公开(公告)号：US09804092B2

公开(公告)日：2017-10-31

申请号：US14766451

申请日：2014-02-11

Applicant: British Columbia Cancer Agency Branch

Inventor： Haishan Zeng ,  Michael Short ,  Jianhua Zhao

IPC: G01N21/65 ,  G01N21/64 ,  G01J3/44 ,  A61B5/00 ,  G01J3/02

CPC classification number: G01N21/65 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/0086 ,  A61B2560/0285 ,  G01J3/0213 ,  G01J3/0221 ,  G01J3/4406 ,  G01N21/64 ,  G01N21/645 ,  G01N2021/6417 ,  G01N2021/6484 ,  G01N2201/08 ,  G01N2201/0833 ,  G01N2201/084

Abstract: Examples of a spectroscopy probe for performing measurements of Raman spectra, reflectance spectra and fluorescence spectra are disclosed. The integrated spectral probe can comprise one or more light sources to provide a white light illumination to generate reflectance spectra, an excitation light to generate an UV/visible fluorescence spectra and a narrow band NIR excitation to induce Raman spectra. The multiple modalities of spectral measurements can be performed within 2 seconds or less. Examples of methods of operating the integrated spectroscopy probe disclosed.

公开(公告)号：US20170082490A1

公开(公告)日：2017-03-23

申请号：US14863225

申请日：2015-09-23

Applicant: Agilent Technologies, Inc.

Inventor： Charles Hoke ,  Christopher Ryan Moon ,  Andrew Ghetler ,  Yang Han

IPC: G01J3/28 ,  G01J3/02 ,  G01J3/10

CPC classification number: G01J3/2823 ,  G01J3/0213 ,  G01J3/0224 ,  G01J3/108 ,  G01J3/28 ,  G01J3/42

Abstract: An imaging scanner and a method for using the same are disclosed. The scanner includes a variable attenuator adapted to receive a light beam generated by a MIR laser and that generates an attenuated light beam therefrom characterized by an attenuation level. The scanner includes an optical assembly that focuses the attenuated light beam to a point on a specimen. A light detector measures an intensity of light leaving the point on the specimen, the light detector being characterized by a detector dynamic range. A controller forms a plurality of MIR images from the intensity as a function of position on the specimen, each of the plurality of MIR images being formed with a different level of attenuation of the light beam. The controller combines the plurality of MIR images to generate a combined MIR image having a dynamic range greater than the detector dynamic range.

公开(公告)号：US09513165B2

公开(公告)日：2016-12-06

申请号：US14431573

申请日：2013-09-25

Applicant: NATIONAL UNIVERSITY CORPORATION KAGAWA UNIVERSITY

Inventor： Ichiro Ishimaru

IPC: G01J3/26 ,  A61B5/145 ,  A61B5/1455 ,  G01J3/453 ,  G01N21/359 ,  G01N21/47 ,  G01N21/49 ,  G01J3/02 ,  A61B5/00 ,  G01J3/45 ,  G01N21/35 ,  G01J3/12

CPC classification number: G01J3/26 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/7257 ,  A61B2562/0238 ,  F04C2270/0421 ,  G01J3/0205 ,  G01J3/0213 ,  G01J3/45 ,  G01J3/4532 ,  G01J3/4535 ,  G01J2003/1213 ,  G01N21/359 ,  G01N21/4738 ,  G01N21/49 ,  G01N2021/3595

Abstract: A spectroscopic measurement device includes a dark filter that is arranged on an optical path between an imaging optical system and a light detection unit and includes a plurality of regions having different transmittances, the filter being configured such that a fixed reflected measurement light and a movable reflected measurement light that are guided to a same point by the imaging optical system and form interference light are transmitted through a same region; and an arithmetic processing unit that obtains an interferogram of the measurement light at a transmittance corresponding to each of two or more regions from a detection signal of each pixel of a light detection unit when a movable reflection unit is moved, and obtains a spectrum of the measurement light based on the interferogram.

Abstract translation: 光谱测量装置包括配置在成像光学系统和光检测单元之间的光路上的暗滤波器，并且包括具有不同透射率的多个区域，所述滤光器被配置为使得固定的反射测量光和可移动的反射 通过成像光学系统被引导到同一点并形成干涉光的测量光通过相同的区域传输; 以及算术处理单元，当可移动反射单元移动时，从光检测单元的每个像素的检测信号中获得与两个或更多个区域中的每一个相对应的透射率的测量光的干涉图，并获得 基于干涉图的测量光。

公开(公告)号：US09498122B2

公开(公告)日：2016-11-22

申请号：US14308678

申请日：2014-06-18

Applicant: Avedro, Inc.

Inventor： Marc D. Friedman ,  David Muller ,  Amit Paranjape

IPC: A61B3/107 ,  A61B3/14 ,  A61B3/113 ,  A61B3/10 ,  A61B5/00

CPC classification number: A61B3/107 ,  A61B3/10 ,  A61B3/1025 ,  A61B3/113 ,  A61B3/14 ,  A61B5/0075 ,  G01J3/0213 ,  G01J3/0237 ,  G01J3/2823 ,  G01J3/4412

Abstract: A system for determining biomechanical properties of corneal tissue includes a light source configured to provide an incident light and a confocal microscopy system configured to scan the incident light across a plurality of cross-sections of corneal tissue. The incident light is reflected by the corneal tissue as scattered light. The system also includes a filter or attenuating device configured to block or attenuate the Rayleigh peak frequency of the scattered light, a spectrometer configured to receive the scattered light and process frequency characteristics of the received scattered light to determine a Brillouin frequency shift in response to the Rayleigh peak frequency being blocked or attenuated by the filter or attenuating device, and a processor configured to generate a three-dimensional profile of the corneal tissue according to the determined Brillouin frequency shift. The three-dimensional profile provides an indicator of one or more biomechanical properties of the corneal tissue.

Abstract translation: 用于确定角膜组织的生物力学性质的系统包括被配置为提供入射光的光源和被配置为扫描穿过角膜组织的多个横截面的入射光的共焦显微镜系统。 入射光被角膜组织反射为散射光。 该系统还包括被配置为阻挡或衰减散射光的瑞利峰值频率的滤波器或衰减装置，被配置为接收散射光的光谱仪和接收的散射光的处理频率特性，以响应于所述散射光的布里渊频移来确定布里渊频移 瑞利峰值频率被滤波器或衰减装置阻挡或衰减，以及处理器，被配置为根据确定的布里渊频移产生角膜组织的三维轮廓。 三维轮廓提供角膜组织的一种或多种生物力学性质的指标。

公开(公告)号：US20160245695A1

公开(公告)日：2016-08-25

申请号：US15027239

申请日：2014-09-24

Applicant: AMS AG

Inventor： Glenn LEE

IPC: G01J3/02 ,  G01J3/51 ,  G01J3/46

CPC classification number: G01J3/0297 ,  G01J3/0213 ,  G01J3/462 ,  G01J3/465 ,  G01J3/505 ,  G01J3/513

Abstract: A colour sensor arrangement comprises a colour sensor arranged to generate at least a first channel signal being indicative of a colour of light incident on the colour sensor. A processing unit is connected to the colour sensor and arranged to generate a tuple of colour signals by processing the at least first channel signal. A memory is connected to the processing unit and a control unit is connected to the processing unit and to the memory. Furthermore, the control unit is arranged to receive calibration data relating the tuple of colour signals to a calibrated tuple of colour signals and arranged to store said calibration data (M) by means of the memory. An interface is connected to the processing unit and comprises an interface terminal.

Abstract translation: 颜色传感器装置包括颜色传感器，其布置成产生至少第一通道信号，其指示入射在颜色传感器上的光的颜色。 处理单元连接到颜色传感器并且被布置成通过处理至少第一通道信号来产生彩色信号的元组。 存储器连接到处理单元，并且控制单元连接到处理单元和存储器。 此外，控制单元被布置成接收与彩色信号的元组相关联的校准数据到校准的彩色信号元组，并且被布置成通过存储器存储所述校准数据（M）。 接口连接到处理单元并包括接口终端。

公开(公告)号：US09285522B2

公开(公告)日：2016-03-15

申请号：US14320935

申请日：2014-07-01

Applicant: SEIKO EPSON CORPORATION

Inventor： Takahiko Yoshizawa

IPC: B32B3/00 ,  G02B5/28 ,  G01J3/26 ,  G02B26/00 ,  B81C1/00 ,  G01J3/02 ,  G01J3/36 ,  G01J3/51

CPC classification number: G02B5/284 ,  B81B2201/0292 ,  B81C1/00126 ,  G01J3/0213 ,  G01J3/26 ,  G01J3/36 ,  G01J3/51 ,  G02B5/28 ,  G02B26/007 ,  Y10T428/24562 ,  Y10T428/24612

Abstract: A tilt structure includes a shaft section formed on a substrate section, a tilt structure film having one end formed on an upper surface of the shaft section, and the other end bonded to the substrate section, and a thin film section provided to the tilt structure film, located on a corner section composed of the upper surface of the shaft section and a side surface of the shaft section, and having a film thickness thinner than the tilt structure film, the tilt structure film is bent in the thin film section, and an acute angle is formed by the substrate section and the tilt structure film.

Abstract translation: 倾斜结构包括形成在基板部分上的轴部分，倾斜结构膜，其一端形成在轴部分的上表面上，另一端接合到基板部分;以及薄膜部分，设置在倾斜结构 薄膜，位于由所述轴部的上表面构成的角部和所述轴部的侧面之间，并且具有比所述倾斜结构膜更薄的膜厚，所述倾斜结构膜在所述薄膜部弯曲，并且 由基板部和倾斜结构膜形成锐角。

公开(公告)号：US09163986B2

公开(公告)日：2015-10-20

申请号：US14056543

申请日：2013-10-17

Applicant: The Boeing Company

Inventor： Anton M. Bouckaert

IPC: G01J3/28

CPC classification number: G01J3/28 ,  G01J3/0213 ,  G01J3/2803

Abstract: A method and system for enhancing spectrometer function may include initially exposing an array of photosensors of the spectrometer to spectral radiation and recording a first data set of photosensor counts within a predetermined measurement range; making a plurality of successive exposures of the photosensors to the radiation, and for each, progressively increasing an intensity of the radiation from the previous exposure, recording counts from the photosensors within the predetermined measurement range, disregarding counts from photosensors that already have recorded counts within the measurement range from a previous exposure to the radiation to make a data set of measured counts, and rescaling the data set of measured counts to adjust for the increasing an intensity of the spectral radiation to form a rescaled data set; and stitching together the first data set and each rescaled data set of measured counts to form a resultant data set of spectral irradiance.

Abstract translation: 用于增强光谱仪功能的方法和系统可以包括：首先将光谱仪的光电传感器阵列暴露于光谱辐射，并将光传感器计数的第一数据组记录在预定测量范围内; 使光电传感器的多次连续曝光到辐射，并且对于每一次，逐渐增加来自先前曝光的辐射的强度，在预定的测量范围内记录来自光电传感器的计数，而不考虑已经记录计数的光电传感器的计数 从先前暴露于辐射的测量范围，以形成测量计数的数据集，以及重新校正测量计数的数据集，以调整以增加光谱辐射的强度以形成重新缩放的数据集; 并将第一数据集和每个重新标定的测量计数的数据集合在一起以形成光谱辐照度的结果数据集。

公开(公告)号：US20130229530A1

公开(公告)日：2013-09-05

申请号：US13410595

申请日：2012-03-02

Applicant: Paul M. Hubel ,  Richard L. Baer

Inventor： Paul M. Hubel ,  Richard L. Baer

IPC: H04N17/02 ,  H04N5/76

CPC classification number: H04N17/02 ,  G01J3/0213 ,  G01J3/505 ,  G01J2003/282 ,  H04N9/735 ,  H04N17/002

Abstract: Determining, applying and storing model spectral response parameters used to correct colors in a digital image. The model spectral response parameters may be estimated through a recursive error analysis and applied or stored to all digital imaging devices of a particular type, thereby occupying minimal firmware storage space and permitting on the fly correction of images.

Abstract translation: 确定，应用和存储用于校正数字图像中颜色的模型光谱响应参数。 可以通过递归误差分析来估计模型光谱响应参数，并将其应用或存储到特定类型的所有数字成像设备，从而占据最小的固件存储空间并允许对图像的飞行校正。

公开(公告)号：US08447087B2

公开(公告)日：2013-05-21

申请号：US13193092

申请日：2011-07-28

Applicant: Victor C. Wong ,  Robert Cuffney

Inventor： Victor C. Wong ,  Robert Cuffney

IPC: G06K9/00

CPC classification number: A61B1/00186 ,  A61B1/00009 ,  A61B1/0005 ,  A61B1/043 ,  A61B1/0607 ,  A61B1/0638 ,  A61B1/0646 ,  A61B1/0684 ,  A61B1/24 ,  A61B5/0066 ,  A61B5/0071 ,  A61B5/0088 ,  A61B5/4547 ,  G01B11/2441 ,  G01J3/02 ,  G01J3/0213 ,  G01J3/0224 ,  G01J3/0272 ,  G01J3/10 ,  G01J3/4406 ,  G01J3/50 ,  G01J3/508 ,  G01N21/4795 ,  G01N21/6445 ,  G01N21/6456 ,  G01N21/6486 ,  G01N2021/1787

Abstract: An apparatus for imaging a tooth has at least one illumination source for providing an incident light having a first spectral range for obtaining a reflectance image of the tooth and a second spectral range for exciting a fluorescence image of the tooth. A first polarizer having a first polarization axis and a compensator in the path of the incident light of the first spectral range are disposed to direct light toward the tooth. A second polarizer is disposed to direct light obtained from the tooth toward a sensor and has a second polarization axis that is orthogonal to the first polarization axis. A lens is positioned in the return path to direct image-bearing light from the tooth toward the sensor for obtaining image data. A filter in the path of the image-bearing light from the tooth is treated to attenuate light in the second spectral range.

Abstract translation: 用于成像牙齿的装置具有至少一个照明源，用于提供具有第一光谱范围的入射光，以获得牙齿的反射图像，以及用于激发牙齿的荧光图像的第二光谱范围。 设置在第一光谱范围的入射光的路径中具有第一偏振轴和补偿器的第一偏振器，以将光引向牙齿。 第二偏振器设置成将从牙齿获得的光引向传感器并具有与第一偏振轴正交的第二偏振轴。 透镜位于返回路径中，以将来自牙齿的图像承载光引向传感器以获得图像数据。 在来自牙齿的图像承载光的路径中的过滤器被处理以衰减第二光谱范围内的光。

公开(公告)号：US08309905B2

公开(公告)日：2012-11-13

申请号：US12548047

申请日：2009-08-26

Applicant: Jean-Francois Blanc ,  Stephane Garin

Inventor： Jean-Francois Blanc ,  Stephane Garin

IPC: G01J3/50

CPC classification number: G02B23/00 ,  G01J3/02 ,  G01J3/0205 ,  G01J3/0213 ,  G01J3/0262 ,  G01J3/2823 ,  G01J3/36 ,  G02B5/285 ,  H01L27/14621

Abstract: The multispectral filter for an image detection device comprises a prismatic plate (85) comprising a first internal face (86) and a second external face (87), the first and the second faces (86, 87) being inclined with respect to one another by an angle β, and comprises at least two different spectral bands (91, 92, 93, 94) deposited either on the first or the second face (86, 87) of the prismatic plate (85), the various spectral bands (91, 92, 93, 94) being spaced a predetermined distance (D) apart.Application to multispectral imagers, in particular to Off Axis imagers.This filter allows the suppression of the ghost images (or spurious echoes) generated at the focal plane of a multispectral imager.

Abstract translation: 用于图像检测装置的多光谱滤光器包括棱镜板（85），其包括第一内表面（86）和第二外表面（87），第一和第二面（86,87）相对于彼此倾斜 并且包括沉积在棱镜板（85）的第一面或第二面（86,87）上的至少两个不同光谱带（91,92,93,94），各种光谱带（ 91,92,93,94）间隔开预定距离（D）。 应用于多光谱成像仪，特别是Off Axis成像仪。 该滤光器允许抑制在多光谱成像器的焦平面处产生的重影图像（或杂散回波）。