公开(公告)号：EA002853B1

公开(公告)日：2002-10-31

申请号：EA200000132

申请日：1998-07-21

Applicant: BASF AG

Inventor： ZEIDER JURGEN ,  NEUMANN JORG ,  LIEPOLD BERND ,  ROSENBERG JOERG ,  BERNDL GUNTHER ,  BREITENBACH JORG ,  VOLLGRAF CHRISTIANE

IPC: A61K9/20 ,  A61K31/192 ,  A61K47/02 ,  A61K47/32 ,  A61P29/00 ,  A61P29/02

Abstract: Настоящееизобретениеотноситсяк быстродействующемуобезболивающемупрепарату, содержащемув качествеобезболивающеговеществаибупрофенв матрицевспомогательныхвеществи имеющемупористуюструктуруи плотностьотболее 1 г/смидо 2,5 г/см. Изобретениетакжеотноситсяк способуполучениятакогопрепарата.

公开(公告)号：DE59804928D1

公开(公告)日：2002-08-29

申请号：DE59804928

申请日：1998-11-30

Applicant: BASF AG

Inventor： KOTHRADE STEPHAN ,  MEFFERT HELMUT ,  BERNDL GUNTHER ,  ERNST ANDREAS ,  SANNER AXEL

IPC: A61K47/32 ,  A23K20/10 ,  A23K40/10 ,  A23K40/20 ,  A23L27/00 ,  A23L33/10 ,  A61K9/16 ,  A61K9/20 ,  A61K9/22 ,  A61K31/277 ,  A61K31/421

Abstract: Solid dosage forms are obtained by mixing at least one polymeric binder, at least one active ingredient, and, where appropriate, conventional additives to form a plastic mixture, and shaping, using as polymeric binder a copolymer of an N-vinyllactam and a copolymerizable monomer having a hydrophobic radical. Dosage forms which show slow release of the active ingredient are obtained in a simple and low-cost manner.

公开(公告)号：DE10026698A1

公开(公告)日：2001-12-06

申请号：DE10026698

申请日：2000-05-30

Applicant: BASF AG

Inventor： BERNDL GUNTHER ,  BREITENBACH JOERG ,  HEGER ROBERT ,  STADLER MICHAEL ,  WILKE PETER ,  ROSENBERG JOERG

IPC: A61F13/53 ,  A23P1/02 ,  A23P1/08 ,  A61F13/49 ,  A61K9/107 ,  A61K9/16 ,  A61K47/00 ,  A61K47/10 ,  A61K47/12 ,  A61K47/14 ,  A61K47/26 ,  A61K47/32 ,  A61K47/34 ,  A61K47/38 ,  A61K9/10

Abstract: The invention relates to self-emulsifying formulations based on an active substance constituent and on a formulation base with a lipid constituent and with a binding agent constituent. The invention also relates to the use of this formulation as a dosed form in the area of life science. The invention also relates to a method for producing self-emulsifying formulations by mixing the formulation constituents while forming a plastic mixture and optionally while preparing the formulations as a dosed form, advantageously while using melt extrusion. The formulations spontaneously form emulsions in water or in aqueous fluids.

公开(公告)号：NO20005769L

公开(公告)日：2000-11-14

申请号：NO20005769

申请日：2000-11-14

Applicant: BASF AG

Inventor： HEGER ROBERT ,  AUWETER HELMUT ,  PFLUEGER PETER ,  BREITENBACH JOERG ,  BINDER RUDOLF ,  ZEIDLER JUERGEN ,  BERNDL GUNTHER

IPC: A61K9/16 ,  A61K9/51 ,  A61K38/00 ,  A61K38/13 ,  A61K47/14 ,  A61K47/36 ,  A61P37/06 ,  A61K9/00

公开(公告)号：CA2369951A1

公开(公告)日：2000-11-02

申请号：CA2369951

申请日：2000-04-11

Applicant: BASF AG

Inventor： SCHROF WOLFGANG ,  VOELKEL RUDIGER ,  ZEIDLER JURGEN ,  BINDER RUDOLF ,  HEGER ROBERT ,  BREITENBACH JORG ,  LIEPOLD BERND ,  BERNDL GUNTHER ,  RIEGER JENS

IPC: A61K47/22 ,  A61K9/16 ,  A61K31/4184 ,  A61K31/4439 ,  A61K45/00 ,  A61K47/34 ,  A61K47/42 ,  A61P1/00 ,  A61P1/04 ,  A61P35/00

Abstract: The invention relates to a solid preparation, containing an acid-sensitive proton-pump blocker as the active substance, whereby said active substance i s present in an x-ray amorphous form and is embedded in molecularly dispersed form in an auxiliary agent matrix.

公开(公告)号：DE19918434A1

公开(公告)日：2000-10-26

申请号：DE19918434

申请日：1999-04-23

Applicant: BASF AG

Inventor： HEGER ROBERT ,  SCHROF WOLFGANG ,  RIEGER JENS ,  VOELKEL RUEDIGER ,  BREITENBACH JOERG ,  ZEIDLER JUERGEN ,  LIEPOLD BERND ,  BERNDL GUNTHER ,  BINDER RUDOLF

IPC: A61K47/22 ,  A61K9/16 ,  A61K31/4184 ,  A61K31/4439 ,  A61K45/00 ,  A61K47/34 ,  A61K47/42 ,  A61P1/00 ,  A61P1/04 ,  A61P35/00 ,  A61K31/415 ,  A61K9/14

Abstract: In a solid preparation (A) containing an acid-labile proton pump blocker (I) as active agent, (I) is in X-ray amorphous form and embedded in an auxiliary matrix. An Independent claim is included for the production of (A).

公开(公告)号：CA2368625A1

公开(公告)日：2000-10-05

申请号：CA2368625

申请日：2000-03-17

Applicant: BASF AG

Inventor： BREITENBACH JORG ,  RUCHATZ FOLKER ,  BERNDL GUNTHER ,  SACK HEINRICH ,  SANNER AXEL

IPC: A61K47/14 ,  A61K9/20 ,  A61K47/32

Abstract: The invention relates to additives in powder form for use in solid pharmaceutical presentation forms. Said aids contain a pharmaceutically acceptable polymer and a liquid or semi-solid surface-active substance with solubilizing action.

公开(公告)号：CA2368138A1

公开(公告)日：2000-10-05

申请号：CA2368138

申请日：2000-03-17

Applicant: BASF AG

Inventor： BERNDL GUNTHER ,  LIEPOLD BERND ,  ROSENBERG JORG ,  BREITENBACH JORG

IPC: A61K47/10 ,  A61K9/16 ,  A61K9/20 ,  A61K47/14 ,  A61K47/34 ,  A61P31/10 ,  A61P35/00 ,  A61P37/06 ,  A61P43/00

Abstract: The invention relates to mechanically stable pharmaceutical presentation for ms for peroral administration which in addition to one or more active ingredien ts and at least one thermoplastically mouldable matrix-forming auxiliary contai n more than 10 and up to 40 % by weight of a surface-active substance which ha s an HLB of between 2 and 18 and is liquid at 20 ~C or has a dropping point at between 20 and 50 ~C.

公开(公告)号：DE19911097A1

公开(公告)日：2000-09-14

申请号：DE19911097

申请日：1999-03-12

Applicant: BASF AG

Inventor： BERNDL GUNTHER ,  REINHOLD ULRICH ,  SIMON DIRK ,  LEHMANN STEPHAN

IPC: A01N25/08 ,  A01N25/10 ,  A61K8/73 ,  A61K8/86 ,  A61K9/20 ,  A61K9/22 ,  A61K31/192 ,  A61K31/565 ,  A61K47/32 ,  A61K47/34 ,  A61K47/36 ,  A61K47/40 ,  A61K47/48 ,  A61Q19/00 ,  C08B37/16 ,  A01N25/34 ,  A23L1/03 ,  A61K7/00 ,  A61K31/715 ,  B01J2/00

Abstract: The invention relates to a method for producing solid dosage forms containing at least one physiologically compatible polymer binding agent, at least one active agent and at least one cyclodextrin as components. According to the method, the components are mixed and plasticised at a temperature below 220 DEG C, without the addition of a solvent. The plastic mixture obtained is shaped into the dosage form. The invention also relates to the dosage forms obtained by said method.

公开(公告)号：BR9810851A

公开(公告)日：2000-07-25

申请号：BR9810851

申请日：1998-07-21

Applicant: BASF AG

Inventor： ZEIDLER JUERGEN ,  NEUMANN JOERG ,  LIEPOLD BERND ,  ROSENBERG JOERG ,  BERNDL GUNTHER ,  BREITENBACH JOERG ,  VOLLGRAF CHRISTIANE

IPC: A61K9/20 ,  A61K31/192 ,  A61K47/02 ,  A61K47/32 ,  A61P29/00 ,  A61K31/19

Abstract: A fast-acting analgesic comprises as analgesic substance ibuprofen in an adjuvant matrix with a porous structure and a density of greater than 1 and up to 2.5 g/cm3.