公开(公告)号：US20240255390A1

公开(公告)日：2024-08-01

申请号：US18436198

申请日：2024-02-08

Applicant: Elemental Scientific, Inc.

Inventor： David Diaz ,  Jonathan Hein ,  Kyle W. Uhlmeyer ,  Daniel R. Wiederin ,  Tyler Yost ,  Kevin Wiederin

IPC: G01N1/10 ,  G01N1/00 ,  G01N1/14 ,  G01N35/00 ,  G01N35/10 ,  H01J49/04

CPC classification number: G01N1/10 ,  G01N1/14 ,  G01N35/00732 ,  G01N35/00871 ,  G01N35/1097 ,  H01J49/045 ,  G01N2001/002

Abstract: A system includes an analysis system at a first location and one or more remote sampling systems at a second location remote from the first location. A sampling system can be configured to receive a remote liquid sample. The system also includes a sample transfer line configured to transport gas from the second location to the first location. The sample transfer line is configured to selectively couple with a remote sampling system for supplying a continuous liquid sample segment to the sample transfer line. The system can further include a sample receiving line at the first location. The sample receiving line is configured to selectively couple with the sample transfer line and the analysis system to receive the continuous liquid sample segment and supply the sample to an analysis device.

公开(公告)号：US20230290627A1

公开(公告)日：2023-09-14

申请号：US18121550

申请日：2023-03-14

Applicant: Labcyte, Inc. ,  DH Technologies Development Pte. Ltd.

Inventor： Sammy Datwani ,  Don W. Arnold ,  Lucien P. Ghislain ,  Chang Liu ,  Thomas Covey

IPC: H01J49/04 ,  H01J49/16 ,  H01J49/00 ,  B01L3/02 ,  G01N29/22 ,  G01N29/02

CPC classification number: H01J49/0454 ,  H01J49/0404 ,  H01J49/165 ,  H01J49/0031 ,  B01L3/0268 ,  G01N29/222 ,  G01N29/02 ,  H01J49/045 ,  H01J49/0445 ,  B01L2400/0439 ,  B01L2400/0436

Abstract: A system and method are provided for loading a sample into an analytical instrument using acoustic droplet ejection (“ADE”) in combination with a continuous flow sampling probe. An acoustic droplet ejector is used to eject small droplets of a fluid sample containing an analyte into the sampling tip of a continuous flow sampling probe, where the acoustically ejected droplet combines with a continuous, circulating flow stream of solvent within the flow probe. Fluid circulation within the probe transports the sample through a sample transport capillary to an outlet that directs the analyte away from the probe to an analytical instrument, e.g., a device that detects the presence, concentration quantity, and/or identity of the analyte. When the analytical instrument is a mass spectrometer or other type of device requiring the analyte to be in ionized form, the exiting droplets pass through an ionization region, e.g., an electrospray ion source, prior to entering the mass spectrometer or other analytical instrument. The method employs active flow control and enables real-time kinetic measurements.

公开(公告)号：US20230253198A1

公开(公告)日：2023-08-10

申请号：US18098471

申请日：2023-01-18

Applicant: THE BOARD OF TRUSTEES OF WESTERN MICHICAN UNIVERSITY

Inventor： Andre R. Venter ,  Roshan Javanshad

IPC: H01J49/16 ,  H01J49/04

CPC classification number: H01J49/167 ,  H01J49/045

Abstract: A mass spectrometry device and process may include the use of helium as a nebulizing gas to provide increased signal strength in mass spectrum results. This may be implemented in, for example, ESI-based and/or DESI-based systems and/or processes. The process may be implemented utilizing a unique ionization source and, optionally, other unique components. One or more process parameters may be adjusted to provide increased signal intensity in mass spectrum results.

公开(公告)号：US20230197431A1

公开(公告)日：2023-06-22

申请号：US18109119

申请日：2023-02-13

Applicant: PerkinElmer Health Sciences Canada, Inc.

Inventor： Chady Stephan

IPC: H01J49/10 ,  H01J49/04 ,  H01J49/16 ,  G01N30/72 ,  G01N21/73

CPC classification number: H01J49/105 ,  H01J49/045 ,  H01J49/049 ,  H01J49/107 ,  H01J49/167 ,  G01N30/7273 ,  G01N21/73

Abstract: Systems and methods for use in introducing samples to an analytical device for single particle compositional analysis. Suitable analytical devices include, for example, an inductively coupled plasma-optical emission spectrometer. Prior to introduction to the analytical device, the sample gas is exchanged with argon gas, for example, using a gas exchange device. The analytical device may be calibrated with a liquid sample which is aerosolized prior to entry into the analytical device.

公开(公告)号：US11648574B2

公开(公告)日：2023-05-16

申请号：US16611334

申请日：2018-04-24

Applicant: SUMCO CORPORATION

Inventor： Taisuke Mizuno ,  Kazumi Inagaki ,  Shin-ichiro Fujii

IPC: B05B7/24 ,  H01J49/04 ,  H01J49/10

CPC classification number: B05B7/2408 ,  B05B7/2497 ,  H01J49/045 ,  H01J49/0445 ,  H01J49/105 ,  B05B7/2424

Abstract: Provided is a spray chamber including a sample introduction port portion into which a gas flow containing sample droplets that have been atomized by a nebulizer is introduced, a discharge port portion that discharges at least a part of the gas flow introduced into the sample introduction port portion to the outside, and a flow passage tube portion that has the sample introduction port portion on one end portion thereof and the discharge port portion on the other end portion thereof and serves as a flow passage for the introduced gas flow, wherein the flow passage tube portion includes a first tube portion having the discharge port portion on one end portion thereof and a second tube portion having the sample introduction port portion on one end portion thereof, the spray chamber includes a double tube portion.

公开(公告)号：US20190011406A1

公开(公告)日：2019-01-10

申请号：US15763951

申请日：2015-09-29

Applicant: SHIMADZU CORPORATION

Inventor： Kazuma MAEDA

IPC: G01N30/72 ,  H01J49/04

CPC classification number: G01N30/7266 ,  G01N27/62 ,  H01J49/0409 ,  H01J49/0445 ,  H01J49/045 ,  H01J49/165

Abstract: A liquid sample introduction system for an ion source which ionizes a liquid sample by supplying the liquid sample to an ionization probe in an ion source and blowing an atomization-promoting gas at the liquid sample exiting from the tip of the ionization probe, the system including: a hermetically closable liquid sample container for holding a liquid sample; a liquid-supply-gas passage having one end connected to a point in a passage for an atomization-promoting gas leading to the ion source, and the other end connected to a space above a liquid level in the liquid sample container; a sample supply passage having one end connected to a space below the liquid level in the liquid sample container and the other end connected to the ionization probe; and a passage-switching unit in the sample supply passage for switching the sample supply passage between the communicating state and the closed state.

公开(公告)号：US09870904B2

公开(公告)日：2018-01-16

申请号：US15104638

申请日：2014-10-31

Applicant: DH Technologies Development PTE Ltd.

Inventor： Thomas R Covey ,  Peter Kovarik

IPC: H01J49/00 ,  H01J49/04 ,  H01J49/16 ,  G01N30/72

CPC classification number: H01J49/045 ,  G01N30/724 ,  G01N30/7246 ,  G01N30/7273 ,  H01J49/0404 ,  H01J49/044 ,  H01J49/0468 ,  H01J49/167

Abstract: Systems and methods for delivering a sample to a mass spectrometer are provided. In one aspect, the systems and methods can provide efficient cooling of an ion source probe to prevent overheating and the resulting degradation in ion sampling. In some aspects, such cooling can result in improved consistency and/or efficiency of ion formation. Moreover, ion source cooling in accordance with various aspects of the present teachings can allow for the use of higher temperatures in the ionization chamber (thereby improving desolvation) and/or can enable the use of lower flow rate sample sources than with conventional techniques.

公开(公告)号：US20170178884A1

公开(公告)日：2017-06-22

申请号：US15372112

申请日：2016-12-07

Applicant: Thermo Fisher Scientific (Bremen) GmbH

Inventor： Ayrat MURTAZIN

IPC: H01J49/04 ,  G01J3/02 ,  G01J3/443

CPC classification number: H01J49/045 ,  G01J3/0267 ,  G01J3/443 ,  H01J49/0409 ,  H01J49/0454

Abstract: A liquid sample introduction system for a plasma spectrometer includes a sample container for holding a liquid sample, a surface acoustic wave (SAW) nebulizer, arranged to receive a liquid sample from the sample container, an electronic controller for supplying electrical power to the SAW nebulizer so as to produce a surface acoustic wave on a surface of the SAW nebulizer, for generating an aerosol from the supplied sample liquid, and an aerosol transport arrangement for receiving the aerosol from the SAW nebulizer and carrying it into a plasma or flame of a spectrometer. The electronic controller is further configured to control the electrical power to the SAW nebulizer so as to permit adjustment of the aerosol parameters, and to control the aerosol transport arrangement so as to permit adjustment of the aerosol delivery into the plasma or flame of the spectrometer.

公开(公告)号：US20170160233A1

公开(公告)日：2017-06-08

申请号：US15322389

申请日：2015-07-21

Applicant: IAS Inc. ,  Shin-Etsu Handotai Co., Ltd.

Inventor： Katsuhiko Kawabata ,  Tatsuya Ichinose ,  Toshihiko Shirakawa R&D Center Imai

IPC: G01N27/62 ,  G01N1/28 ,  G01N35/10

CPC classification number: G01N27/62 ,  B01L3/0203 ,  B01L3/0293 ,  B01L2400/022 ,  G01N1/00 ,  G01N1/28 ,  G01N1/32 ,  G01N35/10 ,  G01N35/1002 ,  G01N35/1016 ,  G01N35/1095 ,  H01J49/045 ,  H01J49/105

Abstract: An object of the present invention is to provide an analysis apparatus in which local analysis of a substrate with ICP-MS is automated. The present invention relates to an automatic analysis apparatus for a local region of a substrate, including: a nozzle for local analysis having: analysis-liquid supply means that ejects analysis liquid onto a substrate; analysis-liquid discharge means that takes the analysis liquid including an object to be analyzed from the substrate into the nozzle to feed the analysis liquid to a nebulizer; and exhaust means including an exhaust channel in the nozzle; automatic liquid-feed means that automatically feeds the collected analysis liquid to ICP-MS; flow adjustment means that adjusts the flow of the analysis liquid; and automatic control means that simultaneously performs local analysis and analysis of the object to be analyzed with the ICP-MS to perform automatic analysis to a plurality of adjacent predetermined regions, successively.

公开(公告)号：US20170084438A1

公开(公告)日：2017-03-23

申请号：US15355501

申请日：2016-11-18

Applicant: Purdue Research Foundation

Inventor： Robert Graham Cooks ,  Jason Duncan ,  Guangming Huang ,  Guangtao Li ,  Xin Yan ,  Ewa Sokol ,  Xin Li

IPC: H01J49/04 ,  H01J49/00

CPC classification number: H01J49/045 ,  G01N27/62 ,  H01J49/0018 ,  H01J49/0445 ,  Y10T436/24

Abstract: The invention generally relates to methods and devices for synchronization of ion generation with cycling of a discontinuous atmospheric interface. In certain embodiments, the invention provides a system for analyzing a sample that includes a mass spectrometry probe that generates sample ions, a discontinuous atmospheric interface, and a mass analyzer, in which the system is configured such that ion formation is synchronized with cycling of the discontinuous atmospheric interface.