公开(公告)号：AU2011242454A1

公开(公告)日：2012-11-08

申请号：AU2011242454

申请日：2011-04-22

Applicant: VERTEX PHARMA

Inventor： VAN GOOR FREDRICK F ,  ALARGOVA ROSSITZA GUEORGUIEVA ,  ALCACIO TIM EDWARD ,  AREKAR SNEHA G ,  BINCH HAYLEY MARIE ,  BOTFIELD MARTYN CURTIS ,  FANNING LEV TYLER DEWEY ,  GROOTENHUIS PETER DIEDERIK JAN ,  HURLEY DENNIS JAMES ,  JOHNSTON STEVEN C ,  KADIYALA IRINA NIKOLAEVNA ,  KAUSHIK RITU ROHIT ,  KESHAVARZ-SHOKRI ALI ,  KRAWIEC MARIUSZ ,  LEE ELAINE CHUNGMIN ,  LUISI BRIAN ,  MEDEK ALES ,  MUDUNURI PRAVEEN ,  NUMA MEHDI ,  SHETH URVI JAGDISHBHAI ,  SILINA ALINA ,  SULLIVAN MARK JEFFREY ,  VERWIJS MARINUS JACOBUS ,  YANG XIAOQING ,  YOUNG CHRISTOPHER RYAN ,  ZAMAN NOREEN TASNEEM ,  ZHANG BEILI ,  ZHANG YUEGANG ,  ZLOKARNIK GREGOR

IPC: A61K31/4704 ,  A61K31/404 ,  A61K31/443

Abstract: The present invention relates to pharmaceutical compositions comprising a compound of Formulas I and II, optionally in combination with a Compound of Formula III and/or a Compound of Formula IV. The invention also relates to solid forms and to pharmaceutical formulations thereof, and to methods of using such compositions in the treatment of CFTR mediated diseases, particularly cystic fibrosis.

公开(公告)号：AU2010327993A8

公开(公告)日：2012-07-19

申请号：AU2010327993

申请日：2010-12-10

Applicant: VERTEX PHARMA

Inventor： SHETH URVI ,  FANNING LEV T D ,  NUMA MEHDI ,  BINCH HAYLEY ,  HURLEY DENNIS JAMES ,  ZHOU JINGLAN ,  HADIDA RUAH SARA S ,  HAZLEWOOD ANNA R ,  SILINA ALINA ,  VAIRAGOUNDAR RAJENDRAN ,  VAN GOOR FREDRICK F ,  GROOTENHUIS PETER DIEDERIK JAN ,  BOTFIELD MARTYN C

IPC: C07D215/56 ,  A61K31/4709 ,  A61P11/00 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D471/08

Abstract: The present invention relates to 4 -oxo- lH-quinoline- 3 carboxamides as modulators of ATP -Binding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present Invention also relates to methods of treating ABC transporter mediated diseases using such modulators.

公开(公告)号：CA2796602A1

公开(公告)日：2011-10-27

申请号：CA2796602

申请日：2011-04-22

Applicant: VERTEX PHARMA

Inventor： VAN GOOR FREDRICK F ,  ALARGOVA ROSSITZA GUEORGUIEVA ,  ALCACIO TIM EDWARD ,  AREKAR SNEHA G ,  BINCH HAYLEY MARIE ,  BOTFIELD MARTYN CURTIS ,  FANNING LEV TYLER DEWEY ,  GROOTENHUIS PETER DIEDERIK JAN ,  HURLEY DENNIS JAMES ,  JOHNSTON STEVEN C ,  KADIYALA IRINA NIKOLAEVNA ,  KAUSHIK RITU ROHIT ,  KESHAVARZ-SHOKRI ALI ,  KRAWIEC MARIUSZ ,  LEE ELAINE CHUNGMIN ,  LUISI BRIAN ,  MEDEK ALES ,  MUDUNURI PRAVEEN ,  NUMA MEHDI ,  SHETH URVI JAGDISHBHAI ,  SILINA ALINA ,  SULLIVAN MARK JEFFREY ,  VERWIJS MARINUS JACOBUS ,  YANG XIAOQING ,  YOUNG CHRISTOPHER RYAN ,  ZAMAN NOREEN TASNEEM ,  ZHANG BEILI ,  ZHANG YUEGANG ,  ZLOKARNIK GREGOR

IPC: A61K31/4704 ,  A61K31/404 ,  A61K31/443

Abstract: The present invention relates to pharmaceutical compositions comprising a compound of Formulas I and II, optionally in combination with a Compound of Formula III and/or a Compound of Formula IV. The invention also relates to solid forms and to pharmaceutical formulations thereof, and to methods of using such compositions in the treatment of CFTR mediated diseases, particularly cystic fibrosis.

公开(公告)号：AU2009308284A1

公开(公告)日：2010-04-29

申请号：AU2009308284

申请日：2009-10-23

Applicant: VERTEX PHARMA

Inventor： BINCH HAYLEY ,  FANNING LEV T D ,  HURLEY DENNIS ,  SHETH URVI ,  SILINA ALINA ,  YANG XIAOQING ,  BOTFIELD MARTYN ,  GROOTENHUIS PETER D J ,  GOOR FREDRICK VAN ,  NUMA MEHDI MICHEL DJAMEL

IPC: C07D451/02 ,  A61K31/439 ,  A61P11/00 ,  C07D453/04 ,  C12Q1/02

Abstract: The present invention relates to modulators of cystic fibrosis transmembrane conductance regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating diseases using modulators of CFTR.

公开(公告)号：CA2634456A1

公开(公告)日：2007-07-05

申请号：CA2634456

申请日：2006-12-22

Applicant: VERTEX PHARMA

Inventor： TERMIN ANDREAS P ,  SILINA ALINA ,  MAKINGS LEWIS R ,  NAKATANI AKIKO ,  GARCIA-GUZMAN BLANCO MIGUEL ,  BERGERON DANIELE M ,  HURLEY DENNIS J ,  DRUTU IOANA ,  RAFFAI GABRIEL

IPC: A61K31/435 ,  A61K31/438 ,  A61K31/4545 ,  A61K31/46 ,  A61K31/497 ,  A61K31/498 ,  A61K31/501 ,  A61K31/506 ,  A61P25/00 ,  A61P43/00 ,  C07D471/00 ,  C07D471/10

Abstract: The present invention relates to spiro compounds of formula XX as modulators of muscarinic receptors, wherein R1, R2, R3, Z1, Z2, L, G, n, m, t and p are defined herein. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.

公开(公告)号：AU2006330866A1

公开(公告)日：2007-07-05

申请号：AU2006330866

申请日：2006-12-22

Applicant: VERTEX PHARMA

Inventor： DRUTU IOANA ,  HURLEY DENNIS J ,  BLANCO MIGUEL GARCIA-GUZMAN ,  MAKINGS LEWIS R ,  NAKATANI AKIKO ,  SILINA ALINA ,  RAFFAI GABRIEL ,  TERMIN ANDREAS P ,  BERGERON DANIELE M

IPC: A61K31/435 ,  A61K31/438 ,  A61K31/4545 ,  A61K31/46 ,  A61K31/497 ,  A61K31/498 ,  A61K31/501 ,  A61K31/506 ,  A61P25/00 ,  A61P43/00 ,  C07D471/00 ,  C07D471/10

Abstract: The present invention relates to spiro compounds of formula XX as modulators of muscarinic receptors, wherein R1, R2, R3, Z1, Z2, L, G, n, m, t and p are defined herein. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.

公开(公告)号：CA2577677A1

公开(公告)日：2006-03-02

申请号：CA2577677

申请日：2005-08-19

Applicant: VERTEX PHARMA

Inventor： TERMIN ANDREAS P ,  SILINA ALINA ,  NAKATANI AKIKO ,  BERGERON DANIELE M ,  DRUTU IOANA ,  RAFFAI GABRIEL ,  HURLEY DENNIS J ,  GARCIA-GUZMAN BLANCO MIGUEL ,  MAKINGS LEWIS R

IPC: A61K31/435 ,  A61K31/438 ,  A61P25/00 ,  A61P43/00 ,  C07D471/00

Abstract: The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith or treating muscarinic receptor mediated diseases.

公开(公告)号：MD3946595T2

公开(公告)日：2024-05-31

申请号：MDE20220156

申请日：2020-04-02

Applicant: VERTEX PHARMA

Inventor： ISHIHARA YOSHIHIRO ,  KRENITSKY PAUL ,  HADIDA RUAH SARA SABINA ,  MCCARTNEY JASON ,  MELILLO VITO ,  MILLER MARK THOMAS ,  SILINA ALINA ,  UY JOHNNY ,  ZHOU JINGLAN

IPC: A61P11/00 ,  C07D239/69 ,  C07D515/08

Abstract: Sunt divulgaţi Compusul I, derivaţi deuteraţi, şi săruri acceptabile farmaceutic ale oricărora din cele anterioare. Sunt de asemenea divulgate metode de tratament a fibrozei chistice care utilizează aceşti compuşi.

公开(公告)号：PL3946595T3

公开(公告)日：2024-03-25

申请号：PL20722087

申请日：2020-04-02

Applicant: VERTEX PHARMA

Inventor： HADIDA RUAH SARA SABINA ,  ISHIHARA YOSHIHIRO ,  KRENITSKY PAUL ,  MCCARTNEY JASON ,  MELILLO VITO ,  MILLER MARK THOMAS ,  SILINA ALINA ,  UY JOHNNY ,  ZHOU JINGLAN

IPC: A61P11/00 ,  C07D239/69 ,  C07D515/08

公开(公告)号：MA55533B1

公开(公告)日：2023-11-30

申请号：MA55533

申请日：2020-04-02

Applicant: VERTEX PHARMA

Inventor： MILLER MARK THOMAS ,  MELILLO VITO ,  MCCARTNEY JASON ,  SILINA ALINA ,  UY JOHNNY ,  ZHOU JINGLAN ,  HADIDA RUAH SARA SABINA ,  ISHIHARA YOSHIHIRO ,  KRENITSKY PAUL

IPC: A61P11/00 ,  C07D239/69 ,  C07D515/08

Abstract: L'invention concerne un composé (i), des dérivés deutérés et des sels pharmaceutiquement acceptables de l'un quelconque de ceux-ci. L'invention concerne également des procédés de traitement de la fibrose kystique à l'aide de ces composés.