-
公开(公告)号：CA2760155A1
公开(公告)日：2010-11-11
申请号：CA2760155
申请日：2010-04-26
Applicant: PACIFIC BIOSCIENCES CALIFORNIA
Inventor： KORLACH JONAS , TURNER STEPHEN , SCHADT ERIC
Abstract: The present invention is generally directed to compositions, methods, and systems for performing single-molecule, real-time analysis of a variety of different biological reactions. The ability to analyze such reactions provides an opportunity to study those reactions as well as to potentially identify factors and/or approaches for impacting such reactions, e.g., to either enhance or inhibit such reactions. In certain preferred embodiments, RNA templates are used in single-molecule real-time sequencing reactions.
-
公开(公告)号：CA2746632A1
公开(公告)日：2010-06-17
申请号：CA2746632
申请日：2009-12-10
Applicant: PACIFIC BIOSCIENCES CALIFORNIA
Inventor： FLUSBERG BENJAMIN , TURNER STEPHEN , LEE JESSICA , JIA LEI , KORLACH JONAS , SORENSON JON , WEBSTER DALE , LYLE JOHN , TRAVERS KEVIN , HANES JEREMIAH
Abstract: Methods, compositions, and systems are provided for characterization of modified nucleic acids. In certain preferred embodiments, single molecule sequencing methods are provided for identification of modified nucleotides within nucleic acid sequences. Modifications detectable by the methods provided herein include chemically modified bases, enzymatically modified bases, abasic sites, non-natural bases, secondary structures, and agents bound to a template nucleic acid.
-
公开(公告)号：CA2719747A1
公开(公告)日：2009-10-01
申请号：CA2719747
申请日：2009-03-27
Applicant: PACIFIC BIOSCIENCES CALIFORNIA
Inventor： TRAVERS KEVIN , OTTO GEOFF , TURNER STEPHEN , HEINER CHERYL , MA CONGCONG
IPC: C12Q1/68
Abstract: Compositions and methods for nucleic acid sequencing include template constructs that comprise double stranded portions in a partially or completely contiguous constructs, to provide for redundant sequence determination through one or both of sequencing sense and antisense strands, and iteratively sequencing the entire construct multiple times. Additional sequence components are also optionally included within such template constructs. Methods are also provided for the use and preparation of these constructs as well as sequencing compositions for their application.
-
公开(公告)号：AU2008282862A1
公开(公告)日：2009-02-05
申请号：AU2008282862
申请日：2008-07-25
Applicant: PACIFIC BIOSCIENCES CALIFORNIA
Inventor： CHRISTIANS FRED , TURNER STEPHEN
-
公开(公告)号：AU2008251861A1
公开(公告)日：2008-11-20
申请号：AU2008251861
申请日：2008-05-09
Applicant: PACIFIC BIOSCIENCES CALIFORNIA
Inventor： TURNER STEPHEN , ZHAO PEGIAN , ZHONG CHENG-FRANK , LUNDQUIST PAUL , ZACCARIN DENIS
-
Patent Agency Ranking
公开(公告)号：AU2006331677A1
公开(公告)日：2007-07-05
申请号：AU2006331677
申请日：2006-12-21
Applicant: PACIFIC BIOSCIENCES CALIFORNIA INC
Inventor： RANK DAVID , KORLACH JONAS , HANZEL DAVID , PHAM THANG , OTTO GEOFF , TURNER STEPHEN , PELUSO PAUL
-
公开(公告)号：AU2006331512A1
公开(公告)日：2007-07-05
申请号：AU2006331512
申请日：2006-12-21
Applicant: PACIFIC BIOSCIENCES CALIFORNIA
Inventor： KORLACH JONAS , OTTO GEOFFREY , HANZEL DAVID , PELUSO PAUL , TURNER STEPHEN , RANK DAVID , PHAM THANG
Abstract: Active surface coupled polymerases, surfaces that include such polymerases, and methods of making and using surface-attached polymerases are provided.
-
公开(公告)号：CA2642937A1
公开(公告)日：2007-06-07
申请号：CA2642937
申请日：2006-12-01
Applicant: PACIFIC BIOSCIENCES CALIFORNIA
Inventor： EID JOHN , OTTO GEOFFREY , MURPHY DEVON , TURNER STEPHEN
Abstract: Compositions, devices, systems and methods for reducing and/or preventing photodamage of one or more reactants in illuminated analytical reactions by one or more of incorporating photodamage mitigating agents within the reaction mixture and/or interrogating different observation regions of the reaction mixture for a period that is less than a photodamage threshold period.
-
公开(公告)号：CA2616439A1
公开(公告)日：2007-02-15
申请号：CA2616439
申请日：2006-08-10
Applicant: PACIFIC BIOSCIENCES CALIFORNIA
Inventor： LUNDQUIST PAUL , TURNER STEPHEN , ZACCARIN DENIS
Abstract: Methods and systems for monitoring a plurality of different optical signals from a single source of such signals, where each such different optical sign al is spatially separated from other such signals and directed to different detectors or locations upon a single detector, which direction is generally accomplished through the use of a small number of optical components and/or manipulations.
-
公开(公告)号：GB2423819A
公开(公告)日：2006-09-06
申请号：GB0608338
申请日：2005-09-16
Applicant: PACIFIC BIOSCIENCES CALIFORNIA
Inventor： TURNER STEPHEN , KORLACH JONAS
Abstract: The present invention relates to optical confinements, method of preparing and methods of using them for analyzing molecules and/or monitoring chemical reactions. The apparatus and methods embodied in the present invention are particularly useful for high-throughput and low-cost single-molecular analysis.
-
-
-
-
-
-
-
-
-
Search Results
146
records
(took 0.026 seconds)
