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    14.
    发明专利
    未知

    公开(公告)号：ES2168740T3

    公开(公告)日：2002-06-16

    申请号：ES98904979

    申请日：1998-02-06

    Applicant: ABBOTT LAB

    Inventor： WANG WEI-BO ,  KERDESKY FRANCIS A J ,  HSIAO CHI-NUNG W ,  LI QUN ,  CHU DANIEL T

    IPC: C07D455/02

    Abstract: A process for the preparation of a compound having the formula: wherein R1, R2, R3, R4, and R5 are defined, from an enamine by chain expansion and ring closure followed by additional derivatization, treatment with a 3-alkoxyl-acryloyl compound, another ring closure, and converting a hydroxyl group to a leaving group.

    15.
    发明专利
    未知

    公开(公告)号：AT217309T

    公开(公告)日：2002-05-15

    申请号：AT94929998

    申请日：1994-09-30

    Applicant: ABBOTT LAB

    Inventor： CHU DANIEL T ,  LI QUN ,  COOPER CURT S ,  FUNG ANTHONY K L ,  LEE CHEUK M ,  PLATTNER JACOB J

    IPC: C07D491/052 ,  A61K31/40 ,  A61K31/435 ,  A61K31/495 ,  A61K31/54 ,  A61K38/00 ,  A61P31/04 ,  C07D213/61 ,  C07D213/68 ,  C07D455/02 ,  C07D471/04 ,  C07D491/107 ,  C07D491/113 ,  C07D491/16 ,  C07D519/00 ,  C07K5/06 ,  A61K31/535

    Abstract: Antibacterical coumpounds having formula (I) and the pharmaceutically acceptable salts, esters and amides thereof, preferred examples of which include those coumpounds wherein R is cycloalkyl of from three to eight carbon atoms or substituted phenyl; R is selected from the group consisting of (a) halogen, (b) loweralkyl, (c) loweralkenyl, (d) cycloalkyl of from three to eight carbons, (e) cycloalkenyl of from four to eight carbons, (f) loweralkoxy, (g) aryloxy, (h) aryl(loweralkyl)oxy, (i) aryl(loweralkyl), (j) cycloalkyl(loweralkyl), (k) amino, (l) (loweralkyl)amino, (m) aryl(loweralkyl)amino, (n) hydroxy substituted (loweralkyl)amino, (o) phenyl, (p) substituted phenyl, (q) bicyclic nitrogen-containing heterocycle, (r) nitrogen-containingaromatic heterocycle, and (s) nitrogen-containing heterocycle having formula (Ia) where x is between zero and three; R is halogen; R is hydrogen, loweralkyl, a pharmaceutically acceptable cation, or a prodrug ester group; R is hydrogen, loweralkyl, halo(loweralkyl), or -NR R ; and R is loweralkyl, as wellas pharmaceutical compositions containing such compounds and the use of the same in the treatment of bacterial infections.

    Process for preparation of chiral 3-amino-pyrrolidine and analogous bicyclic compounds.
    19.
    发明专利
    Process for preparation of chiral 3-amino-pyrrolidine and analogous bicyclic compounds. 未知

    公开(公告)号：ZA979728B

    公开(公告)日：1998-05-22

    申请号：ZA979728

    申请日：1997-10-29

    Applicant: ABBOTT LAB

    Inventor： WANG WEI-BO ,  LI QUN ,  CHU DANIEL T ,  HASVOLD LISA ANNE

    IPC: C07D207/14 ,  C07D455/02 ,  C07D471/04 ,  C07D

    Abstract: A process for the preparation of chiral 3-aminopyrrolidine and analogous bicyclic derivatives from dihydroxy olefins by treatment with titanium isopropoxide, an optically active tartrate ester and tert-butyl hydroperoxide, followed by subsequent alkylation of the intermediate with an alkyl or alkenyl magnesium halide, then pyrrolidine ring formation by condensation with an arylmethylamine, subsequent chiral replacement of a ring hydroxyl group with an amino group with further protection thereof, optional additional substitution closing of the second ring, and hydrogenolysis to remove a ring-nitrogen protecting group.

    Quinolizinone type compounds
    20.
    发明专利
    Quinolizinone type compounds 未知

    公开(公告)号：AU7925894A

    公开(公告)日：1995-05-04

    申请号：AU7925894

    申请日：1994-09-30

    Applicant: ABBOTT LAB

    Inventor： CHU DANIEL T ,  LI QUN ,  COOPER CURT S ,  FUNG ANTHONY K L ,  LEE CHEUK M ,  PLATTNER JACOB J

    IPC: C07D491/052 ,  A61K31/40 ,  A61K31/435 ,  A61K31/495 ,  A61K31/54 ,  A61K38/00 ,  A61P31/04 ,  C07D213/61 ,  C07D213/68 ,  C07D455/02 ,  C07D471/04 ,  C07D491/107 ,  C07D491/113 ,  C07D491/16 ,  C07D519/00 ,  C07K5/06 ,  A61K31/535

    Abstract: Antibacterical coumpounds having formula (I) and the pharmaceutically acceptable salts, esters and amides thereof, preferred examples of which include those coumpounds wherein R is cycloalkyl of from three to eight carbon atoms or substituted phenyl; R is selected from the group consisting of (a) halogen, (b) loweralkyl, (c) loweralkenyl, (d) cycloalkyl of from three to eight carbons, (e) cycloalkenyl of from four to eight carbons, (f) loweralkoxy, (g) aryloxy, (h) aryl(loweralkyl)oxy, (i) aryl(loweralkyl), (j) cycloalkyl(loweralkyl), (k) amino, (l) (loweralkyl)amino, (m) aryl(loweralkyl)amino, (n) hydroxy substituted (loweralkyl)amino, (o) phenyl, (p) substituted phenyl, (q) bicyclic nitrogen-containing heterocycle, (r) nitrogen-containingaromatic heterocycle, and (s) nitrogen-containing heterocycle having formula (Ia) where x is between zero and three; R is halogen; R is hydrogen, loweralkyl, a pharmaceutically acceptable cation, or a prodrug ester group; R is hydrogen, loweralkyl, halo(loweralkyl), or -NR R ; and R is loweralkyl, as wellas pharmaceutical compositions containing such compounds and the use of the same in the treatment of bacterial infections.

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