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公开(公告)号：CA2768700C
公开(公告)日：2014-04-29
申请号：CA2768700
申请日：2005-03-11
Applicant: VERTEX PHARMA
Inventor： TANOURY GERALD J , CHEN MINZHANG , JONES ANDREW D , NYCE PHILIP L , TRUDEAU MARTIN , GUERIN DAVID J , SNOONIAN JOHN R
IPC: C07D405/12 , C07B43/04 , C07B57/00 , C07K5/062
Abstract: The invention relates to processes such as that shown in the scheme and compounds useful for producing modified aspartic acid derivatives, such as aspartic acid aldehyde moieties. Aspartic acid derivatives are useful for preparing caspase inhibitors and/or prodrugs thereof.
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公开(公告)号：CA2557645C
公开(公告)日：2013-09-24
申请号：CA2557645
申请日：2005-02-28
Applicant: VERTEX PHARMA
Inventor： CHARRIER JEAN-DAMIEN , DURRANT STEVEN , MORTIMORE MICHAEL , O'DONNELL MICHAEL , RUTHERFORD ALISTAIR , RAMAYA SHARN , STUDLEY JOHN R , TRUDEAU MARTIN , LOOKER ADAM
IPC: C07D405/12 , A01N1/02 , A61K38/04 , A61K38/06 , C07D207/16 , C07D209/52 , C07D401/12 , C07D401/14 , C07D417/06 , C07D417/12 , C07K5/02 , C07K5/04 , C07K5/062 , C07K5/083
Abstract: The present invention provides a compound of formula (I): wherein the variables are as defined herein. The present invention also provides processes for preparing the compounds of formula (I), and intermediates thereof, pharmaceutical compositions comprising those compounds, and methods of using the compounds and compositions.
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公开(公告)号：AU2013201426A1
公开(公告)日：2013-04-04
申请号：AU2013201426
申请日：2013-03-12
Applicant: VERTEX PHARMA
Inventor： HURTER PATRICIA , ROWE WILLIAM , YOUNG CHRISTOPHER R , COSTACHE ADRIANA , CONNELLY PATRICK , KRAWIEC MARIUSZ , GONG YUCHUAN , TRUDEAU MARTIN , FENG YUSHI
IPC: A61K31/445
Abstract: The present invention relates to solid state forms of N-[2,4-bis(1 ,1-dimethylethyl)-5 hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide (Compound 1), pharmaceutical compositions thereof and methods therewith.
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公开(公告)号：HK1165803A1
公开(公告)日：2012-10-12
申请号：HK12106626
申请日：2012-07-06
Applicant: VERTEX PHARMA
Inventor： DEMATTEI JOHN , LOOKER ADAM R , NEUBERT-LANGILLE BOBBIANNA , TRUDEAU MARTIN , ROEPER STEFANIE , RYAN MICHAEL P , YAP DAHRIKA MILFRED LAO , KRUEGER BRIAN R , GROOTENHUIS PETER D J , VAN GOOR FREDERICK F , BOTFIELD MARTYN C , ZLOKARNIK GREGOR
IPC: C07D20060101
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公开(公告)号：HK1163672A1
公开(公告)日：2012-09-14
申请号：HK12104069
申请日：2012-04-25
Applicant: VERTEX PHARMA
Inventor： TANOURY GERALD J , CHEN MINZHANG , JONES ANDREW D , NYCE PHILIP L , TRUDEAU MARTIN , GUERIN DAVID J , SNOONIAN JOHN R
IPC: C07D20060101 , C07B43/04 , C07B57/00 , C07D405/12
Abstract: The invention relates to a process of producing a compound of comprising purifying a mixture of wherein R 8 is a protecting group, and purifying includes chromatographing, selectively crystallizing, or dynamically crystallizing the mixture.
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Patent Agency Ranking
公开(公告)号：PL211562B1
公开(公告)日：2012-05-31
申请号：PL35091100
申请日：2000-03-17
Applicant: VERTEX PHARMA
Inventor： STAMOS DEAN , TRUDEAU MARTIN , BETHIEL SCOTT , BADIA MICHAEL , SAUNDERS JEFFREY
IPC: C07D263/32 , C07D307/20 , A61K31/27 , A61K31/275 , A61K31/277 , A61K31/341 , A61K31/421 , A61K31/422 , A61K31/454 , A61K31/5377 , A61K31/541 , A61K45/00 , A61P1/18 , A61P9/10 , A61P11/06 , A61P19/02 , A61P29/00 , A61P31/12 , A61P35/00 , A61P37/00 , A61P37/02 , A61P43/00 , C07C275/34 , C07C275/40 , C07C275/42 , C07D413/12 , C07D417/12 , C07F9/653
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公开(公告)号：AT443052T
公开(公告)日：2009-10-15
申请号：AT05008137
申请日：2001-12-12
Applicant: VERTEX PHARMA
Inventor： GRILLOT ANNE-LAURE , CHARIFSON PAUL , STAMOS DEAN , LIAO YUSHENG , TRUDEAU MARTIN
IPC: C07D235/30 , C07D235/32 , A61K31/00 , A61K31/4184 , A61K31/423 , A61K31/4245 , A61K31/437 , A61K31/4412 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K45/06 , A61P31/00 , A61P31/04 , A61P43/00 , C07D213/00 , C07D221/00 , C07D235/00 , C07D263/58 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D413/04 , C07D471/04 , C07D471/14 , C07D491/04 , C07D491/056 , C07D498/04 , C07D521/00 , C07F9/6558 , C07F9/6561
Abstract: The present invention relates to compounds of the formula I or a pharmaceutically acceptable derivative thereof. The compounds are useful as inhibitors of bacterial gyrase activity. The present invention also relates to methods for treating bacterial infections in mammals. The present invention also relates to methods for decreasing bacterial quantity in a biological sample.
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公开(公告)号：AU2006201397B2
公开(公告)日：2009-10-01
申请号：AU2006201397
申请日：2006-04-04
Applicant: VERTEX PHARMA
Inventor： GRILLOT ANNE-LAURE , BADIA MICHAEL , TRUDEAU MARTIN , STAMOS DEAN , CHARIFSON PAUL , LIAO YUSHENG
IPC: C07D235/30 , C07D235/32 , A61K31/00 , A61K31/4184 , A61K31/423 , A61K31/4245 , A61K31/437 , A61K31/4412 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K45/06 , A61P31/00 , A61P31/04 , A61P43/00 , C07D213/00 , C07D221/00 , C07D235/00 , C07D263/58 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D413/04 , C07D471/04 , C07D471/14 , C07D491/04 , C07D491/056 , C07D498/04 , C07D521/00 , C07F9/6558 , C07F9/6561
Abstract: The present invention relates to compounds of the formula I or a pharmaceutically acceptable derivative thereof. The compounds are useful as inhibitors of bacterial gyrase activity. The present invention also relates to methods for treating bacterial infections in mammals. The present invention also relates to methods for decreasing bacterial quantity in a biological sample.
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公开(公告)号：DE60131015T2
公开(公告)日：2008-07-10
申请号：DE60131015
申请日：2001-12-12
Applicant: VERTEX PHARMA
Inventor： GRILLOT ANNE-LAURE , CHARIFSON PAUL , STAMOS DEAN , LIAO YUSHENG , BADIA MICHAEL , TRUDEAU MARTIN
IPC: C07D235/30 , C07D235/32 , A61K31/00 , A61K31/4184 , A61K31/423 , A61K31/4245 , A61K31/437 , A61K31/4412 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K45/06 , A61P31/00 , A61P31/04 , A61P43/00 , C07D213/00 , C07D221/00 , C07D235/00 , C07D263/58 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D413/04 , C07D471/04 , C07D471/14 , C07D491/04 , C07D491/056 , C07D498/04 , C07D521/00 , C07F9/6558 , C07F9/6561
Abstract: The present invention relates to compounds of the formula I or a pharmaceutically acceptable derivative thereof. The compounds are useful as inhibitors of bacterial gyrase activity. The present invention also relates to methods for treating bacterial infections in mammals. The present invention also relates to methods for decreasing bacterial quantity in a biological sample.
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公开(公告)号：NZ526241A
公开(公告)日：2007-01-26
申请号：NZ52624101
申请日：2001-12-12
Applicant: VERTEX PHARMA
Inventor： GRILLOT ANN-LAURE , CHARIFSON PAUL , STAMOS DEAN , LIAO YUSHENG , BADIA MICHAEL , TRUDEAU MARTIN
IPC: C07D235/32 , A61K31/00 , A61K31/4184 , A61K31/423 , A61K31/4245 , A61K31/437 , A61K31/4412 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K45/06 , A61P31/00 , A61P31/04 , A61P43/00 , C07D213/00 , C07D221/00 , C07D235/00 , C07D235/30 , C07D263/58 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D413/04 , C07D471/04 , C07D471/14 , C07D491/04 , C07D491/056 , C07D498/04 , C07D521/00 , C07F9/6558 , C07F9/6561
Abstract: Compounds of the formula I: or a pharmaceutically acceptable derivative or prodrug thereof. The compounds are useful as inhibitors of bacterial gyrase activity. The present invention also relates to methods for treating bacterial infections in mammals. The present invention also relates to methods for decreasing bacterial quantity in a biological sample.
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