公开(公告)号：ZA201203502B

公开(公告)日：2013-01-30

申请号：ZA201203502

申请日：2012-05-14

Applicant: ABBOTT LAB

Inventor： DEGOEY DAVID A ,  HUTCHINS CHARLES W ,  KRUEGER ALLAN C ,  MOTTER CHRISTOPHER E ,  PATEL SACHIN V ,  KEDDY RYAN G ,  HUTCHINSON DOUGLAS K ,  WAGNER ROLF ,  TUFANO MICHAEL D ,  ROCKYWAY TODD W ,  PRATT JOHN K ,  WOLLER KEVIN R ,  CALIFANO JEAN C ,  CASPI DANIEL D ,  GAO YI ,  KATI WARREN M ,  DONNER PAMELA L ,  RANDOLPH JOHN T ,  NELSON LISSA T ,  MATULENKO MARK A ,  JINKERSON TAMMIE K ,  FLENTGE CHARLES A ,  MARING CLARENCE J ,  BETEBENNER DAVID A ,  LIU DACHUN ,  SARRIS KATHY ,  WAGAW SEBLE H ,  LI WENKE ,  BELLIZZI MARY E

IPC: A61K20060101 ,  A61P20060101 ,  C07D20060101

Abstract: Compounds effective in inhibiting replication of Hepatitis C virus ("HCV") are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.

公开(公告)号：NZ590128A

公开(公告)日：2012-08-31

申请号：NZ59012805

申请日：2005-06-29

Applicant: ABBOTT LAB

Inventor： DEGOEY DAVID A

IPC: C07F9/09 ,  A61K31/661 ,  A61P35/00

Abstract: Disclosed are phosphor-ester prodrugs having formula (I), (II) or (III) where A is the lopinavir-compound (ii), and the rest of the variables are as disclosed in the specification. Also disclosed are processes for making prodrugs of formula (I); pharmeacutical composistions containing a prodrug having formula (I), (II), or (III) and the use of a prodrug of formula (I), (II) or (III) in the preparation of a medicament for inhibiting HIV protease, for treating HIV infection, for improving the pharmacokinetics of a drug or for increasing human blood levels of a drug.

公开(公告)号：HRP20110809T1

公开(公告)日：2011-12-31

申请号：HRP20110809

申请日：2011-11-02

Applicant: ABBOTT LAB

Inventor： FLENTGE CHARLES A ,  HUTCHINSON DOUGLAS K ,  BETEBENNER DAVID A ,  DEGOEY DAVID A ,  DONNER PAMELA L ,  KATI WARREN M ,  KRUEGER ALLAN C ,  LIU DACHUN ,  LIU YAYA ,  LONGENECKER KENTON L ,  MARING CLARENCE J ,  MOTTER CHRISTOPHER E ,  PRATT JOHN K ,  RANDOLPH JOHN T ,  ROCKWAY TODD W ,  STEWART KENT D ,  WAGNER ROLF ,  BARNES DAVID M ,  CHEN SHUANG ,  THADDEUS S ,  GAO YI ,  HAIGHT ANTHONY R ,  HENGEVELD JOHN E ,  KOTECKI BRIAN J ,  LOU XIAOCHUN ,  ZHANG GEOFF G Z

IPC: C07D239/22 ,  A61K31/513 ,  A61P31/12 ,  C07D239/54 ,  C07D401/10 ,  C07D403/10 ,  C07D405/10 ,  C07D409/10 ,  C07D413/10 ,  C07D417/10

公开(公告)号：ECSP11010937A

公开(公告)日：2011-05-31

申请号：ECSP11010937

申请日：2011-03-30

Applicant: ABBOTT LAB

Inventor： WOLLER KEVIN ROGER ,  HUTCHINSON DOUGLAS K ,  HUTCHINS CHARLES W ,  BETEBENNER DAVID A ,  PRATT JOHN K ,  WAGNER ROLF ,  TUFANO MICHAEL D ,  ROCKWAY TODD W ,  RANDOLPH JOHN T ,  MOTTER CHRISTOPHER E ,  MARING CLARENCE J ,  LIU DACHUN ,  KRUEGER ALLAN C ,  KATI WARREN M ,  FLENTGE CHARLES A ,  DONNER PAMELA L ,  DEGOEY DAVID A ,  SARRIS KATHY ,  NELSON LISSA T ,  PATEL SACHIN V ,  MATULENKO MARK A ,  KEDDY RYAN G ,  JINKERSON TAMMIE K ,  SOLTWEDEL TODD N ,  LAVIN MICHAEL J ,  WAGAW SEBIE H ,  CALIFANO JEAN C ,  LI WENKE ,  BELLIZZI MARY E ,  CASPI DANIEL D

IPC: C07D403/14

Abstract: Compuestos eficaces para inhibir la replicación del virus de la hepatitis C ("HCV"). Esta invención también se relaciona con procesos de elaboración de tales compuestos, con composiciones que comprenden a dichos compuestos y con métodos de uso de dichos compuestos para tratar una infección por HCV.

公开(公告)号：CA2737601A1

公开(公告)日：2010-12-16

申请号：CA2737601

申请日：2010-06-10

Applicant: ABBOTT LAB

Inventor： DEGOEY DAVID A ,  KATI WARREN M ,  HUTCHINS CHARLES W ,  DONNER PAMELA L ,  KRUEGER ALLAN C ,  RANDOLPH JOHN T ,  MOTTER CHRISTOPHER E ,  NELSON LISSA T ,  PATEL SACHIN V ,  MATULENKO MARK A ,  KEDDY RYAN G ,  JINKERSON TAMMIE K ,  SOLTWEDEL TODD N ,  HUTCHINSON DOUGLAS K ,  FLENTGE CHARLES A ,  WAGNER ROLF ,  MARING CLARENCE J ,  TUFANO MICHAEL D ,  BETEBENNER DAVID A ,  ROCKWAY TODD W ,  LIU DACHUN ,  PRATT JOHN K ,  LAVIN MICHAEL J ,  SARRIS KATHY ,  WOLLER KEVIN R ,  WAGAW SEBLE H ,  CALIFANO JEAN C ,  LI WENKE ,  CASPI DANIEL D ,  BELLIZZI MARY E

IPC: C07D403/14 ,  A61K31/4025 ,  A61K31/4178 ,  A61K31/4184 ,  A61K31/4196 ,  A61K31/4439 ,  A61P31/14 ,  C07D401/14 ,  C07D417/14

Abstract: Compounds effective in inhibiting replication of Hepatitis C virus ("HCV") are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.

公开(公告)号：CA2758484A1

公开(公告)日：2010-10-21

申请号：CA2758484

申请日：2010-04-14

Applicant: ABBOTT LAB

Inventor： DEGOEY DAVID A ,  HUTCHINS CHARLES W ,  KATI WARREN M ,  DONNER PAMELA L ,  NELSON LISSA T ,  JINKERSON TAMMIE K ,  KEDDY RYAN G ,  MOTTER CHRISTOPHER E ,  MATULENKO MARK A ,  KRUEGER ALLAN C ,  PATEL SACHIN V ,  RANDOLPH JOHN T ,  SOLTWEDEL TODD N

IPC: C07D205/02 ,  A61K31/454 ,  A61P29/00 ,  C07D207/16 ,  C07D209/52 ,  C07D401/12 ,  C07D403/04 ,  C07D403/12 ,  C07D413/12 ,  C07D417/12

Abstract: Compounds effective in inhibiting replication of Hepatitis C virus ("HCV") are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.

公开(公告)号：CA2755023A1

公开(公告)日：2010-09-30

申请号：CA2755023

申请日：2010-03-25

Applicant: ABBOTT LAB

Inventor： ROCKWAY TODD W ,  BETEBENNER DAVID A ,  DEGOEY DAVID A ,  FLENTGE CHARLES A ,  HUTCHINSON DOUGLAS K ,  KATI WARREN M ,  KRUEGER ALLAN C ,  LIU DACHUN ,  LONGENECKER KENTON L ,  PRATT JOHN K ,  STEWART KENT D ,  WAGNER ROLF ,  MARING CLARENCE J

IPC: C07D401/04 ,  A61K31/513 ,  A61P31/12 ,  C07D403/04 ,  C07D407/04 ,  C07D409/14

Abstract: This invention relates to: (a) compounds and salts thereof that, inter alia, inhibit HCV; (b) intermediates useful for the preparation of such compounds and salts; (c) compositions comprising such compounds and salts; (d) methods for preparing such intermediates, compounds, salts, and compositions; (e) methods of use of such compounds, salts, and compositions; and (f) kits comprising such compounds, salts, and compositions.

公开(公告)号：PE20090705A1

公开(公告)日：2009-07-17

申请号：PE2008001621

申请日：2008-09-17

Applicant: ABBOTT LAB

Inventor： WAGNER ROLF ,  TUFANO MICHAEL D ,  STEWART KENT D ,  ROCKWAY TODD W ,  RANDOLPH JOHN T ,  PRATT JOHN K ,  MOTTER CHRISTOPHER E ,  MARING CLARENCE J ,  LONGENECKER KENTON L ,  LIU YAYA ,  LIU DACHUN ,  KRUEGER ALLAN C ,  KATI WARREN M ,  HUTCHINSON DOUGLAS K ,  HUANG PEGGY P ,  FLENTGE CHARLES A ,  DONNER PAMELA L ,  DEGOEY DAVID A ,  BETEBENNER DAVID A ,  BARNES DAVID M ,  CHEN SHUANG ,  FRANCZYK THADDEUS S II ,  GAO YI ,  HAIGHT ANTHONY R ,  HENGEVELD JOHN E ,  HENRY RODGER F ,  KOTECKI BRIAN J ,  LOU XIAOCHUN ,  SARRIS KATHY ,  ZHANG GEOFF G Z

IPC: A61K31/513 ,  C07D239/22 ,  C07D239/54 ,  C07D401/10 ,  C07D409/10 ,  C07D417/10

Abstract: REFERIDA A UN COMPUESTO DE FORMULA (I), DONDE---- ES ENLACE SIMPLE CARBONO-CARBONO O UN ENLACE DOBLE CARBONO-CARBONO; R1 ES H, -CH3, GRUPO PROTECTOR DE N; R2 ES H, HALO, -OH, -CH3, CICLOPROPILO, ENTRE OTROS; R3 ES H, OXO, HALO, METILO; R4 ES HALO, ALQUILO, NO2, AZIDO, ENTRE OTROS; R5 ES H, -OH, ALQUILO, ALQUILOXI, ENTRE OTROS; R6 ES CARBOCICLILO DE 2 ANILLOS FUSIONADOS O HETEROCICLILO DE 2 ANILLOS FUSIONADOS, ENTRE OTROS; L ES UN ENLACE. DICHO COMPUESTO TIENE UN PATRON DE DIFRACCION DE RAYOS X DE POLVOS EXPRESADOS EN GRADOS 2 TETA DE 8,3+-0,2; 9,7+-0,2; 10,5+-0,2, ENTRE OTROS. UN COMPUESTO PREFRIDO ES N-(6-(3-TER-BUTIL-5-(2,4-DIOXO-3,4-DIHIDROPIRIMIDIN-1(2H)IL)2-METOXIFENIL)NAFTALEN-2-IL)METANSULFONAMIDA. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA QUE COMPRENDE LA FORMA CRISTALINA Y A UN PROCEDIMIENTO DE PREPARACION DE DICHA COMPOSICION LA CUAL ES UTIL PARA EL TRATAMIENTO DE LA HEPATITIS C

公开(公告)号：HK1121765A1

公开(公告)日：2009-04-30

申请号：HK09101934

申请日：2009-03-02

Applicant: ABBOTT LAB

Inventor： BETEBENNER DAVID A ,  DEGOEY DAVID A ,  MARING CLARENCE J ,  KRUEGER ALLAN C ,  IWASAKI NOBUHIKO ,  ROCKWAY TODD W ,  COOPER CURT S ,  ANDERSON DAVID D ,  DONNER PAMELA L ,  GREEN BRIAN E ,  KEMPF DALE J ,  LIU DACHUN ,  MCDANIEL KEITH F ,  MADIGAN DAROLD L ,  MOTTER CHRISTOPHER E ,  PRATT JOHN K ,  SHANLEY JASON P ,  TUFANO MICHAEL D ,  WAGNER ROLF ,  ZHANG RONG ,  MOLLA AKHTERUZZAMAN ,  MO HONGMEI ,  PILOT-MATIAS TAMI J ,  MASSE SHERIE VL ,  CARRICK ROBERT J ,  HE WEPING ,  LU LIANGJUN ,  GRAMPOVNIK DAVID J

IPC: C07D20060101

Abstract: Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) or other viruses are disclosed. This invention is also directed to compositions comprising such compounds, co-formulation or co-administration of such compounds with other anti-viral or therapeutic agents, processes and intermediates for the syntheses of such compounds, and methods of using such compounds for the treatment of HCV or other viral infections.

公开(公告)号：CA2699981A1

公开(公告)日：2009-03-26

申请号：CA2699981

申请日：2008-09-17

Applicant: ABBOTT LAB

Inventor： WAGNER ROLF ,  TUFANO MICHAEL D ,  STEWART KENT D ,  ROCKWAY TODD W ,  RANDOLPH JOHN T ,  PRATT JOHN K ,  MOTTER CHRISTOPHER E ,  MARING CLARENCE J ,  LONGENECKER KENTON L ,  LIU YAYA ,  LIU DACHUN ,  KRUEGER ALLAN C ,  KATI WARREN M ,  HUTCHINSON DOUGLAS K ,  HUANG PEGGY P ,  FLENTGE CHARLES A ,  DONNER PAMELA L ,  DEGOEY DAVID A ,  BETEBENNER DAVID A ,  BARNES DAVID M ,  CHEN SHUANG ,  FRANCZYK THADDEUS S II ,  GAO YI ,  HAIGHT ANTHONY R ,  HENGEVELD JOHN E ,  HENRY RODGER F ,  KOTECKI BRIAN J ,  LOU XIAOCHUN ,  SARRIS KATHY ,  ZHANG GEOFF G Z

IPC: C07D239/22 ,  A61K31/513 ,  A61P31/12 ,  C07D239/54 ,  C07D401/10 ,  C07D403/10 ,  C07D409/10 ,  C07D413/10 ,  C07D417/10

Abstract: Present application relates to the compounds of formula I useful to treat hepatitis C (HCV) infections. In the structure of the disclosed compounds is the uracil or thymine derivative linked via a phenylene into either fused 2-ring cyclic system (R6) or alternatively via additional two-atom linker (L) to a 5-6 membered monocycle (R6). Application further discloses polymorphs and pseudopolymorphs of two specific compounds: N-(6(3-t-butyl-5-(2>4-dioxo-3,4-dihydropyrimidin-1 (2H)- y!)2-methoxy-phenyl)naphthalen-2-yl)methanesulfonamide and (E)-N-(4(3-t- butyl-5-(2,4-dioxo-3)4-dihydropyrimidin-1 (2H)-yl)2-methoxy-styryl- phenyl)methanesulfonamide.