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公开(公告)号:AU5921801A
公开(公告)日:2001-11-07
申请号:AU5921801
申请日:2001-04-25
Applicant: ABBOTT LAB
Inventor: WANG WEI-BO , CURTIN MICHAEL L , FAKHOURY STEPHEN A , GWALTNEY STEPHEN L II , HASVOLD LISA A , HUTCHINS CHARLES W , LI QUI , LIN NAN-HORNG , NELSON LISSA TAKA JENNINGS , O'CONNOR STEPHEN J , SHAM HING L , SULLIVAN GERALD M , WANG GARY T , WANG XILU
IPC: C07D233/22 , A61K31/381 , A61K31/415 , A61K31/4164 , A61K31/4178 , A61K31/4245 , A61K31/426 , A61K31/4406 , A61K31/4412 , A61K31/443 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/454 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61P17/06 , A61P27/02 , A61P27/06 , A61P29/00 , A61P35/00 , A61P35/02 , A61P37/06 , A61P43/00 , C07D213/30 , C07D213/36 , C07D213/38 , C07D213/40 , C07D213/42 , C07D213/57 , C07D213/61 , C07D213/64 , C07D213/80 , C07D213/82 , C07D213/84 , C07D213/85 , C07D231/12 , C07D233/26 , C07D233/54 , C07D249/04 , C07D249/08 , C07D277/20 , C07D277/24 , C07D277/28 , C07D277/30 , C07D333/16 , C07D333/24 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/10 , C07D405/12 , C07D409/10 , C07D413/10 , C07D413/12 , C07D417/06 , C07D417/10 , C07D417/12 , C07D233/00
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公开(公告)号:NZ336876A
公开(公告)日:2000-12-22
申请号:NZ33687698
申请日:1998-02-06
Applicant: ABBOTT LAB
Inventor: WANG WEI-BO , KERDESKY FRANCIS A J , LI QUN , CHU DANIEL T , HSIAO CHI-NUNG W
IPC: C07D455/02
Abstract: Substituted pyrazole-3-yl benzazoles of formula (I) and salts thereof wherein: R1 is H, alkyl or alkyl halide; R2 is CN, alkyl, haloalkyl, alkoxy, haloalkoxy, alkylthio, haloalkylthio, alkylsulphinyl, haloalkylsulphinyl, alkylsulphonyl, or haloalkylsulphonyl; R3 is H, CN, NO2, halogen, alkyl or haloalkyl; R4 is H, halogen; R5 is H, CN, halogen, alkyl, haloalkyl, alkoxy or haloalkoxy; Z is N=C(XR6)O or N=C(XR6)S, bonded to alpha by the nitrogen, oxygen or sulphur; X is a chemical bond, oxygen, sulphur, S(O), SO2, NH or N(R7); R6 and R7 are alkyl, haloalkyl, cyanoalkyl, hydroxyalkyl, alkenyl, cyanoalkenyl, haloalkenyl, alkinyl, cyanoalkinyl, haloalkinyl, alkoxyalkyl, haloalkoxyalkyl, alkenyloxyalkyl, alkinyloxyalkyl, cycloalkyloxyalkyl, aminoalkyl, alkylaminoalkyl, di(alkyl)aminoalkyl, alkylthioalkyl, haloalkylthioalkyl, alkenylthio alkyl, alkinylthioalkyl, alkylsulphinylalkyl, haloalkylsulphinylalkyl, alkenylsulphinylalkyl, alkinylsulphinylalkyl, alkylsulphonylalkyl, haloalkylsulphonylalkyl, alkenylsulphonylalkyl, alkinylsulphonylalkyl, hydroxycarbonylalkyl, alkoxycarbonylalkyl, which can carry a CN or alkoxycarbonyl group, alkylthiocarbonylalkyl, aminocarbonylalkyl, alkylaminocarbonylalkyl, di(alkyl)aminocarbonylalkyl, dialkylphosphonylalkyl, alkoxyiminoalkyl, alkenyloxyiminoalkyl, optionally substituted cycloalkyl, cycloalkylalkyl, phenyl, phenylalkyl, 3 to 7member heterocyclic or heterocyclylalkyl, wherein each cycloalkyl ring and each heterocyclyl ring contain a CO or CS ring member; if X is a chemical bond, O, S, NH or N(R7), R6 also being alkylcarbonyl, haloalkylcarbonyl, alkoxycarbonyl, alkylsulphonyl or haloalkylsulphonyl; if X is a chemical bond, R6 additionally designating CN, SH, NH2, halogen, CH2CH(halogen)R8, CH=CHR8 or CH=C(halogen)R8, or R6 plus R7 designating an optionally substituted 1,3propylene, tetramethylene, pentamethylene or ethylene oxyethylene chain R8 is COOH, alkoxycarbonyl, alkylthiocarbonyl, CONH2, alkylaminocarbonyl, dialkylaminocarbonyl or dialkylphosphonyl. These substances are useful as herbicides and for the desiccation and/or defoliation of plants
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公开(公告)号:AU6408499A
公开(公告)日:2000-04-26
申请号:AU6408499
申请日:1999-10-01
Applicant: ABBOTT LAB
Inventor: WANG WEI-BO , LI QUN , HASVOLD LISA A , CHEN HUI-JU , LI LEPING , LARTEY PAUL A , CLAIBORNE AKIYO , STEINER BETH A , BENNANI YOUSSEF , DICKMAN DANIEL , DING HONG
IPC: C07C67/343 , C07D295/155 , C07K7/56 , C07K7/00
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公开(公告)号:CZ9902881A3
公开(公告)日:1999-11-17
申请号:CZ288199
申请日:1998-02-06
Applicant: ABBOTT LAB
Inventor: WANG WEI-BO , KERDESKY FRANCIS A J , HSAIO CHI-NUNG W , LI QUN , CHU DANIEL T
IPC: C07D455/02
CPC classification number: C07D455/02
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公开(公告)号:NO994108A
公开(公告)日:1999-10-25
申请号:NO994108
申请日:1999-08-25
Applicant: ABBOTT LAB
Inventor: WANG WEI-BO , KERDESKY FRANCIS A J , HSIAO CHI-NUNG W , LI QUN , CHU DANIEL T
IPC: C07D455/02
CPC classification number: C07D455/02
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公开(公告)号:CA2222322A1
公开(公告)日:1996-12-12
申请号:CA2222322
申请日:1996-06-05
Applicant: ABBOTT LAB
Inventor: CHU DANIEL T , LEE CHEUK M , FUNG ANTHONY K L , MA ZHENKUN , COOPER CURT S , LI QUN , WANG WEI-BO , PLATTNER JACOB J
IPC: A61K31/00 , A61K31/44 , A61K31/505 , A61K31/519 , A61K31/529 , A61K38/00 , A61P31/00 , A61P31/04 , C07D213/61 , C07D213/68 , C07D455/02 , C07D471/04 , C07D491/16 , C07D495/16 , C07D519/00 , C07K5/06 , A61K31/435 , A61K31/495 , A61K31/535 , A61K31/54 , A61K31/55 , A61K38/04 , C07K5/04
Abstract: Antibacterial compounds having formula (I) and the pharmaceutically acceptable salts, esters and amides thereof, selected preferred examples of which include those compounds wherein A is =CR6-; R1 is cycloalkyl of from three to eight carbon atoms or substituted phenyl; R2 is selected from the group consisting of (a), (b), (c) and (d); R3 is halogen; R4 is hydrogen, loweralkyl, a pharmaceutically acceptable cation, or a prodrug ester group; R5 is hydrogen, loweralkyl, halo(loweralkyl), or -NR13R14; and R6 is halogen, loeralkyl, halo(loweralkyl), hydroxy-substituted loweralkyl, loweralkoxy(loweralkyl), loweralkoxy, or amino(loweralkyl), as well as pharmaceutical compositions containing such compounds and the use of the same in the treatment of bacterial infections.
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公开(公告)号:CA2281734A1
公开(公告)日:1998-09-03
申请号:CA2281734
申请日:1998-02-06
Applicant: ABBOTT LAB
Inventor: CHU DANIEL T , HSIAO CHI-NUNG W , LI-QUN , KERDESKY FRANCIS A J , WANG WEI-BO
IPC: C07D455/02
Abstract: A process for the preparation of a compound having formula (a) wherein R1, R2, R3, R4, and R5 are defined, from an enamine by chain expansion and ring closure followed by additional derivatization, treatment with a 3-alkoxyl-acryloyl compound, another ring closure, and converting a hydroxyl group to a leaving group.
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公开(公告)号:ZA98836B
公开(公告)日:1998-08-05
申请号:ZA98836
申请日:1998-02-02
Applicant: ABBOTT LAB
Inventor: WANG WEI-BO , HSAIO CHI-NUNG W , CHU DANIEL T , KERDESKY FRANCIS A J , LI QUN
IPC: C07D455/02 , C07D
Abstract: A process for the preparation of a compound having the formula: wherein R1, R2, R3, R4, and R5 are defined, from an enamine by chain expansion and ring closure followed by additional derivatization, treatment with a 3-alkoxyl-acryloyl compound, another ring closure, and converting a hydroxyl group to a leaving group.
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公开(公告)号:ZA9800836B
公开(公告)日:1998-08-05
申请号:ZA9800836
申请日:1998-02-02
Applicant: ABBOTT LAB
Inventor: WANG WEI-BO , HSAIO CHI-NUNG W , CHU DANIEL T , KERDESKY FRANCIS A J , LI QUN
IPC: C07D455/02 , C07D
CPC classification number: C07D455/02
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公开(公告)号:MX9709416A
公开(公告)日:1998-07-31
申请号:MX9709416
申请日:1997-12-02
Applicant: ABBOTT LAB
Inventor: CHU DANIEL T , LI QUN , COOPER CURT S , FUNG ANTHONY K , LEE CHEUK M , PLATTNER JACOB J , MA ZHENKUN , WANG WEI-BO
IPC: A61K31/00 , A61K31/44 , A61K31/505 , A61K31/519 , A61K31/529 , A61K38/00 , A61P31/00 , A61P31/04 , C07D213/61 , C07D213/68 , C07D455/02 , C07D471/04 , C07D491/16 , C07D495/16 , C07D519/00 , C07K5/06
Abstract: Compuestos antibacterianos que tienen la formula (I) y las sales, ésteres y amidas farmacéuticamente aceptables de los mismos, cuyos ejemplos preferidos seleccionados incluyen aquellos compuestos en donde A es =CR6-; R1 es cicloalquilo de desde tres hasta ocho átomos de carbono o fenilo sustituido; R2 se selecciona a partir del grupo que consiste de (a), (b), (c) y (d); R3 es halogeno; R4 es hidrogeno inferior, un cation farmacéuticamente aceptable, o un grupoéster de profármaco; R5 es hidrogeno, alquilo inferor, halo(alquilo inferior), o -NR13R14, y R6 es halogeno, alquilo inferior, o amino(alquilo inferior), así como composiciones farmacéuticas que contienen estos compuestos, y el uso de las mismas en el tratamiento de infecfciones bacterianas.
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