公开(公告)号：NZ512372A

公开(公告)日：2003-01-31

申请号：NZ51237200

申请日：2000-01-27

Applicant: ABBOTT LAB

Inventor： HOLMES JAMES H ,  MICHAELIDES MICHAEL R ,  STEINMAN DOUGLAS H ,  CURTIN MICHAEL L ,  DAI YUJIA ,  DAVIDSEN STEVEN K ,  HEYMAN HOWARD R

IPC: A61K31/341 ,  A61K31/357 ,  A61K31/40 ,  A61K31/421 ,  A61P1/02 ,  A61P1/04 ,  A61P17/02 ,  A61P19/02 ,  A61P19/10 ,  A61P27/02 ,  A61P29/00 ,  A61P35/00 ,  A61P35/04 ,  A61P43/00 ,  C07D207/09 ,  C07D207/14 ,  C07D207/48 ,  C07D263/04 ,  C07D307/14 ,  C07D317/28

Abstract: Compounds having formula (I) are matric metalloproteinase inhibitors. Also disclosed are matrix metalloproteinase-inhibiting pharmaceutical compositions and uses of the compounds of formula (I) in inhibiting matrix metalloproteinase in a mammal. In formula (I): W1 is -O-, -CH20- or -CH2- wherein each group is drawn with its left-hand end being the end which attaches to the carbon containing R1 and R2, and its right-hand end being the end which attaches to the carbon containing R3 and R4. X is -O- or -N (R7)-, wherein R7 is hydrogen, alkyl, -SO2-alkyl, or alkanoyl. R1 and R2 are independently selected hydrogen, alkyl or hydroxyalkyl. R3 and R4 are independently selected hydrogen or alkyl or R3 and R4 taken together are oxo, or R3 and R4, taken together with the carbon atom to which they are attached, form a cycloalkyl ring. R5 and R6 are independently selected from hydrogen, alkyl, perfluoroalkyl, halo, haloalkyl, alkoxy, hydroxy, hydroxyalkyl, alkoxyalkyl or nitro. Y1 is a covalent bond, -O-, alkylene of two to four carbon atoms, piperidineneyl, alkenylene of two carbon atoms, alkynylene of two carbon atoms, SO2- or -C(O)-. Ar is phenyl, pyridyl, pyrazinyl, pyridazinyl, furyl, thienyl, isoxazolyl, oxazolyl, thiazolyl or isothiazolyl, which can be optionally substituted with one, two, or three substituents.

公开(公告)号：PL349771A1

公开(公告)日：2002-09-09

申请号：PL34977100

申请日：2000-01-27

Applicant: ABBOTT LAB

Inventor： CURTIN MICHAEL L ,  DAI YUJIA ,  DAVIDSEN STEVEN K ,  HEYMAN HOWARD R ,  HOLMES JAMES H ,  MICHAELIDES MICHAEL R ,  STEINMAN DOUGLAS H

IPC: A61K31/341 ,  A61K31/357 ,  A61K31/40 ,  A61K31/421 ,  A61P1/02 ,  A61P1/04 ,  A61P17/02 ,  A61P19/02 ,  A61P19/10 ,  A61P27/02 ,  A61P29/00 ,  A61P35/00 ,  A61P35/04 ,  A61P43/00 ,  C07D207/09 ,  C07D207/14 ,  C07D207/48 ,  C07D263/04 ,  C07D307/14 ,  C07D317/28 ,  A61K31/335

Abstract: Compounds having the formula are matrix metalloproteinase inhibitors. Also disclosed are matrix metalloproteinase-inhibiting compositions and methods of inhibiting matrix metalloproteinase in a mammal.

公开(公告)号：PT734386E

公开(公告)日：2002-07-31

申请号：PT95904287

申请日：1994-12-08

Applicant: ABBOTT LAB

Inventor： CARRERA GEORGE M JR ,  XU LIANHONG ,  SUMMERS JAMES B JR ,  DAVIDSEN STEVEN K ,  CURTIN MICHAEL L ,  HEYMAN ROBIN H ,  SHEPPARD GEROGE S ,  GARLAND ROBERT B

IPC: A61K31/41 ,  A61K31/425 ,  A61K31/435 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/505 ,  A61P7/02 ,  A61P11/00 ,  C07D487/04 ,  A61P11/16 ,  A61P17/00 ,  A61P29/00 ,  A61P37/08 ,  C07D401/12 ,  C07D403/10 ,  C07D403/12 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  A61K31/50

Abstract: The present invention relates to compounds of formula and the pharmaceutically acceptable salts thereof which are potent antagonists of PAF and are useful in the treatment of PAF-related disorders including asthma, shock, respiratory distress syndrome, acute inflammation, transplanted organ rejection, gastrointestinal ulceration, allergic skin diseases, delayed cellular immunity, parturition, fetal lung maturation, and cellular differentiation.

公开(公告)号：DK0734386T3

公开(公告)日：2002-05-27

申请号：DK95904287

申请日：1994-12-08

Applicant: ABBOTT LAB

Inventor： SHEPPARD GEORGE S ,  CARRERA GEORGE M JR ,  SUMMERS JAMES B JR ,  DAVIDSEN STEVEN K ,  CURTIN MICHAEL L ,  HEYMAN H ROBIN ,  XU LIANHONG ,  GARLAND ROBERT B

IPC: C07D487/04 ,  A61K31/41 ,  A61K31/425 ,  A61K31/435 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/505 ,  A61P7/02 ,  A61P11/00 ,  A61P11/16 ,  A61P17/00 ,  A61P29/00 ,  A61P37/08 ,  C07D401/12 ,  C07D403/10 ,  C07D403/12 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  A61K31/50

Abstract: The present invention relates to compounds of formula and the pharmaceutically acceptable salts thereof which are potent antagonists of PAF and are useful in the treatment of PAF-related disorders including asthma, shock, respiratory distress syndrome, acute inflammation, transplanted organ rejection, gastrointestinal ulceration, allergic skin diseases, delayed cellular immunity, parturition, fetal lung maturation, and cellular differentiation.

公开(公告)号：NZ501166A

公开(公告)日：2001-12-21

申请号：NZ50116698

申请日：1998-07-27

Applicant: ABBOTT LAB

Inventor： HOLMS JAMES H ,  STEINMAN DOUGLAS ,  XU LIANGHONG ,  CURTIN MICHAEL L ,  FLORJANCIC ALAN S ,  GONG JIANCHUN ,  HEYMAN H ROBERT ,  MICHAELIDES MICHAEL R ,  WADA CAROL K ,  DAVIDSEN STEVEN K ,  DELLARIA JOSEPH F ,  GIESER JAMIE ,  GUO YAN

IPC: C07D233/74 ,  A61K31/275 ,  A61K31/351 ,  A61K31/352 ,  A61K31/4035 ,  A61K31/4166 ,  A61K31/4178 ,  A61K31/421 ,  A61K31/428 ,  A61K31/4439 ,  A61K31/4465 ,  A61K31/45 ,  A61K31/454 ,  A61K31/50 ,  A61P1/02 ,  A61P1/04 ,  A61P19/02 ,  A61P19/10 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  C07C259/06 ,  C07C311/05 ,  C07C311/18 ,  C07C317/28 ,  C07C317/40 ,  C07C323/47 ,  C07C323/62 ,  C07D207/40 ,  C07D207/404 ,  C07D207/416 ,  C07D209/48 ,  C07D211/88 ,  C07D213/68 ,  C07D233/76 ,  C07D233/78 ,  C07D237/14 ,  C07D263/44 ,  C07D275/04 ,  C07D275/06 ,  C07D309/14 ,  C07D311/18 ,  C07D401/06 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  A61K31/165 ,  A61K31/277 ,  A61K31/425 ,  A61K31/18 ,  A61K31/4015 ,  A61K31/42 ,  A61K31/44

Abstract: A compound of formula (I) or a pharmaceutically acceptable salt or prodrug thereof, wherein: A is H; n is zero; R1 and R3 are independently H or alkyl; R2 and R4 are independently H; alkyl; alkenyl; alkoxyalkyl; alkoxycarbonylalkyl; haloalkyl; hydroxyalkyl; (alkylene)-S(O)p-alkyl; phenyl; phenylalkoxyalkyl; phenylalkyl; phenoxyalkyl; -(alkylene)-N(R5)S02-phenyl; (heterocycle)oxyalkyl; -(alkylene)-S(O)p-heterocycle; -(alkylene)-heterocycle; or -(alkylene)-NR6R7 or R1 and R2, taken together with the carbon atom to which they are attached form a ring selected from spiroalkyl of 3 to 8 carbon atoms and tetrahydropyranyl; or R3 and R4, taken together with the carbon atom to which they are attached, form a spiroalkyl group of 3 to 8 carbon atoms; or R1 and R3 taken together with the carbon atoms to which they are attached are a 5, 6, or 7-membered carbocyclic ring; X is -0-; -NR5S02-; -S(O)p-; or -C(O)-; wherein each group is drawn with its left-hand end being the end which attaches to the alkylene group and its right-hand end being the end which attaches to Ar1; Ar1 is optionally substituted phenyl; Y is a covalent bond, -O-, alkylene, piperidinyl, alkenylene of two carbon atoms, alkynylene of two carbon atoms, -S(0)p- or -C(O)-; and Ar2 is an optionally substituted aryl group selected from the group consisting of phenyl; pyridyl; pyrazinyl; pyridazinyl; furyl; thienyl; isoxazolyl; oxazolyl; thiazolyl and isothiazolyl; All other variables are as defined in the specification. A pharmaceutical composition comprising the compound of formula (I) and a pharmaceutically acceptable carrier is also described. The compound of formula (I) is used for inhibiting matrix metalloproteinases in mammals.

公开(公告)号：UY26684A1

公开(公告)日：2001-11-30

申请号：UY26684

申请日：2001-04-25

Applicant: ABBOTT LAB

Inventor： WANG WEI-BO ,  II STEPHEN L GWALTNEY ,  LI QUIN ,  CONNOR STEPHEN J O ,  WANG GARY T ,  CURTIN MICHAEL L ,  HASVOLD LISA A ,  LIN NAN-HORNG ,  SHAM HING L ,  WANG XILU ,  FAKHOURY STEPHEN A ,  HUTCHINS CHARLES W ,  JENNINGS LISSA TAKA ,  SULLIVAN GERARD M

Abstract: Compuestos de la fórmula (I) o una sal del mismo aceptable para el uso farmacéutico que inhiben la farnesiltransferasa. Métodos para preparar los compuestos, composiciones de uso farmacéutico que contienen los compuestos, y métodos de tratamiento que usan los compuestos.

公开(公告)号：BR9810760A

公开(公告)日：2001-11-27

申请号：BR9810760

申请日：1998-07-27

Applicant: ABBOTT LAB

Inventor： CURTIN MICHAEL L ,  DAVIDSEN STEVEN K ,  DELLARIA JOSEPH F ,  FLORJANCIC ALAN S ,  GIESLER JAMIE ,  GONG JIANCHUN ,  GUO YAN ,  HEYMAN H ROBIN ,  HOLMS JAMES H ,  MICHAELIDES MICHAEL R ,  STEINMAN DOUGLAS H ,  WADA CAROL K ,  XU LIANHONG

IPC: C07D233/74 ,  A61K31/275 ,  A61K31/351 ,  A61K31/352 ,  A61K31/4035 ,  A61K31/4166 ,  A61K31/4178 ,  A61K31/421 ,  A61K31/428 ,  A61K31/4439 ,  A61K31/4465 ,  A61K31/45 ,  A61K31/454 ,  A61K31/50 ,  A61P1/02 ,  A61P1/04 ,  A61P19/02 ,  A61P19/10 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  C07C259/06 ,  C07C311/05 ,  C07C311/18 ,  C07C317/28 ,  C07C317/40 ,  C07C323/47 ,  C07C323/62 ,  C07D207/40 ,  C07D207/404 ,  C07D207/416 ,  C07D209/48 ,  C07D211/88 ,  C07D213/68 ,  C07D233/76 ,  C07D233/78 ,  C07D237/14 ,  C07D263/44 ,  C07D275/04 ,  C07D275/06 ,  C07D309/14 ,  C07D311/18 ,  C07D401/06 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07C259/00

Abstract: Compounds having formula (I) are matrix metalloproteinase inhibitors. Also disclosed are matrix metalloproteinase-inhibiting compositions and methods of inhibiting matrix metalloproteinase in a mammal.

公开(公告)号：NO20013669L

公开(公告)日：2001-09-27

申请号：NO20013669

申请日：2001-07-26

Applicant: ABBOTT LAB

Inventor： CURTIN MICHAEL L ,  DAI YUJIA ,  DAVIDSEN STEVEN K ,  HEYMAN HOWARD R ,  HOLMES JAMES H ,  MICHAELIDES MICHAEL R ,  STEINMAN DOUGLAS H

IPC: A61K31/341 ,  A61K31/357 ,  A61K31/40 ,  A61K31/421 ,  A61P1/02 ,  A61P1/04 ,  A61P17/02 ,  A61P19/02 ,  A61P19/10 ,  A61P27/02 ,  A61P29/00 ,  A61P35/00 ,  A61P35/04 ,  A61P43/00 ,  C07D207/09 ,  C07D207/14 ,  C07D207/48 ,  C07D263/04 ,  C07D307/14 ,  C07D317/28 ,  A61K31/335

Abstract: Compounds having the formula are matrix metalloproteinase inhibitors. Also disclosed are matrix metalloproteinase-inhibiting compositions and methods of inhibiting matrix metalloproteinase in a mammal.

公开(公告)号：NO20013669D0

公开(公告)日：2001-07-26

申请号：NO20013669

申请日：2001-07-26

Applicant: ABBOTT LAB

Inventor： CURTIN MICHAEL L ,  DAI YUJIA ,  DAVIDSEN STEVEN K ,  HEYMAN HOWARD R ,  HOLMES JAMES H ,  MICHAELIDES MICHAEL R ,  STEINMAN DOUGLAS H

IPC: A61K31/341 ,  A61K31/357 ,  A61K31/40 ,  A61K31/421 ,  A61P1/02 ,  A61P1/04 ,  A61P17/02 ,  A61P19/02 ,  A61P19/10 ,  A61P27/02 ,  A61P29/00 ,  A61P35/00 ,  A61P35/04 ,  A61P43/00 ,  C07D207/09 ,  C07D207/14 ,  C07D207/48 ,  C07D263/04 ,  C07D307/14 ,  C07D317/28 ,  C07D

Abstract: Compounds having the formula are matrix metalloproteinase inhibitors. Also disclosed are matrix metalloproteinase-inhibiting compositions and methods of inhibiting matrix metalloproteinase in a mammal.

公开(公告)号：HK1028023A1

公开(公告)日：2001-02-02

申请号：HK00107516

申请日：2000-11-23

Applicant: ABBOTT LAB

Inventor： CURTIN MICHAEL L ,  DAVIDSEN STEVEN K ,  DELLARIA JOSEPH F JR ,  FLORJANCIC ALAN S ,  GIESLER JAMIE ,  GONG JIANCHUN ,  GUO YAN ,  HEYMAN H ROBIN ,  HOLMS JAMES H ,  MICHAELIDES MICHAEL R ,  STEINMAN DOUGLAS H ,  WADA CAROL K ,  XU LIANHONG

IPC: C07D233/74 ,  A61K31/275 ,  A61K31/351 ,  A61K31/352 ,  A61K31/4035 ,  A61K31/4166 ,  A61K31/4178 ,  A61K31/421 ,  A61K31/428 ,  A61K31/4439 ,  A61K31/4465 ,  A61K31/45 ,  A61K31/454 ,  A61K31/50 ,  A61P1/02 ,  A61P1/04 ,  A61P19/02 ,  A61P19/10 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  C07C259/06 ,  C07C311/05 ,  C07C311/18 ,  C07C317/28 ,  C07C317/40 ,  C07C323/47 ,  C07C323/62 ,  C07D207/40 ,  C07D207/404 ,  C07D207/416 ,  C07D209/48 ,  C07D211/88 ,  C07D213/68 ,  C07D233/76 ,  C07D233/78 ,  C07D237/14 ,  C07D263/44 ,  C07D275/04 ,  C07D275/06 ,  C07D309/14 ,  C07D311/18 ,  C07D401/06 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07C

Abstract: Compounds having formula (I) are matrix metalloproteinase inhibitors. Also disclosed are matrix metalloproteinase-inhibiting compositions and methods of inhibiting matrix metalloproteinase in a mammal.