公开(公告)号：NZ561729A

公开(公告)日：2010-12-24

申请号：NZ56172906

申请日：2006-04-11

Applicant: ABBOTT LAB

Inventor： ZHU GUIDONG ,  GONG JIANCHUN ,  GANDHI VIRAJKUMAR B ,  PENNING THOMAS D ,  GIRANDA VINCENT

IPC: C07D401/04 ,  A61K31/4184 ,  A61K31/454 ,  A61K31/55 ,  A61P9/10 ,  C07D403/04

Abstract: Disclosed is a benzimidazole carboxamide derivative of formula (I), or a salt thereof, wherein A is a nonaromatic ring comprising 1 or 2 nitrogen atoms, as described in the specification, and where the rest of the substituents are also described in the specification. Also disclosed is the use of the above compounds as poly(ADP-ribose)polymerase (PARP) inhibitors, and for treating inflammation, sepsis, and septic shock.

公开(公告)号：DOP2010000113A

公开(公告)日：2010-07-31

申请号：DO2010000113

申请日：2010-04-16

Applicant: ABBOTT LAB

Inventor： GIRANDA VINCENT L ,  GONG JIANCHUN ,  PENNING THOMAS D ,  BORCHARDT THOMAS B

IPC: C07D231/56

Abstract: Forma cristalina 2 de N-[4-(3-amino-1 H-indazol-4-il)fenil]-N'-(2-fluoro-5metilfenil)urea,1/4 maneras para elaborarla, formulaciones que comprenden a la misma y elaboradas con la misma y metodos de tratamiento de pacientes que padecen una enfermedad para usarla.

公开(公告)号：ZA200904501B

公开(公告)日：2010-05-26

申请号：ZA200904501

申请日：2009-06-26

Applicant: ABBOTT LAB

Inventor： ZHU GUIDONG ,  GONG JIANCHUN ,  GANDHI VIRAJKUMAR B ,  PENNING THOMAS D ,  GIRANDA VINCENT

IPC: A61K20100101 ,  A61P20100101 ,  C07D20100101

Abstract: Compounds of Formula (I) (I) inhibit the PARP enzyme and are useful for treating a disease or a disorder associated with PARP. Also disclosed are pharmaceutical compositions comprising compounds of Formula (I), methods of treatment comprising compounds of Formula (I), and methods of inhibiting the PARP enzyme comprising compounds of Formula (I).

公开(公告)号：CA2407043C

公开(公告)日：2010-02-16

申请号：CA2407043

申请日：2001-04-25

Applicant: ABBOTT LAB

Inventor： BRUNCKO MILAN ,  DALTON CHRISTOPHER R ,  GIRANDA VINCENT L ,  GONG JIANCHUN ,  MCCLELLAN WILLIAM J ,  NIENABER VICKI L ,  ROCKWAY TODD W ,  SAUER DARYL R ,  WEITZBERG MOSHE

IPC: C07D217/02 ,  A61K31/472 ,  A61K31/4725 ,  A61P9/00 ,  A61P15/16 ,  A61P15/18 ,  A61P19/02 ,  A61P27/02 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  C07D217/04 ,  C07D217/06 ,  C07D217/26 ,  C07D401/06 ,  C07D405/04 ,  C07D405/10

Abstract: Compounds having formula (I) are inhibitors of urokinase and are useful in the treatment of diseases in which urokinase plays a role. Also disclosed are urokinase-inhibiting compositions, methods for the preparation of urokinase-inhibitors, and a method of inhibiting urokinase in a mammal.

公开(公告)号：CA2641776A1

公开(公告)日：2007-08-23

申请号：CA2641776

申请日：2007-02-15

Applicant: ABBOTT LAB

Inventor： PENNING THOMAS D ,  GONG JIANCHUN ,  GIRANDA VINCENT L ,  GANDHI VIRAJKUMAR B ,  ZHU GUI-DONG

IPC: C07D471/04 ,  A61K31/438 ,  A61P35/00 ,  C07D491/04 ,  C07D495/04

Abstract: Compounds of Formula (I) inhibit the PARP enzyme and are useful for treating a disease or a disorder associated with PARP. Also disclosed are pharmaceutical compositions comprising compounds of Formula (I), methods of treatment comprising compounds of Formula (I), and methods of inhibiting the PARP enzyme comprising compounds of Formula (I).

公开(公告)号：DE60117783T2

公开(公告)日：2006-11-30

申请号：DE60117783

申请日：2001-04-25

Applicant: ABBOTT LAB

Inventor： BRUNCKO MILAN ,  DALTON R ,  GIRANDA L ,  GONG JIANCHUN ,  MCCLELLAN J ,  NIENABER L ,  ROCKWAY W ,  SAUER R ,  WEITZBERG MOSHE

IPC: C07D217/02 ,  A61K31/472 ,  A61K31/4725 ,  A61P9/00 ,  A61P15/16 ,  A61P15/18 ,  A61P19/02 ,  A61P27/02 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  C07D217/04 ,  C07D217/06 ,  C07D217/26 ,  C07D401/06 ,  C07D405/04 ,  C07D405/10

公开(公告)号：AU2002353147A8

公开(公告)日：2003-06-30

申请号：AU2002353147

申请日：2002-12-12

Applicant: ABBOTT LAB

Inventor： HUTCHINS CHARLES ,  SONG XIAOHONG ,  LI QUN ,  LI TONGMEI ,  ROSENBERG SAUL H ,  STOLL VINCENT S ,  PACKARD GARRICK ,  GIRANDA VINCENT L ,  GONG JIANCHUN ,  DIEBOLD ROBERT ,  WOODS KEITH W ,  FISCHER JOHN P ,  THOMAS SHEELA A ,  ZHU GUI-DONG ,  ABRAMS JASON N ,  DINGES JURGEN ,  GANDHI VIRAJ

IPC: C07D239/48 ,  A61K31/416 ,  A61K31/4365 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/455 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/496 ,  A61K31/497 ,  A61K31/502 ,  A61K31/505 ,  A61K31/506 ,  A61K31/517 ,  A61K31/519 ,  A61K31/52 ,  A61K31/5377 ,  A61P35/00 ,  A61P43/00 ,  C07D213/63 ,  C07D213/65 ,  C07D213/75 ,  C07D213/82 ,  C07D231/56 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D473/34 ,  C07D475/02 ,  C07D495/04 ,  C07D498/04

公开(公告)号：AU2002353147A1

公开(公告)日：2003-06-30

申请号：AU2002353147

申请日：2002-12-12

Applicant: ABBOTT LAB

Inventor： LI QUN ,  WOODS KEITH W ,  ZHU GUI-DONG ,  FISCHER JOHN P ,  GONG JIANCHUN ,  LI TONGMEI ,  GANDHI VIRAJ ,  THOMAS SHEELA A ,  PACKARD GARRICK ,  SONG XIAOHONG ,  ABRAMS JASON N ,  DIEBOLD ROBERT ,  DINGES JURGEN ,  HUTCHINS CHARLES ,  STOLL VINCENT S ,  ROSENBERG SAUL H ,  GIRANDA VINCENT L

IPC: C07D239/48 ,  A61K31/416 ,  A61K31/4365 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/455 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/496 ,  A61K31/497 ,  A61K31/502 ,  A61K31/505 ,  A61K31/506 ,  A61K31/517 ,  A61K31/519 ,  A61K31/52 ,  A61K31/5377 ,  A61P35/00 ,  A61P43/00 ,  C07D213/63 ,  C07D213/65 ,  C07D213/75 ,  C07D213/82 ,  C07D231/56 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D473/34 ,  C07D475/02 ,  C07D495/04 ,  C07D498/04

公开(公告)号：NZ501166A

公开(公告)日：2001-12-21

申请号：NZ50116698

申请日：1998-07-27

Applicant: ABBOTT LAB

Inventor： HOLMS JAMES H ,  STEINMAN DOUGLAS ,  XU LIANGHONG ,  CURTIN MICHAEL L ,  FLORJANCIC ALAN S ,  GONG JIANCHUN ,  HEYMAN H ROBERT ,  MICHAELIDES MICHAEL R ,  WADA CAROL K ,  DAVIDSEN STEVEN K ,  DELLARIA JOSEPH F ,  GIESER JAMIE ,  GUO YAN

IPC: C07D233/74 ,  A61K31/275 ,  A61K31/351 ,  A61K31/352 ,  A61K31/4035 ,  A61K31/4166 ,  A61K31/4178 ,  A61K31/421 ,  A61K31/428 ,  A61K31/4439 ,  A61K31/4465 ,  A61K31/45 ,  A61K31/454 ,  A61K31/50 ,  A61P1/02 ,  A61P1/04 ,  A61P19/02 ,  A61P19/10 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  C07C259/06 ,  C07C311/05 ,  C07C311/18 ,  C07C317/28 ,  C07C317/40 ,  C07C323/47 ,  C07C323/62 ,  C07D207/40 ,  C07D207/404 ,  C07D207/416 ,  C07D209/48 ,  C07D211/88 ,  C07D213/68 ,  C07D233/76 ,  C07D233/78 ,  C07D237/14 ,  C07D263/44 ,  C07D275/04 ,  C07D275/06 ,  C07D309/14 ,  C07D311/18 ,  C07D401/06 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  A61K31/165 ,  A61K31/277 ,  A61K31/425 ,  A61K31/18 ,  A61K31/4015 ,  A61K31/42 ,  A61K31/44

Abstract: A compound of formula (I) or a pharmaceutically acceptable salt or prodrug thereof, wherein: A is H; n is zero; R1 and R3 are independently H or alkyl; R2 and R4 are independently H; alkyl; alkenyl; alkoxyalkyl; alkoxycarbonylalkyl; haloalkyl; hydroxyalkyl; (alkylene)-S(O)p-alkyl; phenyl; phenylalkoxyalkyl; phenylalkyl; phenoxyalkyl; -(alkylene)-N(R5)S02-phenyl; (heterocycle)oxyalkyl; -(alkylene)-S(O)p-heterocycle; -(alkylene)-heterocycle; or -(alkylene)-NR6R7 or R1 and R2, taken together with the carbon atom to which they are attached form a ring selected from spiroalkyl of 3 to 8 carbon atoms and tetrahydropyranyl; or R3 and R4, taken together with the carbon atom to which they are attached, form a spiroalkyl group of 3 to 8 carbon atoms; or R1 and R3 taken together with the carbon atoms to which they are attached are a 5, 6, or 7-membered carbocyclic ring; X is -0-; -NR5S02-; -S(O)p-; or -C(O)-; wherein each group is drawn with its left-hand end being the end which attaches to the alkylene group and its right-hand end being the end which attaches to Ar1; Ar1 is optionally substituted phenyl; Y is a covalent bond, -O-, alkylene, piperidinyl, alkenylene of two carbon atoms, alkynylene of two carbon atoms, -S(0)p- or -C(O)-; and Ar2 is an optionally substituted aryl group selected from the group consisting of phenyl; pyridyl; pyrazinyl; pyridazinyl; furyl; thienyl; isoxazolyl; oxazolyl; thiazolyl and isothiazolyl; All other variables are as defined in the specification. A pharmaceutical composition comprising the compound of formula (I) and a pharmaceutically acceptable carrier is also described. The compound of formula (I) is used for inhibiting matrix metalloproteinases in mammals.

公开(公告)号：BR9810760A

公开(公告)日：2001-11-27

申请号：BR9810760

申请日：1998-07-27

Applicant: ABBOTT LAB

Inventor： CURTIN MICHAEL L ,  DAVIDSEN STEVEN K ,  DELLARIA JOSEPH F ,  FLORJANCIC ALAN S ,  GIESLER JAMIE ,  GONG JIANCHUN ,  GUO YAN ,  HEYMAN H ROBIN ,  HOLMS JAMES H ,  MICHAELIDES MICHAEL R ,  STEINMAN DOUGLAS H ,  WADA CAROL K ,  XU LIANHONG

IPC: C07D233/74 ,  A61K31/275 ,  A61K31/351 ,  A61K31/352 ,  A61K31/4035 ,  A61K31/4166 ,  A61K31/4178 ,  A61K31/421 ,  A61K31/428 ,  A61K31/4439 ,  A61K31/4465 ,  A61K31/45 ,  A61K31/454 ,  A61K31/50 ,  A61P1/02 ,  A61P1/04 ,  A61P19/02 ,  A61P19/10 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  C07C259/06 ,  C07C311/05 ,  C07C311/18 ,  C07C317/28 ,  C07C317/40 ,  C07C323/47 ,  C07C323/62 ,  C07D207/40 ,  C07D207/404 ,  C07D207/416 ,  C07D209/48 ,  C07D211/88 ,  C07D213/68 ,  C07D233/76 ,  C07D233/78 ,  C07D237/14 ,  C07D263/44 ,  C07D275/04 ,  C07D275/06 ,  C07D309/14 ,  C07D311/18 ,  C07D401/06 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07C259/00

Abstract: Compounds having formula (I) are matrix metalloproteinase inhibitors. Also disclosed are matrix metalloproteinase-inhibiting compositions and methods of inhibiting matrix metalloproteinase in a mammal.