公开(公告)号：US09883829B2

公开(公告)日：2018-02-06

申请号：US14598111

申请日：2015-01-15

Applicant: OptiScan Biomedical Corporation

Inventor： Jennifer H. Gable ,  James R. Braig ,  Kenneth I. Li ,  Mark Wechsler ,  Peng Zheng ,  Richard Keenan

IPC: A61B5/157 ,  A61B5/15 ,  A61B5/155 ,  A61B5/145 ,  A61M5/172 ,  A61B5/1455 ,  A61B10/00 ,  G01N21/3577 ,  A61B5/153 ,  A61B5/00 ,  A61M5/142 ,  A61M5/168 ,  A61M5/36 ,  A61M5/38 ,  G01N21/03 ,  G01N21/35

CPC classification number: A61B5/157 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/0086 ,  A61B5/1411 ,  A61B5/1427 ,  A61B5/1451 ,  A61B5/14517 ,  A61B5/14532 ,  A61B5/14535 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/15003 ,  A61B5/150213 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150267 ,  A61B5/150358 ,  A61B5/150755 ,  A61B5/150862 ,  A61B5/150992 ,  A61B5/153 ,  A61B5/155 ,  A61B5/4839 ,  A61B10/0064 ,  A61B2560/0443 ,  A61M5/14212 ,  A61M5/14232 ,  A61M5/16854 ,  A61M5/1723 ,  A61M5/365 ,  A61M5/38 ,  A61M2205/12 ,  A61M2205/3306 ,  A61M2230/20 ,  A61M2230/201 ,  G01N21/03 ,  G01N21/3577 ,  G01N2021/3595 ,  G01N2201/02 ,  G01N2201/061 ,  G06F19/00 ,  Y10T137/4478 ,  Y10T137/7722 ,  Y10T137/86485 ,  Y10T436/111666 ,  Y10T436/2575

Abstract: Disclosed is an apparatus for analyzing the composition of bodily fluid. The apparatus can include a fluid handling network including a patient end configured to maintain fluid communication with a bodily fluid in a patient and a pump unit in operative engagement with the fluid handling network. The pump unit can have an infusion mode, in which the pump unit is operable to deliver infusion fluid to the patient through the patient end, and a sample draw mode, in which the pump unit is operable to draw a sample of the bodily fluid from the patient through the patient end. The apparatus can include a spectroscopic analyzer positioned to analyze at least a portion of the sample; a processor in communication with or incorporated into the spectroscopic analyzer; and stored program instructions executable by the processor to obtain measurements of two or more properties of the sample.

公开(公告)号：US09874515B2

公开(公告)日：2018-01-23

申请号：US14895946

申请日：2013-06-04

Applicant: Foss Analytical

Inventor： Per Waaben Hansen

IPC: G01N21/35 ,  G01N21/27 ,  G01J3/02 ,  G01J3/42 ,  G01J3/45

CPC classification number: G01N21/35 ,  G01J3/0291 ,  G01J3/42 ,  G01J3/45 ,  G01N21/274 ,  G01N2021/3595 ,  G01N2201/061 ,  G01N2201/12746

Abstract: A method of determining a pathlength deviation of a sample (610), the method comprising: exposing the sample (610) to electromagnetic radiation at a plurality of wavenumbers, determining electromagnetic absorption in the sample (610) at the plurality of wavenumbers, determining a first wavenumber associated with a first absorption level of an absorption band and a second wavenumber associated with a second absorption level of the absorption band, wherein the second wavenumber is different from the first wavenumber, determining a difference between the first wavenumber and the second wavenumber, and determining the pathlength deviation based on the difference.

公开(公告)号：US09869638B2

公开(公告)日：2018-01-16

申请号：US14760685

申请日：2014-07-23

Applicant: Suzhou Helmen Precision Instruments Co., Ltd.

Inventor： Kai Jiang ,  Yawei Tang ,  Ping Wang

IPC: G01J1/58 ,  G01N21/64

CPC classification number: G01N21/6408 ,  G01N21/6428 ,  G01N2021/6413 ,  G01N2021/6439 ,  G01N2201/061 ,  G01N2201/12

Abstract: The present invention relates to a method for detecting time-resolved fluorescence based on a principle of phase balanced frequency multiplication modulation. A stimulating light source modulated by using a baseband signal acts on a to-be-measured target to trigger fluorescence, so that the fluorescence intensifies and decays periodically; then, a frequency-doubled square signal is used to control a sampling period and divide an ascending period of the fluorescence into two and a decay period of the fluorescence into two; after independent sampling is performed separately, sampling differences of the two parts are separately calculated and then added to obtain an intensity representative value of a fluorescence signal and to obtain a concentration value of the to-be-measured target. The method in the present invention can not only likewise cancel fluorescence interference of a substrate in a sample, but also can cancel ambient bias light, power-frequency interference of a spatial electromagnetic wave or other signals, and therefore improves signal intensity in fluorescence measurement on the detection sample, has an advantage that cannot be accomplished in a conventional time-resolved fluorescence method, and can be applied in fluorescence intensity detection of a target in fields such as biology, chemistry, and medicine.

公开(公告)号：US20170336319A1

公开(公告)日：2017-11-23

申请号：US15613315

申请日：2017-06-05

Applicant: Viavi Solutions Inc.

Inventor： Curtis R. HRUSKA ,  Charles A. HULSE ,  Brett J. BRYARS ,  Marc K. VON GUNTEN ,  Christopher G. PEDERSON ,  Nada A. O'BRIEN ,  Jerry ZIEBA ,  Benjamin F. CATCHING

IPC: G01N21/35 ,  G01J3/10 ,  G01N21/359 ,  G01J3/02 ,  G01J3/26 ,  G01J5/08 ,  G01J3/42 ,  G01J3/12

CPC classification number: G01N21/35 ,  G01J3/0205 ,  G01J3/0272 ,  G01J3/10 ,  G01J3/26 ,  G01J3/42 ,  G01J5/08 ,  G01J2003/1234 ,  G01N21/359 ,  G01N2201/0221 ,  G01N2201/061 ,  G01N2201/068

Abstract: A portable spectrometer device includes an illumination source for directing at a sample, and a tapered light pipe (TLP) for capturing light interacting with the sample at a first focal ratio and for delivering the light at a second focal ratio lower than the first focal ratio. A linearly variable filter (LVF) separates the captured light into a spectrum of constituent wavelength signals; and a detector array, including a plurality of pixels, each of the plurality of pixels disposed to receive at least a portion of a plurality of the constituent wavelength signals provides a power reading for each constituent wavelength. Preferably, the TLP is lensed at one end, and recessed in a protective boot with stepped inner walls. The gap between the TLP and LVF is minimized to further enhance resolution and robustness.

公开(公告)号：US09823188B1

公开(公告)日：2017-11-21

申请号：US14834508

申请日：2015-08-25

Applicant: Manoj Kumar Ram ,  Muhammad Rahman

Inventor： Manoj Kumar Ram ,  Muhammad Rahman

IPC: G01N21/3577 ,  G01N21/94 ,  G01N21/31

CPC classification number: G01N21/3577 ,  G01N21/3103 ,  G01N21/94 ,  G01N2021/3595 ,  G01N2201/061 ,  G01N2201/12

Abstract: In some embodiments, a system for detecting the presence of a contaminant on a surface includes an infrared light source configured to shine infrared light on the surface, an infrared light detector configured to detect infrared light reflected from the surface, and a computing device configured to receive an infrared reflectance signal from the infrared light detector and detect the presence of the contaminant from a feature in the reflectance signal.

公开(公告)号：US20170299519A1

公开(公告)日：2017-10-19

申请号：US15466269

申请日：2017-03-22

Applicant: PATHWAY GENOMICS CORPORATION

Inventor： Tanya Moreno ,  Cindy Wang ,  David Becker

IPC: G01N21/64 ,  B01L7/00

CPC classification number: G01N21/6428 ,  B01L7/52 ,  G01N21/6452 ,  G01N2201/061

Abstract: Dual mode genetics testing systems are devised about a single element testing platform. A microfluidic network and system of interconnected receiving cells and reaction vessels supports at the same time genotyping and copy number analysis where the platform may be subject to a common thermal cycle schedule to cause the proper reactions (DNA replication) necessary in both test types. Further, the microfluidic platform which includes reaction vessels for genotyping which are spatially removed from reaction vessels for copy number analysis, is coupled to optical scanner and detection systems specifically arranged to apply test specific detection routines on each of these distinct regions or portions of the dual mode test platform.

公开(公告)号：US09784670B1

公开(公告)日：2017-10-10

申请号：US14602189

申请日：2015-01-21

Applicant: Theranos, Inc.

Inventor： Karan Mohan ,  Samartha Anekal

IPC: G02B26/08 ,  G01N21/00 ,  G01N21/25 ,  G01N21/76 ,  G01N21/64 ,  G02B5/08 ,  G02B27/42 ,  G02B5/18 ,  G02B5/04 ,  G02B7/182

CPC classification number: G01N21/255 ,  G01N21/645 ,  G01N21/76 ,  G01N2201/061 ,  G02B5/04 ,  G02B5/08 ,  G02B5/18 ,  G02B7/182 ,  G02B27/42

Abstract: The devices and systems disclosed herein provide multiple optical capabilities in a single device or system. Methods for using these devices and systems are provided. These devices and systems are configurable for operation in each of a spectroscopy mode, a fluorescence mode, and a luminescence mode, and are capable of performing spectroscopic, fluorescence, and luminescence observations, measurements, and analyses when operated in the corresponding spectroscopy mode, fluorescence mode, or luminescence mode. These devices and systems include mirror dispersion elements having multiple faces including an optical dispersion element on one face (e.g., a diffraction grating or a prism) and a reflective element on another face (e.g., a mirror). These multiple capabilities eliminate the need to move or load a sample in multiple devices when subjecting a sample to multiple analyses, and thus provide greater accuracy, precision, and speed while reducing complexity and cost of sample analysis.

公开(公告)号：US20170269482A1

公开(公告)日：2017-09-21

申请号：US15453049

申请日：2017-03-08

Applicant: Stichting VU ,  Universiteit van Amsterdam ,  Stichting voor Fundamenteel Onderzoek der Materie ,  ASML Netherlands B.V.

Inventor： Dirk Ewoud Boonzajer Flaes ,  Stefan Michiel Witte ,  Kjeld Sijbrand Eduard Eikema

IPC: G03F7/20 ,  G01B11/00 ,  G01N21/956 ,  G01N21/47

CPC classification number: G03F7/7065 ,  G01B11/00 ,  G01N21/4788 ,  G01N21/956 ,  G01N2201/061 ,  G01N2201/0635 ,  G02B21/16 ,  G03F7/70625 ,  G03F7/70633 ,  H05G2/003 ,  H05G2/008

Abstract: In an inspection apparatus, a target on the surface is illuminated with illuminating radiation that comprises first and second illuminating components. The illuminating components form one or more periodic illuminating patterns on the surface. A plurality of scattered radiation patterns formed by the illuminating radiation after scattering by the target is captured at a detector for a number of values of a controllable characteristic of at least one of the illuminating components. The captured radiation is then used to reconstruct data describing the target.

公开(公告)号：US09766186B2

公开(公告)日：2017-09-19

申请号：US14674856

申请日：2015-03-31

Applicant: KLA-Tencor Corporation

Inventor： Hong Chen ,  Kenong Wu ,  Eugene Shifrin ,  Masatoshi Yamaoka

IPC: G01N21/95 ,  G01N21/00 ,  G01N21/94

CPC classification number: G01N21/9501 ,  G01N21/00 ,  G01N21/94 ,  G01N21/95 ,  G01N2201/061 ,  G01N2201/10

Abstract: Systems and methods for detecting defects on a wafer are provided. One method includes generating test image(s) for at least a portion of an array region in die(s) on a wafer from frame image(s) generated by scanning the wafer with an inspection system. The method also includes generating a reference image for cell(s) in the array region from frame images generated by the scanning of the wafer. In addition, the method includes determining difference image(s) for at least one cell in the at least the portion of the array region in the die(s) by subtracting the reference image from portion(s) of the test image(s) corresponding to the at least one cell. The method further includes detecting defects on the wafer in the at least one cell based on the difference image(s).

公开(公告)号：US09752927B2

公开(公告)日：2017-09-05

申请号：US15117598

申请日：2015-02-05

Applicant: VICTORIA LINK LTD

Inventor： Justin M. Hodgkiss ,  Kai Chen

IPC: G01J1/42 ,  G01N21/63 ,  G01N21/64 ,  G01N21/65 ,  G01J3/28 ,  G01J3/02 ,  G01J3/44

CPC classification number: G01J1/4228 ,  G01J3/0232 ,  G01J3/2889 ,  G01J3/4406 ,  G01J2003/4424 ,  G01N21/636 ,  G01N21/6408 ,  G01N21/65 ,  G01N2201/061 ,  G01N2201/0696

Abstract: A transient grating (TG) is used as an optical gating element with sub-picosecond time resolution for luminescence measurements from a photo-detector array. The transient grating is formed in a gate medium by one or more pulsed gate beams. For photoluminescence measurements such as photoluminescence spectroscopy or imaging, a source is excited by a pulsed excitation beam, and the pulsed gate beams are synchronized to the pulsed excitation beam with an adjustable delay between the excitation of the source and the formation of the TG. Moreover, a source or its spectra can be imaged at two different regions of the photo-detector array at two different times spaced in time by a selected duration of time with sub-picosecond resolution over a range of a nanosecond or more. A beam from the source is deflected to the different regions by changing the frequency or geometry of the pulsed gate beams.