公开(公告)号：US09030663B2

公开(公告)日：2015-05-12

申请号：US13285292

申请日：2011-10-31

Applicant: Michael G. Braun ,  Jeremy T. Dobler

Inventor： Michael G. Braun ,  Jeremy T. Dobler

IPC: G01N21/00 ,  G01J3/433 ,  G01N21/3504 ,  G01J3/02 ,  G01N21/31 ,  G01J1/42

CPC classification number: G01J3/433 ,  G01J3/0297 ,  G01J2001/4242 ,  G01N21/314 ,  G01N21/3504 ,  G01N2021/3513

Abstract: Remote absorption spectroscopy uses coded electromagnetic transmission directed through a medium under investigation to one or more remote receivers. The coded transmission includes at least one wavelength coincident with an absorption band of interest and one wavelength in an off-line band and a predefined relationship between spectral components in and outside the absorption band is controlled. The relationship between spectral components may be evaluated at the receiver to determine whether deviation thereof from the controlled relationship at the transmitter exists at the receiver. The deviation of the received optical signal from the prescribed relationship is processed to indicate the absorption of the radiation in the absorption band.

Abstract translation: 远程吸收光谱仪使用通过正在研究的介质引导的编码电磁传输到一个或多个远程接收器。 编码的传输包括与感兴趣的吸收频带和离线频带中的一个波长一致的至少一个波长和吸收频带内外的频谱分量之间的预定关系。 可以在接收机处评估频谱分量之间的关系，以确定其在发射机处的受控关系的偏差是否存在于接收机处。 处理接收到的光信号与规定关系的偏差，以表示吸收带中的辐射的吸收。

公开(公告)号：US09007591B2

公开(公告)日：2015-04-14

申请号：US14091069

申请日：2013-11-26

Applicant: HORIBA, Ltd.

Inventor： Kimihiko Arimoto ,  So Takagi ,  Takaaki Yada

IPC: G01N21/00 ,  G01J9/00 ,  G01N21/01 ,  G01J3/02

CPC classification number: G01J3/0297 ,  G01J3/0218 ,  G01J3/42

Abstract: The present invention includes: an optical fiber being provided either of between a light source and a measurement cell and between the measurement cell and a light detection part; and light path switching means adapted to achieve switching between a measurement cell passage state in which a light path formed by light transmission means passes through the measurement cell and a measurement cell non-passage state in which the light path formed by the light transmission means passes through a region different from the measurement cell, wherein calibration processing for a first calibration with a long calibration cycle is performed in the measurement cell passage state, and calibration processing for a second calibration with a short calibration cycle is performed in the measurement cell non-passage state.

Abstract translation: 本发明包括：光纤，其设置在光源和测量单元之间，并且在测量单元和光检测部之间; 以及光路切换装置，其适于实现由光传输装置形成的光路通过测量单元的测量单元通过状态与由光传输装置形成的光路通过的测量单元非通过状态之间的切换 通过与测量单元不同的区域，其中在测量单元通过状态下执行具有长校准周期的第一校准的校准处理，并且在测量单元非均匀性中执行具有短校准周期的第二校准的校准处理， 通过状态

公开(公告)号：US09006684B2

公开(公告)日：2015-04-14

申请号：US12738843

申请日：2008-10-08

Applicant: Jyrki Laitinen ,  Petri Kivelä

Inventor： Jyrki Laitinen ,  Petri Kivelä

IPC: G01J1/58 ,  G01N21/64 ,  G01J3/02 ,  G01J3/10 ,  G01J3/18 ,  G01J3/44 ,  G01N21/25

CPC classification number: G01N21/6452 ,  G01J3/02 ,  G01J3/0218 ,  G01J3/0297 ,  G01J3/10 ,  G01J3/18 ,  G01J3/4406 ,  G01N21/253 ,  G01N21/6428 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6471 ,  G01N2021/6484 ,  G01N2201/0627 ,  G01N2201/0806

Abstract: The invention relates to an apparatus and method for optically analyzing samples contained in sample sites of a sample holder by means of fluorescence. The apparatus comprises a first light source comprising a plurality of individual light sources having narrow wavelength bands, means for further limiting wavelength bands of the light emitted by the individual light sources, means for guiding the reduced-wavelength light to the sample sites of the sample holder, and a detector for detecting light from the sample sites. According to the invention said means for further reducing the wavelength bands emitted by the individual light sources comprise a wavelength-tunable single monochromator. The invention allows manufacturing of a microplate reader having the capability for fluorescence measurements at a continuous wavelength range, while maintaining the cost of the device at a reasonable level.

Abstract translation: 本发明涉及一种用于通过荧光光学分析样品保持器的样品位点中包含的样品的装置和方法。 该装置包括：第一光源，其包括具有窄波长带的多个单独的光源;用于进一步限制由各个光源发射的光的波长带的装置;用于将所述还原波长的光引导到所述样品的样品位置的装置 支架和用于检测来自样品位点的光的检测器。 根据本发明，用于进一步减少由各个光源发射的波长带的装置包括波长可调单色器。 本发明允许制造具有在连续波长范围内的荧光测量能力的酶标仪，同时将装置的成本保持在合理的水平。

公开(公告)号：US08988682B2

公开(公告)日：2015-03-24

申请号：US14058055

申请日：2013-10-18

Applicant: Apple Inc.

Inventor： Ye Yin ,  Gabriel G. Marcu ,  Jiaying Wu

IPC: G01J3/46 ,  G01J3/28

CPC classification number: G01J3/28 ,  G01J3/0218 ,  G01J3/0243 ,  G01J3/0291 ,  G01J3/0294 ,  G01J3/0297 ,  G01J3/462 ,  G01J3/465 ,  G01J3/50 ,  G01J3/502 ,  G01J3/506 ,  G01J3/51 ,  G01J3/513 ,  G01J3/524

Abstract: This specification describes various embodiments that relate to methods for providing a wideband colorimeter that can include more accurate outputs. In one embodiment, a narrowband instrument, such as a spectrometer or spectrograph, can be used for calibration of a wideband colorimeter, so that more accurate outputs can be provided. In one embodiment, an optical test equipment, which consists of both a wideband colorimeter and a narrowband spectrograph, can be used for providing a more accurately calibrated wideband colorimeter. As an example, a spectra-camera, which is a hybrid system consisting of both a wideband colorimeter and a narrowband spectrograph, can be used for simultaneous testing by both the wideband colorimeter and the narrowband spectrograph. By doing simultaneous testing, accurate calibration of the wideband colorimeter can be achieved. This specification further describes a mathematical model to characterize a wideband three channel colorimeter with a narrowband multiple channel spectrometer.

Abstract translation: 本说明书描述了涉及用于提供宽带色度计的方法的各种实施例，其可以包括更精确的输出。 在一个实施例中，诸如光谱仪或光谱仪的窄带仪器可以用于宽带色度计的校准，从而可以提供更精确的输出。 在一个实施例中，由宽带色度计和窄带光谱仪组成的光学测试设备可用于提供更准确校准的宽带色度计。 作为示例，作为由宽带色度计和窄带光谱仪组成的混合系统的光谱相机可以用于宽带色度计和窄带光谱仪的同时测试。 通过同时测试，可以实现宽带色度计的精确校准。 该说明书进一步描述了用窄带多通道光谱仪来表征宽带三通道色度计的数学模型。

公开(公告)号：US20140233030A1

公开(公告)日：2014-08-21

申请号：US14346948

申请日：2013-05-23

Applicant: Sumitomo Electric Industries, Ltd.

Inventor： Masato Tanaka ,  Ichiro Sogawa

IPC: G01J3/28

CPC classification number: G01J3/2823 ,  G01J3/0205 ,  G01J3/0208 ,  G01J3/0218 ,  G01J3/0291 ,  G01J3/0294 ,  G01J3/0297 ,  G01J3/18 ,  G01J3/2803 ,  G01J3/36

Abstract: A method of adjusting a spectroscopic imaging device is provided with which a relative arrangement relationship among components can be easily adjusted in the spectroscopic imaging device. A spectroscopic imaging device 30 includes a collimating lens 32, a diffraction grating 33, a condensing lens 34, an array light receiving unit 35, and adjustment means for adjusting a relative arrangement relationship among these components. An etalon filter is disposed on an optical path of light inputted to the collimating lens 32 and the relative arrangement relationship among the components is adjusted so that the focal point of light of each wavelength condensed by the condensing lens 34 is positioned on a predetermined line of the array light receiving unit 35.

Abstract translation: 提供了一种调整分光成像装置的方法，其可以在分光成像装置中容易地调整各部件之间的相对配置关系。 分光成像装置30包括准直透镜32，衍射光栅33，聚光透镜34，阵列光接收单元35和用于调节这些分量之间的相对布置关系的调节装置。 标准具过滤器设置在输入到准直透镜32的光的光路上，并且调整各部件之间的相对配置关系，使得由聚光透镜34聚光的每个波长的光的焦点位于 阵列光接收单元35。

公开(公告)号：US08780346B2

公开(公告)日：2014-07-15

申请号：US13919362

申请日：2013-06-17

Applicant: Seiko Epson Corporation

Inventor： Tatsuaki Funamoto

IPC: G01J3/447

CPC classification number: G01N21/255 ,  G01J3/0224 ,  G01J3/0297 ,  G01J3/2823 ,  G01J2003/2826

Abstract: A spectroscopic image capturing apparatus including a light source section and an imaging section, wherein the light source section includes a light source portion, a first lens group, and a first polarizer, and the imaging section includes a second polarizer, a second lens group, an optical filter, and an imaging unit.

Abstract translation: 1.一种分光图像拍摄装置，包括光源部分和成像部分，其中所述光源部分包括光源部分，第一透镜组和第一偏振器，并且所述成像部分包括第二偏振器，第二透镜组， 光学滤波器和成像单元。

公开(公告)号：US08767206B2

公开(公告)日：2014-07-01

申请号：US14000366

申请日：2012-02-03

Applicant: Kenji Imura

Inventor： Kenji Imura

IPC: G01J3/28

CPC classification number: G01J3/28 ,  G01J3/0297 ,  G01J3/18 ,  G01J2003/102

Abstract: Wavelength information indicating a correspondence relationship between a plurality of light receiving elements of a light receiving unit and wavelengths of pieces of lights is stored. First and second intensity distributions of the light related to first and second dispersion images are acquired based on a signal outputted from each of the light receiving elements when a monochromatic light is passed through a opening of a light shielding body and first and second dispersion images related to primary and secondary diffracted light are formed on the light receiving unit. An estimated intensity distribution of the light related to the second dispersion image is calculated from the first intensity distribution according to a predetermined relational expression. A change amount related to the wavelength information is calculated based on the estimated intensity distribution and the second intensity distribution. The wavelength information is corrected according to the change amount.

Abstract translation: 存储指示光接收单元的多个光接收元件与多个光的波长之间的对应关系的波长信息。 基于从单个光通过遮光体的开口而从每个光接收元件输出的信号，获得与第一和第二色散图像相关的光的第一和第二强度分布，以及第一和第二色散图像 在光接收单元上形成初级和次级衍射光。 根据预定的关系式从第一强度分布计算与第二色散图像相关的光的估计强度分布。 基于估计的强度分布和第二强度分布来计算与波长信息相关的变化量。 根据变化量校正波长信息。

公开(公告)号：US20140146317A1

公开(公告)日：2014-05-29

申请号：US14091069

申请日：2013-11-26

Applicant: HORIBA, Ltd.

Inventor： Kimihiko Arimoto ,  So Takagi ,  Takaaki Yada

IPC: G01J3/02

CPC classification number: G01J3/0297 ,  G01J3/0218 ,  G01J3/42

Abstract: The present invention includes: an optical fiber being provided either of between a light source and a measurement cell and between the measurement cell and a light detection part; and light path switching means adapted to achieve switching between a measurement cell passage state in which a light path formed by light transmission means passes through the measurement cell and a measurement cell non-passage state in which the light path formed by the light transmission means passes through a region different from the measurement cell, wherein calibration processing for a first calibration with a long calibration cycle is performed in the measurement cell passage state, and calibration processing for a second calibration with a short calibration cycle is performed in the measurement cell non-passage state.

Abstract translation: 本发明包括：光纤，其设置在光源和测量单元之间，并且在测量单元和光检测部之间; 以及光路切换装置，其适于实现由光传输装置形成的光路通过测量单元的测量单元通过状态与由光传输装置形成的光路通过的测量单元非通过状态之间的切换 通过与测量单元不同的区域，其中在测量单元通过状态下执行具有长校准周期的第一校准的校准处理，并且在测量单元非均匀性中执行具有短校准周期的第二校准的校准处理， 通过状态

公开(公告)号：US20130301046A1

公开(公告)日：2013-11-14

申请号：US13471341

申请日：2012-05-14

Applicant: Janyce Lipson

Inventor： Jan Lipson ,  Donald A. Ice ,  Rudolf J. Hofmeister ,  Yuxin Zhou ,  Harold G. Sampson ,  Qingfeng Huang ,  James Stewart

IPC: G01J3/42 ,  H01L27/146 ,  G01J1/44

CPC classification number: G01J3/021 ,  G01J1/32 ,  G01J3/0297 ,  G01J3/10 ,  H01L27/14601 ,  H01L27/14806

Abstract: Various systems and methods of monitoring laser safety by sensing contact of the system with a sample are provided. The system includes a focusing element for focusing an incident light from a laser light source onto a sample, an optical element having a collection zone for collecting a signal from the sample, a reflected light sensor for sensing a reflected light from the sample, wherein the reflected light sensor is located outside the collection zone of the optical element and on an inner surface of a housing of the system, an electrical circuit operably connected to the reflected light sensor and the laser light source and configured to control power to the laser light source in accordance with the reflected light sensed by the reflected light sensor and a spectral analyzer for processing the signal. Methods and other systems are also described and illustrated.

Abstract translation: 提供了通过感测系统与样品的接触来监测激光器安全性的各种系统和方法。 该系统包括用于将来自激光源的入射光聚焦到样本上的聚焦元件，具有用于收集来自样品的信号的收集区域的光学元件，用于感测来自样品的反射光的反射光传感器，其中， 反射光传感器位于光学元件的收集区域的外部并且位于系统的壳体的内表面上，可操作地连接到反射光传感器和激光源并被配置为控制激光源的功率的电路 根据由反射光传感器感测的反射光和用于处理信号的光谱分析器。 还描述和示出了方法和其他系统。

公开(公告)号：US08582096B2

公开(公告)日：2013-11-12

申请号：US12969295

申请日：2010-12-15

Applicant: Zhongping Chen ,  Gangjun Liu ,  Mihael Balu ,  Bruce Tromberg ,  Eric Olaf Potma

Inventor： Zhongping Chen ,  Gangjun Liu ,  Mihael Balu ,  Bruce Tromberg ,  Eric Olaf Potma

IPC: G01J3/44

CPC classification number: G01J3/44 ,  A61B1/00165 ,  A61B1/043 ,  A61B5/0066 ,  A61B5/0084 ,  A61B5/02007 ,  A61B5/441 ,  G01J3/02 ,  G01J3/0218 ,  G01J3/0297 ,  G01N21/65 ,  G01N2021/653 ,  G01N2201/08 ,  G01N2201/0866

Abstract: A fiber-delivered probe suitable for CARS imaging of thick tissues is practical. The disclosed design is based on two advances. First, a major problem in CARS probe design is the presence of a very strong anti-Stokes component in silica delivery fibers generated through a FWM process. Without proper spectral filtering, this component affects the CARS image from the tissue sample. The illustrated embodiments of the invention efficiently suppress this spurious anti-Stokes component through the use of a separate fiber for excitation delivery and for signal detection, which allows the incorporation of dichroic optics for anti-Stokes rejection. Second, the detection of backscattered CARS radiation from the sample is optimized by using a large core multi mode fiber in the detection channel. This scheme produces high quality CARS images free of detector aperture effects. Miniaturization of this fiber-delivered probe results in a practical handheld probe for clinical CARS imaging.

Abstract translation: 适用于厚组织CARS成像的纤维输送探针是实用的。 所公开的设计基于两个进展。 首先，CARS探针设计中的一个主要问题是在通过FWM工艺生成的二氧化硅输送纤维中存在非常强的反斯托克斯组分。 没有适当的光谱过滤，该组件会影响来自组织样本的CARS图像。 本发明的所示实施例通过使用用于激发传递和信号检测的单独光纤来有效地抑制这种寄生的反斯托克斯分量，这允许并入用于反斯托克斯抑制的二向色光学器件。 其次，通过在检测通道中使用大型核心多模光纤，优化了样品背散射CARS辐射的检测。 该方案可生成高品质的CARS图像，无需检测器孔径效果。 该光纤传送探针的小型化导致临床CARS成像的实用手持式探头。