES H, ALQUILO, ARILO, CICLOALQUILO, ENTRE OTROS; R9 ES H, ALCOXIALQUILO, ALQUILO, AMIDOALQUILO, ENTRE OTROS; R12 ES H, ALCOXI, ALQUILO, ENTRE OTROS; m, n, p, q SON 0-4. SON COMPUESTOS PREFERIDOS 4-(((6-CLORO-2-(3-CLOROFENIL)-3-PIRIDINIL)METOXI)(1-METIL-1H-IMIDAZOL-5-IL)METIL)BENZONITRILO, 4-(((2-(3-CLOROFENIL)-6-METIL-3-PIRIDINIL)METOXI)(1-METIL-1H-IMIDAZOL-5-IL)METIL)BENZONITRILO, ENTRE OTROS. LOS COMPUESTOS MENCIONADOS SON INHIBIDORES DE LA FARNESIL TRANSFERASA Y SON UTILES PARA EL TRATAMIENTO DE TUMORES

公开(公告)号：CZ290252B6

公开(公告)日：2002-06-12

申请号：CZ288199

申请日：1998-02-06

Applicant: ABBOTT LAB

Inventor： WANG WEI-BO ,  KERDESKY FRANCIS A J ,  HSIAO CHI-NUNG W ,  LI QUN ,  CHU DANIEL T

IPC: C07D455/02

Abstract: In the present invention there is disclosed a process for preparing carboxylic acid of the general formula II, in which the substituents Re1 through Re5 have specific meaning, by reacting enamine with acid chloride and further by reacting the resulting intermediate with malonamic acid ester in the presence of a base. Subsequently the obtained compound is protected on the hydroxy position by treatment thereof for example with methyl chloride. The resulting compound then reacts with an alkali metal base and subsequently with 3-alkoxyacryloyl compound and the formed intermediates is reacted with a catalytic amount of acid in order to close a ring and finally the resulting acid is reacted with a halogenating agent.

公开(公告)号：CA2407093A1

公开(公告)日：2001-11-01

申请号：CA2407093

申请日：2001-04-25

Applicant: ABBOTT LAB

Inventor： GWALTNEY STEPHEN L II ,  SULLIVAN GERALD M ,  WANG GARY T ,  FAKHOURY STEPHEN A ,  HUTCHINS CHARLES W ,  LI QUN ,  SHAM HING L ,  HASVOLD LISA A ,  WANG XILU ,  LIN NAN-HORNG ,  CURTIN MICHAEL L ,  WANG WEI-BO ,  O'CONNOR STEPHEN J ,  JENNINGS NELSON LISSA TAKA

IPC: C07D233/22 ,  A61K31/381 ,  A61K31/415 ,  A61K31/4164 ,  A61K31/4178 ,  A61K31/4245 ,  A61K31/426 ,  A61K31/4406 ,  A61K31/4412 ,  A61K31/443 ,  A61K31/4436 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/4709 ,  A61K31/496 ,  A61P17/06 ,  A61P27/02 ,  A61P27/06 ,  A61P29/00 ,  A61P35/00 ,  A61P35/02 ,  A61P37/06 ,  A61P43/00 ,  C07D213/30 ,  C07D213/36 ,  C07D213/38 ,  C07D213/40 ,  C07D213/42 ,  C07D213/57 ,  C07D213/61 ,  C07D213/64 ,  C07D213/80 ,  C07D213/82 ,  C07D213/84 ,  C07D213/85 ,  C07D231/12 ,  C07D233/26 ,  C07D233/54 ,  C07D249/04 ,  C07D249/08 ,  C07D277/20 ,  C07D277/24 ,  C07D277/28 ,  C07D277/30 ,  C07D333/16 ,  C07D333/24 ,  C07D401/06 ,  C07D401/10 ,  C07D401/12 ,  C07D401/14 ,  C07D405/10 ,  C07D405/12 ,  C07D409/10 ,  C07D413/10 ,  C07D413/12 ,  C07D417/06 ,  C07D417/10 ,  C07D417/12 ,  A61K31/33 ,  C07D213/74 ,  C07D409/12

Abstract: Compounds of formula (I) or pharmaceutically acceptable salts thereof, inhib it farnesyltransferase. Methods for making the compounds, pharmaceutical compositions containing the compounds, and methods of treatment using the compounds are disclosed.

公开(公告)号：CA2378942A1

公开(公告)日：2001-02-08

申请号：CA2378942

申请日：2000-07-21

Applicant: ABBOTT LAB

Inventor： SHAM HING L ,  LI QUN ,  WANG LE ,  WOODS KEITH W

IPC: C07D233/64 ,  A61K31/4164 ,  A61P35/00 ,  A61P43/00 ,  C07D233/54

Abstract: Compounds of formula (I) or a pharmaceutically acceptable salt or prodrug thereof, wherein R1 is selected from the group consisting of hydrogen, methy l, ethyl, propyl, and isolpropyl; and one of R2 or R3 is 3,4,5-trimethoyxphenyl , and the other is phenyl substituted with one, two, or three substitutents independently selected from the group consisting of alkoxy, halo, and -NR4R5 , wherein R4 and R5 are independently selected from the group consisting of hydrogen and alkyl, inhibit celluar proliferation. Processes for the preparation of the compounds, pharmaceutical compositions containing the compounds, and methods of treatment using the compounds are disclosed.