公开(公告)号：AU2018226453A1

公开(公告)日：2018-09-27

申请号：AU2018226453

申请日：2018-09-06

Applicant: VERTEX PHARMA

Inventor： ALARGOVA ROSSITZA GUEORGUIEVA ,  ALCACIO TIM EDWARD ,  JOHNSTON STEVEN C ,  VAN GOOR FREDRICK F ,  KESHAVARZ-SHOKRI ALI ,  LEE ELAINE CHUNGMIN ,  MEDEK ALES ,  SULLIVAN MARK JEFFREY ,  ZAMAN NOREEN TASNEEM ,  ZHANG BEILI ,  ZHANG YUEGANG ,  ZLOKARNIK GREGOR ,  AREKAR SNEHA G ,  KADIYALA IRINA NIKOLAEVNA ,  MUDUNURI PRAVEEN ,  KRAWIEC MARIUSZ

IPC: A61K31/4704 ,  A61K31/404 ,  A61K31/443

Abstract: The present invention relates to pharmaceutical compositions comprising a compound of Formula I in combination with one or both of a Compound of Formula II and/or a Compound of Formula III. The invention also relates to solid forms and to pharmaceutical formulations thereof, and to methods of using such compositions in the treatment of CFTR mediated diseases, particularly cystic fibrosis. o o WR W4 N r O H WRw2 Formula I T \ N Formula II R 0 RN, R8 Ry Formula III

公开(公告)号：CL2016001110A1

公开(公告)日：2017-10-20

申请号：CL2016001110

申请日：2016-05-10

Applicant: VERTEX PHARMA

Inventor： SHI YI ,  LEDEBOER MARK WILLEM ,  NTI-ADDAE KWAME W ,  WALDO MICHAEL ,  O'NEIL SIMON ADAM ,  VAN ALSTEN JOHN GREGG ,  MACIKENAS DAINIUS ,  MUDUNURI PRAVEEN ,  JURKAUSKAS VALDAS ,  MEDEK ALES ,  JONES STEVEN ,  BYRN RANDAL ,  ASMAL MOHAMMED ,  ROBERTSON SARAH MARIE ,  TSAL WANJUNG

IPC: A61K31/506 ,  A61P31/16 ,  C07D403/04 ,  C07D471/04

公开(公告)号：AU2015330923A1

公开(公告)日：2017-05-25

申请号：AU2015330923

申请日：2015-10-07

Applicant: VERTEX PHARMA

Inventor： STROHMEIER MARK ,  CAESAR JR JOHN P ,  CONNELLY PATRICK RAYMOND ,  FAWAZ MAJED ,  LUSS-LUSIS EDUARD ,  MCCLAIN BRIAN R ,  MEDEK ALES ,  MIAO HAI ,  NTI-ADDAE KWAME WIREDU ,  YIN PING ,  ZHANG YUEGANG

IPC: C07D215/56

Abstract: The present disclosure relates to co-crystals comprising N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide (Compound 1) and a co-former and methods for their preparation. The present disclosure further relates to pharmaceutical compositions comprising the co-crystal forms, as well as methods of treatment therewith and kits.

公开(公告)号：CA2932757A1

公开(公告)日：2015-06-11

申请号：CA2932757

申请日：2014-12-05

Applicant: VERTEX PHARMA

Inventor： CHARRIER JEAN-DAMIEN ,  DAVIS CHRISTOPHER JOHN ,  FRAYSSE DAMIEN ,  ETXEBARRIA I JARDI GORKA ,  PEGG SIMON ,  PIERARD FRANCOISE ,  PINDER JOANNE ,  STUDLEY JOHN ,  ZWICKER CARL ,  SANGHVI TAPAN ,  WALDO MICHAEL ,  MEDEK ALES ,  SHAW DAVID MATTHEW ,  PANESAR MANINDER ,  ZHANG YUEGANG ,  ALEM NAZIHA

IPC: C07D487/04 ,  A61K31/519 ,  A61P35/00 ,  C07B59/00

Abstract: The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and solid forms of the compounds of this invention. The compounds of this invention have formula I-A or I-B: wherein the variables are as defined herein.

公开(公告)号：CA2930103A1

公开(公告)日：2015-05-21

申请号：CA2930103

申请日：2014-11-12

Applicant: VERTEX PHARMA

Inventor： NTI-ADDAE KWAME W ,  WALDO MICHAEL ,  O'NEIL SIMON ADAM ,  VAN ALSTEN JOHN GREGG ,  MACIKENAS DAINIUS ,  MUDUNURI PRAVEEN ,  SHI YI ,  LEDEBOER MARK WILLEM ,  JURKAUSKAS VALDAS ,  MEDEK ALES ,  JONES STEVEN ,  BYRN RANDAL ,  ASMAL MOHAMMED ,  ROBERTSON SARAH MARIE ,  TSAI WANJUNG

IPC: C07D403/04 ,  A61K31/506 ,  A61P31/16 ,  C07D471/04

Abstract: Polymorphic forms of Compound (1) or a pharmaceutically acceptable salt thereof, wherein Compound (1) is represented by the following structural formula: are Form A of HCl salt of Compound (1)·1/2?20, Form F of HCl salt of Compound (1)·3?20, Form D of HCl salt of Compound (1), Form A of Compound (1), and Form A of tosylate salt of Compound (1). Such polymorphic forms are employed for treating influenza, inhibiting the replication of influenza viruses, or reducing the amount of influenza viruses in a biological sample or in a subject.

公开(公告)号：UA108087C2

公开(公告)日：2015-03-25

申请号：UAA201206183

申请日：2010-10-21

Applicant: VERTEX PHARMA

Inventor： ZHANG BEILI ,  KRAWIEC MARIUSZ ,  LUISI BRIAN ,  MEDEK ALES

IPC: C07D487/08 ,  A61K31/407 ,  A61P11/00

Abstract: Данийвинахідстосуєтьсяпосутікристалічнихі твердихформ N-(4-(7-азабіцикло[2.2.1]гептан-7-іл)-2-(трифторметил)феніл)-4-оксо-5-(трифторметил)-1,4-дигідрохінолін-3-карбоксаміду (формиА-НСl, формиВ, формиВ-НСl абобудь-якоїкомбінаціїцихформ), їхфармацевтичнихкомпозиційі способівлікуванняз їхзастосуванням.

公开(公告)号：UY34701A

公开(公告)日：2014-10-31

申请号：UY34701

申请日：2013-03-21

Applicant: VERTEX PHARMA

Inventor： MUDUNURI PRAVEEN ,  CHUN JUNG YOUNG ,  KULDIPKUMAR ANUJ K ,  MEDEK ALES ,  ANN FERRIS LORI ,  RICHARD WILLCOX DAVID ,  WALDO MICHAEL ,  ALOYSIUS NUGENT WILLIAM

IPC: C12N15/00

Abstract: La presente solicitud se refiere a formas de estado sólido, por ejemplo, a formas cristalinas de 2?C?metiluridin?5??(O?fenil?N?(S)?1?(isopropoxicarbonil)etil)tiofosforamidato, a composiciones farmacéuticas que pueden incluir una o mas formas sólidas de 2??C?metiluridin?5?(O?fenil?N?(S)?1?(isopropoxicarbonil)etil)tiofosforamidato, y a métodos para tratar o mejorar enfermedades y/o condiciones con una o mas formas sólidas de 2??C?metiluridin?5?(O?fenil?N?(S)?1?(isopropoxicarbonil)etil) tiofosforamidato. En la presente se revelan también métodos para tratar una o mas formas sólidas de 2??C?metiluridin?5??(O?fenil?N?(S)?1?(isopropoxicarbonil)etil) tiofosforamidato en combinación uno o más otros agentes.

公开(公告)号：NZ602557A

公开(公告)日：2014-09-26

申请号：NZ60255711

申请日：2011-03-21

Applicant: VERTEX PHARMA

Inventor： KRAWIEC MARIUSZ ,  AREKAR SNEHA G ,  MUDUNURI PRAVEEN ,  JOHNSTON STEVEN C ,  SULLIVAN MARK JEFFREY ,  MEDEK ALES

IPC: C07D215/56 ,  A61K31/47 ,  A61P11/00

Abstract: The present disclosure relates to solid state forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide (Compound 1, Ivacaftor), pharmaceutical compositions thereof and methods therewith. The compounds are useful in the treatment of CFTR-mediated diseases such as cystic fibrosis.

公开(公告)号：MX2012004791A

公开(公告)日：2013-02-01

申请号：MX2012004791

申请日：2010-10-21

Applicant: VERTEX PHARMA

Inventor： ZHANG BEILI ,  KRAWIEC MARIUSZ ,  LUISI BRIAN ,  MEDEK ALES

IPC: C07D487/08 ,  A61K31/407 ,  A61P11/00

Abstract: La presente invención se relaciona con formas sustancialmente cristalinas y en estado sólido de formas sólidas de N-(4-(7-azabiciclo[2.2.1]heptan-7-il)-2-trifluorometil)fenil)-4-o xo-5-(trifluorometil)-1,4-dihidroquinolin-3-carboxamida (Forma A-HC1, Forma B B-HC1, o cualquier combinación de estas formas), las composiciones farmacéuticamente aceptables de la misma, y los métodos de tratamiento con la misma.

公开(公告)号：AU2011242454A1

公开(公告)日：2012-11-08

申请号：AU2011242454

申请日：2011-04-22

Applicant: VERTEX PHARMA

Inventor： VAN GOOR FREDRICK F ,  ALARGOVA ROSSITZA GUEORGUIEVA ,  ALCACIO TIM EDWARD ,  AREKAR SNEHA G ,  BINCH HAYLEY MARIE ,  BOTFIELD MARTYN CURTIS ,  FANNING LEV TYLER DEWEY ,  GROOTENHUIS PETER DIEDERIK JAN ,  HURLEY DENNIS JAMES ,  JOHNSTON STEVEN C ,  KADIYALA IRINA NIKOLAEVNA ,  KAUSHIK RITU ROHIT ,  KESHAVARZ-SHOKRI ALI ,  KRAWIEC MARIUSZ ,  LEE ELAINE CHUNGMIN ,  LUISI BRIAN ,  MEDEK ALES ,  MUDUNURI PRAVEEN ,  NUMA MEHDI ,  SHETH URVI JAGDISHBHAI ,  SILINA ALINA ,  SULLIVAN MARK JEFFREY ,  VERWIJS MARINUS JACOBUS ,  YANG XIAOQING ,  YOUNG CHRISTOPHER RYAN ,  ZAMAN NOREEN TASNEEM ,  ZHANG BEILI ,  ZHANG YUEGANG ,  ZLOKARNIK GREGOR

IPC: A61K31/4704 ,  A61K31/404 ,  A61K31/443

Abstract: The present invention relates to pharmaceutical compositions comprising a compound of Formulas I and II, optionally in combination with a Compound of Formula III and/or a Compound of Formula IV. The invention also relates to solid forms and to pharmaceutical formulations thereof, and to methods of using such compositions in the treatment of CFTR mediated diseases, particularly cystic fibrosis.