公开(公告)号：ZA948309B

公开(公告)日：1995-08-04

申请号：ZA948309

申请日：1994-10-21

Applicant: ABBOTT LAB

Inventor： DELLARIA JOSEPH F ,  BASHA ANWER ,  BLACK LAWRENCE A ,  CHERNESKY LINDA J ,  LEE WENDY

IPC: C07C275/32 ,  C07C317/42 ,  C07C323/41 ,  C07C323/44 ,  C07C335/20 ,  C07D295/215 ,  A01N ,  A61K

Abstract: Compounds of structure where W is selected from the group consisting of where Q is oxygen or sulfur, R7 and R8 are independently selected from hydrogen and alkyl, or R7 and R8, together with the nitrogen atoms to which they are attached, define a radical of formula L1 and L2 are independently selected from a valence bond, alkylene, propenylene, and propynylene; R1, R2, R3, and R4 are independently selected from alkyl, alkoxy, haloalkyl, halogen, cyano, amino, alkoxycarbonyl, and dialkylaminocarbonyl; Y is oxygen, >NR11, where R11 is hydrogen or alkyl, or where n=0, 1, or 2; and R5 and R6 are alkyl, inhibit the biosynthesis of leukotrienes. These compounds are useful in the treatment or amelioration of allergic and inflammatory disease states.

公开(公告)号：ZA9408309B

公开(公告)日：1995-08-04

申请号：ZA9408309

申请日：1994-10-21

Applicant: ABBOTT LAB

Inventor： DELLARIA JOSEPH F ,  BASHA ANWER ,  BLACK LAWRENCE A ,  CHERNESKY LINDA J ,  LEE WENDY

IPC: C07C275/32 ,  C07C317/42 ,  C07C323/41 ,  C07C323/44 ,  C07C335/20 ,  C07D295/215 ,  A01N ,  A61K

CPC classification number: C07D295/215 ,  C07C275/32 ,  C07C317/42 ,  C07C323/41 ,  C07C323/44 ,  C07C335/20 ,  C07C2601/14

公开(公告)号：ZA9408250B

公开(公告)日：1995-08-02

申请号：ZA9408250

申请日：1994-10-20

Applicant: ABBOTT LAB

Inventor： DELLARIA JOSEPH F ,  BLACK LAWRENCE A ,  LEE WENDY ,  BASHA ANWER ,  CHERNESKY LINDA J

IPC: C07D309/10 ,  C07D405/12 ,  A01N ,  A61K

CPC classification number: C07D405/12 ,  C07D309/10

公开(公告)号：CA2655604C

公开(公告)日：2016-08-09

申请号：CA2655604

申请日：2007-06-22

Applicant: ABBOTT LAB

Inventor： LIU HUAQING ,  BLACK LAWRENCE A ,  BENNANI YOUSSEF L ,  COWART MARLON D

IPC: C07D207/06 ,  A61K31/397 ,  A61K31/4025 ,  A61K31/4196 ,  A61K31/4365 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/455 ,  A61K31/501 ,  A61K31/506 ,  A61K31/55 ,  A61P25/00 ,  C07D401/10 ,  C07D403/10 ,  C07D417/10 ,  C07D495/04

Abstract: Compounds of formula (I) are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising the histamine-3 receptor ligands, methods for using such compounds and compositions, and a process for preparing compounds within the scope of formula (I).

公开(公告)号：CA2566896C

公开(公告)日：2012-10-30

申请号：CA2566896

申请日：2005-04-29

Applicant: ABBOTT LAB

Inventor： ALTENBACH ROBERT J ,  BLACK LAWRENCE A ,  CHANG SOU-JEN ,  COWART MARLON D ,  FAGHIH RAMIN ,  GFESSER GREGORY A ,  KU YI-YIN ,  LIU HUAQING ,  LUKIN KIRILL A ,  NERSESIAN DIANA L ,  PU YU-MING ,  CURTIS MICHAEL P

IPC: C07D417/14 ,  A61K31/4709 ,  A61P25/00 ,  A61P25/28 ,  C07D215/12 ,  C07D401/04 ,  C07D401/08 ,  C07D401/14 ,  C07D409/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04

Abstract: Compounds of formula (I) wherein R1 or R2 is an aromatic or non-aromatic ring directly joined or joined by a linker, as represented by L2and L3, to a heteroaromatic core, and X, X', Y, Y', Z, Z', R1, R2, R3, R3a, R3b, R4, R5, L, L2, and L3 are as defined herein, are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising the histamine-3 receptor ligands, methods for using such compounds and compositions, and a process for preparing compounds within the scope of formula (I).

公开(公告)号：BRPI0712823A2

公开(公告)日：2012-07-24

申请号：BRPI0712823

申请日：2007-06-22

Applicant: ABBOTT LAB

Inventor： LIU HUAQING ,  BLACK LAWRENCE A ,  BENNANI YOUSSEF L ,  COWART MARLON D

IPC: C07D207/06 ,  A61K31/397 ,  A61K31/4025 ,  A61K31/4196 ,  A61K31/4365 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/455 ,  A61K31/501 ,  A61K31/506 ,  A61K31/55 ,  A61P25/00 ,  C07D401/10 ,  C07D403/10 ,  C07D417/10 ,  C07D495/04

Abstract: Compounds of formula (I) are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising the histamine-3 receptor ligands, methods for using such compounds and compositions, and a process for preparing compounds within the scope of formula (I).

公开(公告)号：CA2440238C

公开(公告)日：2011-09-13

申请号：CA2440238

申请日：2002-03-11

Applicant: ABBOTT LAB

Inventor： COWART MARLON D ,  BENNANI YOUSSEF L ,  FAGHIH RAMIN ,  GFESSER GREGORY A ,  BLACK LAWRENCE A

IPC: C07D307/79 ,  A61K31/343 ,  A61K31/4025 ,  A61K31/4245 ,  A61K31/427 ,  A61K31/437 ,  A61K31/4427 ,  A61K31/4439 ,  A61K31/5377 ,  A61K31/55 ,  A61P1/00 ,  A61P1/08 ,  A61P3/04 ,  A61P7/08 ,  A61P9/00 ,  A61P9/10 ,  A61P11/02 ,  A61P11/06 ,  A61P25/00 ,  A61P25/04 ,  A61P25/06 ,  A61P25/08 ,  A61P25/14 ,  A61P25/16 ,  A61P25/18 ,  A61P25/20 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  A61P25/30 ,  A61P29/00 ,  A61P31/04 ,  A61P35/00 ,  A61P43/00 ,  C07D307/81 ,  C07D311/18 ,  C07D333/54 ,  C07D405/04 ,  C07D405/06 ,  C07D405/14 ,  C07D407/04 ,  C07D409/04 ,  C07D409/10 ,  C07D409/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14 ,  C07D471/04 ,  C07D491/08 ,  C07D491/10 ,  C07D521/00

Abstract: Compounds of formula (I), or a pharmaceutically acceptable salt, ester, amide, or prodrug thereof, which are useful for the modulation of the histamine-3 receptors in mammals and which are useful for the treatment of disorders ameliorated by histamine-3 receptor ligands.

公开(公告)号：BRPI0708258A2

公开(公告)日：2011-05-24

申请号：BRPI0708258

申请日：2007-02-16

Applicant: ABBOTT LAB

Inventor： COWART MARLON D ,  ZHAO CHEN ,  SUN MINGHUA ,  BLACK LAWRENCE A ,  ZHENG GUO ZHU ,  GREGG ROBERT J ,  ZHANG GEOFF G ,  SHEIKH AHMAD Y ,  LOU XIAOCHUN ,  HENRY RODGER F ,  BARNES DAVID M ,  KOLACZKOWSKI LAWRENCE ,  HAIGHT ANTHONY R ,  CHANG SOU-JEN ,  WITTENBERGER STEVEN J ,  FICKES MICHAEL G

IPC: C07D487/04 ,  A61K31/407

Abstract: Octahydro-pyrrolo[3,4-b]pyrrole derivatives are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Octahydro-pyrrolo[3,4-b]pyrrole compounds, methods for using such compounds, compositions for making them, and processes for preparing such compounds are disclosed herein.

公开(公告)号：ZA201004689B

公开(公告)日：2011-03-30

申请号：ZA201004689

申请日：2010-07-02

Applicant: ABBOTT LAB

Inventor： HSIEH GIN C ,  ALTENBACH ROBERT J ,  WAKEFIELD BRIAN D ,  LIU HUAQING ,  GFESSER GREGORY A ,  BLACK LAWRENCE A ,  ZHAO CHEN ,  COWART MARLON D

公开(公告)号：MX2010006893A

公开(公告)日：2010-10-05

申请号：MX2010006893

申请日：2008-12-18

Applicant: ABBOTT LAB

Inventor： ALTENBACH ROBERT J ,  BLACK LAWRENCE A ,  COWART MARLON D ,  GFESSER GREGORY A ,  ZHAO CHEN ,  WAKEFIELD BRIAN D ,  LIU HUAQINQ ,  HSIEH GIN C

IPC: C07D413/04 ,  A61K31/423 ,  A61K31/428 ,  A61P3/10 ,  A61P25/00 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14

Abstract: Se describen compuestos de la fórmula (I) que son útiles para tratar condiciones o trastornos evitados mediante o mejorados mediante ligandos del receptor histamina-3. También se describen composiciones farmacéuticas de los compuestos de la fórmula (I), métodos para utilizar dichos compuestos y composiciones, y un procedimiento para preparar los compuestos.