中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

160 records (took 0.044 seconds)

    페닐테트라졸 유도체 또는 이의 약학적으로 허용가능한 염을 유효성분으로 포함하는 골다공증 또는 비만의 예방 또는 치료용 약학적 조성물
    124.
    发明公开
    페닐테트라졸 유도체 또는 이의 약학적으로 허용가능한 염을 유효성분으로 포함하는 골다공증 또는 비만의 예방 또는 치료용 약학적 조성물 失效
    用于预防或治疗包含苯并噻唑衍生物的药物或药物的药物组合物或其作为活性成分的药物可接受的盐

    公开(公告)号：KR1020100130139A

    公开(公告)日：2010-12-10

    申请号：KR1020090121291

    申请日：2009-12-08

    Applicant: 한국화학연구원

    Inventor： 김낙정 ,  배명애 ,  유성은 ,  강남숙 ,  허정녕 ,  이규양 ,  서지희 ,  장성연 ,  황은숙 ,  홍정호

    IPC: C07D487/04 ,  A61K31/437 ,  A61P19/08 ,  A61P3/04

    Abstract: PURPOSE: A pharmaceutical composition containing phenyltetrazole derivatives for preventing or treating osteoporosis, obesity, diabetes or hyperlipidemia is provided to control TAZ(transcriptional coactivator with PDZbinding motif) protein. CONSTITUTION: A pharmaceutical composition for preventing or treating osteoporosis contains a compound of chemical formula 1 or pharmaceutically acceptable salt thereof as an active ingredient. A pharmaceutical composition for preventing or treating obesity, diabetes or hyperlipidemia contains the compound of chemical formula 1 or pharmaceutically acceptable salt thereof as an active ingredient. The compound is phenyltetrazole derivatives.

    Abstract translation: 目的：提供含有苯基四唑衍生物用于预防或治疗骨质疏松症，肥胖症，糖尿病或高脂血症的药物组合物以控制TAZ（具有PDZ结合基序的转录共激活物）蛋白质。 构成：用于预防或治疗骨质疏松症的药物组合物含有化学式1的化合物或其药学上可接受的盐作为活性成分。 用于预防或治疗肥胖症，糖尿病或高脂血症的药物组合物含有化学式1的化合物或其药学上可接受的盐作为活性成分。 该化合物是苯基四唑衍生物。

    아마이드로 치환된 벤조퓨란 및 벤조싸이오펜 유도체, 이의제조 방법 및 이를 포함하는 약학적 조성물
    127.
    发明公开
    아마이드로 치환된 벤조퓨란 및 벤조싸이오펜 유도체, 이의제조 방법 및 이를 포함하는 약학적 조성물 失效
    酰胺取代的苯并呋喃衍生物及其制备方法以及含有它们的药物组合物

    公开(公告)号：KR1020090037744A

    公开(公告)日：2009-04-16

    申请号：KR1020070103244

    申请日：2007-10-12

    Applicant: 한국화학연구원

    Inventor： 서지희 ,  유성은 ,  이규양 ,  김낙정 ,  김은희 ,  정용삼 ,  이윤숙 ,  서해영

    IPC: C07D307/85 ,  C07D405/12 ,  C07D491/048 ,  C07D413/04

    CPC classification number: C07D307/85 ,  C07D333/70 ,  C07D401/12 ,  C07D409/12 ,  C07D413/04 ,  C07D491/048 ,  C07D495/04

    Abstract: Benzofuran and bezothiophene derivatives substituted with amide, a preparation process thereof, and a pharmaceutical composition containing the same are provided to prevent and treat ischemic diseases such as cerebral ischemia mediated by ischemic cell death. Benzofuran and bezothiophene derivatives substituted with amide are represented by the chemical formula 1. The benzofuran and bezothiophene derivatives substituted with amide of the chemical formula 1 is obtained by reacting a compound of the chemical formula 2 and a compound of the chemical formula 3. The benzofuran and bezothiophene derivatives substituted with amide or their pharmaceutically acceptable salts is contained as an active ingredient of a pharmaceutical composition for preventing and treating ischemic diseases.

    Abstract translation: 提供了被酰胺取代的苯并呋喃和噻唑并噻吩衍生物及其制备方法和含有它们的药物组合物，以预防和治疗缺血性疾病如缺血性细胞死亡介导的脑缺血。 由酰胺取代的苯并呋喃和噻唑并噻吩衍生物由化学式1表示。化学式1的被酰胺取代的苯并呋喃和异噻吩衍生物是通过使化学式2的化合物与化学式3的化合物反应得到的。苯并呋喃 作为预防和治疗缺血性疾病的药物组合物的活性成分，含有被酰胺取代的噻唑并噻吩衍生物或其药学上可接受的盐。

    아릴 피페리딘기-함유 이미다졸 유도체, 이의 제조방법 및이를 유효성분으로 포함하는 약학적 조성물
    128.
    发明公开
    아릴 피페리딘기-함유 이미다졸 유도체, 이의 제조방법 및이를 유효성분으로 포함하는 약학적 조성물 失效
    具有芳基哌啶取代基的咪唑衍生物，其制备方法和含有它们的药物组合物

    公开(公告)号：KR1020080100022A

    公开(公告)日：2008-11-14

    申请号：KR1020070046064

    申请日：2007-05-11

    Applicant: 한국화학연구원

    Inventor： 김낙정 ,  유성은 ,  이규양 ,  서지희 ,  이병호 ,  오광석 ,  천혜경 ,  이상달 ,  정원훈

    IPC: C07D401/06 ,  C07D471/04 ,  A61K31/454

    Abstract: An imidazol derivative having an aryl piperidine substituent is provided to prevent and cure diseases relating to MCH by acting on an antagonist to a melanin-concentrating hormone receptor. An imidazole derivative or a salt pharmaceutically allowable is indicated as a chemical formula 1. In the chemical formula 1: R1 is a group 1 or a group 2; X is H, halogen, OR4, C1~C4 of straight-chain or side chain alkyl, CF3, phenyl, CN, NO2, -CO2R5 or -CONR6R7; R4, R5, R6 and R7 are independently H, halogen, C1~C3 of straight-chain or side chain alkyl or phenyl; R2 is H, halogen, C1~C3 of straight-chain or side chain alkyl, phenyl, OR4, NO2, CN, pyridyl or -CONR6R7; R3 is C1~C3 of straight-chain or side chain alkyl and phenyl substituted into halogen or methyl; A is CH or N; and n is an integer of 2 - 5.

    Abstract translation: 提供具有芳基哌啶取代基的咪唑衍生物，以通过作用于黑色素浓缩激素受体的拮抗剂来预防和治愈与MCH相关的疾病。 咪唑衍生物或药学上允许的盐表示为化学式1.在化学式1中：R1是1或2组; X是直链或侧链烷基，CF 3，苯基，CN，NO 2，-CO 2 R 5或-CONR 6 R 7的H，卤素，OR 4，C 1 -C 4; R4，R5，R6和R7独立地为H，卤素，C1-C3直链或侧链烷基或苯基; R2是H，卤素，C1-C3直链或侧链烷基，苯基，OR4，NO2，CN，吡啶基或-CONR6R7; R3是直链或侧链烷基的C1〜C3，被卤素或甲基取代的苯基; A是CH或N; n为2〜5的整数。

    아미노싸이오펜 유도체를 함유하는 허혈성 질환의 예방또는 치료용 조성물
    129.
    发明授权
    아미노싸이오펜 유도체를 함유하는 허혈성 질환의 예방또는 치료용 조성물 失效
    用于预防或治疗含有氨基胆碱衍生物的化学疾病的组合物

    公开(公告)号：KR100860539B1

    公开(公告)日：2008-09-26

    申请号：KR1020070045992

    申请日：2007-05-11

    Applicant: 한국화학연구원

    Inventor： 서지희 ,  유성은 ,  이규양 ,  김낙정 ,  김은희 ,  정용삼 ,  이윤숙 ,  서해영

    IPC: A61K31/381 ,  A61P9/10

    CPC classification number: A61K31/381

    Abstract: An aminothiophene derivative is provided to decrease ischemic apoptosis, thereby being used as a composition for preventing and treating ischemic diseases mediated by the ischemic apoptosis or for protecting organs. A composition for preventing or treating ischemic diseases comprises an aminothiophene derivative represented by a formula(1) or (2), or a pharmaceutically acceptable salt thereof as an effective ingredient, wherein the ischemic disease is cerebral ischemia, cardiac ischemia, diabetic cardiovascular diseases, cardiac failure, cardiac hypertrophy, retinal ischemia, ischemic colitis, ischemic acute renal failure, stroke, cerebral wound, Alzheimer's disease, Parkinson's disease, hypoxia in newborn, glaucoma and diabetic neuropathy. In the formulae, R^1 is H, CO2R^2, CH2OR^2, CONR^2R^3, or a group(1); each R^2 and R^3 is independently H, or C1-6 linear or branched alkyl, or halogen or hydroxy substituted alkyl; B is H, phenyl, or C1-3 alkyl or halogen substituted phenyl; n is an integer from 0 to 2; Y is S, O, SO or SO2; Z is H, halogen, NO2, NH2, C1-3 linear or branched alkyl or OR^4; R^4 is H or C1-3 linear or branched alkyl; and A is CH, N or N-O. Further, the ischemic diseases are selected from cerebral ischemic damage, Ischemic Heart Failure, cardiac failure, retinal ischemia or Alzheimer's disease.

    Abstract translation: 提供氨基噻吩衍生物以减少缺血性细胞凋亡，从而用作预防和治疗由缺血性细胞凋亡或保护器官介导的缺血性疾病的组合物。 用于预防或治疗缺血性疾病的组合物包含由式（1）或（2）表示的氨基噻吩衍生物或其药学上可接受的盐作为有效成分，其中缺血性疾病是脑缺血，心脏缺血，糖尿病心血管疾病， 心脏衰竭，心脏肥大，视网膜缺血，缺血性结肠炎，缺血性急性肾衰竭，中风，脑伤，阿尔茨海默病，帕金森病，新生儿缺氧，青光眼和糖尿病性神经病变。 在式中，R 1是H，CO 2 R 2，CH 2 OR 2，CONR 2 R 3，或基团（1）; 每个R 2和R 3独立地是H或C 1-6直链或支链烷基，或卤素或羟基取代的烷基; B是H，苯基或C 1-3烷基或卤素取代的苯基; n为0〜2的整数; Y是S，O，SO或SO2; Z是H，卤素，NO 2，NH 2，C 1-3直链或支链烷基或OR 4; R 4是H或C 1-3直链或支链烷基; A是CH，N或N-O。 此外，缺血性疾病选自脑缺血性损伤，缺血性心力衰竭，心力衰竭，视网膜缺血或阿尔茨海默病。

    신규한 1-[1-(3,4-디알콕시아릴)-피리딜메틸]-1Ｈ-피라졸화합물, 이의 제조방법 및 이를 포함하는 약제학적 조성물
    130.
    发明授权
    신규한 1-[1-(3,4-디알콕시아릴)-피리딜메틸]-1Ｈ-피라졸화합물, 이의 제조방법 및 이를 포함하는 약제학적 조성물 失效
    1- [1-（3,4-二甲氧基乙基） - 吡咯烷基] -1H-吡唑化合物，其制备方法和包含该化合物的药物组合物

    公开(公告)号：KR100833799B1

    公开(公告)日：2008-05-30

    申请号：KR1020070002725

    申请日：2007-01-10

    Applicant: 한국화학연구원

    Inventor： 전동주 ,  노재성 ,  송종환 ,  이계형 ,  김익연 ,  박창민 ,  소원영 ,  이지선 ,  김은주 ,  강남숙 ,  천혜경 ,  조영식 ,  송진숙 ,  배명애 ,  김지현 ,  조중명 ,  노성구 ,  현영란 ,  이철순 ,  이재일 ,  유성은

    IPC: C07D401/06 ,  C07D413/14

    Abstract: 1-[1-(3,4-Dialkoxyaryl)-pyridylmethyl]-1H-pyrazole compounds are provided to inhibit activity of PDE-4(phosphodiesterase-4) with high activity and selectivity without side effects, so that the compounds are useful for treating inflammation diseases, neurodegenerative disease and cancers. 1-[1-(3,4-Dialkoxyaryl)-pyridylmethyl]-1H-pyrazole compounds represented by the formula(1) are provided, wherein A is N or CH; R1 is linear or branched, saturated or unsaturated (C1-C7)alkyl or halogen-substituted linear or branched, saturated or unsaturated (C1-C7)alkyl; R2 is hydrogen atom, (C3-C7)cycloalkyl or (C3-C8)cycloalkylmethyl; R3, R4 and R5 are each independently hydrogen atom, phenyl, pyridinyl, N-oxypyridinyl, linear or branched, saturated or unsaturated (C1-C7)alkyl, (C3-C7)cycloalkyl, (C3-C10)cycloalkyl(C1-C7)alkyl, halogen atom, cyano, nitro, amino, mono- or di(C1-C7)alkylamino, mono- or di(C1-C7)alkylaminocarbonyl, (C3-C7)cycloalkylamino, 3- to 7-membered saturated or unsaturated hetero ring containing oxygen, nitrogen or sulfur in hetero ring, guanidinyl, ureido, benzyl, benzyloxy, formyl, (C1-C7)alkanoyl, (C1-C7)alkoxy, (C1-C7)alkoxy(C1-C7)alkyl, hydroxy(C1-C7)alkyl, carboxyl or (C1-C7)alkoxycarbonyl; and R6 is pyridinyl or N-oxypyridinyl group.

    Abstract translation: 提供1- [1-（3,4-二烷氧基芳基） - 吡啶基甲基] -1H-吡唑化合物以抑制具有高活性和选择性的PDE-4（磷酸二酯酶-4）的活性而没有副作用，使得该化合物可用于 治疗炎症疾病，神经退行性疾病和癌症。 提供由式（1）表示的1- [1-（3,4-二烷氧基芳基） - 吡啶基甲基] -1H-吡唑化合物，其中A是N或CH; R1是直链或支链饱和或不饱和（C1-C7）烷基或卤素取代的直链或支链饱和或不饱和（C1-C7）烷基; R2是氢原子，（C3-C7）环烷基或（C3-C8）环烷基甲基; R 3，R 4和R 5各自独立地为氢原子，苯基，吡啶基，N-氧代吡啶基，直链或支链，饱和或不饱和的（C1-C7）烷基，（C3-C7）环烷基，（C3-C10）环烷基 ）（C 1 -C 7）烷基氨基羰基，（C 3 -C 7）环烷基氨基，3至7元饱和或不饱和的（C 1 -C 7）烷基氨基， 杂环中含氧，氮或硫的杂环，胍基，脲基，苄基，苄氧基，甲酰基，（C1-C7）烷酰基，（C1-C7）烷氧基，（C1-C7）烷氧基（C1-C7） （C 1 -C 7）烷基，羧基或（C 1 -C 7）烷氧基羰基; R6是吡啶基或N-氧代吡啶基。

Patent Agency Ranking