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    Method and device for performing analyses in parallel
    61.
    发明申请
    Method and device for performing analyses in parallel 失效
    并行执行分析的方法和装置

    公开(公告)号：US20030155499A1

    公开(公告)日：2003-08-21

    申请号：US10276758

    申请日：2003-03-17

    Inventor： Jan Axelsson

    IPC: H01J049/00 ,  B01D059/44

    CPC classification number: H01J49/009 ,  G01N30/466 ,  G01N30/7266 ,  G01N2030/628

    Abstract: The present invention relates to analysis devices having means (3, 5, 7) for producing a plurality of ion beams of samples substantially simultaneously; mass separating means for individually mass separating each ion beam in parallel and detecting means (131-13n) for detecting said mass separated ion beams substantially simultaneously, and to methods for using such devices.

    Abstract translation: 本发明涉及具有用于基本上同时产生多个样本的离子束的装置（3,5,7）的分析装置; 用于单独地将每个离子束单独地分离的质量分离装置和用于基本上同时检测所述质量分离的离子束的检测装置（131-13n）以及用于使用这些装置的方法。

    Time-of-flight mass spectrometer array instrument
    62.
    发明授权
    Time-of-flight mass spectrometer array instrument 有权
    飞行时间质谱仪阵列仪

    公开(公告)号：US06580070B2

    公开(公告)日：2003-06-17

    申请号：US10030395

    申请日：2002-01-08

    Applicant: Timothy J. Cornish ,  Scott A. Ecelberger

    Inventor： Timothy J. Cornish ,  Scott A. Ecelberger

    IPC: H01J4900

    CPC classification number: H01J49/009 ,  H01J49/40

    Abstract: A time-of-flight mass spectrometer (TOF-MS) array instrument is provided. Each TOF-MS of the array instrument includes (1) a gridless, focusing ionization extraction device allowing for the use of very high extraction energies in a maintenance-free design, (2) a fiberglass-clad flexible circuit-board reflector using rolled flexible circuit-board material, and (3) a low-noise, center-hole microchannel plate detector assembly that significantly reduces the noise (or “ringing”) inherent in the coaxial design. The miniature TOF-MS array allows for the bundling of a plurality of mass analyzers, e.g., a plurality of TOF-MSs, into a single array working in parallel fashion to greatly enhance the throughput of each TOF-MS in the array by multiplexing the data collection process. A preferred embodiment of the TOF-MS array instrument incorporates 16 TOF-MS units that are arranged in mirror-image clusters of eight units.

    Abstract translation: 提供飞行时间质谱仪（TOF-MS）阵列仪。 阵列仪器的每个TOF-MS包括（1）无栅格聚焦电离提取装置，允许在免维护设计中使用非常高的提取能量，（2）使用滚动柔性的玻璃纤维包覆柔性电路板反射器 电路板材料，以及（3）低噪声中心孔微通道板检测器组件，其显着地减少了同轴设计中固有的噪声（或“振铃”）。 微型TOF-MS阵列允许将多个质量分析器（例如，多个TOF-MS）捆绑成并行工作的单个阵列，以通过多路复用来大大增强阵列中每个TOF-MS的吞吐量 数据收集过程。 TOF-MS阵列仪器的优选实施例包括布置在八个单元的镜像簇中的16个TOF-MS单元。

    ION TRAP ARRAY MASS SPECTROMETER
    63.
    发明申请
    ION TRAP ARRAY MASS SPECTROMETER 有权
    离子阱阵列质谱仪

    公开(公告)号：US20030089846A1

    公开(公告)日：2003-05-15

    申请号：US09578673

    申请日：2000-05-25

    Inventor： Robert G. Cooks ,  Ethan R. Badman ,  Zheng Ouyang ,  James M. Wells

    IPC: H01J049/00

    CPC classification number: H01J49/424 ,  H01J49/0013 ,  H01J49/009

    Abstract: A mass spectrometer having an array of parallel and/or tandem ion traps. The ion traps are preferably formed by providing a body of conductive material with a plurality of holes forming ring electrodes and electrodes on opposite faces of said body, opposite the ends of said ring electrodes, to define with the ring electrodes a plurality of parallel ion traps.

    Abstract translation: 具有并联和/或串联离子阱的阵列的质谱仪。 离子阱优选通过在导电材料体上形成多个孔，所述多个孔在所述主体的与所述环形电极的端部相对的相对面上形成环形电极和电极，以与所述环形电极限定多个平行的离子阱 。

    Quadrupole field mass analyser
    64.
    发明授权
    Quadrupole field mass analyser 失效
    四极场质量分析仪

    公开(公告)号：US3935453A

    公开(公告)日：1976-01-27

    申请号：US506707

    申请日：1974-09-17

    Applicant: Helmut Liebl

    Inventor： Helmut Liebl

    IPC: H01J49/00 ,  H01J49/42 ,  H01J39/34

    CPC classification number: H01J49/009 ,  H01J49/06 ,  H01J49/4215 ,  H01J49/48

    Abstract: A mass spectrometry apparatus, a quadrupole field mass analyser, is discld together with a novel method of investigating ions in or for mass spectrometry. The apparatus and method employ multiple-channel quadrupole mass filter devices to which the ions are fed via a relatively large entry aperture afforded preferably by a transverseley-split spherical or cylindrical capacitance analyser arranged in conjunction with a stop aperture device to remove ions having energies which are not within a predetermined energy band. The ions are accelerated into the first half of the capacitance analyser, decelerated to pass into the filter devices, and then reaccelerated to the ion detection device.

    Abstract translation: 公开了一种质谱装置，四极场质量分析仪以及用于质谱法测定离子的新方法。 该装置和方法采用多通道四极质量过滤装置，离子通过相对较大的入口孔被提供给该离子，优选地通过与止动孔装置结合排列的横切分离的球形或圆柱形电容分析器来提供，以去除具有能量 不在预定的能带内。 离子被加速到电容分析仪的前半部分，减速进入过滤装置，然后重新加速到离子检测装置。

    METHOD FOR OPTIMIZING A PARAMETER SETTING OF AT LEAST ONE MASS SPECTROMETRY DEVICE
    65.
    发明公开
    METHOD FOR OPTIMIZING A PARAMETER SETTING OF AT LEAST ONE MASS SPECTROMETRY DEVICE 审中-公开

    公开(公告)号：US20230326729A1

    公开(公告)日：2023-10-12

    申请号：US18333174

    申请日：2023-06-12

    Applicant: Roche Diagnostics Operations, Inc.

    Inventor： Benjamin Tiemann ,  Daniel Intelmann

    IPC: H01J49/00 ,  H01J49/06

    CPC classification number: H01J49/0009 ,  H01J49/063 ,  H01J49/0031 ,  H01J49/009 ,  G01N30/724

    Abstract: A method for optimizing at least one parameter setting of at least one mass spectrometry device (110) operating at unit resolution is disclosed. The method comprises the following steps:



    a) determining at least one analyte detection window for detecting an analyte of interest with the mass spectrometry device (110), wherein the analyte detection window is defined by a central mass to charge ratio value of the analyte and a predefined width, wherein the central mass to charge ratio value of the analyte is set to a theoretical mass to charge ratio value of the analyte of interest having more than one decimal place and/or a mass to charge ratio value of the analyte of interest determined by a high resolution mass spectrometry measurement having more than one decimal place;
    b) determining at least one internal standard detection window for detecting an internal standard substance with the mass spectrometry device (110), wherein the internal standard detection window is defined by a central mass to charge ratio value of the internal standard substance and the pre-defined width, wherein the central mass to charge ratio value of the internal standard substance is set to a mass to charge ratio value of the internal standard substance calculated relative to the analyte of interest and having more than one decimal place and/or to a mass to charge ratio value of the internal standard substance determined by a high resolution mass spectrometry measurement having more than one decimal place.

    Glycopeptide analyzer
    69.
    发明授权
    Glycopeptide analyzer 有权
    糖肽分析仪

    公开(公告)号：US09460903B2

    公开(公告)日：2016-10-04

    申请号：US14553311

    申请日：2014-11-25

    Applicant: SHIMADZU CORPORATION

    Inventor： Masaki Murase

    IPC: H01J49/40 ,  H01J49/16 ,  H01J49/02 ,  H01J49/00 ,  G01N33/68 ,  H01J49/42 ,  C12Q1/68 ,  C40B20/08

    CPC classification number: H01J49/009 ,  C12Q1/6872 ,  C12Q2565/627 ,  C40B20/08 ,  G01N33/6842 ,  G01N33/6851 ,  H01J49/40 ,  H01J49/42 ,  Y10T436/24

    Abstract: The same sample S is analyzed using an ion-trap (IT) mass spectrometer section 11 in which ions are captured in an ion trap before mass spectrometry and a time-of-flight (TOF) mass spectrometer section 12 in which ions generated from the sample are directly subjected to mass spectrometry. A mass spectrum creator 21 creates an IT mass spectrum and a TOF mass spectrum from the measured results. A glycopeptide detector 23 detects fragment ion peaks related to neutral loss of sugars from the IT mass spectrum as well as peaks corresponding to intact molecular ions from the TOF mass spectrum, and furthermore, detects peaks common to the two spectra as glycopeptide ions. A quantitative analyzer 24 determines relative quantities of glycoforms of the glycopeptide based on the TOF mass spectrum. A structural analyzer 25 analyzes the structure of the glycopeptide using the result of an MSn analysis of the sample S.

    Abstract translation: 使用离子捕获（IT）质谱仪部分11分析相同的样品S，其中在质谱法之前的离子阱中捕获离子，并且在飞行时间（TOF）质谱仪部分12中捕获离子，其中从 样品直接进行质谱分析。 质谱产生器21根据测量结果产生IT质谱和TOF质谱。 糖肽检测器23检测与来自IT质谱的糖的中性损失相关的片段离子峰以及对应于来自TOF质谱的完整分子离子的峰，此外，检测作为糖肽离子的两个光谱共有的峰。 定量分析器24基于TOF质谱确定糖肽的糖形成相对量。 结构分析仪25使用样品S的MSn分析结果分析糖肽的结构。

    TIME-OF-FLIGHT MASS SPECTROMETRY USING MULTI-CHANNEL DETECTORS
    70.
    发明申请
    TIME-OF-FLIGHT MASS SPECTROMETRY USING MULTI-CHANNEL DETECTORS 有权
    使用多通道探测器的飞行时间质谱

    公开(公告)号：US20160225602A1

    公开(公告)日：2016-08-04

    申请号：US14959795

    申请日：2015-12-04

    Applicant: Agilent Technologies,Inc.

    Inventor： Trygve Ristroph ,  Julia Zaks

    IPC: H01J49/40

    CPC classification number: H01J49/40 ,  H01J49/009

    Abstract: A time-of-flight mass spectrometer (TOF-MS) utilizes a multi-channel ion detector to detect ions traveling in separate flight paths, spatially dispersed along a drift axis and/or a transverse axis, in a flight tube of a TOF analyzer. The ion beams may be dispersed by drift energy, deflection along the drift and/or transverse axis, ion mass, or a combination of two or more of the foregoing. The dispersion may be carried out before, at, or after an ion accelerator of the TOF analyzer. Ion packets may be accelerated into the flight tube at a multi-pulse firing rate. Tandem MS may be implemented on parallel ion beams simultaneously.

    Abstract translation: 飞行时间质谱仪（TOF-MS）利用多通道离子检测器来检测在TOF分析仪的飞行管中沿着漂移轴和/或横向轴线分散的分开的飞行路径中的离子行进 。 离子束可以通过漂移能量分散，沿着漂移和/或横向轴线的偏转，离子质量或上述两种或更多种的组合。 分散体可以在TOF分析仪的离子加速剂之前，之中或之后进行。 离子包可以以多脉冲发射速率加速到飞行管中。 串联MS可以同时在并行离子束上实现。

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