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公开(公告)号：UY38403A
公开(公告)日：2020-04-30
申请号：UY38403
申请日：2019-10-07
Applicant: VERTEX PHARMA
Inventor： JONES PETER , NUHANT PHILIPPE MARCEL , BANDARAGE UPUL KEERTHI , BLIGH CAVAN MCKEON , BOUCHER DIANE M , DEWEY FANNING LEV TYLER , ECCLES MARY ELIZABETH , FIMOGNARI JR ROBERT FRANCIS , GAGNON KEVIN JAMES , BOYD MICHAEL JOHN , GARCÍA BARRANTES PEDRO M , GIROUX SIMON , GREY JR RONALD LEE , HALL AMY BETH , HOOD SARAH CAROL , HURLEY DENNIS JAMES , HUSSEY JOSHUA KENNEDY , JOHNSON JR , KESAVAN SARATHY , LOOKER ADAM , MAXWELL BRAD D , MAXWELL JOHN PATRICK , MEDEK ALES , NAVAMAL METTACHIT , RODAY SETU , ROEPER STEFANIE , SAWANT RUPA , SHI YI , SWETT REBECCA JANE , TANG QING , TAPLEY TIMOTHY LEWIS , THOMSON STEPHEN A , WALDO MICHAEL , XU JINWANG , DAMAGNEZ VERONIQUE , BRODNEY MICHAEL AARON
IPC: A61P1/16 , A61K31/4162 , A61K31/437 , A61K31/497 , A61P11/00 , C07D471/14 , C07D487/04 , C07D487/14 , C07F5/04
Abstract: Nuevos compuestos, composiciones y métodos de uso y preparación de los mismos, que pueden ser útiles para el tratamiento de la deficiencia de alfa-1 antitripsina (AATD).
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公开(公告)号：ME03336B
公开(公告)日：2019-10-20
申请号：MEP201955
申请日：2014-03-12
Applicant: VERTEX PHARMA
Inventor： CHARIFSON PAUL , DENG HONGBO , GU WENXIN , GIROUX SIMON , JACKSON KATRINA LEE , LI PAN , XU JINWANG , MAXWELL JOHN PATRICK , TANG QING , RONKIN STEVEN M , PIERCE ALBERT CHARLES , LAUFFER DAVID J , MORRIS MARK A , COURT JOHN J , COTTRELL KEVIN M , WAAL NATHAN D
IPC: A61K31/517 , A61P35/00 , C07D403/12 , C07D405/12 , C07D413/04 , C07D417/12 , C07D491/052
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公开(公告)号：HRP20190373T1
公开(公告)日：2019-04-19
申请号：HRP20190373
申请日：2019-02-26
Applicant: VERTEX PHARMA
Inventor： MAXWELL JOHN PATRICK , CHARIFSON PAUL S , TANG QING , RONKIN STEVEN M , JACKSON KATRINA LEE , PIERCE ALBERT CHARLES , LAUFFER DAVID J , LI PAN , GIROUX SIMON , XU JINWANG , MORRIS MARK A , COURT JOHN J , COTTRELL KEVIN M , DENG HONGBO , WAAL NATHAN D , GU WENXIN
IPC: C07D403/12 , A61K31/517 , A61P35/00 , C07D405/12 , C07D413/04 , C07D417/12 , C07D491/052
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公开(公告)号：HUE037516T2
公开(公告)日：2018-09-28
申请号：HUE14800181
申请日：2014-10-17
Applicant: VERTEX PHARMA
Inventor： CHARIFSON PAUL , COTTRELL KEVIN , DENG HONGBO , DUFFY JOHN , GAO HUAI , GIROUX SIMON , GREEN JEREMY , JACKSON KATRINA , KENNEDY JOSEPH , LAUFFER DAVID , LEDEBOER MARK , LI PAN , MAXWELL JOHN , MORRIS MARK , PIERCE ALBERT , WAAL NATHAN , XU JINWANG
IPC: A61P35/00
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公开(公告)号：AU2014244555B2
公开(公告)日：2018-06-28
申请号：AU2014244555
申请日：2014-03-12
Applicant: VERTEX PHARMA
Inventor： MAXWELL JOHN PATRICK , CHARIFSON PAUL S , TANG QING , RONKIN STEVEN M , JACKSON KATRINA LEE , PIERCE ALBERT CHARLES , LAUFFER DAVID J , LI PAN , GIROUX SIMON , XU JINWANG , COTTRELL KEVIN M , MORRIS MARK A , WAAL NATHAN D , COURT JOHN J , GU WENXIN , DENG HONGBO
IPC: C07D403/12 , A61K31/517 , A61P35/00 , C07D405/12 , C07D413/04 , C07D417/12 , C07D491/052
Abstract: The present invention relates to compounds (I) useful as inhibitors of DNA-PK. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
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Patent Agency Ranking
公开(公告)号：LT3057959T
公开(公告)日：2018-06-11
申请号：LT14800181
申请日：2014-10-17
Applicant: VERTEX PHARMA
Inventor： CHARIFSON PAUL , COTTRELL KEVIN , DENG HONGBO , DUFFY JOHN , GAO HUAI , GIROUX SIMON , GREEN JEREMY , JACKSON KATRINA , KENNEDY JOSEPH , LAUFFER DAVID , LEDEBOER MARK , LI PAN , MAXWELL JOHN , MORRIS MARK , PIERCE ALBERT , WAAL NATHAN , XU JINWANG
IPC: C07D403/12 , A61K31/506 , A61P35/00 , C07D401/14 , C07D403/14 , C07D405/14 , C07D471/04 , C07D493/04
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公开(公告)号：UA115983C2
公开(公告)日：2018-01-25
申请号：UAA201412561
申请日：2013-04-23
Applicant: VERTEX PHARMA
Inventor： CHARIFSON PAUL S , COTTRELL KEVIN MICHAEL , DENG HONGBO , DUFFY JOHN P , GAO HUAI , GIROUX SIMON , GREEN JEREMY , JACKSON KATRINA LEE , MAXWELL JOHN PATRICK , MORRIS MARK A , PIERCE ALBERT CHARLES , WAAL NATHAN D , KENNEDY JOSEPH M , LAUFFER DAVID J , LEDEBOER MARK WILLEM , LI PAN , XU JINWANG
IPC: C07D401/14 , C07D239/42 , C07D401/04 , C07D403/04 , C07D403/10 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/10 , C07D413/14 , C07D417/04 , C07D417/14 , C07D471/04 , C07D491/048
Abstract: Винахід, щопропонується, стосуєтьсясполук, яківідповідаютьнаступнійформулі EMBED ISISServer , (I) якізастосовуютьсяякінгібіториДНК-ПК. Такожу винаходіпропонуютьсяфармацевтичноприйнятнікомпозиції, щомістятьвказанісполуки, іспособиз використаннямкомпозиційу лікуваннірізнихзахворювань, станівабопорушень, такихякрак.
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公开(公告)号：SG11201507203RA
公开(公告)日：2015-10-29
申请号：SG11201507203R
申请日：2014-03-12
Applicant: VERTEX PHARMA
Inventor： MAXWELL JOHN PATRICK , CHARIFSON PAUL S , TANG QING , RONKIN STEVEN M , JACKSON KATRINA LEE , PIERCE ALBERT CHARLES , LAUFFER DAVID J , LI PAN , GIROUX SIMON , XU JINWANG , COTTRELL KEVIN M , MORRIS MARK A , WAAL NATHAN D , COURT JOHN J , GU WENXIN , DENG HONGBO
IPC: A61K31/517 , A61P35/00 , C07D403/12 , C07D405/12 , C07D413/04 , C07D417/12 , C07D491/052
Abstract: The present invention relates to compounds useful as inhibitors of DNA-PK. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
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公开(公告)号：PT2663556E
公开(公告)日：2014-11-27
申请号：PT12708416
申请日：2012-01-13
Applicant: VERTEX PHARMA
Inventor： WANG TIANSHENG , SHANNON DEAN , GIROUX SIMON
IPC: C07D405/10 , C07D405/14
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公开(公告)号：ZA201305232B
公开(公告)日：2014-11-26
申请号：ZA201305232
申请日：2013-07-11
Applicant: VERTEX PHARMA
Inventor： SHANNON DEAN , WANG TIANSHENG , GIROUX SIMON
IPC: C07D20060101
Abstract: The present application is directed to compounds, intermediates and methods for preparing compounds of formula (I) or a pharmaceutically acceptable salts thereof, wherein R is H or F, and each of R3, R4, and R5 are as defined herein. The compounds of formula (I) and pharmaceutical compositions comprising said compounds and salts inhibit bacterial gyrase and/or Topo IV and are useful in treating bacterial infections.
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